MA38986A3 - Inhibiteurs marqués de l'antigène membranaire spécifique de la prostate (psma), leur utilisation comme agents d'imagerie et agents pharmaceutiques pour le traitement du cancer de la prostate - Google Patents
Inhibiteurs marqués de l'antigène membranaire spécifique de la prostate (psma), leur utilisation comme agents d'imagerie et agents pharmaceutiques pour le traitement du cancer de la prostateInfo
- Publication number
- MA38986A3 MA38986A3 MA38986A MA38986A MA38986A3 MA 38986 A3 MA38986 A3 MA 38986A3 MA 38986 A MA38986 A MA 38986A MA 38986 A MA38986 A MA 38986A MA 38986 A3 MA38986 A3 MA 38986A3
- Authority
- MA
- Morocco
- Prior art keywords
- treatment
- prostate cancer
- psma
- agents
- specific membrane
- Prior art date
Links
- 206010060862 Prostate cancer Diseases 0.000 title abstract 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 title abstract 2
- 239000012216 imaging agent Substances 0.000 title abstract 2
- 101710181478 Envelope glycoprotein GP350 Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 239000008177 pharmaceutical agent Substances 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000009206 nuclear medicine Methods 0.000 abstract 1
- 239000012217 radiopharmaceutical Substances 0.000 abstract 1
- 229940121896 radiopharmaceutical Drugs 0.000 abstract 1
- 230000002799 radiopharmaceutical effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La présente invention concerne de façon générale le domaine des produits radio-pharmaceutiques et leur utilisation en médecine nucléaire comme marqueurs, agents d'imagerie et pour le traitement de divers stades du cancer de la prostate. Ainsi, la présente invention concerne des composés qui sont représentés par la formule générale (ia) ou (ib).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20130004991 EP2862857A1 (fr) | 2013-10-18 | 2013-10-18 | Inhibiteurs marqués de l'antigène membranaire spécifique de la prostate (PSMA), leur utilisation comme agents d'imagerie et agents pharmaceutiques pour le traitement du cancer de la prostate |
| PCT/EP2014/002808 WO2015055318A1 (fr) | 2013-10-18 | 2014-10-17 | Inhibiteurs marqués de l'antigène membranaire spécifique de la prostate (psma), leur utilisation comme agents d'imagerie et agents pharmaceutiques pour le traitement du cancer de la prostate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA38986A3 true MA38986A3 (fr) | 2018-06-29 |
| MA38986B1 MA38986B1 (fr) | 2019-05-31 |
Family
ID=49513705
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA38986A MA38986B1 (fr) | 2013-10-18 | 2014-10-17 | Inhibiteurs marqués de l'antigène membranaire spécifique de la prostate (psma), leur utilisation comme agents d'imagerie et agents pharmaceutiques pour le traitement du cancer de la prostate |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP2862857A1 (fr) |
| CY (1) | CY1126819T1 (fr) |
| MA (1) | MA38986B1 (fr) |
| PT (1) | PT4095130T (fr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6792875B2 (ja) * | 2015-07-07 | 2020-12-02 | ファイブ イレブン ファーマ インコーポレイテッド | Hbed−ビスホスホネート、その放射性金属コンジュゲート、およびセラノスティック剤としてのそれらの使用 |
| US10688200B2 (en) * | 2015-12-31 | 2020-06-23 | Five Eleven Pharma Inc. | Urea-based prostate specific membrane antigen (PSMA) inhibitors for imaging and therapy |
| KR20250057132A (ko) | 2016-03-22 | 2025-04-28 | 더 존스 홉킨스 유니버시티 | 전립선 암의 내부방사선요법을 위한 전립선-특이적 막 항원 표적화된 고-친화성 제제 |
| WO2018233798A1 (fr) | 2017-06-20 | 2018-12-27 | ITM Isotopen Technologien München AG | Nouveaux agents de liaison à psma et utilisation de ces agents |
| WO2018215627A1 (fr) | 2017-05-24 | 2018-11-29 | ITM Isotopen Technologien München AG | Nouveaux agents de liaison au psma et utilisation de ces agents |
| US11478558B2 (en) * | 2017-05-30 | 2022-10-25 | The Johns Hopkins University | Prostate-specific membrane antigen targeted high-affinity agents for endoradiotherapy of prostate cancer |
| WO2020108753A1 (fr) | 2018-11-28 | 2020-06-04 | ITM Isotopen Technologien München AG | Nouveaux agents de liaison à l'antigene tumoral et utilisations de ces agents |
| WO2020224780A1 (fr) | 2019-05-08 | 2020-11-12 | ITM Isotopen Technologien München AG | Acide para-aminohippurique (pah) en tant que substance protectrice rénale |
| CN112321673B (zh) * | 2020-11-04 | 2022-09-20 | 北京市肿瘤防治研究所 | 一种前列腺特异性膜抗原靶向抑制剂及应用和探针 |
| WO2022096103A1 (fr) | 2020-11-05 | 2022-05-12 | ITM Isotopen Technologien München AG | Association d'acide para-aminohippurique (pah) et de complexes radiomarqués destinée au traitement du cancer |
| WO2022101352A1 (fr) * | 2020-11-12 | 2022-05-19 | Abx Advanced Biochemical Compounds Gmbh | Ligands de l'antigène membranaire spécifique de la prostate (psma) contenant des blocs de construction de lieur hétéroaromatiques |
| WO2022111800A1 (fr) | 2020-11-25 | 2022-06-02 | Itm Solucin Gmbh | Formulations stables pour complexes de radionucléides |
| CN113372285B (zh) * | 2021-05-28 | 2024-06-18 | 西南医科大学附属医院 | 前列腺特异性膜抗原抑制剂、其放射性核素标记物及制法和应用 |
| CN115010629B (zh) * | 2022-06-07 | 2024-02-23 | 西南医科大学附属医院 | 前列腺特异性膜抗原抑制剂、其核素标记物及制法和应用 |
| KR20250130683A (ko) | 2023-01-10 | 2025-09-02 | 썬 파마 어드밴스트 리서치 컴패니 리미티드 | 리간드-약물 접합체 |
| KR20250148672A (ko) * | 2023-02-16 | 2025-10-14 | 노로이 바이오사이언스 씨오., 엘티디. | Psma 표적 방사성 약물 및 그 합성과 응용 |
| WO2025218879A1 (fr) | 2024-04-15 | 2025-10-23 | Itm Technologies Munich Se | Formulations stables comprenant des complexes marqués par actinium-225 et leurs procédés de préparation |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE045028T2 (hu) | 2011-08-05 | 2019-12-30 | Molecular Insight Pharm Inc | Radiojelzett prosztataspecifikus membrán antigén inhibitorok |
-
2013
- 2013-10-18 EP EP20130004991 patent/EP2862857A1/fr not_active Withdrawn
-
2014
- 2014-10-17 MA MA38986A patent/MA38986B1/fr unknown
- 2014-10-17 PT PT221787369T patent/PT4095130T/pt unknown
-
2024
- 2024-04-18 CY CY20241100272T patent/CY1126819T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2862857A1 (fr) | 2015-04-22 |
| CY1126819T1 (el) | 2025-05-09 |
| PT4095130T (pt) | 2024-04-04 |
| MA38986B1 (fr) | 2019-05-31 |
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