MA41197B1 - Traitement de le pemphigus - Google Patents

Traitement de le pemphigus

Info

Publication number
MA41197B1
MA41197B1 MA41197A MA41197A MA41197B1 MA 41197 B1 MA41197 B1 MA 41197B1 MA 41197 A MA41197 A MA 41197A MA 41197 A MA41197 A MA 41197A MA 41197 B1 MA41197 B1 MA 41197B1
Authority
MA
Morocco
Prior art keywords
pemphigus
corticosteroids
therapy
relates
present
Prior art date
Application number
MA41197A
Other languages
English (en)
Inventor
Steven Gourlay
Original Assignee
Principia Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Principia Biopharma Inc filed Critical Principia Biopharma Inc
Publication of MA41197B1 publication Critical patent/MA41197B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne des procédés de traitement, avec un inhibiteur de btk, d'une maladie bulleuse, en particulier du pemphigus vulgaire ou du pemphigus foliacé chez un mammifère, l'utilisation d'un inhibiteur de btk en tant que thérapie de remplacement d'une thérapie par corticoïdes pour les maladies pouvant être traitées avec des corticoïdes, telles qu'une maladie auto-immune ou une maladie inflammatoire et en particulier lorsque des corticoïdes sont utilisés comme thérapie de première ou de seconde ligne. La présente invention concerne également des formulations pharmaceutiques comprenant ces inhibiteurs de btk.
MA41197A 2014-12-18 2015-12-18 Traitement de le pemphigus MA41197B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462093891P 2014-12-18 2014-12-18
PCT/US2015/066868 WO2016100914A1 (fr) 2014-12-18 2015-12-18 Traitement du pemphigus

Publications (1)

Publication Number Publication Date
MA41197B1 true MA41197B1 (fr) 2021-01-29

Family

ID=55080225

Family Applications (1)

Application Number Title Priority Date Filing Date
MA41197A MA41197B1 (fr) 2014-12-18 2015-12-18 Traitement de le pemphigus

Country Status (14)

Country Link
US (2) US10485797B2 (fr)
EP (1) EP3233103B1 (fr)
CN (1) CN107257686B (fr)
AU (2) AU2015364335B2 (fr)
CA (1) CA2970723C (fr)
EA (1) EA036269B1 (fr)
ES (1) ES2843323T3 (fr)
IL (1) IL252839B (fr)
MA (1) MA41197B1 (fr)
MX (1) MX381283B (fr)
PL (1) PL3233103T3 (fr)
PT (1) PT3233103T (fr)
SG (1) SG11201704808VA (fr)
WO (1) WO2016100914A1 (fr)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SMT201900344T1 (it) 2012-09-10 2019-07-11 Principia Biopharma Inc Composti di pirazolopirimidina come inibitori di chinasi
PL2989106T3 (pl) 2013-04-25 2017-08-31 Beigene, Ltd. Połączone związki heterocykliczne jako inhibitory kinazy białkowej
SMT202300039T1 (it) 2013-09-13 2023-03-17 Beigene Switzerland Gmbh Anticorpi anti-pd1 e loro uso come terapia e per diagnostica
CN112353806A (zh) 2014-02-21 2021-02-12 普林斯匹亚生物制药公司 Btk抑制剂的盐和固体形式
TWI726608B (zh) 2014-07-03 2021-05-01 英屬開曼群島商百濟神州有限公司 抗pd-l1抗體及其作為治療及診斷之用途
SG11201704808VA (en) 2014-12-18 2017-07-28 Principia Biopharma Inc Treatment of pemphigus
US20180305350A1 (en) 2015-06-24 2018-10-25 Principia Biopharma Inc. Tyrosine kinase inhibitors
IL263815B (en) 2016-06-29 2022-07-01 Principia Biopharma Inc Modified release formulations of 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[4,3-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4 -Methyl-4-[4-(Oxtan-3-yl)piperazin-1-yl)pent-2-ananitrile
WO2018007885A1 (fr) 2016-07-05 2018-01-11 Beigene, Ltd. Association d'un antagoniste de pd-1 et d'un inhibiteur du raf pour le traitement du cancer.
IL293319B1 (en) 2016-08-16 2026-01-01 Beone Medicines Ltd Crystal structure of s)–7–(1–acryloylpiperidin–4–yl)–2–(4–)phenoxyphenyl)–4,5,6,7–tetra–hydropyrazolo(1,5–a)pyrimidine–3–carboxamide, methods of preparation and uses thereof
CN110087680B (zh) * 2016-08-19 2024-03-19 百济神州有限公司 使用包含btk抑制剂的组合产品治疗癌症
SI3555099T1 (sl) * 2016-12-15 2021-11-30 F. Hoffmann-La Roche Ag Postopek priprave zaviralcev BTK
CN108329274B (zh) * 2017-01-13 2021-09-03 正大天晴药业集团股份有限公司 布鲁顿酪氨酸激酶抑制剂
EP3573989A4 (fr) * 2017-01-25 2020-11-18 Beigene, Ltd. Formes cristallines de (s) -7- (1- (but-2-ynoyl) pipéridin-4-yl) -2- (4-phénoxyphényl) -4, 5, 6, 7-tétrahy dropyrazolo [1, 5-a]pyrimidine-3-carboxamide, préparation et utilisations associées
CN108727404B (zh) * 2017-04-14 2020-05-12 中国科学院上海药物研究所 噻吩并[3,2-d]嘧啶类化合物、其制备方法及用途
EP3645569A4 (fr) 2017-06-26 2021-03-24 BeiGene, Ltd. Immunothérapie pour carcinome hépatocellulaire
WO2019034009A1 (fr) 2017-08-12 2019-02-21 Beigene, Ltd. Inhibiteur de btk ayant une double sélectivité améliorée
US11786529B2 (en) 2017-11-29 2023-10-17 Beigene Switzerland Gmbh Treatment of indolent or aggressive B-cell lymphomas using a combination comprising BTK inhibitors
US20210113568A1 (en) * 2018-04-27 2021-04-22 Ono Pharmaceutical Co., Ltd. PREVENTIVE AND/OR THERAPEUTIC AGENT FOR AUTOIMMUNE DISEASE COMPRISING COMPOUND HAVING Btk INHIBITORY ACTIVITY AS ACTIVE INGREDIENT
WO2020057549A1 (fr) * 2018-09-18 2020-03-26 Beijing Innocare Pharma Tech Co., Ltd. Formes cristallines de 6- (1-acryloylpipéridin-4-yl)-2-(4-phénoxyphényl) nicotinamide
SG11202103861YA (en) * 2018-11-06 2021-05-28 Beijing Innocare Pharma Tech Co Ltd Amorphous solid dispersion comprising 6- (1-acryloylpiperidin-4-yl) -2- (4-phenoxyphenyl) nicotinamide
CN109939223B (zh) * 2019-04-04 2020-04-07 中南大学湘雅二医院 一种白介素2在制备用于治疗寻常型天疱疮口腔糜烂药物的应用
EP3981399A4 (fr) 2019-06-10 2023-05-31 BeiGene Switzerland GmbH Comprimé solide pour voie orale comprenant un inhibiteur de tyrosine kinase de bruton et son procédé de préparation
CN115190798A (zh) 2019-10-09 2022-10-14 普林斯匹亚生物制药公司 通过施用(R)-2-[3-[4-氨基-3-(2-氟-4-苯氧基-苯基)吡唑并[3,4-d]嘧啶-1-基]哌啶-1-羰基]-4-甲基-4-[4-(氧杂环丁-3-基)哌嗪-1-基]戊-2-烯腈治疗天疱疮的方法
AU2020365951B2 (en) 2019-10-14 2026-07-16 Principia Biopharma Inc. Methods for treating immune thrombocytopenia by administering (R)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile
KR102993352B1 (ko) 2019-12-20 2026-07-22 프린시피아 바이오파마, 인코퍼레이티드 2-[3-[4-아미노-3-(2-플루오로-4-페녹시-페닐)피라졸로[3,4-d]피리미딘-1-일]피페리딘-1-카르보닐]-4-메틸-4-[4-(옥세탄-3-일)피페라진-1-일]펜트-2-에네니트릴의 고체 형태
CA3163850A1 (fr) * 2020-01-08 2021-07-15 Principia Biopharma Inc. Compositions pharmaceutiques topiques comprenant le 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4,4-dimethylpent-2-enenitril
WO2021150723A1 (fr) 2020-01-22 2021-07-29 Principia Biopharma Inc. Formes cristallines de 2-[3-[4-amino-3-(2-fluoro-4-phénoxy-phényle) -1h-pyrazolo [3,4-d]pyrimidine-1-yl]pipéridine-1-carbonyl]-4-méthyl-4-[4-(oxétane-3-yl]pipéridine-1-carbonyl]-4-méthyl-4-[4- (oxétane-3-yl)) pipérazine-1-yl] pent-2-enenitrile
WO2021207662A1 (fr) * 2020-04-10 2021-10-14 Genentech, Inc. Utilisation d'il-22-fc pour le traitement ou la prévention de la pneumonie, du syndrome de détresse respiratoire aiguë ou du syndrome de libération de cytokines
EP4322957A1 (fr) * 2021-04-16 2024-02-21 Principia Biopharma Inc. Procédés de traitement de la thrombocytopénie immunitaire induite par des médicaments et des vaccins par administration de composés spécifiques
US11786531B1 (en) 2022-06-08 2023-10-17 Beigene Switzerland Gmbh Methods of treating B-cell proliferative disorder
EP4611755A1 (fr) 2022-10-31 2025-09-10 Principia Biopharma Inc. Méthodes de traitement de thrombocytopénie immunitaire par administration de (r)-2-[3- [4-amino-3-(2-fluoro-4-phénoxy-phényl)pyrazolo[3,4-d]pyrimidin-l-yl]pipéridine-l-carbonyl]-4-méthyl-4-[4-(oxétan-3-yl)pipérazin-l-yl]pent-2-ènenitrile
WO2024124113A1 (fr) 2022-12-09 2024-06-13 Principia Biopharma Inc. Méthodes de traitement de la thrombocytopénie immunitaire chez des sujets présentant un déficit cognitif par administration de rilzabrutinib
CN116849178A (zh) * 2023-06-26 2023-10-10 武汉大学中南医院 胎源性成年骨关节炎易感模型的构建方法、共性干预靶标及其应用
AU2024306785A1 (en) 2023-06-30 2026-02-19 Principia Biopharma Inc. Methods for treating persistent or chronic immune thrombocytopenia in children, adolescents and adults by administering (r)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy- phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4- methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile
AU2024292378A1 (en) 2023-07-17 2026-03-05 Kadmon Corporation, Llc Combination therapy comprising btk inhibitor and belumosudil
CN122094692A (zh) 2023-10-25 2026-05-26 普林斯匹亚生物制药公司 用于治疗与特应性皮炎和/或结节性痒疹相关的搔痒的瑞扎布鲁替尼
AU2024394777A1 (en) 2023-12-06 2026-07-23 Principia Biopharma Inc. Treatment of moderate-to-severe asthma by administering rilzabrutinib
WO2026024765A1 (fr) 2024-07-23 2026-01-29 Principia Biopharma Inc. Traitement de la thrombose veineuse avec du rilzabrutinib et ses dérivés
WO2026024885A1 (fr) 2024-07-24 2026-01-29 Principia Biopharma Inc. Rizalbrutinib pour le traitement de l'anémie hémolytique auto-immune à anticorps chaud
WO2026035812A1 (fr) 2024-08-08 2026-02-12 Principia Biopharma Inc. Méthodes de traitement de la drépanocytose par administration d'un inhibiteur de btk

Family Cites Families (123)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4082819A (en) 1977-03-02 1978-04-04 The Standard Oil Company Rubber-modified acrylonitrile-vinyl ether-indene polymers
JPS5663950A (en) 1979-10-30 1981-05-30 Mitsubishi Chem Ind Ltd Cyclopropanecarboxylic ester
FR2535721A1 (fr) 1982-11-08 1984-05-11 Sanofi Sa Derives de la piperidinedione protecteurs du myocarde presentant une acticite antiarythmique, leur procede de preparation et les medicaments qui contiennent lesdits derives
US4911920A (en) 1986-07-30 1990-03-27 Alcon Laboratories, Inc. Sustained release, comfort formulation for glaucoma therapy
JPS623848A (ja) 1985-06-28 1987-01-09 Nippon Steel Corp 疲労強度のすぐれたスタツド付きフラツシユバツト溶接アンカ−チエ−ン
FR2588189B1 (fr) 1985-10-03 1988-12-02 Merck Sharp & Dohme Composition pharmaceutique de type a transition de phase liquide-gel
JP2518353B2 (ja) 1988-06-09 1996-07-24 住友化学工業株式会社 シアノ酢酸アミド誘導体およびその製造中間体
CA2018801C (fr) 1990-06-12 2000-08-22 Pierre Louis Beaulieu Derives peptidiques comprenant une terminaison-n1,4-dioxo-c4
JPH04177244A (ja) 1990-11-10 1992-06-24 Konica Corp ハロゲン化銀写真感光材料
CA2033447C (fr) 1990-12-31 1999-08-31 Robert Deziel Complexe synergique pour le traitement des infections herpetiques
DK0495421T3 (da) 1991-01-15 1996-12-09 Alcon Lab Inc Anvendelse af carragenaner i topiske ophthalmiske sammensætninger
US5212162A (en) 1991-03-27 1993-05-18 Alcon Laboratories, Inc. Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
JPH05301838A (ja) 1991-10-15 1993-11-16 Mitsubishi Kasei Corp スチレン誘導体
US5792771A (en) 1992-11-13 1998-08-11 Sugen, Inc. Quinazoline compounds and compositions thereof for the treatment of disease
WO1995024190A2 (fr) 1994-03-07 1995-09-14 Sugen, Inc. Inhibiteurs de tyrosine-kinase receptrice destines a inhiber les troubles lies a la proliferation cellulaire et compositions les contenant
JPH0827090A (ja) 1994-05-13 1996-01-30 Sumitomo Chem Co Ltd シアノ酢酸アミド誘導体、その用途およびその製造中間体
US6331555B1 (en) 1995-06-01 2001-12-18 University Of California Treatment of platelet derived growth factor related disorders such as cancers
PL335839A1 (en) 1997-03-14 2000-05-22 Basf Ag Cycloalkylalkane carboxamides as well as their production and application
US7863444B2 (en) 1997-03-19 2011-01-04 Abbott Laboratories 4-aminopyrrolopyrimidines as kinase inhibitors
IL125947A0 (en) 1997-09-17 1999-04-11 American Cyanamid Co 3-(1,2-benzisothiazol- and isoxazol-5-yl)-2,4(1h,3h)-pyrimidinedione or thione and 3-(1,2-benzisothiazol- and isoxazol-5-yl)-4(3)-pyrimidinone or thione herbicidal agents
DE69814122T2 (de) 1997-10-09 2004-03-18 Dexcel Pharma Technologies Ltd. Darreichungsform zur verzögerten, vollständigen wirkstoffabgabe im verdauungstrakt
US6713474B2 (en) 1998-09-18 2004-03-30 Abbott Gmbh & Co. Kg Pyrrolopyrimidines as therapeutic agents
CA2366932C (fr) 1999-04-15 2009-08-25 Bristol-Myers Squibb Company Inhibiteurs cycliques de proteine tyrosine kinase
KR20020088406A (ko) 1999-09-17 2002-11-27 애보트 게엠베하 운트 콤파니 카게 치료제로서의 피라졸로피리미딘
AU2000240570A1 (en) 2000-03-29 2001-10-08 Knoll Gesellschaft Mit Beschraenkter Haftung Pyrrolopyrimidines as tyrosine kinase inhibitors
AR042586A1 (es) 2001-02-15 2005-06-29 Sugen Inc 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
MXPA03008560A (es) 2001-03-22 2004-06-30 Abbot Gmbh & Co Kg Pirazolopirimidinas como agentes terapeuticos.
WO2003037890A2 (fr) 2001-11-01 2003-05-08 Icagen, Inc. Piperidines
JP3991812B2 (ja) 2001-12-11 2007-10-17 住友化学株式会社 エステル化合物およびその用途
AU2003210983A1 (en) 2002-02-11 2003-09-04 The Brigham And Women's Hospital, Inc. Kinase inhibitors and methods of use thereof
NI200300043A (es) 2002-03-28 2003-11-05 Warner Lambert Co AMINOACIDOS CON AFINIDAD POR LA PROTEINA a2DELTA.
FR2842735B1 (fr) 2002-07-26 2006-01-06 Flamel Tech Sa Microcapsules a liberation modifiee de principes actifs peu solubles pour l'administration per os
GB0219024D0 (en) 2002-08-15 2002-09-25 Pfizer Ltd Synergistic combinations
US7419981B2 (en) 2002-08-15 2008-09-02 Pfizer Inc. Synergistic combinations of an alpha-2-delta ligand and a cGMP phosphodieterse 5 inhibitor
GB0226370D0 (en) 2002-11-12 2002-12-18 Novartis Ag Organic compounds
JP2006518368A (ja) 2003-02-21 2006-08-10 ファイザー・インク プロテインキナーゼ阻害剤としてのｎ−ヘテロシクリル置換アミノチアゾール誘導体
WO2004100868A2 (fr) 2003-04-23 2004-11-25 Abbott Laboratories Procede servant a traiter le rejet d'un transplant
JP4727579B2 (ja) 2003-08-01 2011-07-20 中外製薬株式会社 マロニル−ＣｏＡデカルボキシラーゼ阻害剤として有用なシアノアミド化合物
KR20060115350A (ko) 2003-09-02 2006-11-08 화이자 프로덕츠 인크. 지프라시돈의 지속 방출형 투여 형태
WO2005023773A1 (fr) 2003-09-04 2005-03-17 Pfizer Limited Procede pour la preparation d'arylpyrazoles substitues
GB0322140D0 (en) 2003-09-22 2003-10-22 Pfizer Ltd Combinations
BRPI0414798A (pt) 2003-09-25 2006-11-21 Warner Lambert Co métodos para usar aminoácidos com afinidade para a proteìna alfa2delta
WO2005074603A2 (fr) 2004-02-03 2005-08-18 Abbott Laboratories Utilisation d'aminobenzoxazoles comme agents therapeutiques
JP4552456B2 (ja) 2004-02-27 2010-09-29 住友化学株式会社 エステル化合物およびその用途
EP1724264A1 (fr) 2004-03-10 2006-11-22 Ono Pharmaceutical Co., Ltd. Nitriles et compositions medicinales contenant ceux-ci en tant qu'ingredient actif
US7807719B2 (en) 2004-09-14 2010-10-05 Chaim Roifman Compounds useful for modulating abnormal cell proliferation
US20060079494A1 (en) 2004-09-27 2006-04-13 Santi Daniel V Specific kinase inhibitors
CA2597587A1 (fr) 2005-02-11 2006-08-17 Coley Pharmaceutical Group, Inc. Composes cycliques imidazo[4,5-c] substitues par oxime et hydroxylamine et procedes associes
US20080260818A1 (en) 2005-03-28 2008-10-23 Dexcel Pharma Technologies Ltd. Controlled Absorption of Statins in the Intestine
EP2029138A1 (fr) 2005-06-03 2009-03-04 Xenon Pharmaceuticals Inc. Derives aminothiazole utilises en tant qu'inhibiteurs de la stearoyle-coa desaturase humaine
US20080176865A1 (en) 2005-06-15 2008-07-24 Pfizer Limited Substituted arylpyrazoles
US7645786B2 (en) 2005-06-15 2010-01-12 Pfizer Inc. Substituted arylpyrazoles
EP1893581B1 (fr) 2005-06-15 2010-01-27 Pfizer Limited Arylpyrazoles substitues pour une utilisation contre les parasites
US20070149464A1 (en) 2005-06-15 2007-06-28 Pfizer Inc. Combination
US20080146643A1 (en) 2005-06-15 2008-06-19 Pfizer Limited Combination
GB0517205D0 (en) 2005-08-22 2005-09-28 Novartis Ag Organic compounds
CA2623327A1 (fr) 2005-10-07 2007-04-19 Kissei Pharmaceutical Co., Ltd. Compose heterocyclique azote et composition pharmaceutique le contenant
JP5193876B2 (ja) 2005-12-02 2013-05-08 バイエル・ヘルスケア・エルエルシー オーロラキナーゼの阻害により癌を処置するために有用なピロロトリアジン誘導体
KR20080098490A (ko) 2006-01-13 2008-11-10 파마시클릭스, 인코포레이티드 티로신 키나제 억제제 및 이의 용도
WO2007115269A2 (fr) 2006-03-31 2007-10-11 The Board Of Regents Of The University Of Texas System Médicaments anticancéreux biodisponibles par voie orale associés à l'acide caféique
US7645748B2 (en) 2006-04-03 2010-01-12 Forbes Medi-Tech Inc. Sterol/stanol phosphorylnitroderivatives and use thereof
US8846697B2 (en) 2006-05-31 2014-09-30 The Regents Of The University Of California Purine analogs
WO2008005954A2 (fr) 2006-06-30 2008-01-10 The Board Of Regents Of The University Of Texas System Modulateurs de protéine signal en tant qu'agents thérapeutiques
RU2481336C2 (ru) 2006-07-06 2013-05-10 Эррэй Биофарма Инк. Циклопента(d)пиримидины в качестве ингибиторов протеинкиназ акт
EP2529621B1 (fr) 2006-09-22 2016-10-05 Pharmacyclics LLC Inhibiteurs de la tyrosine kinase de bruton
WO2008054827A2 (fr) 2006-11-03 2008-05-08 Pharmacyclics, Inc. Sonde d'activité de la tyrosine kinase de bruton et son procédé d'utilisation
AU2007323335A1 (en) 2006-11-23 2008-05-29 Novartis Ag Pyrimidines and their use as CXCR2 receptor antagonists
WO2008116064A2 (fr) 2007-03-21 2008-09-25 Bristol-Myers Squibb Company Composés hétérocycliques fusionnés utiles en tant que modulateurs de kinases
GB2447933A (en) 2007-03-27 2008-10-01 Chemence Ltd Cyanoacrylate monomer for forming an adhesive polymer
EP2139487B1 (fr) 2007-03-28 2015-11-11 Pharmacyclics LLC Inhibiteurs de la tyrosine kinase de bruton
ATE522536T1 (de) 2008-02-25 2011-09-15 Hoffmann La Roche Pyrrolopyrazin-kinasehemmer
RU2503676C2 (ru) 2008-02-25 2014-01-10 Ф.Хоффманн-Ля Рош Аг Пирролопиразиновые ингибиторы киназы
CA2722418C (fr) 2008-05-13 2013-09-17 Irm Llc Heterocycles fusionnes contenant de l'azote et compositions a base de ceux-ci utilisees comme inhibiteurs de kinase
JP2011520986A (ja) 2008-05-22 2011-07-21 アムジエン・インコーポレーテツド タンパク質キナーゼ阻害薬としての複素環類
CN102159214A (zh) 2008-07-16 2011-08-17 药品循环公司 用于实体肿瘤的治疗的布鲁顿酪氨酸激酶的抑制剂
RU2011105768A (ru) 2008-08-01 2012-09-10 Биокрист Фармасьютикалз, Инк. (Us) Производные пиперидина в качестве ингибиторов jakз
US8450337B2 (en) 2008-09-30 2013-05-28 Moleculin, Llc Methods of treating skin disorders with caffeic acid analogs
US20100113520A1 (en) 2008-11-05 2010-05-06 Principia Biopharma, Inc. Kinase knockdown via electrophilically enhanced inhibitors
US20120028981A1 (en) 2008-11-05 2012-02-02 Principia Biopharma Inc. Kinase Knockdown Via Electrophilically Enhanced Inhibitors
US8426428B2 (en) 2008-12-05 2013-04-23 Principia Biopharma, Inc. EGFR kinase knockdown via electrophilically enhanced inhibitors
KR20120063515A (ko) 2009-09-09 2012-06-15 아빌라 테라퓨틱스, 인크. Ｐｉ３ 키나제 억제제 및 이들의 용도
US7741330B1 (en) 2009-10-12 2010-06-22 Pharmacyclics, Inc. Pyrazolo-pyrimidine inhibitors of Bruton's tyrosine kinase
CN102711765A (zh) 2009-11-16 2012-10-03 加利福尼亚大学董事会 激酶抑制剂
EP2571880A1 (fr) 2010-05-20 2013-03-27 F.Hoffmann-La Roche Ag Dérivés de pyrrolo[2,3-b]pyrazine-7-carboxamide et leur utilisation comme inhibiteurs de jak et syk
US8940725B2 (en) 2010-05-31 2015-01-27 Ono Pharmaceutical Co., Ltd. Purinone derivative
MX380504B (es) 2010-06-03 2025-03-12 Pharmacyclics Llc El uso de inhibidores de la tirosina quinasa de bruton (btk).
US20120071497A1 (en) 2010-06-03 2012-03-22 Pharmacyclics, Inc. Methods of treating abc-dlbcl using inhibitors of bruton's tyrosine kinase
CN101880243A (zh) 2010-06-04 2010-11-10 贵阳柏丝特化工有限公司 一种含氟氰拟除虫菊酯化合物及其合成方法与用途
PH12013500246A1 (en) 2010-08-10 2019-10-11 Celgene Avilomics Res Inc Besylate salt of a btk inhibitor
WO2012158810A1 (fr) 2011-05-17 2012-11-22 Principia Biopharma Inc. Inhibiteurs de tyrosine kinase
DK2710007T3 (da) 2011-05-17 2020-01-27 Principia Biopharma Inc Kinasehæmmere
WO2012158795A1 (fr) 2011-05-17 2012-11-22 Principia Biopharma Inc. Dérivés de pyrazolopyrimidine utilisés comme inhibiteurs de tyrosine kinase
AU2012255860C1 (en) 2011-05-17 2015-12-10 Principia Biopharma Inc. Tyrosine kinase inhibitors
US8828426B2 (en) 2011-06-07 2014-09-09 Zx Pharma, Llc Multiparticulate L-carnitine compositions and related methods
WO2013003629A2 (fr) 2011-06-28 2013-01-03 Pharmacyclics, Inc. Procédés et compositions visant à inhiber la résorption osseuse
KR20140048968A (ko) 2011-07-13 2014-04-24 파마시클릭스, 인코포레이티드 브루톤형 티로신 키나제의 억제제
WO2013010869A1 (fr) 2011-07-19 2013-01-24 Msd Oss B.V. 4-imidazopyridazin-1-yl-benzamides et 4-imidazotriazin-1-yl-benzamides inhibiteurs de btk
EP2548877A1 (fr) 2011-07-19 2013-01-23 MSD Oss B.V. Dérivés de 4-(pyridine condensée à 5 chaînons)benzamide comme inhibiteurs de BTK
CN103889987B (zh) * 2011-07-19 2016-09-14 默沙东有限责任公司 作为btk抑制剂的选择的咪唑并吡嗪类
KR20140063700A (ko) 2011-09-20 2014-05-27 셀좀 리미티드 키나제 억제제로서의 피라졸로[4,3-c]피리딘 유도체
US20140303191A1 (en) 2011-10-19 2014-10-09 Pharmacyclics, Inc. Use of inhibitors of bruton's tyrosine kinase (btk)
US8377946B1 (en) 2011-12-30 2013-02-19 Pharmacyclics, Inc. Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
US8501724B1 (en) 2012-01-31 2013-08-06 Pharmacyclics, Inc. Purinone compounds as kinase inhibitors
EP2858500A4 (fr) 2012-06-08 2016-04-06 Biogen Ma Inc Inhibiteurs de la tyrosine kinase de bruton
CN104487441B (zh) * 2012-06-18 2018-06-01 普林斯匹亚生物制药公司 有用于治疗癌症和自身免疫性疾病的可逆的共价吡咯并嘧啶或吡唑并嘧啶
WO2014004707A1 (fr) 2012-06-29 2014-01-03 Principia Biopharma Inc. Formulations comprenant de l'ibrutinib
US9572811B2 (en) 2012-08-03 2017-02-21 Principia Biopharma Inc. Treatment of dry eye
SMT201900344T1 (it) 2012-09-10 2019-07-11 Principia Biopharma Inc Composti di pirazolopirimidina come inibitori di chinasi
US20150291554A1 (en) 2012-11-02 2015-10-15 Pfizer Inc. Bruton's Tyrosine Kinase Inhibitors
KR20150084923A (ko) 2012-11-15 2015-07-22 파마시클릭스, 인코포레이티드 키나제 억제제로서의 피롤로피리미딘 화합물
US20140142099A1 (en) 2012-11-20 2014-05-22 Principia Biopharma Inc. Purinone Derivatives as Tyrosine Kinase Inhibitors
JO3377B1 (ar) * 2013-03-11 2019-03-13 Takeda Pharmaceuticals Co مشتقات بيريدينيل وبيريدينيل مندمج
US8957080B2 (en) 2013-04-09 2015-02-17 Principia Biopharma Inc. Tyrosine kinase inhibitors
SG11201605417QA (en) 2014-02-03 2016-08-30 Cadila Healthcare Ltd Heterocyclic compounds
CN112353806A (zh) 2014-02-21 2021-02-12 普林斯匹亚生物制药公司 Btk抑制剂的盐和固体形式
SG11201704808VA (en) 2014-12-18 2017-07-28 Principia Biopharma Inc Treatment of pemphigus
CN107427468B (zh) 2014-12-24 2022-02-25 普林斯匹亚生物制药公司 Btk抑制剂的部位特异性给药
HRP20230305T1 (hr) 2014-12-24 2023-05-26 Principia Biopharma Inc. Pripravci za ileo-jejunalnu dostavu lijeka
EP3912979B1 (fr) 2015-06-03 2026-03-25 Principia Biopharma Inc. Inhibiteurs de kinase de tyrosine
US20180305350A1 (en) 2015-06-24 2018-10-25 Principia Biopharma Inc. Tyrosine kinase inhibitors
CN105753863B (zh) 2015-09-11 2018-07-31 东莞市真兴贝特医药技术有限公司 氧代二氢咪唑并吡啶类化合物及其应用
US10358446B2 (en) 2015-10-14 2019-07-23 Zibo Biopolar Changsheng Pharmaceutical Co., Ltd. Bruton's tyrosine kinase inhibitors
IL263815B (en) 2016-06-29 2022-07-01 Principia Biopharma Inc Modified release formulations of 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[4,3-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4 -Methyl-4-[4-(Oxtan-3-yl)piperazin-1-yl)pent-2-ananitrile

Also Published As

Publication number Publication date
BR112017013022A2 (pt) 2018-02-27
SG11201704808VA (en) 2017-07-28
US20180050027A1 (en) 2018-02-22
AU2015364335B2 (en) 2020-11-26
IL252839B (en) 2021-03-25
US20200101059A1 (en) 2020-04-02
EP3233103A1 (fr) 2017-10-25
CN107257686A (zh) 2017-10-17
EP3233103B1 (fr) 2020-10-14
CN107257686B (zh) 2021-01-29
US10485797B2 (en) 2019-11-26
CA2970723A1 (fr) 2016-06-23
MX381283B (es) 2025-03-12
PL3233103T3 (pl) 2021-04-19
AU2020264338A1 (en) 2020-12-03
IL252839A0 (en) 2017-08-31
EA036269B1 (ru) 2020-10-21
MX2017007973A (es) 2018-02-09
CA2970723C (fr) 2023-09-05
ES2843323T3 (es) 2021-07-16
WO2016100914A1 (fr) 2016-06-23
US10946008B2 (en) 2021-03-16
AU2015364335A1 (en) 2017-07-20
PT3233103T (pt) 2021-01-18
EA201791243A1 (ru) 2017-12-29

Similar Documents

Publication Publication Date Title
MX2024008539A (es) Compuestos bifuncionales para degradar la tirosina cinasa de bruton (btk) mediante la trayectoria de ubiquitina proteosoma.
MX381283B (es) Tratamiento de pénfigo.
ZA202204929B (en) Rimegepant for cgrp related disorders
EP4374851A3 (fr) Composition ophtalmique pour le traitement d'une maladie de l' il sec
CY1110435T1 (el) Μεθοδοι και συνθεσεις για τη θεραπεια οφθαλμικων καταστασεων με παραγωγα ρετινολης
MA40768B1 (fr) Dérivés d'indole mono ou di-substitué en tant qu'inhibiteurs de réplication du virus de la dengue
PH12017500927A1 (en) Envenomation therapies and related pharmaceutical compositions, systems and kits
MA38961A1 (fr) Composés 3-phenyl-1h-pyrazolo[3,4-d]pyrimidin-4-ylamine substitués inhibiteurs de la tyrosine kinase de bruton utilisés pour traiter par exemple les maladies auto-immunes, respiratoires et inflammatoires, cancer, mastocytose et osteoporose
EP3708168A3 (fr) Combinaisons comprenant du dextrométhorphane deutéré et de la quinidine destinées au traitement de l'agitation dans le cadre d'une démence
MX2019007586A (es) Composiciones que comprenden tacrolimus para el tratamiento de enfermedades inflamatorias intraoculares.
EP4335418A3 (fr) Compositions et méthodes pour le traitement du ptérygion
TW201613919A (en) Inhibitors of Bruton's tyrosine kinase
MX2017015574A (es) Inhibidores de tirosina quinasa de bruton.
WO2014194254A8 (fr) Traitement anticancer au moyen de modulateurs isoformes de la kinase p13
MX360045B (es) Combinaciones farmacéuticas de un inhibidor de cdk4/6 y un inhibidor de b-raf.
MX2017010982A (es) Uso de pridopidina para mejorar la funcion cognitiva y para tratamiento de enfermedad de alzheimer.
MA46366B1 (fr) Procédé sûr et efficace de traitement du psoriasis avec un anticorps spécifique contre l'il-23
MA41238A (fr) Dérivés 5-[(pipérazin-1-yl)-3-oxo-propyl]-imidazolidine-2,4-dione en tant qu'inhibiteurs d'adamts pour le traitement de l'ostéoarthrit
AU2012286851A8 (en) Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
NZ792518A (en) Formulations for administration of eflornithine
MX2022000712A (es) Moduladores de nlrp3.
EP4324454A3 (fr) Agents de reticulation et procedes associes
EP4286013A3 (fr) Inhibiteurs de lrrc33 et utilisations de ceux-ci
MX2017007054A (es) Composiciones y métodos para usar solabegron de liberación modificada para sintomas del tracto urinario inferior.
ZA202002103B (en) Compounds as mpges-1 inhibitors