MA40818B2 - Improved delivery of viral particles to the striatum and cortex - Google Patents
Improved delivery of viral particles to the striatum and cortexInfo
- Publication number
- MA40818B2 MA40818B2 MA40818A MA40818A MA40818B2 MA 40818 B2 MA40818 B2 MA 40818B2 MA 40818 A MA40818 A MA 40818A MA 40818 A MA40818 A MA 40818A MA 40818 B2 MA40818 B2 MA 40818B2
- Authority
- MA
- Morocco
- Prior art keywords
- striatum
- cortex
- viral particles
- improved delivery
- mammal
- Prior art date
Links
- 210000001577 neostriatum Anatomy 0.000 title abstract 3
- 239000002245 particle Substances 0.000 title abstract 3
- 230000003612 virological effect Effects 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 241000702421 Dependoparvovirus Species 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 210000003710 cerebral cortex Anatomy 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
La présente invention concerne de nouveaux procédés d'administration de particules virales adéno-associées recombinées (raav) au système nerveux central d'un mammifère (p. Ex., l'homme). Selon certains aspects, les procédés impliquent l'administration des particules raav contenant un acide nucléique hétérologue au striatum et l'induction de l'expression de l'acide nucléique hétérologue dans au moins le cortex cérébral et le striatum du mammifère.The present invention relates to novel methods of delivering recombinant adeno-associated virus (raav) particles to the central nervous system of a mammal (eg, human). In some aspects, the methods involve administering the raav particles containing heterologous nucleic acid to the striatum and inducing expression of the heterologous nucleic acid in at least the cerebral cortex and striatum of the mammal.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562114544P | 2015-02-10 | 2015-02-10 | |
| PCT/US2016/017210 WO2016130591A2 (en) | 2015-02-10 | 2016-02-09 | Enhanced delivery of viral particles to the striatum and cortex |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA40818A1 MA40818A1 (en) | 2018-01-31 |
| MA40818B2 true MA40818B2 (en) | 2022-04-29 |
Family
ID=61730514
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA40818A MA40818B2 (en) | 2015-02-10 | 2016-02-09 | Improved delivery of viral particles to the striatum and cortex |
Country Status (2)
| Country | Link |
|---|---|
| HR (1) | HRP20220042T1 (en) |
| MA (1) | MA40818B2 (en) |
-
2016
- 2016-02-09 HR HRP20220042TT patent/HRP20220042T1/en unknown
- 2016-02-09 MA MA40818A patent/MA40818B2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20220042T1 (en) | 2022-04-01 |
| MA40818A1 (en) | 2018-01-31 |
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