MA39568A1 - Dérivé de macrolide de polyène - Google Patents

Dérivé de macrolide de polyène

Info

Publication number
MA39568A1
MA39568A1 MA39568A MA39568A MA39568A1 MA 39568 A1 MA39568 A1 MA 39568A1 MA 39568 A MA39568 A MA 39568A MA 39568 A MA39568 A MA 39568A MA 39568 A1 MA39568 A1 MA 39568A1
Authority
MA
Morocco
Prior art keywords
polyene macrolide
macrolide derivative
formula
derivative
polyene
Prior art date
Application number
MA39568A
Other languages
English (en)
Inventor
Keisuke Miyazaki
Kenji Takaya
Takafumi Ohara
Hideki Sugimoto
Manabu Fujitani
Yuki Ogata
Naoyuki Suzuki
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of MA39568A1 publication Critical patent/MA39568A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

L'invention concerne un dérivé d'amphotéricine b représenté par la formule (i). Dans ladite formule, chaque symbole est tel que défini dans la description.Le composé de l'invention, qui se caractérise en ce qu'il présente une structure d'urée, une structure cyclique, hydroxyalkyle ou monoalkylcarbamoyle substitué à la position 16 (x), présente une activité antifongique.
MA39568A 2014-06-12 2015-06-12 Dérivé de macrolide de polyène MA39568A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2014121341 2014-06-12
PCT/JP2015/066976 WO2015190587A1 (fr) 2014-06-12 2015-06-12 Dérivé de macrolide de polyène

Publications (1)

Publication Number Publication Date
MA39568A1 true MA39568A1 (fr) 2017-09-29

Family

ID=54833670

Family Applications (1)

Application Number Title Priority Date Filing Date
MA39568A MA39568A1 (fr) 2014-06-12 2015-06-12 Dérivé de macrolide de polyène

Country Status (16)

Country Link
US (2) US10246478B2 (fr)
EP (1) EP3156410A4 (fr)
JP (1) JP6601818B2 (fr)
KR (1) KR102106765B1 (fr)
CN (1) CN106414473B (fr)
AU (1) AU2015272398B2 (fr)
BR (1) BR112016028890A8 (fr)
CA (1) CA2951516C (fr)
EA (1) EA037093B1 (fr)
IL (1) IL249430B (fr)
MA (1) MA39568A1 (fr)
MX (1) MX378786B (fr)
PH (1) PH12016502357A1 (fr)
SG (1) SG11201610162XA (fr)
TW (1) TWI702223B (fr)
WO (1) WO2015190587A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6755859B2 (ja) 2014-10-17 2020-09-16 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイＴｈｅ Ｂｏａｒｄ Ｏｆ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｉｌｌｉｎｏｉｓ アムホテリシンｂの毒性が低減された誘導体の規模変更可能な合成法
WO2016112260A1 (fr) * 2015-01-08 2016-07-14 The Board Of Trustees Of The University Of Illinois Synthèse concise de dérivés d'urée d'amphotéricine b
CA3213127A1 (fr) * 2015-04-15 2016-10-20 Sfunga Therapeutics, Inc. Derives d'amphotericine b
WO2017100171A1 (fr) * 2015-12-08 2017-06-15 Kalyra Pharmaceuticals, Inc. Composés antifongiques et procédés s'y rapportant
WO2018106571A1 (fr) * 2016-12-06 2018-06-14 Kalyra Pharmaceuticals, Inc. Composés antifongiques et procédés
US11198705B2 (en) 2018-09-07 2021-12-14 The Board Of Trustees Of The University Of Illinois Hybrid Amphotericin B derivatives with reduced toxicity
EP4009985A4 (fr) * 2019-08-08 2023-09-06 The Board Of Trustees Of The University Of Illinois Dérivés amides hybrides d'amphotéricine b
CA3190997A1 (fr) * 2020-08-10 2022-02-17 The Board Of Trustees Of The University Of Illinois Derives amides hybrides d'amphotericine b
CN111909226A (zh) * 2020-08-11 2020-11-10 深圳市儿童医院 一种葡萄糖酸修饰的两性霉素b衍生物及其用途
CN115536716B (zh) * 2021-06-29 2025-08-08 中国科学院上海药物研究所 两性霉素b半合成衍生物及其制备方法和用途
CN113773355B (zh) * 2021-08-23 2023-03-10 湖南省微生物研究院 一种多烯大环内酯类化合物及其制备方法和应用
WO2026008878A1 (fr) * 2024-07-04 2026-01-08 Algipharma As Conjugués oligomère de polyène-alginate antimycosiques

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL122086B1 (en) 1979-04-09 1982-06-30 Politechnika Gdanska Process for preparing amides of antibiotics from the group of polyene macrolides and their derivativesvykh makrolidov i ikh proizvodnykh
ZA807892B (en) * 1979-12-24 1981-12-30 Dumex Ltd As Water soluble guanidine derivatives of polyene marcrolides and the esters thereof
JPS56123794A (en) * 1980-02-29 1981-09-29 Nippon Denso Co Ltd Load driving unit for vehicle
JPH024295A (ja) * 1988-06-22 1990-01-09 Toshiba Corp 医用画像診断装置
GB8829593D0 (en) * 1988-12-19 1989-02-08 Beecham Group Plc Novel compounds
FR2654339B1 (fr) 1989-11-14 1994-10-28 Mayoly Spindler Laboratoires Nouveaux derives solubles et non toxiques des macrolides polyeniques basiques, leur preparation et leurs applications.
FR2683723B1 (fr) * 1991-11-14 1995-05-19 Mayoly Spindler Laboratoires Nouveaux medicaments antiviraux actifs sur le virus vih.
AU3460693A (en) 1992-02-12 1993-09-03 Smithkline Beecham Plc Amphotericin B derivative
GB9203476D0 (en) 1992-02-19 1992-04-08 Smithkline Beecham Plc Novel compounds
US5606038A (en) 1995-04-10 1997-02-25 Competitive Technologies, Inc. Amphiphilic polyene macrolide antibiotic compounds
PL180253B1 (pl) 1995-05-13 2001-01-31 Politechnika Gdanska Pochodne N-metylo-N-glikozylowe estrów metylowych antybiotyków z grupy makrolidów polienowych i ich sole oraz sposób ich otrzymywania PL PL PL PL PL PL
FR2776927B1 (fr) 1998-04-07 2002-07-05 Univ Paris Curie Compositions pour la vectorisation de molecules
EP1198755A2 (fr) 1999-08-02 2002-04-24 Glaxo Group Limited Procedes informatises permettant d'estimer les couts et avantages relatifs aux interventions de gestion therapeutique
AU780724B2 (en) 2000-01-14 2005-04-14 Migenix Inc. Derivatives of polyene macrolides and preparation and use thereof
EP1987049A1 (fr) * 2006-02-23 2008-11-05 ETH Zürich Dérivés d'amphotéricine
US8217013B2 (en) 2007-07-30 2012-07-10 Shanghai Institute Of Pharmaceutical Industry Polyene diester antibiotics
MX365184B (es) 2010-12-21 2019-05-21 Centro De Investig Y De Estudios Avanzados Del I P N Nuevos compuestos analogos de la anfotericina y composiciones farmaceuticas que los contienen.
WO2013186384A1 (fr) * 2012-06-15 2013-12-19 Blirt S.A. Dérivés de seconde génération n-substitués de l'amphotéricine b antibiotique antifongique et leurs procédés de préparation et d'utilisation
JP6600303B2 (ja) 2013-10-07 2019-10-30 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイ 治療指数が改善されたアンフォテリシンｂ誘導体
WO2016112243A1 (fr) * 2015-01-08 2016-07-14 The Board Of Trustees Of The University Of Illinois Dérivés d'urée de l'amphotéricine b dérivée d'amines secondaires
CA3213127A1 (fr) 2015-04-15 2016-10-20 Sfunga Therapeutics, Inc. Derives d'amphotericine b

Also Published As

Publication number Publication date
AU2015272398B2 (en) 2018-04-26
EA201692508A1 (ru) 2017-04-28
BR112016028890A8 (pt) 2021-03-23
TWI702223B (zh) 2020-08-21
EP3156410A4 (fr) 2018-01-03
MX378786B (es) 2025-03-11
KR102106765B1 (ko) 2020-05-06
MX2016015455A (es) 2017-03-23
BR112016028890A2 (pt) 2017-08-22
EA037093B1 (ru) 2021-02-04
IL249430B (en) 2020-05-31
US10246478B2 (en) 2019-04-02
JPWO2015190587A1 (ja) 2017-04-20
IL249430A0 (en) 2017-02-28
SG11201610162XA (en) 2017-01-27
JP6601818B2 (ja) 2019-11-06
KR20170016957A (ko) 2017-02-14
WO2015190587A1 (fr) 2015-12-17
TW201625655A (zh) 2016-07-16
PH12016502357A1 (en) 2017-02-13
US20170190729A1 (en) 2017-07-06
US20190135847A1 (en) 2019-05-09
CA2951516A1 (fr) 2015-12-17
EP3156410A1 (fr) 2017-04-19
AU2015272398A1 (en) 2016-12-08
CA2951516C (fr) 2019-04-02
CN106414473A (zh) 2017-02-15
US10696707B2 (en) 2020-06-30
CN106414473B (zh) 2020-03-13

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