MA41197B1 - Traitement de le pemphigus - Google Patents
Traitement de le pemphigusInfo
- Publication number
- MA41197B1 MA41197B1 MA41197A MA41197A MA41197B1 MA 41197 B1 MA41197 B1 MA 41197B1 MA 41197 A MA41197 A MA 41197A MA 41197 A MA41197 A MA 41197A MA 41197 B1 MA41197 B1 MA 41197B1
- Authority
- MA
- Morocco
- Prior art keywords
- pemphigus
- corticosteroids
- therapy
- relates
- present
- Prior art date
Links
- 241000721454 Pemphigus Species 0.000 title abstract 2
- 229940124291 BTK inhibitor Drugs 0.000 abstract 3
- 239000003246 corticosteroid Substances 0.000 abstract 3
- 229960001334 corticosteroids Drugs 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 201000011152 Pemphigus Diseases 0.000 abstract 1
- 208000037979 autoimmune inflammatory disease Diseases 0.000 abstract 1
- 238000009093 first-line therapy Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 201000001976 pemphigus vulgaris Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000009256 replacement therapy Methods 0.000 abstract 1
- 238000009094 second-line therapy Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La présente invention concerne des procédés de traitement, avec un inhibiteur de btk, d'une maladie bulleuse, en particulier du pemphigus vulgaire ou du pemphigus foliacé chez un mammifère, l'utilisation d'un inhibiteur de btk en tant que thérapie de remplacement d'une thérapie par corticoïdes pour les maladies pouvant être traitées avec des corticoïdes, telles qu'une maladie auto-immune ou une maladie inflammatoire et en particulier lorsque des corticoïdes sont utilisés comme thérapie de première ou de seconde ligne. La présente invention concerne également des formulations pharmaceutiques comprenant ces inhibiteurs de btk.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462093891P | 2014-12-18 | 2014-12-18 | |
| PCT/US2015/066868 WO2016100914A1 (fr) | 2014-12-18 | 2015-12-18 | Traitement du pemphigus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA41197B1 true MA41197B1 (fr) | 2021-01-29 |
Family
ID=55080225
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA41197A MA41197B1 (fr) | 2014-12-18 | 2015-12-18 | Traitement de le pemphigus |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US10485797B2 (fr) |
| EP (1) | EP3233103B1 (fr) |
| CN (1) | CN107257686B (fr) |
| AU (2) | AU2015364335B2 (fr) |
| CA (1) | CA2970723C (fr) |
| EA (1) | EA036269B1 (fr) |
| ES (1) | ES2843323T3 (fr) |
| IL (1) | IL252839B (fr) |
| MA (1) | MA41197B1 (fr) |
| MX (1) | MX381283B (fr) |
| PL (1) | PL3233103T3 (fr) |
| PT (1) | PT3233103T (fr) |
| SG (1) | SG11201704808VA (fr) |
| WO (1) | WO2016100914A1 (fr) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6203848B2 (ja) | 2012-09-10 | 2017-09-27 | プリンシピア バイオファーマ インコーポレイテッド | キナーゼ阻害剤としてのピラゾロピリミジン化合物 |
| RS55770B1 (sr) | 2013-04-25 | 2017-07-31 | Beigene Ltd | Fuzionisana heterociklična jedinjenja kao inhibitori protein kinaze |
| DK3044234T3 (da) | 2013-09-13 | 2020-05-18 | Beigene Switzerland Gmbh | Anti-PD1-antistoffer og anvendelse deraf som terapeutika og diagnostika |
| KR20160117614A (ko) | 2014-02-21 | 2016-10-10 | 프린시피아 바이오파마, 인코퍼레이티드 | Btk 억제제의 염 및 고체 형태 |
| KR102130600B1 (ko) | 2014-07-03 | 2020-07-08 | 베이진 엘티디 | Pd-l1 항체와 이를 이용한 치료 및 진단 |
| AU2015364335B2 (en) | 2014-12-18 | 2020-11-26 | Principia Biopharma Inc. | Treatment of pemphigus |
| EP3313839A1 (fr) | 2015-06-24 | 2018-05-02 | Principia Biopharma Inc. | Inhibiteurs de la tyrosine kinase |
| KR102391693B1 (ko) | 2016-06-29 | 2022-04-29 | 프린시피아 바이오파마, 인코퍼레이티드 | 2-[3-[4-아미노-3-(2-플루오로-4-페녹시-페닐)피라졸로[3,4-d]피리미딘-1-일]피페리딘-1-카르보닐]-4-메틸-4-[4-(옥세탄-3-일)피페라진-1-일]펜트-2-엔니트릴의 변형 방출 제제 |
| WO2018007885A1 (fr) | 2016-07-05 | 2018-01-11 | Beigene, Ltd. | Association d'un antagoniste de pd-1 et d'un inhibiteur du raf pour le traitement du cancer. |
| TWI884890B (zh) | 2016-08-16 | 2025-05-21 | 瑞士商百濟神州瑞士有限責任公司 | (s)-7-(1-丙烯醯基六氫吡啶-4-基)-2-(4-苯氧基苯基)-4,5,6,7-四氫吡唑並[1,5-a]嘧啶-3-甲醯胺的晶型、其製備和用途 |
| WO2018033135A1 (fr) * | 2016-08-19 | 2018-02-22 | Beigene, Ltd. | Utilisation d'une combinaison comprenant un inhibiteur de btk pour le traitement de cancers |
| SG10201913918UA (en) | 2016-12-15 | 2020-03-30 | Hoffmann La Roche | Process for preparing btk inhibitors |
| CN108329274B (zh) * | 2017-01-13 | 2021-09-03 | 正大天晴药业集团股份有限公司 | 布鲁顿酪氨酸激酶抑制剂 |
| EP3573989A4 (fr) * | 2017-01-25 | 2020-11-18 | Beigene, Ltd. | Formes cristallines de (s) -7- (1- (but-2-ynoyl) pipéridin-4-yl) -2- (4-phénoxyphényl) -4, 5, 6, 7-tétrahy dropyrazolo [1, 5-a]pyrimidine-3-carboxamide, préparation et utilisations associées |
| CN108727404B (zh) * | 2017-04-14 | 2020-05-12 | 中国科学院上海药物研究所 | 噻吩并[3,2-d]嘧啶类化合物、其制备方法及用途 |
| WO2019001417A1 (fr) | 2017-06-26 | 2019-01-03 | Beigene, Ltd. | Immunothérapie pour carcinome hépatocellulaire |
| CN110997677A (zh) | 2017-08-12 | 2020-04-10 | 百济神州有限公司 | 具有改进的双重选择性的Btk抑制剂 |
| CN111801334B (zh) | 2017-11-29 | 2023-06-09 | 百济神州瑞士有限责任公司 | 使用包含btk抑制剂的组合治疗惰性或侵袭性b-细胞淋巴瘤 |
| EP3789040A4 (fr) * | 2018-04-27 | 2022-03-09 | ONO Pharmaceutical Co., Ltd. | Agent préventif et/ou thérapeutique pour maladie auto-immune comprenant un composé ayant une activité inhibitrice de btk en tant que principe actif |
| EP3853217B1 (fr) | 2018-09-18 | 2023-06-07 | Beijing InnoCare Pharma Tech Co., Ltd. | Forme cristalline de 6-(1-acryloylpipéridin-4-yl)-2-(4-phénoxyphényl) nicotinamide |
| SG11202103861YA (en) * | 2018-11-06 | 2021-05-28 | Beijing Innocare Pharma Tech Co Ltd | Amorphous solid dispersion comprising 6- (1-acryloylpiperidin-4-yl) -2- (4-phenoxyphenyl) nicotinamide |
| CN109939223B (zh) * | 2019-04-04 | 2020-04-07 | 中南大学湘雅二医院 | 一种白介素2在制备用于治疗寻常型天疱疮口腔糜烂药物的应用 |
| CN113939289A (zh) | 2019-06-10 | 2022-01-14 | 百济神州瑞士有限责任公司 | 一种含有布鲁顿氏酪氨酸激酶抑制剂的口服固体片剂及其制备方法 |
| BR112022005575A2 (pt) | 2019-10-09 | 2022-06-21 | Principia Biopharma Inc | Métodos de tratar pênfigo por administração de (r)-2-[3-[4-amino-3-(2-fluoro-4-fenóxi-fenil)pirazolo[3,4-d]pirimidin-1-il]piperidina-1-carbonil]-4-metil-4-[4-(oxetan-3-il)piperazin-1-il]pent-2-enonitrila |
| TWI877239B (zh) | 2019-10-14 | 2025-03-21 | 美商普林斯匹亞生物製藥公司 | 藉由投予(R)-2-[3-[4-胺基-3-(2-氟-4-苯氧基-苯基)吡唑并[3,4-d]嘧啶-1-基]哌啶-1-羰基]-4-甲基-4-[4-(氧呾-3-基)哌-1-基]戊-2-烯腈來治療免疫血小板減少症之方法 |
| JP7750841B2 (ja) * | 2020-01-08 | 2025-10-07 | プリンシピア バイオファーマ インコーポレイテッド | 2-[3-[4-アミノ-3-(2-フルオロ-4-フェノキシ-フェニル)-1h-ピラゾロ[3,4-d]ピリミジン-1-イル]ピペリジン-1-カルボニル]-4,4-ジメチルペント-2-エンニトリルを含む局所用医薬組成物 |
| MX2022009009A (es) | 2020-01-22 | 2022-08-15 | Principia Biopharma Inc | Formas cristalinas de 2-[3-[4-amino-3-(2-fluoro-4-fenoxi-fenil)-1h -pirazolo[3,4-d]pirimidin-1-il]piperidin-1-carbonil]-4-metil-4-[4 -(oxetan-3-il)piperazin-1-il]pent-2-enonitrilo. |
| WO2021207662A1 (fr) * | 2020-04-10 | 2021-10-14 | Genentech, Inc. | Utilisation d'il-22-fc pour le traitement ou la prévention de la pneumonie, du syndrome de détresse respiratoire aiguë ou du syndrome de libération de cytokines |
| TW202308638A (zh) * | 2021-04-16 | 2023-03-01 | 美商普林斯匹亞生物製藥公司 | 藉由投予特定化合物治療藥物及疫苗誘發的免疫性血小板減少症之方法 |
| US11786531B1 (en) | 2022-06-08 | 2023-10-17 | Beigene Switzerland Gmbh | Methods of treating B-cell proliferative disorder |
| KR20250088633A (ko) | 2022-10-31 | 2025-06-17 | 프린시피아 바이오파마, 인코퍼레이티드 | (R)-2-[3-[4-아미노-3-(2-플루오로-4-페녹시-페닐)피라졸로[3,4-d]피리미딘-1-일]피페리딘-1-카르보닐]-4-메틸-4-[4-(옥세탄-3-일)피페라진-1-일]펜트-2-엔니트릴을투여하여 면역 혈소판 감소증을 치료하는 방법 |
| KR20250114128A (ko) | 2022-12-09 | 2025-07-28 | 프린시피아 바이오파마, 인코퍼레이티드 | 인지 장애가 있는 대상체의 면역성 혈소판감소증을 릴자브루티닙 투여로 치료하는 방법 |
| CN116849178A (zh) * | 2023-06-26 | 2023-10-10 | 武汉大学中南医院 | 胎源性成年骨关节炎易感模型的构建方法、共性干预靶标及其应用 |
| AU2024306785A1 (en) | 2023-06-30 | 2026-02-19 | Principia Biopharma Inc. | Methods for treating persistent or chronic immune thrombocytopenia in children, adolescents and adults by administering (r)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy- phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4- methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile |
| WO2025019544A1 (fr) | 2023-07-17 | 2025-01-23 | Kadmon Corporation, Llc | Polythérapie comprenant un inhibiteur de btk et du bélumosudil |
| WO2025090702A1 (fr) | 2023-10-25 | 2025-05-01 | Principia Biopharma Inc. | Rilzabrutinib destiné à être utilisé dans le traitement des démangeaisons associées à la dermatite atopique et/ou au prurigo nodulaire |
| WO2025122747A1 (fr) | 2023-12-06 | 2025-06-12 | Principia Biopharma Inc. | Traitement de l'asthme modéré à sévère par administration de rilzabrutinib |
| WO2026024765A1 (fr) | 2024-07-23 | 2026-01-29 | Principia Biopharma Inc. | Traitement de la thrombose veineuse avec du rilzabrutinib et ses dérivés |
| WO2026024885A1 (fr) | 2024-07-24 | 2026-01-29 | Principia Biopharma Inc. | Rizalbrutinib pour le traitement de l'anémie hémolytique auto-immune à anticorps chaud |
| WO2026035812A1 (fr) | 2024-08-08 | 2026-02-12 | Principia Biopharma Inc. | Méthodes de traitement de la drépanocytose par administration d'un inhibiteur de btk |
Family Cites Families (123)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4082819A (en) | 1977-03-02 | 1978-04-04 | The Standard Oil Company | Rubber-modified acrylonitrile-vinyl ether-indene polymers |
| JPS5663950A (en) | 1979-10-30 | 1981-05-30 | Mitsubishi Chem Ind Ltd | Cyclopropanecarboxylic ester |
| FR2535721A1 (fr) | 1982-11-08 | 1984-05-11 | Sanofi Sa | Derives de la piperidinedione protecteurs du myocarde presentant une acticite antiarythmique, leur procede de preparation et les medicaments qui contiennent lesdits derives |
| US4911920A (en) | 1986-07-30 | 1990-03-27 | Alcon Laboratories, Inc. | Sustained release, comfort formulation for glaucoma therapy |
| JPS623848A (ja) | 1985-06-28 | 1987-01-09 | Nippon Steel Corp | 疲労強度のすぐれたスタツド付きフラツシユバツト溶接アンカ−チエ−ン |
| FR2588189B1 (fr) | 1985-10-03 | 1988-12-02 | Merck Sharp & Dohme | Composition pharmaceutique de type a transition de phase liquide-gel |
| JP2518353B2 (ja) | 1988-06-09 | 1996-07-24 | 住友化学工業株式会社 | シアノ酢酸アミド誘導体およびその製造中間体 |
| CA2018801C (fr) | 1990-06-12 | 2000-08-22 | Pierre Louis Beaulieu | Derives peptidiques comprenant une terminaison-n1,4-dioxo-c4 |
| JPH04177244A (ja) | 1990-11-10 | 1992-06-24 | Konica Corp | ハロゲン化銀写真感光材料 |
| CA2033447C (fr) | 1990-12-31 | 1999-08-31 | Robert Deziel | Complexe synergique pour le traitement des infections herpetiques |
| DE69212850T2 (de) | 1991-01-15 | 1997-03-06 | Alcon Lab Inc | Verwendung von Karrageenan in topischen ophthalmologischen Zusammensetzungen |
| US5212162A (en) | 1991-03-27 | 1993-05-18 | Alcon Laboratories, Inc. | Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions |
| JPH05301838A (ja) | 1991-10-15 | 1993-11-16 | Mitsubishi Kasei Corp | スチレン誘導体 |
| US5792771A (en) | 1992-11-13 | 1998-08-11 | Sugen, Inc. | Quinazoline compounds and compositions thereof for the treatment of disease |
| AU2096895A (en) | 1994-03-07 | 1995-09-25 | Sugen, Incorporated | Receptor tyrosine kinase inhibitors for inhibiting cell proliferative disorders and compositions thereof |
| JPH0827090A (ja) | 1994-05-13 | 1996-01-30 | Sumitomo Chem Co Ltd | シアノ酢酸アミド誘導体、その用途およびその製造中間体 |
| US6331555B1 (en) | 1995-06-01 | 2001-12-18 | University Of California | Treatment of platelet derived growth factor related disorders such as cancers |
| PL335839A1 (en) | 1997-03-14 | 2000-05-22 | Basf Ag | Cycloalkylalkane carboxamides as well as their production and application |
| US7863444B2 (en) | 1997-03-19 | 2011-01-04 | Abbott Laboratories | 4-aminopyrrolopyrimidines as kinase inhibitors |
| IL125947A0 (en) | 1997-09-17 | 1999-04-11 | American Cyanamid Co | 3-(1,2-benzisothiazol- and isoxazol-5-yl)-2,4(1h,3h)-pyrimidinedione or thione and 3-(1,2-benzisothiazol- and isoxazol-5-yl)-4(3)-pyrimidinone or thione herbicidal agents |
| JP2001519379A (ja) | 1997-10-09 | 2001-10-23 | ペリオ、プロダクツ、リミテッド | 遅延性総放出胃腸薬物送達システム |
| US6713474B2 (en) | 1998-09-18 | 2004-03-30 | Abbott Gmbh & Co. Kg | Pyrrolopyrimidines as therapeutic agents |
| EP1169038B9 (fr) | 1999-04-15 | 2013-07-10 | Bristol-Myers Squibb Company | Inhibiteurs cycliques de proteine tyrosine kinase |
| SK3812002A3 (en) | 1999-09-17 | 2003-09-11 | Abbott Gmbh & Co Kg | Pyrazolopyrimidines as therapeutic agents |
| AU2000240570A1 (en) | 2000-03-29 | 2001-10-08 | Knoll Gesellschaft Mit Beschraenkter Haftung | Pyrrolopyrimidines as tyrosine kinase inhibitors |
| AR042586A1 (es) | 2001-02-15 | 2005-06-29 | Sugen Inc | 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa |
| MXPA03008560A (es) | 2001-03-22 | 2004-06-30 | Abbot Gmbh & Co Kg | Pirazolopirimidinas como agentes terapeuticos. |
| WO2003037890A2 (fr) | 2001-11-01 | 2003-05-08 | Icagen, Inc. | Piperidines |
| JP3991812B2 (ja) | 2001-12-11 | 2007-10-17 | 住友化学株式会社 | エステル化合物およびその用途 |
| WO2003068157A2 (fr) | 2002-02-11 | 2003-08-21 | The Brigham And Women's Hospital, Inc. | Inhibiteurs de kinase et leurs procedes d'utilisation |
| NI200300043A (es) | 2002-03-28 | 2003-11-05 | Warner Lambert Co | AMINOACIDOS CON AFINIDAD POR LA PROTEINA a2DELTA. |
| FR2842735B1 (fr) | 2002-07-26 | 2006-01-06 | Flamel Tech Sa | Microcapsules a liberation modifiee de principes actifs peu solubles pour l'administration per os |
| GB0219024D0 (en) | 2002-08-15 | 2002-09-25 | Pfizer Ltd | Synergistic combinations |
| US7419981B2 (en) | 2002-08-15 | 2008-09-02 | Pfizer Inc. | Synergistic combinations of an alpha-2-delta ligand and a cGMP phosphodieterse 5 inhibitor |
| GB0226370D0 (en) | 2002-11-12 | 2002-12-18 | Novartis Ag | Organic compounds |
| MXPA05008878A (es) | 2003-02-21 | 2005-10-05 | Pfizer | Derivados de aminotiazol sustituidos con cicloalquilo que contiene n y composiciones farmaceuticas para inhibir la proliferacion celular, y metodos para su uso. |
| WO2004100868A2 (fr) | 2003-04-23 | 2004-11-25 | Abbott Laboratories | Procede servant a traiter le rejet d'un transplant |
| ES2295930T3 (es) | 2003-08-01 | 2008-04-16 | Chugai Seiyaku Kabushiki Kaisha | Compuestos de cianoamida utiles como inhibidores de malonil-coa descarboxilasa. |
| KR20090080143A (ko) | 2003-09-02 | 2009-07-23 | 화이자 프로덕츠 인크. | 지프라시돈의 지속 방출형 투여 형태 |
| WO2005023773A1 (fr) | 2003-09-04 | 2005-03-17 | Pfizer Limited | Procede pour la preparation d'arylpyrazoles substitues |
| GB0322140D0 (en) | 2003-09-22 | 2003-10-22 | Pfizer Ltd | Combinations |
| KR100774625B1 (ko) | 2003-09-25 | 2007-11-08 | 워너-램버트 캄파니 엘엘씨 | 치료제 베타 아미노산 |
| WO2005074603A2 (fr) | 2004-02-03 | 2005-08-18 | Abbott Laboratories | Utilisation d'aminobenzoxazoles comme agents therapeutiques |
| JP4552456B2 (ja) | 2004-02-27 | 2010-09-29 | 住友化学株式会社 | エステル化合物およびその用途 |
| EP1724264A1 (fr) | 2004-03-10 | 2006-11-22 | Ono Pharmaceutical Co., Ltd. | Nitriles et compositions medicinales contenant ceux-ci en tant qu'ingredient actif |
| US7807719B2 (en) | 2004-09-14 | 2010-10-05 | Chaim Roifman | Compounds useful for modulating abnormal cell proliferation |
| JP2008514635A (ja) | 2004-09-27 | 2008-05-08 | コーザン バイオサイエンシス インコーポレイテッド | 特異的キナーゼ阻害剤 |
| WO2006086634A2 (fr) | 2005-02-11 | 2006-08-17 | Coley Pharmaceutical Group, Inc. | Composes cycliques imidazo[4,5-c] substitues par oxime et hydroxylamine et procedes associes |
| AU2006228525A1 (en) | 2005-03-28 | 2006-10-05 | Dexcel Pharma Technologies Ltd. | Controlled absorption of statins in the intestine |
| AU2006343359A1 (en) | 2005-06-03 | 2007-11-15 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
| US20080176865A1 (en) | 2005-06-15 | 2008-07-24 | Pfizer Limited | Substituted arylpyrazoles |
| CA2612287C (fr) | 2005-06-15 | 2011-01-25 | Pfizer Limited | Arylpyrazoles substitues pour une utilisation contre les parasites |
| US7645786B2 (en) | 2005-06-15 | 2010-01-12 | Pfizer Inc. | Substituted arylpyrazoles |
| US20070149464A1 (en) | 2005-06-15 | 2007-06-28 | Pfizer Inc. | Combination |
| US20080146643A1 (en) | 2005-06-15 | 2008-06-19 | Pfizer Limited | Combination |
| GB0517205D0 (en) | 2005-08-22 | 2005-09-28 | Novartis Ag | Organic compounds |
| CA2623327A1 (fr) | 2005-10-07 | 2007-04-19 | Kissei Pharmaceutical Co., Ltd. | Compose heterocyclique azote et composition pharmaceutique le contenant |
| WO2007064932A2 (fr) | 2005-12-02 | 2007-06-07 | Bayer Healthcare Llc. | Dérivés de pyrrolotriazine utiles pour traiter le cancer par inhibition de la kinase aurora |
| WO2007087068A2 (fr) | 2006-01-13 | 2007-08-02 | Pharmacyclics, Inc. | Inhibiteurs de tyrosine kinase et leurs utilisations |
| EP2514742B1 (fr) | 2006-03-31 | 2014-12-31 | The Board of Regents of The University of Texas System | Médicaments anticancéreux biodisponible par voie orale associés à l'acide caféique |
| US7645748B2 (en) | 2006-04-03 | 2010-01-12 | Forbes Medi-Tech Inc. | Sterol/stanol phosphorylnitroderivatives and use thereof |
| US8846697B2 (en) | 2006-05-31 | 2014-09-30 | The Regents Of The University Of California | Purine analogs |
| WO2008005954A2 (fr) | 2006-06-30 | 2008-01-10 | The Board Of Regents Of The University Of Texas System | Modulateurs de protéine signal en tant qu'agents thérapeutiques |
| EP2049500B1 (fr) | 2006-07-06 | 2011-09-07 | Array Biopharma, Inc. | Cyclopenta [d] pyrimidines utiles en tant qu'inhibiteurs de la protéine kinase akt |
| PT2530083T (pt) | 2006-09-22 | 2016-08-01 | Pharmacyclics Llc | Inibidores de tirosina cinase de bruton |
| ES2403546T3 (es) | 2006-11-03 | 2013-05-20 | Pharmacyclics, Inc. | Sonda de actividad de la tirosina-cinasa de Bruton y procedimiento de utilización |
| US20100063080A1 (en) | 2006-11-23 | 2010-03-11 | Neil John Press | CXCR2 inhibitors |
| WO2008116064A2 (fr) | 2007-03-21 | 2008-09-25 | Bristol-Myers Squibb Company | Composés hétérocycliques fusionnés utiles en tant que modulateurs de kinases |
| GB2447933A (en) | 2007-03-27 | 2008-10-01 | Chemence Ltd | Cyanoacrylate monomer for forming an adhesive polymer |
| CA2874756C (fr) | 2007-03-28 | 2018-05-29 | Pharmacyclics, Inc. | Inhibiteurs de la tyrosine kinase de bruton |
| JP5529049B2 (ja) | 2008-02-25 | 2014-06-25 | エフ.ホフマン−ラ ロシュ アーゲー | ピロロピラジンキナーゼ阻害剤 |
| ATE522535T1 (de) | 2008-02-25 | 2011-09-15 | Hoffmann La Roche | Pyrrolotriazin-kinasehemmer |
| MX2010012457A (es) | 2008-05-13 | 2010-12-07 | Irm Llc | Heterociclos que contienen nitrogeno fusionado y composiciones de los mismos como inhibidores de cinasa. |
| CA2724715A1 (fr) | 2008-05-22 | 2009-11-26 | Amgen Inc. | Heterocycles en tant qu'inhibiteurs de proteine kinase |
| US20110224235A1 (en) | 2008-07-16 | 2011-09-15 | Pharmacyclics, Inc. | Inhibitors of bruton's tyrosine kinase for the treatment of solid tumors |
| KR20110050654A (ko) | 2008-08-01 | 2011-05-16 | 바이오크리스트 파마수티컬즈, 인코퍼레이티드 | Jak3 억제제로서의 피페리딘 유도체 |
| US8450337B2 (en) | 2008-09-30 | 2013-05-28 | Moleculin, Llc | Methods of treating skin disorders with caffeic acid analogs |
| US20100113520A1 (en) | 2008-11-05 | 2010-05-06 | Principia Biopharma, Inc. | Kinase knockdown via electrophilically enhanced inhibitors |
| US20120028981A1 (en) | 2008-11-05 | 2012-02-02 | Principia Biopharma Inc. | Kinase Knockdown Via Electrophilically Enhanced Inhibitors |
| US8426428B2 (en) | 2008-12-05 | 2013-04-23 | Principia Biopharma, Inc. | EGFR kinase knockdown via electrophilically enhanced inhibitors |
| JP2013504325A (ja) | 2009-09-09 | 2013-02-07 | アビラ セラピューティクス, インコーポレイテッド | Pi3キナーゼインヒビターおよびその使用 |
| US7741330B1 (en) | 2009-10-12 | 2010-06-22 | Pharmacyclics, Inc. | Pyrazolo-pyrimidine inhibitors of Bruton's tyrosine kinase |
| WO2011060440A2 (fr) | 2009-11-16 | 2011-05-19 | The Regents Of The University Of California | Inhibiteurs de kinases |
| KR20130083386A (ko) | 2010-05-20 | 2013-07-22 | 에프. 호프만-라 로슈 아게 | 피롤로[2,3-b]피라진-7-카복스아마이드 유도체 및 JAK 및 SYK 억제제로서의 그의 용도 |
| MY169745A (en) | 2010-05-31 | 2019-05-14 | Ono Pharmaceutical Co | Purinone derivative |
| US20120071497A1 (en) | 2010-06-03 | 2012-03-22 | Pharmacyclics, Inc. | Methods of treating abc-dlbcl using inhibitors of bruton's tyrosine kinase |
| MX342405B (es) | 2010-06-03 | 2016-09-28 | Pharmacyclics Inc | El uso de inhibidores de la tirosina quinasa de bruton (btk). |
| CN101880243A (zh) | 2010-06-04 | 2010-11-10 | 贵阳柏丝特化工有限公司 | 一种含氟氰拟除虫菊酯化合物及其合成方法与用途 |
| PT2603081T (pt) | 2010-08-10 | 2017-01-13 | Celgene Avilomics Res Inc | Sal de besilato de um inibidor de btk |
| US9376438B2 (en) | 2011-05-17 | 2016-06-28 | Principia Biopharma, Inc. | Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors |
| PL2710007T3 (pl) | 2011-05-17 | 2020-06-01 | The Regents Of The University Of California | Inhibitory kinazy |
| WO2012158810A1 (fr) | 2011-05-17 | 2012-11-22 | Principia Biopharma Inc. | Inhibiteurs de tyrosine kinase |
| US8962831B2 (en) | 2011-05-17 | 2015-02-24 | Principia Biopharma Inc. | Tyrosine kinase inhibitors |
| US8828426B2 (en) | 2011-06-07 | 2014-09-09 | Zx Pharma, Llc | Multiparticulate L-carnitine compositions and related methods |
| BR112013033534A2 (pt) | 2011-06-28 | 2017-02-07 | Pharmacyclics Inc | métodos e composições para inibição de reabsorção de osso |
| CA2841080A1 (fr) | 2011-07-13 | 2013-01-17 | Pharmacyclics, Inc. | Inhibiteurs de tyrosine kinase de bruton |
| CA2841886C (fr) * | 2011-07-19 | 2016-08-16 | Merck Sharp & Dohme B.V. | 4-imidazopyridazin-1-yl-benzamides et 4-imidazotriazin-1-yl-benzamides en tant qu'inhibiteurs de btk |
| JP2014522860A (ja) | 2011-07-19 | 2014-09-08 | メルク・シャープ・アンド・ドーム・ベー・フェー | Btk阻害剤としての4−イミダゾピリダジン−1−イル−ベンズアミドおよび4−イミダゾトリアジン−1−イル−ベンズアミド |
| EP2548877A1 (fr) | 2011-07-19 | 2013-01-23 | MSD Oss B.V. | Dérivés de 4-(pyridine condensée à 5 chaînons)benzamide comme inhibiteurs de BTK |
| CN103874699A (zh) | 2011-09-20 | 2014-06-18 | 赛尔佐姆有限公司 | 吡唑并[4,3-c]吡啶衍生物作为激酶抑制剂 |
| MX391121B (es) | 2011-10-19 | 2025-03-19 | Pharmacyclics Llc | Uso de inhibidores de la tirosina cinasa de bruton (btk). |
| US8377946B1 (en) | 2011-12-30 | 2013-02-19 | Pharmacyclics, Inc. | Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors |
| US8501724B1 (en) | 2012-01-31 | 2013-08-06 | Pharmacyclics, Inc. | Purinone compounds as kinase inhibitors |
| WO2013185082A2 (fr) | 2012-06-08 | 2013-12-12 | Biogen Idec Ma Inc. | Inhibiteurs de la tyrosine kinase de bruton |
| US20160045503A1 (en) | 2012-06-18 | 2016-02-18 | Principia Biopharma Inc. | Formulations containing reversible covalent compounds |
| WO2014004707A1 (fr) | 2012-06-29 | 2014-01-03 | Principia Biopharma Inc. | Formulations comprenant de l'ibrutinib |
| US9572811B2 (en) | 2012-08-03 | 2017-02-21 | Principia Biopharma Inc. | Treatment of dry eye |
| JP6203848B2 (ja) | 2012-09-10 | 2017-09-27 | プリンシピア バイオファーマ インコーポレイテッド | キナーゼ阻害剤としてのピラゾロピリミジン化合物 |
| GEP201606597B (en) | 2012-11-02 | 2017-01-10 | Pfizer | Bruton's tyrosine kinase inhibitors |
| EP2920180A4 (fr) | 2012-11-15 | 2016-04-13 | Pharmacyclics Inc | Composés pyrrolopyrimidines en tant qu'inhibiteurs de kinase |
| US20140142099A1 (en) | 2012-11-20 | 2014-05-22 | Principia Biopharma Inc. | Purinone Derivatives as Tyrosine Kinase Inhibitors |
| JO3377B1 (ar) | 2013-03-11 | 2019-03-13 | Takeda Pharmaceuticals Co | مشتقات بيريدينيل وبيريدينيل مندمج |
| US8957080B2 (en) * | 2013-04-09 | 2015-02-17 | Principia Biopharma Inc. | Tyrosine kinase inhibitors |
| NZ721617A (en) | 2014-02-03 | 2018-01-26 | Cadila Healthcare Ltd | Heterocyclic compounds |
| KR20160117614A (ko) | 2014-02-21 | 2016-10-10 | 프린시피아 바이오파마, 인코퍼레이티드 | Btk 억제제의 염 및 고체 형태 |
| AU2015364335B2 (en) | 2014-12-18 | 2020-11-26 | Principia Biopharma Inc. | Treatment of pemphigus |
| MX378435B (es) | 2014-12-24 | 2025-03-11 | Principia Biopharma Inc | Administración específica del sitio de un inhibidor de btk. |
| FI3236943T3 (fi) | 2014-12-24 | 2023-04-27 | Principia Biopharma Inc | Koostumuksia ileo-jejunaaliseen lääkkeenantoon |
| LT3303334T (lt) | 2015-06-03 | 2021-07-12 | Principia Biopharma Inc. | Tirozinkinazės inhibitoriai |
| EP3313839A1 (fr) | 2015-06-24 | 2018-05-02 | Principia Biopharma Inc. | Inhibiteurs de la tyrosine kinase |
| CN105753863B (zh) | 2015-09-11 | 2018-07-31 | 东莞市真兴贝特医药技术有限公司 | 氧代二氢咪唑并吡啶类化合物及其应用 |
| EP3414234B1 (fr) | 2015-10-14 | 2022-06-29 | Zibo Biopolar Changsheng Pharmaceutical Co. Ltd. | Inhibiteurs de la tyrosine kinase de bruton |
| KR102391693B1 (ko) | 2016-06-29 | 2022-04-29 | 프린시피아 바이오파마, 인코퍼레이티드 | 2-[3-[4-아미노-3-(2-플루오로-4-페녹시-페닐)피라졸로[3,4-d]피리미딘-1-일]피페리딘-1-카르보닐]-4-메틸-4-[4-(옥세탄-3-일)피페라진-1-일]펜트-2-엔니트릴의 변형 방출 제제 |
-
2015
- 2015-12-18 AU AU2015364335A patent/AU2015364335B2/en active Active
- 2015-12-18 US US15/537,294 patent/US10485797B2/en active Active
- 2015-12-18 ES ES15823107T patent/ES2843323T3/es active Active
- 2015-12-18 CN CN201580076193.1A patent/CN107257686B/zh active Active
- 2015-12-18 SG SG11201704808VA patent/SG11201704808VA/en unknown
- 2015-12-18 WO PCT/US2015/066868 patent/WO2016100914A1/fr not_active Ceased
- 2015-12-18 CA CA2970723A patent/CA2970723C/fr active Active
- 2015-12-18 EP EP15823107.6A patent/EP3233103B1/fr active Active
- 2015-12-18 MA MA41197A patent/MA41197B1/fr unknown
- 2015-12-18 PT PT158231076T patent/PT3233103T/pt unknown
- 2015-12-18 MX MX2017007973A patent/MX381283B/es unknown
- 2015-12-18 EA EA201791243A patent/EA036269B1/ru not_active IP Right Cessation
- 2015-12-18 PL PL15823107T patent/PL3233103T3/pl unknown
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2017
- 2017-06-12 IL IL252839A patent/IL252839B/en active IP Right Grant
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2019
- 2019-10-04 US US16/593,352 patent/US10946008B2/en active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| IL252839B (en) | 2021-03-25 |
| BR112017013022A2 (pt) | 2018-02-27 |
| MX2017007973A (es) | 2018-02-09 |
| CN107257686B (zh) | 2021-01-29 |
| WO2016100914A1 (fr) | 2016-06-23 |
| PT3233103T (pt) | 2021-01-18 |
| US10485797B2 (en) | 2019-11-26 |
| CA2970723A1 (fr) | 2016-06-23 |
| MX381283B (es) | 2025-03-12 |
| PL3233103T3 (pl) | 2021-04-19 |
| US10946008B2 (en) | 2021-03-16 |
| EA036269B1 (ru) | 2020-10-21 |
| AU2015364335B2 (en) | 2020-11-26 |
| ES2843323T3 (es) | 2021-07-16 |
| EP3233103B1 (fr) | 2020-10-14 |
| EP3233103A1 (fr) | 2017-10-25 |
| EA201791243A1 (ru) | 2017-12-29 |
| AU2015364335A1 (en) | 2017-07-20 |
| AU2020264338A1 (en) | 2020-12-03 |
| US20200101059A1 (en) | 2020-04-02 |
| SG11201704808VA (en) | 2017-07-28 |
| CA2970723C (fr) | 2023-09-05 |
| IL252839A0 (en) | 2017-08-31 |
| CN107257686A (zh) | 2017-10-17 |
| US20180050027A1 (en) | 2018-02-22 |
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