MA40721A - Protéines de fusion de l'interleukine-2/récepteur alpha de l'interleukine-2 et procédés d'utilisation - Google Patents

Protéines de fusion de l'interleukine-2/récepteur alpha de l'interleukine-2 et procédés d'utilisation

Info

Publication number
MA40721A
MA40721A MA040721A MA40721A MA40721A MA 40721 A MA40721 A MA 40721A MA 040721 A MA040721 A MA 040721A MA 40721 A MA40721 A MA 40721A MA 40721 A MA40721 A MA 40721A
Authority
MA
Morocco
Prior art keywords
interleukin
methods
fusion proteins
alpha receptor
receptor
Prior art date
Application number
MA040721A
Other languages
English (en)
Other versions
MA40721B1 (fr
Inventor
Thomas Malek
Original Assignee
The Univ Of Miami
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53836871&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA40721(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by The Univ Of Miami filed Critical The Univ Of Miami
Publication of MA40721A publication Critical patent/MA40721A/fr
Publication of MA40721B1 publication Critical patent/MA40721B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Cell Biology (AREA)
  • Neurology (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
MA40721A 2014-08-06 2015-08-05 Protéines de fusion de l'interleukine-2/récepteur alpha de l'interleukine-2 et procédés d'utilisation MA40721B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462033726P 2014-08-06 2014-08-06
EP15750560.3A EP3177307B1 (fr) 2014-08-06 2015-08-05 Protéines de fusion de l'interleukine-2/récepteur alpha de l'interleukine-2 et procédés d'utilisation
PCT/US2015/043792 WO2016022671A1 (fr) 2014-08-06 2015-08-05 Protéines de fusion de l'interleukine-2/récepteur alpha de l'interleukine-2 et procédés d'utilisation

Publications (2)

Publication Number Publication Date
MA40721A true MA40721A (fr) 2017-06-13
MA40721B1 MA40721B1 (fr) 2024-08-30

Family

ID=53836871

Family Applications (2)

Application Number Title Priority Date Filing Date
MA40094A MA40094B1 (fr) 2014-08-06 2015-08-04 Protéines de fusion de l'interleukine-2/récepteur alpha de l'interleukine-2 et procédés d'utilisation
MA40721A MA40721B1 (fr) 2014-08-06 2015-08-05 Protéines de fusion de l'interleukine-2/récepteur alpha de l'interleukine-2 et procédés d'utilisation

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MA40094A MA40094B1 (fr) 2014-08-06 2015-08-04 Protéines de fusion de l'interleukine-2/récepteur alpha de l'interleukine-2 et procédés d'utilisation

Country Status (32)

Country Link
US (3) US12084483B2 (fr)
EP (2) EP4438621A3 (fr)
JP (3) JP6723982B2 (fr)
KR (1) KR102653758B1 (fr)
CN (2) CN107074967B (fr)
AU (3) AU2015301071C1 (fr)
BR (1) BR112017001940A2 (fr)
CA (1) CA2957273C (fr)
CL (1) CL2017000284A1 (fr)
CO (1) CO2017002166A2 (fr)
DK (1) DK3177307T3 (fr)
EA (2) EA202091342A3 (fr)
ES (1) ES2986097T3 (fr)
FI (1) FI3177307T3 (fr)
HR (1) HRP20241258T1 (fr)
HU (1) HUE068478T2 (fr)
IL (2) IL250007B (fr)
LT (1) LT3177307T (fr)
MA (2) MA40094B1 (fr)
MX (1) MX388977B (fr)
MY (1) MY180831A (fr)
PE (1) PE20170503A1 (fr)
PH (1) PH12017500042A1 (fr)
PT (1) PT3177307T (fr)
RS (1) RS65930B1 (fr)
SA (1) SA517380842B1 (fr)
SG (2) SG10201913695PA (fr)
SI (1) SI3177307T1 (fr)
SM (1) SMT202400414T1 (fr)
TN (1) TN2017000020A1 (fr)
WO (1) WO2016022671A1 (fr)
ZA (1) ZA201700245B (fr)

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MA40094B1 (fr) 2014-08-06 2022-05-31 Univ Miami Protéines de fusion de l'interleukine-2/récepteur alpha de l'interleukine-2 et procédés d'utilisation
JP7178906B2 (ja) * 2016-05-19 2022-11-28 ザ ジェネラル ホスピタル コーポレイション ナチュラルキラー細胞および制御性Ｔ細胞の活性を強化するためのプラットフォームである、その受容体ＩＬ－２Ｒβに繋ぎ止められたインターロイキン－２
AU2017335771A1 (en) 2016-09-28 2019-02-28 Musc Foundation For Research Development Antibodies that bind interleukin-2 and uses thereof
EP3596108A4 (fr) 2017-03-15 2020-12-23 Pandion Operations, Inc. Immunotolérance ciblée
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US10174092B1 (en) 2017-12-06 2019-01-08 Pandion Therapeutics, Inc. IL-2 muteins
EP3746103A4 (fr) 2017-12-06 2022-03-30 The Board of Trustees of the Leland Stanford Junior University Protéines modifiées pour améliorer la sensibilité d'une cellule à l'il-2
US10946068B2 (en) 2017-12-06 2021-03-16 Pandion Operations, Inc. IL-2 muteins and uses thereof
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US20220378933A1 (en) * 2019-09-19 2022-12-01 Proviva Therapeutics (Hong Kong) Limited Il-2 compositions and methods of use thereof
BR112022007158A2 (pt) * 2019-10-18 2022-07-05 Alkermes Pharma Ireland Ltd Agentes imunomodulatórios de il-2 em combinação com inibidores do ponto de verificação imunológico
WO2021127487A2 (fr) 2019-12-20 2021-06-24 Regeneron Pharmaceuticals, Inc. Nouveaux agonistes d'il2 et leurs procédés d'utilisation
EP4107187A4 (fr) 2020-02-21 2024-07-03 Pandion Operations, Inc. Immunotolérance ciblée sur un tissu avec un effecteur cd39
EP4143220A4 (fr) 2020-04-30 2024-05-29 Immune Targeting Inc. Composition d'il2 activable et procédés d'utilisation
CN116194480A (zh) * 2020-08-13 2023-05-30 百时美施贵宝公司 将il-2重定向到目的靶细胞的方法
TW202317623A (zh) 2021-06-14 2023-05-01 美商再生元醫藥公司 基於il2之治療劑及其使用方法
WO2023154894A2 (fr) * 2022-02-11 2023-08-17 Alkermes Pharma Ireland Limited Compositions et procédés d'immunothérapie anticancéreuse
US20250154216A1 (en) * 2022-02-16 2025-05-15 University Of Miami Il-2 and tl1a fusion proteins and methods of use thereof
CN114875069B (zh) * 2022-04-22 2023-09-15 四川大学 基因工程修饰的il2细胞因子的重组载体、宿主细胞及其用途
AU2024224039A1 (en) * 2023-02-22 2025-06-26 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Anti-il2ra antibodies and uses thereof
WO2025207491A1 (fr) * 2024-03-25 2025-10-02 Mural Oncology, Inc. Compositions et méthodes pour immunothérapie anticancéreuse

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Also Published As

Publication number Publication date
CN107074967A (zh) 2017-08-18
WO2016022671A1 (fr) 2016-02-11
JP2017523789A (ja) 2017-08-24
KR102653758B1 (ko) 2024-04-04
ZA201700245B (en) 2024-06-26
PT3177307T (pt) 2024-09-13
EA201790063A1 (ru) 2017-06-30
FI3177307T3 (fi) 2024-10-04
EP4438621A2 (fr) 2024-10-02
MA40094A1 (fr) 2021-09-30
SG11201700706WA (en) 2017-02-27
EA202091342A2 (ru) 2020-11-30
SA517380842B1 (ar) 2021-12-26
HRP20241258T1 (hr) 2024-12-06
PH12017500042A1 (en) 2017-05-22
SMT202400414T1 (it) 2024-11-15
US20250163118A1 (en) 2025-05-22
AU2015301071C1 (en) 2020-07-02
RS65930B1 (sr) 2024-10-31
HUE068478T2 (hu) 2025-01-28
SI3177307T1 (sl) 2024-09-30
AU2022204034A1 (en) 2022-07-14
JP6723982B2 (ja) 2020-07-15
AU2015301071B2 (en) 2020-03-05
AU2020203352B2 (en) 2022-03-10
IL250007B (en) 2020-07-30
JP7272663B2 (ja) 2023-05-12
JP2021000084A (ja) 2021-01-07
IL275944A (en) 2020-08-31
MA40094B1 (fr) 2022-05-31
AU2020203352A1 (en) 2020-07-02
DK3177307T3 (da) 2024-10-07
SG10201913695PA (en) 2020-03-30
JP2023099045A (ja) 2023-07-11
NZ728042A (en) 2024-07-26
EP3177307B1 (fr) 2024-07-17
CL2017000284A1 (es) 2017-11-17
EP3177307A1 (fr) 2017-06-14
KR20170030646A (ko) 2017-03-17
CA2957273C (fr) 2023-03-14
IL250007A0 (en) 2017-03-30
TN2017000020A1 (en) 2018-07-04
MX388977B (es) 2025-03-20
CN107074967B (zh) 2021-06-08
MA40721B1 (fr) 2024-08-30
EA035956B1 (ru) 2020-09-04
US12084483B2 (en) 2024-09-10
EA202091342A3 (ru) 2020-12-30
MX2017001062A (es) 2017-07-14
IL275944B (en) 2022-02-01
MY180831A (en) 2020-12-10
PE20170503A1 (es) 2017-05-11
BR112017001940A2 (pt) 2017-11-28
EP4438621A3 (fr) 2024-12-18
US20170233448A1 (en) 2017-08-17
LT3177307T (lt) 2024-08-12
CO2017002166A2 (es) 2017-05-19
CN113912737A (zh) 2022-01-11
CA2957273A1 (fr) 2016-02-11
AU2015301071A1 (en) 2017-02-02
US20230079120A1 (en) 2023-03-16
NZ766851A (en) 2024-07-26
ES2986097T3 (es) 2024-11-08

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