MA39909A - Conjugué anticorps de l'igf-1r-médicament et son utilisation pour le traitement du cancer - Google Patents

Conjugué anticorps de l'igf-1r-médicament et son utilisation pour le traitement du cancer

Info

Publication number
MA39909A
MA39909A MA039909A MA39909A MA39909A MA 39909 A MA39909 A MA 39909A MA 039909 A MA039909 A MA 039909A MA 39909 A MA39909 A MA 39909A MA 39909 A MA39909 A MA 39909A
Authority
MA
Morocco
Prior art keywords
antibody
drug
conjugate
igf
treatment
Prior art date
Application number
MA039909A
Other languages
English (en)
Other versions
MA39909B1 (fr
Inventor
Charlotte Beau-Larvor
Matthieu Broussas
Thierry Champion
Liliane Goetsch
Jean-François Haeuw
Michel Perez
Ian Rilatt
Alain Robert
Original Assignee
Pf Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pf Medicament filed Critical Pf Medicament
Publication of MA39909A publication Critical patent/MA39909A/fr
Publication of MA39909B1 publication Critical patent/MA39909B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/68031—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being an auristatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne un conjugué anticorps-médicament pouvant se lier à l'igf-1r. Selon un aspect, l'invention concerne un conjugué anticorps-médicament comprenant un anticorps pouvant se lier à l'igf-1r, ledit anticorps étant conjugué à au moins un médicament choisi parmi des dérivés de la dolastatine 10 et des auristatines. L'invention concerne également une méthode de traitement et l'utilisation dudit conjugué anticorps-médicament pour le traitement du cancer.
MA39909A 2014-04-25 2015-04-27 Conjugué anticorps de l'igf-1r-médicament et son utilisation pour le traitement du cancer MA39909B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14305620 2014-04-25
EP15720045.2A EP3134124B1 (fr) 2014-04-25 2015-04-27 Conjugué anticorps-médicament igf-1r et son utilisation pour le traitement du cancer
PCT/EP2015/059045 WO2015162291A1 (fr) 2014-04-25 2015-04-27 Conjugué anticorps de l'igf-1r-médicament et son utilisation pour le traitement du cancer

Publications (2)

Publication Number Publication Date
MA39909A true MA39909A (fr) 2017-03-01
MA39909B1 MA39909B1 (fr) 2019-05-31

Family

ID=50630736

Family Applications (2)

Application Number Title Priority Date Filing Date
MA39909A MA39909B1 (fr) 2014-04-25 2015-04-27 Conjugué anticorps de l'igf-1r-médicament et son utilisation pour le traitement du cancer
MA047811A MA47811A (fr) 2014-04-25 2015-04-27 Kit comprenant un conjugué anticorps-médicament igf-1r et son utilisation pour le traitement du cancer

Family Applications After (1)

Application Number Title Priority Date Filing Date
MA047811A MA47811A (fr) 2014-04-25 2015-04-27 Kit comprenant un conjugué anticorps-médicament igf-1r et son utilisation pour le traitement du cancer

Country Status (27)

Country Link
US (2) US10633448B2 (fr)
EP (2) EP3498301A1 (fr)
JP (1) JP6258523B2 (fr)
KR (1) KR101795984B1 (fr)
CN (1) CN106456800B (fr)
AU (1) AU2015250759B2 (fr)
BR (1) BR112016024619A2 (fr)
CA (1) CA2946469C (fr)
CY (1) CY1121783T1 (fr)
DK (1) DK3134124T3 (fr)
ES (1) ES2727103T3 (fr)
HR (1) HRP20190888T8 (fr)
HU (1) HUE044862T2 (fr)
IL (1) IL248455B (fr)
LT (1) LT3134124T (fr)
MA (2) MA39909B1 (fr)
MX (1) MX372912B (fr)
MY (1) MY186711A (fr)
PL (1) PL3134124T3 (fr)
PT (1) PT3134124T (fr)
RS (1) RS58742B1 (fr)
RU (1) RU2692563C2 (fr)
SA (1) SA516380120B1 (fr)
SI (1) SI3134124T1 (fr)
TN (1) TN2016000472A1 (fr)
UA (1) UA120364C2 (fr)
WO (1) WO2015162291A1 (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112016024619A2 (pt) * 2014-04-25 2017-10-10 Pf Medicament conjugado de anticorpo ao igf-1r-fármaco e seu uso para o tratamento de câncer
JP6968790B2 (ja) 2015-10-26 2021-11-17 ピエール、ファーブル、メディカマン Ｉｇｆ−１ｒ発現癌の処置のための組成物
US11340233B2 (en) * 2016-03-07 2022-05-24 Pierre Fabre Medicament Universal method to capture and analyze ADCs for characterization of drug distribution and the drug-to-antibody ratio in biological samples
KR102858995B1 (ko) 2018-09-27 2025-09-11 피에르 파브르 메디카먼트 설포말레이미드계 링커 및 상응하는 컨쥬게이트
CN111327570B (zh) 2018-12-14 2021-09-17 北京京东尚科信息技术有限公司 验证方法、装置和计算机可读存储介质
EP3735991A1 (fr) * 2019-05-06 2020-11-11 Pierre Fabre Medicament Adc pour un traitement concomitant ou postérieur au docétaxel
AU2021248635B2 (en) * 2020-04-02 2025-10-23 Mersana Therapeutics, Inc. Antibody drug conjugates comprising STING agonists
EP3909612A1 (fr) 2020-05-12 2021-11-17 Life Science Inkubator Betriebs GmbH & Co. KG Composition de nanoparticules
CN118059229A (zh) * 2020-10-14 2024-05-24 维里迪安治疗公司 用于治疗甲状腺眼病的组合物和方法
KR20230158005A (ko) 2021-03-18 2023-11-17 씨젠 인크. 생물학적 활성 화합물의 내재화된 접합체로부터의 선택적 약물 방출
IL317567A (en) * 2022-06-10 2025-02-01 Acelyrin Inc ANTI-IGF-1R antibody compounds
EP4353220A1 (fr) 2022-10-12 2024-04-17 Pierre Fabre Medicament Utilisation d'une composition aqueuse liquide pour la solubilisation et la stabilisation d'un conjugué anticorps-médicament
WO2024180233A1 (fr) 2023-03-02 2024-09-06 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Vaccin thérapeutique contre le hpv basé sur des épitopes cibles validés
AU2024241633A1 (en) 2023-03-30 2025-11-06 Revolution Medicines, Inc. Compositions for inducing ras gtp hydrolysis and uses thereof
WO2024229406A1 (fr) 2023-05-04 2024-11-07 Revolution Medicines, Inc. Polythérapie pour une maladie ou un trouble lié à ras
AU2024279572A1 (en) * 2023-05-31 2025-12-04 Lirum Therapeutics, Inc. Methods for treating igf-1r-related cancers with an insulin-like growth factor 1 receptor ligand conjugated to a cytotoxic agent
US20250049810A1 (en) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
TW202530228A (zh) 2023-10-12 2025-08-01 美商銳新醫藥公司 Ｒａｓ抑制劑
WO2025171296A1 (fr) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Inhibiteurs de ras
TW202547461A (zh) 2024-05-17 2025-12-16 美商銳新醫藥公司 Ｒａｓ抑制劑
WO2025255438A1 (fr) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Procédés de traitement d'une maladie ou d'un trouble lié à la protéine ras
WO2025265060A1 (fr) 2024-06-21 2025-12-26 Revolution Medicines, Inc. Compositions thérapeutiques et procédés de gestion d'effets liés au traitement
WO2026006747A1 (fr) 2024-06-28 2026-01-02 Revolution Medicines, Inc. Inhibiteurs de ras
WO2026015801A1 (fr) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Méthodes de traitement d'une maladie ou d'un trouble liés à ras
WO2026015825A1 (fr) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Utilisation d'un inhibiteur de ras pour traiter le cancer du pancréas
WO2026015796A1 (fr) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Méthodes de traitement d'une maladie ou d'un trouble lié à ras
WO2026015790A1 (fr) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Méthodes de traitement d'une maladie ou d'un trouble lié à ras
WO2026050446A1 (fr) 2024-08-29 2026-03-05 Revolution Medicines, Inc. Inhibiteurs de ras

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
GB9014932D0 (en) 1990-07-05 1990-08-22 Celltech Ltd Recombinant dna product and method
WO1994004679A1 (fr) 1991-06-14 1994-03-03 Genentech, Inc. Procede pour fabriquer des anticorps humanises
JPH05244982A (ja) 1991-12-06 1993-09-24 Sumitomo Chem Co Ltd 擬人化ｂ−ｂ１０
US5639641A (en) 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
CA2173150C (fr) 1993-10-01 2004-11-30 Kyoichi Sakakibara Nouveau derive peptidique
US7241444B2 (en) 2002-01-18 2007-07-10 Pierre Fabre Medicament Anti-IGF-IR antibodies and uses thereof
US20050276812A1 (en) * 2004-06-01 2005-12-15 Genentech, Inc. Antibody-drug conjugates and methods
KR101270829B1 (ko) 2004-09-23 2013-06-07 제넨테크, 인크. 시스테인 유전자조작 항체 및 접합체
EP1940470B1 (fr) 2005-09-26 2013-04-17 Medarex, Inc. Conjugués anticorps-medicament et leur utilisation
WO2008079849A2 (fr) 2006-12-22 2008-07-03 Genentech, Inc. Anticorps liés au récepteur du facteur de croissance semblable à l'insuline
AR065803A1 (es) 2007-03-23 2009-07-01 Smithkline Beecham Corp Uso de un polipeptido de il- 18 humana y un anticuerpo anti- cd para preparar unmedicamento
AR066476A1 (es) 2007-05-08 2009-08-19 Genentech Inc Anticuerpos anti-muc16 disenados con cisteina y conjugaods de anticuerpos y farmacos
CA2698541C (fr) 2007-10-19 2018-01-09 Genentech, Inc. Anticorps anti-tenb2 modifies par des cysteines et conjugues anticorps-medicament
KR101674097B1 (ko) 2008-04-11 2016-11-08 시애틀 지네틱스, 인크. 췌장, 난소 및 다른 암의 검출 및 치료
EP2403524A4 (fr) 2009-03-06 2012-09-26 Agensys Inc Conjugues anticorps-medicament (adc) se liant aux proteines 24p4c12
WO2010146059A2 (fr) 2009-06-16 2010-12-23 F. Hoffmann-La Roche Ag Biomarqueurs pour une thérapie par inhibiteur d'igf-1r
AR080793A1 (es) 2010-03-26 2012-05-09 Roche Glycart Ag Anticuerpos biespecificos
WO2011130598A1 (fr) 2010-04-15 2011-10-20 Spirogen Limited Pyrrolobenzodiazépines et conjugués de celles-ci
CN103200950B (zh) 2010-06-10 2016-03-16 西雅图基因公司 新颖的耳他汀衍生物及其用途
ES2553874T3 (es) 2010-09-29 2015-12-14 Seattle Genetics, Inc. N-Carboxialquil-auristatinas y su uso
CA2815363C (fr) * 2010-10-22 2020-07-14 Seattle Genetics, Inc. Effets synergiques entre des conjugues d'anticorps et de medicament a base d'auristatine et des inhibiteurs de la voie pi3k-akt-mtor
CA2813411C (fr) 2010-11-05 2016-08-02 Rinat Neuroscience Corporation Conjugues de polypeptides obtenus par genie biologique, et procede de fabrication correspondants au moyen de transglutaminase
JP6023097B2 (ja) 2011-03-16 2016-11-09 シアトル ジェネティックス， インコーポレイテッド Ｎカルボキシアルキルオーリスタチンおよびその使用
US9150644B2 (en) * 2011-04-12 2015-10-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Human monoclonal antibodies that bind insulin-like growth factor (IGF) I and II
EP2714685B1 (fr) 2011-05-27 2016-10-19 Ambrx, Inc. Compositions contenant des dérivés de dolastatine liés à des acides aminés non naturel
KR102179369B1 (ko) 2011-05-27 2020-11-16 암브룩스, 인코포레이티드 비-천연 아미노산 연결된 돌라스타틴 유도체를 함유하는 조성물, 이를 수반하는 방법, 및 용도
US8815226B2 (en) 2011-06-10 2014-08-26 Mersana Therapeutics, Inc. Protein-polymer-drug conjugates
KR102143664B1 (ko) 2012-06-07 2020-08-11 암브룩스, 인코포레이티드 전립선 특이적 막 항원 항체 약물 접합체
SG11201408494UA (en) 2012-06-19 2015-02-27 Ambrx Inc Anti-cd70 antibody drug conjugates
US20140017265A1 (en) 2012-07-05 2014-01-16 Mersana Therapeutics, Inc. Terminally Modified Polymers and Conjugates Thereof
AU2013302273A1 (en) 2012-08-14 2015-02-19 Angiochem Inc. Conjugates including an antibody moiety, a polypeptide that traverses the blood-brain barrier, and a cytotoxin
US20150314007A1 (en) 2012-12-21 2015-11-05 Glykos Finland Oy Linker-payload molecule conjugates
FR3005051A1 (fr) 2013-04-25 2014-10-31 Pf Medicament Derives de la dolastatine 10 et d'auristatines
HUE047952T2 (hu) 2014-04-25 2020-05-28 Pf Medicament Ellenanyag-drog konjugátum és alkalmazása rák kezelésében történõ alkalmazásra
BR112016024619A2 (pt) * 2014-04-25 2017-10-10 Pf Medicament conjugado de anticorpo ao igf-1r-fármaco e seu uso para o tratamento de câncer
MA39378B2 (fr) * 2014-04-25 2021-02-26 Pf Medicament Anticorps igf-1r et son utilisation comme véhicule d'adressage pour le traitement du cancer
JP6968790B2 (ja) * 2015-10-26 2021-11-17 ピエール、ファーブル、メディカマン Ｉｇｆ−１ｒ発現癌の処置のための組成物

Also Published As

Publication number Publication date
EP3134124B1 (fr) 2019-02-20
DK3134124T3 (da) 2019-05-06
LT3134124T (lt) 2019-05-27
PL3134124T3 (pl) 2019-09-30
IL248455B (en) 2020-01-30
SI3134124T1 (sl) 2019-06-28
JP2017513900A (ja) 2017-06-01
US10633448B2 (en) 2020-04-28
KR20160146817A (ko) 2016-12-21
MY186711A (en) 2021-08-12
HRP20190888T1 (hr) 2019-07-12
US20170043031A1 (en) 2017-02-16
BR112016024619A2 (pt) 2017-10-10
RS58742B1 (sr) 2019-06-28
RU2016145444A3 (fr) 2018-11-22
CA2946469C (fr) 2019-10-29
US11661457B2 (en) 2023-05-30
AU2015250759A1 (en) 2016-11-10
HUE044862T2 (hu) 2019-11-28
MX372912B (es) 2020-04-27
ES2727103T8 (es) 2020-03-02
CA2946469A1 (fr) 2015-10-29
CN106456800A (zh) 2017-02-22
EP3498301A1 (fr) 2019-06-19
SA516380120B1 (ar) 2019-02-27
UA120364C2 (uk) 2019-11-25
IL248455A0 (en) 2016-11-30
CN106456800B (zh) 2018-05-01
JP6258523B2 (ja) 2018-01-10
ES2727103T3 (es) 2019-10-14
RU2016145444A (ru) 2018-05-28
US20200270352A1 (en) 2020-08-27
KR101795984B1 (ko) 2017-11-10
WO2015162291A1 (fr) 2015-10-29
TN2016000472A1 (en) 2018-04-04
MA47811A (fr) 2019-06-19
PT3134124T (pt) 2019-06-03
AU2015250759B2 (en) 2017-11-30
EP3134124A1 (fr) 2017-03-01
HRP20190888T8 (hr) 2019-10-04
CY1121783T1 (el) 2020-07-31
RU2692563C2 (ru) 2019-06-25
MA39909B1 (fr) 2019-05-31
MX2016013704A (es) 2017-03-31

Similar Documents

Publication Publication Date Title
MA39909A (fr) Conjugué anticorps de l'igf-1r-médicament et son utilisation pour le traitement du cancer
MX378281B (es) Conjugado farmaco-anticuerpo y su uso para el tratamiento contra el cancer.
PH12016501411A1 (en) Bifunctional cytotoxic agents
PH12018501043A1 (en) Site specific her2 antibody drug conjugates
PH12016502061A1 (en) Novel antii-rnf43 antibodies and methods of use
PH12017500002A1 (en) Anti-cdh6 antibody drug conjugates
PH12018500380A1 (en) Anti-dll3 antibody drug conjugates and methods of use
MX2019001471A (es) Anticuerpos anti-siglec-7 para el tratamiento del cancer.
ZA201708265B (en) Tigit-binding agents and uses thereof
EP3711780A3 (fr) Conjugués anticorps-médicament anti-ptk7
NZ731467A (en) Anti-tim3 antibodies and methods of use
PH12017500406A1 (en) Novel anti-mfi2 antibodies and methods of use
EP4603508A3 (fr) Anticorps anti-fzd et méthodes d'utilisation
MX2018006249A (es) Nuevos anticuerpos anti-emr2 y metodos de uso.
HK1254231A1 (zh) 米托-和厚朴酚化合物及其合成方法和用途
EP3714043A4 (fr) Compositions et méthodes pour traiter le cancer
WO2015175599A3 (fr) Immunothérapie à l'aide d'agents de liaison
HK40028770A (en) Compositions and methods for treating cancer with anti-egfr antibodies
HK40032238A (en) Compositions and methods for treating cancer
HK1234311A1 (en) Novel anti-rnf43 antibodies and methods of use
HK40021222A (en) Methods for treating cancer using ps-targeting antibodies with immuno-oncology agents
HK40015034A (en) Compositions and methods for treating cancer
HK1238261A1 (en) Novel anti-mfi2 antibodies and methods of use
EP3441465A4 (fr) Composition médicamenteuse pour traitement du cancer mettant en oeuvre un anticorps anti-mct5