MA40987A - Différenciation de cellules souches pluripotentes afin de former des organoïdes rénaux - Google Patents

Différenciation de cellules souches pluripotentes afin de former des organoïdes rénaux

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Publication number
MA40987A
MA40987A MA040987A MA40987A MA40987A MA 40987 A MA40987 A MA 40987A MA 040987 A MA040987 A MA 040987A MA 40987 A MA40987 A MA 40987A MA 40987 A MA40987 A MA 40987A
Authority
MA
Morocco
Prior art keywords
growth factor
fibroblast growth
renal organoids
pluripotent stem
stem cells
Prior art date
Application number
MA040987A
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English (en)
Inventor
Melissa Little
Minoru Takasato
Original Assignee
Univ Queensland
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Publication date
Application filed by Univ Queensland filed Critical Univ Queensland
Publication of MA40987A publication Critical patent/MA40987A/fr

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0684—Cells of the urinary tract or kidneys
    • C12N5/0687—Renal stem cells; Renal progenitors
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0684—Cells of the urinary tract or kidneys
    • C12N5/0686—Kidney cells
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells

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  • Health & Medical Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
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  • Developmental Biology & Embryology (AREA)
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  • Tropical Medicine & Parasitology (AREA)
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  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

L'invention porte sur un procédé de production d'organoïdes rénaux comprenant des néphrons, des bourgeons urétraux et des vaisseaux sanguins et / ou des progéniteurs de ceux-ci. Dans un mode de réalisation, les procédés comprennent la mise en contact de cellules de mésoderme intermédiaires avec: le facteur de croissance des fibroblastes 9 et / ou le facteur de croissance des fibroblastes 20 et / ou le facteur de croissance des fibroblastes 2 et éventuellement un ou plusieurs choisis dans le groupe constitué par: la protéine morphogénique osseuse 7; héparine; un agoniste wnt; l'acide rétinoïque; et un antagoniste de la ra dans des conditions favorisant la formation d'organoïdes rénaux vascularisés. Un autre mode de réalisation comprend la production de cellules mésodermes en mettant en contact séquentiellement des cellules souches pluripotentes avec un agoniste wnt et un facteur de croissance fibroblastique 9 et / ou un facteur de croissance fibroblastique 20 et / ou un facteur de croissance fibroblastique 2, suivie d'une ré-exposition relativement courte à l'agoniste wnt. Les organoides rénaux peuvent avoir des utilisations finales telles que la réparation et la régénération du rein, la réimpression des reins ou des composants fonctionnels de ceux-ci, les réseaux de cellules rénales et les composés de criblage pour la néphrotoxicité.
MA040987A 2014-12-15 2015-12-15 Différenciation de cellules souches pluripotentes afin de former des organoïdes rénaux MA40987A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AU2014277667A AU2014277667B2 (en) 2014-12-15 2014-12-15 Differentiation of pluripotent stem cells to form renal organoids

Publications (1)

Publication Number Publication Date
MA40987A true MA40987A (fr) 2017-10-25

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
MA040987A MA40987A (fr) 2014-12-15 2015-12-15 Différenciation de cellules souches pluripotentes afin de former des organoïdes rénaux

Country Status (9)

Country Link
US (3) US20190032020A1 (fr)
EP (3) EP3234108A4 (fr)
JP (1) JP7059007B2 (fr)
KR (2) KR102723169B1 (fr)
CN (2) CN107208051B (fr)
AU (2) AU2014277667B2 (fr)
CA (1) CA2969249A1 (fr)
MA (1) MA40987A (fr)
WO (1) WO2016094948A1 (fr)

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KR20230107694A (ko) 2023-07-17
JP2017537655A (ja) 2017-12-21
US20200339957A1 (en) 2020-10-29
AU2022204362B2 (en) 2025-04-10
WO2016094948A1 (fr) 2016-06-23
US20250075188A1 (en) 2025-03-06
AU2022204362A1 (en) 2022-07-14
KR102723169B1 (ko) 2024-10-29
EP4130242A1 (fr) 2023-02-08
KR20170110579A (ko) 2017-10-11
EP3234108A4 (fr) 2018-05-09
CN107208051B (zh) 2022-02-08
EP3234108A1 (fr) 2017-10-25
CN114591884B (zh) 2024-12-06
EP4279583A3 (fr) 2024-02-21
KR102555627B1 (ko) 2023-07-19
CA2969249A1 (fr) 2016-06-23
CN107208051A (zh) 2017-09-26
US20190032020A1 (en) 2019-01-31
AU2014277667B2 (en) 2022-07-14
JP7059007B2 (ja) 2022-04-25
EP4279583A2 (fr) 2023-11-22
CN114591884A (zh) 2022-06-07
AU2014277667A1 (en) 2016-06-30
US12134785B2 (en) 2024-11-05

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