MA39707A - Dérivés de 1,2-dihydro-3h-pyrrolo [1,2-c]imidazol-3-one et leur utilisation comme agents antibactériens - Google Patents

Dérivés de 1,2-dihydro-3h-pyrrolo [1,2-c]imidazol-3-one et leur utilisation comme agents antibactériens

Info

Publication number
MA39707A
MA39707A MA039707A MA39707A MA39707A MA 39707 A MA39707 A MA 39707A MA 039707 A MA039707 A MA 039707A MA 39707 A MA39707 A MA 39707A MA 39707 A MA39707 A MA 39707A
Authority
MA
Morocco
Prior art keywords
sup
pyrrolo
imidazol
dihydro
derivatives
Prior art date
Application number
MA039707A
Other languages
English (en)
Other versions
MA39707B1 (fr
Inventor
Gaelle Chapoux
Jean-Christophe Gauvin
Azely Mirre
Philippe Panchaud
Christine Schmitt
Jean-Luc Specklin
Jean-Philippe Surivet
Original Assignee
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idorsia Pharmaceuticals Ltd filed Critical Idorsia Pharmaceuticals Ltd
Publication of MA39707A publication Critical patent/MA39707A/fr
Publication of MA39707B1 publication Critical patent/MA39707B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

<!--startfragment-->l'invention concerne des composés antibactériens de la formule (i), dans laquelle r<sup>1</sup> est l'un des groupes représentés ci-dessous (aa), a est une liaison, ch=ch ou c≡c; u est n ou ch; v est n ou ch; w représente n ou ch; r<sup>1a</sup>, r<sup>2a</sup>, r<sup>3a</sup>, r<sup>1b</sup> et r<sup>1c</sup> sont tels que définis dans les revendications; les sels de ceux-ci.<!--endfragment-->
MA39707A 2014-03-04 2015-03-03 Dérivés de 1,2-dihydro-3h-pyrrolo [1,2-c]imidazol-3-one et leur utilisation comme agents antibactériens MA39707B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14157636 2014-03-04
EP15707154.9A EP3114126B1 (fr) 2014-03-04 2015-03-03 Dérivés de 1,2-dihydro-3h-pyrrolo [1,2-c]imidazol-3-one et leur utilisation comme agents antibactériens
PCT/EP2015/054358 WO2015132228A1 (fr) 2014-03-04 2015-03-03 Dérivés 1,2-dihydro-3h-pyrrolo[1,2-c]imidazol-3-one et leur utilisation en tant qu'agents antibactériens

Publications (2)

Publication Number Publication Date
MA39707A true MA39707A (fr) 2017-01-11
MA39707B1 MA39707B1 (fr) 2019-01-31

Family

ID=50189621

Family Applications (1)

Application Number Title Priority Date Filing Date
MA39707A MA39707B1 (fr) 2014-03-04 2015-03-03 Dérivés de 1,2-dihydro-3h-pyrrolo [1,2-c]imidazol-3-one et leur utilisation comme agents antibactériens

Country Status (31)

Country Link
US (1) US10106544B2 (fr)
EP (1) EP3114126B1 (fr)
JP (1) JP6516370B2 (fr)
KR (1) KR20160127127A (fr)
CN (1) CN106061977B (fr)
AR (1) AR099612A1 (fr)
AU (1) AU2015226250B2 (fr)
BR (1) BR112016020278A8 (fr)
CA (1) CA2938383A1 (fr)
CL (1) CL2016002207A1 (fr)
CY (1) CY1121362T1 (fr)
DK (1) DK3114126T3 (fr)
EA (1) EA030708B1 (fr)
ES (1) ES2709382T3 (fr)
HR (1) HRP20190013T1 (fr)
HU (1) HUE042371T2 (fr)
IL (1) IL247544A0 (fr)
LT (1) LT3114126T (fr)
MA (1) MA39707B1 (fr)
MX (1) MX2016011380A (fr)
PH (1) PH12016501699A1 (fr)
PL (1) PL3114126T3 (fr)
PT (1) PT3114126T (fr)
SA (1) SA516371717B1 (fr)
SG (1) SG11201607304WA (fr)
SI (1) SI3114126T1 (fr)
TR (1) TR201900393T4 (fr)
TW (1) TW201542556A (fr)
UA (1) UA118868C2 (fr)
WO (1) WO2015132228A1 (fr)
ZA (1) ZA201606794B (fr)

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AR097617A1 (es) 2013-09-13 2016-04-06 Actelion Pharmaceuticals Ltd Derivados antibacterianos del 2h-indazol
JP6407288B2 (ja) 2013-12-19 2018-10-17 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ 抗菌性１ｈ−インダゾール及び１ｈ−インドール誘導体
EP3143007B1 (fr) 2014-05-16 2018-07-11 Idorsia Pharmaceuticals Ltd Dérivés de quinazoline-4 antibactérienne (3h)-one
AR105646A1 (es) * 2015-08-11 2017-10-25 Actelion Pharmaceuticals Ltd Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida
AR105839A1 (es) * 2015-08-28 2017-11-15 Actelion Pharmaceuticals Ltd Derivados antibacterianos pirrolidin-2-ona anulares
AR105848A1 (es) * 2015-08-31 2017-11-15 Actelion Pharmaceuticals Ltd Derivados heterocíclicos antibacterianos
AR105889A1 (es) 2015-09-03 2017-11-22 Actelion Pharmaceuticals Ltd Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos
TW201840569A (zh) 2017-03-01 2018-11-16 瑞士商愛杜西亞製藥有限公司 (2r)-n-羥基-4-(6-((1-(2-羥基乙基)氮雜環丁烷-3-基)丁-1,3-二炔-1-基)-3-氧基-1h-吡咯并[1,2-c]咪唑-2(3h)-基)-2-甲基-2-(甲磺醯基)丁醯胺之結晶形式
WO2019038362A1 (fr) 2017-08-24 2019-02-28 Idorsia Pharmaceuticals Ltd Pyrroloimidazolones antibactériennes
WO2019086452A1 (fr) 2017-10-31 2019-05-09 Idorsia Pharmaceuticals Ltd Composés hétéroaromatiques antibactériens
US20240382465A1 (en) * 2021-08-05 2024-11-21 Zhejiang Hisun Pharmaceutical Co., Ltd. Aromatic acetylene derivative, and preparation method therefor and use thereof

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TWI343377B (en) 2002-03-13 2011-06-11 Array Biopharma Inc N3 alkylated benzimidazole derivatives as mek inhibitors
US7781591B2 (en) 2006-06-13 2010-08-24 Wyeth Llc Substituted 3-cyanopyridines as protein kinase inhibitors
DE102004017930A1 (de) 2004-04-14 2005-11-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel
WO2006063281A2 (fr) 2004-12-10 2006-06-15 Emory University Analogues de nucleosides de cyclobutyle a substitution 2' et 3' pour le traitement des infections virales et de la proliferation cellulaire anormale
JP2008001635A (ja) 2006-06-22 2008-01-10 Toray Ind Inc グリシン誘導体及びその用途
DE102008044132A1 (de) 2008-11-27 2010-06-02 BSH Bosch und Siemens Hausgeräte GmbH Kältegerät mit zweiseitig anschlagbarer Tür
CA2758144C (fr) 2009-04-06 2014-05-13 Daiichi Sankyo Company, Limited Compose cyclique ayant un groupe phenyle substitue
EP2432468A2 (fr) 2009-05-20 2012-03-28 Ardea Biosciences, Inc. Procédés pour moduler des taux d'acide urique
CN102548975A (zh) 2009-07-07 2012-07-04 安瑟生物科技私人有限公司 组蛋白去乙酰化酶抑制剂
CA2774250C (fr) * 2009-10-13 2013-12-17 Pfizer Inc. Derives d'acide hydroxamique a liaison c utiles comme agents antibacteriens
PL2512474T3 (pl) 2009-12-16 2015-03-31 Pfizer N-przyłączone pochodne kwasu hydroksamowego użyteczne jako środki przeciwbakteryjne
AR083760A1 (es) 2010-11-10 2013-03-20 Achaogen Inc Agentes antibacterianos y composiciones farmaceuticas
US8853213B2 (en) 2011-01-03 2014-10-07 Hanmi Pharm. Co., Ltd Bicyclic compound for modulating G protein-coupled receptors
GEP20156370B (en) * 2011-03-07 2015-09-25 Pfizer Fluoro-pyridinone derivatives useful as antibacterial agents
EP2694481B1 (fr) * 2011-04-08 2015-12-30 Pfizer Inc Dérivés d'imidazole, de pyrazole et de triazole, utiles en tant qu'agents antibactériens
EP2694488B1 (fr) 2011-04-08 2014-11-12 Pfizer Inc Dérivés d'isoxazole utiles en tant qu'agents antibactériens
US8859559B2 (en) 2011-12-20 2014-10-14 Boehringer Ingelheim International Gmbh Substituted pyrazines and their use in the treatment of disease
WO2013170030A1 (fr) 2012-05-09 2013-11-14 Achaogen, Inc. Agents antibactériens
EP2847168A1 (fr) * 2012-05-10 2015-03-18 Achaogen, Inc. Agents antibactériens
WO2014165075A1 (fr) 2013-03-12 2014-10-09 Achaogen, Inc. Agents antibactériens
AR097617A1 (es) 2013-09-13 2016-04-06 Actelion Pharmaceuticals Ltd Derivados antibacterianos del 2h-indazol
JP6407288B2 (ja) 2013-12-19 2018-10-17 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ 抗菌性１ｈ−インダゾール及び１ｈ−インドール誘導体
EP3143007B1 (fr) 2014-05-16 2018-07-11 Idorsia Pharmaceuticals Ltd Dérivés de quinazoline-4 antibactérienne (3h)-one
AR105646A1 (es) 2015-08-11 2017-10-25 Actelion Pharmaceuticals Ltd Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida
AR105839A1 (es) 2015-08-28 2017-11-15 Actelion Pharmaceuticals Ltd Derivados antibacterianos pirrolidin-2-ona anulares
AR105848A1 (es) 2015-08-31 2017-11-15 Actelion Pharmaceuticals Ltd Derivados heterocíclicos antibacterianos
AR105889A1 (es) 2015-09-03 2017-11-22 Actelion Pharmaceuticals Ltd Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos
RU2018124788A (ru) 2015-12-08 2020-01-15 Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед Замещенные бензазиноны в качестве антибактериальных соединений

Also Published As

Publication number Publication date
US20170107223A1 (en) 2017-04-20
SA516371717B1 (ar) 2018-10-25
JP6516370B2 (ja) 2019-05-22
AR099612A1 (es) 2016-08-03
KR20160127127A (ko) 2016-11-02
SG11201607304WA (en) 2016-09-29
EP3114126B1 (fr) 2018-10-31
WO2015132228A1 (fr) 2015-09-11
JP2017508746A (ja) 2017-03-30
PT3114126T (pt) 2019-02-06
MA39707B1 (fr) 2019-01-31
LT3114126T (lt) 2018-12-27
ES2709382T3 (es) 2019-04-16
PH12016501699A1 (en) 2016-10-03
CY1121362T1 (el) 2020-05-29
UA118868C2 (uk) 2019-03-25
AU2015226250B2 (en) 2018-12-13
ZA201606794B (en) 2018-11-28
TR201900393T4 (tr) 2019-02-21
EA030708B1 (ru) 2018-09-28
BR112016020278A2 (fr) 2017-08-15
IL247544A0 (en) 2016-11-30
PL3114126T3 (pl) 2019-03-29
DK3114126T3 (en) 2019-02-25
AU2015226250A1 (en) 2016-10-20
TW201542556A (zh) 2015-11-16
BR112016020278A8 (pt) 2017-12-26
HRP20190013T1 (hr) 2019-02-22
CN106061977B (zh) 2018-10-26
US10106544B2 (en) 2018-10-23
EA201691775A1 (ru) 2017-03-31
CL2016002207A1 (es) 2017-03-24
EP3114126A1 (fr) 2017-01-11
MX2016011380A (es) 2016-12-07
CA2938383A1 (fr) 2015-09-11
HUE042371T2 (hu) 2019-06-28
SI3114126T1 (sl) 2019-01-31
CN106061977A (zh) 2016-10-26

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