MA40181A - Système de rhinovaccination pour vaccin contre la grippe - Google Patents

Système de rhinovaccination pour vaccin contre la grippe

Info

Publication number
MA40181A
MA40181A MA040181A MA40181A MA40181A MA 40181 A MA40181 A MA 40181A MA 040181 A MA040181 A MA 040181A MA 40181 A MA40181 A MA 40181A MA 40181 A MA40181 A MA 40181A
Authority
MA
Morocco
Prior art keywords
influenza vaccine
rhinovaccination system
rhinovaccination
influenza
adjuvant
Prior art date
Application number
MA040181A
Other languages
English (en)
Inventor
Taizou Kamishita
Takashi Miyazaki
Original Assignee
Toko Yakuhin Kogyo Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toko Yakuhin Kogyo Kk filed Critical Toko Yakuhin Kogyo Kk
Publication of MA40181A publication Critical patent/MA40181A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
    • A61M11/007—Syringe-type or piston-type sprayers or atomisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/06—Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
    • B05B1/34—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl
    • B05B1/3405—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl
    • B05B1/341—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet
    • B05B1/3421—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet with channels emerging substantially tangentially in the swirl chamber
    • B05B1/3431—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet with channels emerging substantially tangentially in the swirl chamber the channels being formed at the interface of cooperating elements, e.g. by means of grooves
    • B05B1/3436—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet with channels emerging substantially tangentially in the swirl chamber the channels being formed at the interface of cooperating elements, e.g. by means of grooves the interface being a plane perpendicular to the outlet axis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/02—Membranes or pistons acting on the contents inside the container, e.g. follower pistons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00—Characteristics of a physical parameter; associated device therefor
    • A61M2206/10—Flow characteristics
    • A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0618—Nose
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Dispersion Chemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Mycology (AREA)
  • Mechanical Engineering (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un système de rhinovaccination pour vaccin contre la grippe tel qu'une seringue à usage médical destinée à une administration dans la muqueuse nasale, est remplie d'une composition de vaccin contre la grippe qui est caractéristique en ce qu'elle contient une base sous forme de gel comprenant un antigène particulaire complet inactivé du virus de la grippe et un polymère carboxyvinyl mais aucun adjuvant.
MA040181A 2014-06-25 2015-06-24 Système de rhinovaccination pour vaccin contre la grippe MA40181A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2014130365 2014-06-25

Publications (1)

Publication Number Publication Date
MA40181A true MA40181A (fr) 2017-05-03

Family

ID=54938207

Family Applications (1)

Application Number Title Priority Date Filing Date
MA040181A MA40181A (fr) 2014-06-25 2015-06-24 Système de rhinovaccination pour vaccin contre la grippe

Country Status (25)

Country Link
US (1) US11103453B2 (fr)
EP (1) EP3162378B1 (fr)
JP (1) JP6456379B2 (fr)
KR (1) KR102491446B1 (fr)
CN (1) CN106573045B (fr)
AU (1) AU2015281148B2 (fr)
CA (1) CA2951982C (fr)
DK (1) DK3162378T3 (fr)
ES (1) ES2973258T3 (fr)
FI (1) FI3162378T3 (fr)
HU (1) HUE065638T2 (fr)
IL (1) IL249500A0 (fr)
LT (1) LT3162378T (fr)
MA (1) MA40181A (fr)
MX (1) MX2017000154A (fr)
MY (1) MY192073A (fr)
NZ (1) NZ727360A (fr)
PH (1) PH12016502529B1 (fr)
PL (1) PL3162378T3 (fr)
PT (1) PT3162378T (fr)
RU (1) RU2696483C2 (fr)
SG (2) SG11201610567TA (fr)
SI (1) SI3162378T1 (fr)
TW (1) TWI721949B (fr)
WO (1) WO2015199129A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2019283122B2 (en) 2018-06-05 2026-02-05 Centro De Ingenieria Genetica Y Biotecnologia Hepatitis B vaccine transnasal administration system
JP7288270B2 (ja) * 2018-09-26 2023-06-07 デンカ株式会社 不活化全粒子インフルエンザワクチン及びその調製法
CN113058149B (zh) * 2021-04-27 2024-11-29 任进 内外两用喷注器
GB202202890D0 (en) * 2022-03-02 2022-04-13 Consort Medical Ltd Improvements relating to nasal pieces
US11759586B1 (en) * 2022-04-13 2023-09-19 Ferrer Medical Innovations, LLC Nasal spray bottle with improved nozzle and system of application
CN219022752U (zh) * 2022-07-28 2023-05-16 纳索菲德(上海)制药技术有限公司 向鼻内喷射药液的喷雾头及其装置

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3669359A (en) 1970-09-18 1972-06-13 Precision Valve Corp Aerosol mechanical break-up nozzle insert
JPH0291553A (ja) 1988-09-29 1990-03-30 Toshiba Corp 産業用ｃｔ装置
JPH0529703Y2 (fr) 1988-12-28 1993-07-29
JPH0678245B2 (ja) * 1989-07-04 1994-10-05 東興薬品工業株式会社 鼻腔内噴霧投与用インフルエンザワクチンゲル製剤
US5158761A (en) * 1989-04-05 1992-10-27 Toko Yakuhin Kogyo Kabushiki Kaisha Spray gel base and spray gel preparation using thereof
US5215739A (en) * 1989-04-05 1993-06-01 Toko Yakuhin Kogyo Kabushiki Kaisha Spray gel base and spray gel preparation using thereof
JP2922935B2 (ja) * 1989-08-11 1999-07-26 東興薬品工業株式会社 粘稠液用鼻孔内噴霧容器の使捨てアダプタ
JPH03114248A (ja) 1990-08-30 1991-05-15 Ibiden Co Ltd 半導体搭載用プリント配線基板の製造方法
IT1249600B (it) 1991-02-21 1995-03-09 Elettro Plastica Spa Erogatore nasale di sostanze farmaceutiche nebulizzate
US5601077A (en) 1991-08-07 1997-02-11 Becton, Dickinson And Company Nasal syringe sprayer with removable dose limiting structure
KR0151476B1 (ko) * 1995-04-29 1998-10-15 배순훈 헤드드럼 조립체 및 그 조립방법
FR2773784B1 (fr) 1998-01-16 2000-03-24 Valois Sa Tete de pulverisation pour un distributeur de produit fluide
EP1092447B1 (fr) 1999-10-14 2004-01-07 Becton Dickinson and Company Dispositif d'administration nasale avec buse de pulvérisation
ATE453421T1 (de) 2002-05-09 2010-01-15 Glaxo Group Ltd Flüssigkeit abgebende vorrichtung
DK2014305T3 (en) 2006-04-21 2017-10-16 Toko Yakuhin Kogyo Kk SPRAYABLE GEL-SHAPED SKIN / MOSPHONE ADHESIVE AND ADMINISTRATIVE SYSTEM FOR USING THE PREPARATION
US8136703B2 (en) * 2006-04-21 2012-03-20 Toko Yakuhin Kogyo Kabushiki Kaisha Fluid container and airless fluid dispensing system
EP2730340B1 (fr) 2007-11-29 2018-10-24 Glaxo Group Limited Dispositif de distribution
WO2010114169A1 (fr) 2009-03-31 2010-10-07 Japan As Represented By The Director-General Of National Institute Of Infectious Diseases Méthode de prophylaxie de la grippe utilisant un vaccin à administration intranasale
FR2951442B1 (fr) 2009-10-20 2012-01-20 Valois Sas Tete de distribution pour dispositif de distribution de produit fluide.
CA2869155C (fr) * 2012-03-30 2017-01-31 Yoshino Kogyosho Co., Ltd. Dispositif de pulverisation de type seringue doseuse
JP5917367B2 (ja) 2012-10-31 2016-05-11 株式会社吉野工業所 蓄圧式シリンジ型空気混合液噴出器
HK1209646A1 (en) * 2012-12-28 2016-04-08 日本国立感染症研究所 Nasal influenza vaccine composition

Also Published As

Publication number Publication date
EP3162378A1 (fr) 2017-05-03
PT3162378T (pt) 2024-03-05
PH12016502529A1 (en) 2017-04-10
RU2017101987A (ru) 2018-08-02
FI3162378T3 (fi) 2024-03-18
CA2951982C (fr) 2024-09-10
US20170128363A1 (en) 2017-05-11
SI3162378T1 (sl) 2024-04-30
CN106573045A (zh) 2017-04-19
SG11201610567TA (en) 2017-01-27
AU2015281148B2 (en) 2020-07-30
RU2696483C2 (ru) 2019-08-02
AU2015281148A1 (en) 2017-01-12
PL3162378T3 (pl) 2024-04-29
LT3162378T (lt) 2024-03-12
TWI721949B (zh) 2021-03-21
US11103453B2 (en) 2021-08-31
WO2015199129A1 (fr) 2015-12-30
TW201625327A (zh) 2016-07-16
MY192073A (en) 2022-07-25
DK3162378T3 (da) 2024-03-18
KR102491446B1 (ko) 2023-01-20
SG10201811438XA (en) 2019-02-27
EP3162378B1 (fr) 2024-01-10
NZ727360A (en) 2023-05-26
PH12016502529B1 (en) 2017-04-10
JPWO2015199129A1 (ja) 2017-05-25
CA2951982A1 (fr) 2015-12-30
ES2973258T3 (es) 2024-06-19
CN106573045B (zh) 2020-10-27
KR20170023089A (ko) 2017-03-02
JP6456379B2 (ja) 2019-01-23
EP3162378A4 (fr) 2018-01-17
IL249500A0 (en) 2017-02-28
HUE065638T2 (hu) 2024-06-28
MX2017000154A (es) 2017-05-01
RU2017101987A3 (fr) 2018-09-26

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