MA40076A - Inhibiteurs de syk - Google Patents

Inhibiteurs de syk

Info

Publication number
MA40076A
MA40076A MA040076A MA40076A MA40076A MA 40076 A MA40076 A MA 40076A MA 040076 A MA040076 A MA 040076A MA 40076 A MA40076 A MA 40076A MA 40076 A MA40076 A MA 40076A
Authority
MA
Morocco
Prior art keywords
syk inhibitors
compounds
formula
present disclosure
treatment
Prior art date
Application number
MA040076A
Other languages
English (en)
Inventor
Peter A Blomgren
Astrid Clarke
Kevin S Currie
Paolo Julie Di
Jeffrey E Kropf
Seung H Lee
Jennifer R Lo
Scott A Mitchell
Aaron C Schmitt
Sundaramoorthi Swaminathan
Jin-Ming Xiong
Jianjun Xu
Zhongdong Zhao
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of MA40076A publication Critical patent/MA40076A/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
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  • Engineering & Computer Science (AREA)
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  • Epidemiology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)

Abstract

La présente invention porte sur des composés qui sont des inhibiteurs de syk et sur leur utilisation dans le traitement de divers états pathologiques, parmi lesquels le cancer et les troubles inflammatoires. Dans des modes de réalisation particuliers, la structure de ces composés est représentée par la formule (i) dans laquelle r
MA040076A 2014-07-14 2015-07-09 Inhibiteurs de syk MA40076A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462024284P 2014-07-14 2014-07-14

Publications (1)

Publication Number Publication Date
MA40076A true MA40076A (fr) 2016-01-21

Family

ID=54361233

Family Applications (1)

Application Number Title Priority Date Filing Date
MA040076A MA40076A (fr) 2014-07-14 2015-07-09 Inhibiteurs de syk

Country Status (16)

Country Link
US (3) US9504684B2 (fr)
EP (1) EP3169329A1 (fr)
JP (2) JP6292691B2 (fr)
KR (1) KR20170023186A (fr)
CN (1) CN106572999A (fr)
AR (1) AR101177A1 (fr)
AU (2) AU2015290041B2 (fr)
CA (1) CA2955249A1 (fr)
EA (1) EA201790088A1 (fr)
MA (1) MA40076A (fr)
MX (1) MX2017000612A (fr)
NZ (1) NZ726366A (fr)
SG (1) SG11201610904UA (fr)
TW (1) TW201617074A (fr)
UY (1) UY36207A (fr)
WO (1) WO2016010809A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101743784B1 (ko) 2008-12-08 2017-06-05 질레드 코네티컷 인코포레이티드 이미다조피라진 ｓｙｋ 억제제
ES2530449T3 (es) 2010-03-11 2015-03-02 Gilead Connecticut Inc Inhibidores de Syk de imidazopiridinas
EA029281B1 (ru) 2013-07-30 2018-03-30 Джилид Коннектикут, Инк. Полиморф ингибиторов syk
JP6159028B2 (ja) 2013-07-31 2017-07-05 ギリアード サイエンシーズ， インコーポレイテッド Ｓｙｋ阻害剤
US9687492B2 (en) 2013-12-04 2017-06-27 Gilead Sciences, Inc. Methods for treating cancers
TWI735853B (zh) 2013-12-23 2021-08-11 美商克洛諾斯生技有限公司 脾酪胺酸激酶抑制劑
CA2942997C (fr) 2014-03-19 2022-09-13 Boehringer Ingelheim International Gmbh Inhibiteurs de sik de type heteroaryle
CA2955180A1 (fr) 2014-07-14 2016-01-21 Gilead Sciences, Inc. Combinaisons renfermant de l'entospletinib et un vinca-alcaloide servant au traitement de cancers
KR20180051624A (ko) * 2015-09-11 2018-05-16 베링거 인겔하임 인터내셔날 게엠베하 피라졸릴 치환된 헤테로아릴 및 의약으로서의 이의 용도
US10261071B2 (en) * 2016-07-13 2019-04-16 The United States Of America As Represented By The Secretary Of The Navy Volatile organic compounds as diagnostic breath markers for pulmonary oxygen toxicity
WO2018053190A1 (fr) * 2016-09-14 2018-03-22 Gilead Sciences, Inc. Inhibiteurs de syk
TW201822764A (zh) 2016-09-14 2018-07-01 美商基利科學股份有限公司 Syk抑制劑
WO2018195471A1 (fr) 2017-04-21 2018-10-25 Gilead Sciences, Inc. Inhibiteurs de syk en association avec des agents d'hypométhylation
CN115028640A (zh) 2017-08-25 2022-09-09 吉利德科学公司 Syk抑制剂的多晶型物
KR101973074B1 (ko) * 2018-11-30 2019-04-26 주식회사 티움바이오 퓨로피리미딘 화합물의 염 및 결정형, 및 이를 포함하는 약학적 조성물
WO2020172431A1 (fr) 2019-02-22 2020-08-27 Gilead Sciences, Inc. Formes solides de pyrazines condensées en tant qu'inhibiteur de syk
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