MA40940A - Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomaines - Google Patents

Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomaines

Info

Publication number
MA40940A
MA40940A MA040940A MA40940A MA40940A MA 40940 A MA40940 A MA 40940A MA 040940 A MA040940 A MA 040940A MA 40940 A MA40940 A MA 40940A MA 40940 A MA40940 A MA 40940A
Authority
MA
Morocco
Prior art keywords
bromodoma
inhibitors
substituted pyrrolopyridines
pyrrolopyridines
substituted
Prior art date
Application number
MA040940A
Other languages
English (en)
Inventor
Brian K Albrecht
Steven F Bellon
Daniel J Burdick
Alexandre Cote
Terry Crawford
Les A Dakin
Michael Charles Hewitt
Tsui Vickie Hsiao-Wei
Yves Leblanc
Steven R Magnuson
Christopher G Nasveschuk
F Anthony Romero
Yong Tang
Alexander M Taylor
Shumei Wang
Original Assignee
Constellation Pharmaceuticals Inc
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Constellation Pharmaceuticals Inc, Genentech Inc filed Critical Constellation Pharmaceuticals Inc
Publication of MA40940A publication Critical patent/MA40940A/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Virology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
MA040940A 2014-11-10 2015-11-09 Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomaines MA40940A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462077707P 2014-11-10 2014-11-10

Publications (1)

Publication Number Publication Date
MA40940A true MA40940A (fr) 2017-09-19

Family

ID=54602075

Family Applications (1)

Application Number Title Priority Date Filing Date
MA040940A MA40940A (fr) 2014-11-10 2015-11-09 Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomaines

Country Status (6)

Country Link
US (1) US10150767B2 (fr)
EP (1) EP3218374B1 (fr)
JP (1) JP6669745B2 (fr)
CN (1) CN107108614B (fr)
MA (1) MA40940A (fr)
WO (1) WO2016077380A1 (fr)

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MA40943A (fr) * 2014-11-10 2017-09-19 Constellation Pharmaceuticals Inc Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomaines
CN107108613B (zh) 2014-11-10 2020-02-25 基因泰克公司 布罗莫结构域抑制剂及其用途
EP3250571B1 (fr) 2015-01-29 2022-11-30 Genentech, Inc. Composés thérapeutiques et leurs utilisations
US11319318B2 (en) 2015-03-05 2022-05-03 Boehringer Ingelheim International Gmbh Pyridinones and isoquinolinones as inhibitors of the bromodomain BRD9
AR104259A1 (es) * 2015-04-15 2017-07-05 Celgene Quanticel Res Inc Inhibidores de bromodominio
PT3442972T (pt) 2016-04-15 2020-05-29 Abbvie Inc Inibidores de bromodomínio
AU2017254713C1 (en) 2016-04-22 2021-04-29 Dana-Farber Cancer Institute, Inc. Bifunctional molecules for degradation of EGFR and methods of use
CN110167939B (zh) * 2017-01-11 2021-12-31 江苏豪森药业集团有限公司 吡咯并[2,3-c]吡啶类衍生物、其制备方法及其在医药上的应用
ES2928773T3 (es) 2017-01-17 2022-11-22 Heparegenix Gmbh Inhibidores de proteína cinasas para fomentar la regeneración hepática o reducir o prevenir la muerte de hepatocitos
WO2018188047A1 (fr) * 2017-04-14 2018-10-18 Abbvie Inc. Inhibiteurs de bromodomaine
CN108976278B (zh) * 2017-06-05 2021-04-06 海创药业股份有限公司 一种嵌合分子及其制备和应用
JP7840635B2 (ja) * 2017-12-20 2026-04-06 貝達薬業股▲ふん▼有限公司 ブロモドメインタンパク質阻害剤である化合物、および組成物
JP2021512960A (ja) * 2018-02-06 2021-05-20 シャンハイ ハイファ ファーマシューティカル カンパニー，リミティッド Ｂｅｔ阻害活性を有する化合物並びにその製造方法及び使用
CN108465108B (zh) * 2018-03-12 2020-07-07 上海宇玫博生物科技有限公司 一种预防或治疗脑胶质瘤的特异性基因靶点
US10442799B1 (en) 2018-04-07 2019-10-15 Fuqiang Ruan Heterocyclic compounds and uses thereof
WO2020007322A1 (fr) * 2018-07-04 2020-01-09 清华大学 Composé ciblé pour la dégradation d'une protéine bet et utilisation associée
CN110776508B (zh) * 2018-07-27 2021-07-16 海创药业股份有限公司 一种brd4抑制剂及其制备方法和用途
CN110818609A (zh) * 2018-08-11 2020-02-21 中国药科大学 3-乙酰基吲哚类brpf1抑制剂的制备方法及其用途
EP3841115A4 (fr) * 2018-08-20 2022-08-24 University of Georgia Research Foundation, Inc. Compositions et procédés permettant d'améliorer le brunissement de tissus adipeux blancs
CN109125729A (zh) * 2018-09-06 2019-01-04 苏州吉玛基因股份有限公司 与非小细胞肺癌诊疗相关的基因BRD9及其siRNAs和应用
WO2020132004A1 (fr) * 2018-12-20 2020-06-25 Saint Louis University Inhibiteurs de bet pour moduler l'expression de dux4 dans la fshd
GB201905721D0 (en) * 2019-04-24 2019-06-05 Univ Dundee Compounds
WO2020219168A1 (fr) * 2019-04-24 2020-10-29 Convergene, Llc Inhibiteurs de bromodomaines à petites molécules et leurs utilisations
US11171132B2 (en) * 2019-10-03 2021-11-09 Globalfoundries U.S. Inc. Bi-directional breakdown silicon controlled rectifiers
CN112625036A (zh) * 2019-10-08 2021-04-09 上海海和药物研究开发股份有限公司 一类具有brd4抑制活性的化合物、其制备方法及用途
CN115667237A (zh) * 2020-07-17 2023-01-31 成都苑东生物制药股份有限公司 作为bet抑制剂的新型杂环化合物
TW202237095A (zh) 2020-12-03 2022-10-01 德商艾斯巴赫生物有限公司 Ａｌｃ１抑制劑及與ｐａｒｐｉ之協同性
CN115232123A (zh) * 2021-04-23 2022-10-25 江苏恒瑞医药股份有限公司 含氮杂环类化合物、其制备方法及其在医药上的应用
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US20170342067A1 (en) 2017-11-30
CN107108614A (zh) 2017-08-29
CN107108614B (zh) 2021-06-01
JP2017533249A (ja) 2017-11-09
WO2016077380A1 (fr) 2016-05-19
EP3218374B1 (fr) 2021-12-29
HK1243076A1 (zh) 2018-07-06
JP6669745B2 (ja) 2020-03-18
EP3218374A1 (fr) 2017-09-20

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