MA41788A - Modulation de l'immunité tumorale par proteines médiatrices de la délivrance d'o2 - Google Patents

Modulation de l'immunité tumorale par proteines médiatrices de la délivrance d'o2

Info

Publication number
MA41788A
MA41788A MA041788A MA41788A MA41788A MA 41788 A MA41788 A MA 41788A MA 041788 A MA041788 A MA 041788A MA 41788 A MA41788 A MA 41788A MA 41788 A MA41788 A MA 41788A
Authority
MA
Morocco
Prior art keywords
mediatory
proteins
modulation
delivery
tumor immunity
Prior art date
Application number
MA041788A
Other languages
English (en)
Inventor
Stephen P L Cary
Ana Krtolica
Moan Natacha Le
Kevin G Leong
Jonathan A Winger
Original Assignee
Omniox Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omniox Inc filed Critical Omniox Inc
Publication of MA41788A publication Critical patent/MA41788A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1092—Details
    • A61N2005/1098—Enhancing the effect of the particle by an injected agent or implanted device
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MA041788A 2015-03-17 2016-03-17 Modulation de l'immunité tumorale par proteines médiatrices de la délivrance d'o2 MA41788A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562134523P 2015-03-17 2015-03-17

Publications (1)

Publication Number Publication Date
MA41788A true MA41788A (fr) 2021-03-31

Family

ID=56297072

Family Applications (1)

Application Number Title Priority Date Filing Date
MA041788A MA41788A (fr) 2015-03-17 2016-03-17 Modulation de l'immunité tumorale par proteines médiatrices de la délivrance d'o2

Country Status (14)

Country Link
US (2) US20180243364A1 (fr)
EP (1) EP3270961A2 (fr)
JP (2) JP7049832B2 (fr)
KR (1) KR20170132789A (fr)
CN (1) CN107580499A (fr)
AU (1) AU2016232866B2 (fr)
CA (1) CA2979974A1 (fr)
HK (2) HK1250137A1 (fr)
IL (1) IL254507B (fr)
MA (1) MA41788A (fr)
MX (1) MX2017011847A (fr)
RU (1) RU2731450C2 (fr)
SG (2) SG11201707583RA (fr)
WO (1) WO2016149562A2 (fr)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3922643A1 (fr) * 2013-01-07 2021-12-15 Omniox, Inc. Formes polymères de protéines h-nox
WO2016149562A2 (fr) 2015-03-17 2016-09-22 Omniox, Inc. Modulation de l'immunité tumorale par distribution d'o2 induite par une protéine
US12281339B2 (en) * 2016-07-05 2025-04-22 Polaris Group Combination cancer immunotherapies with arginine depletion agents
WO2020037052A1 (fr) * 2018-08-15 2020-02-20 Omniox, Inc. Protéines h-nox pour le traitement d'affections cardiovasculaires et pulmonaires
CN114245807B (zh) 2019-06-25 2025-05-02 吉利德科学公司 Flt3l-fc融合蛋白和使用方法
PH12022550835A1 (en) 2019-10-18 2023-07-03 Forty Seven Inc Combination therapies for treating myelodysplastic syndromes and acute myeloid leukemia
NZ786589A (en) 2019-10-31 2025-03-28 Forty Seven Llc Anti-cd47 and anti-cd20 based treatment of blood cancer
TWI778443B (zh) 2019-11-12 2022-09-21 美商基利科學股份有限公司 Mcl1抑制劑
CN115362003B (zh) 2019-12-24 2024-03-22 卡尔那生物科学株式会社 二酰基甘油激酶调节化合物
TWI890283B (zh) 2020-02-14 2025-07-11 美商基利科學股份有限公司 結合ccr8之抗體及融合蛋白及其用途
JP7564888B2 (ja) 2020-05-01 2024-10-09 ギリアード サイエンシーズ, インコーポレイテッド Cd73阻害性2,4-ジオキソピリミジン化合物
US20240139280A1 (en) * 2021-04-14 2024-05-02 OncoC4, Inc. Use of hif-1-alpha inhibitors in cancer immunotherapy
TW202302145A (zh) 2021-04-14 2023-01-16 美商基利科學股份有限公司 CD47/SIRPα結合及NEDD8活化酶E1調節次單元之共抑制以用於治療癌症
WO2022245671A1 (fr) 2021-05-18 2022-11-24 Gilead Sciences, Inc. Méthodes d'utilisation de protéines de fusion flt3l-fc
MX2023014762A (es) 2021-06-23 2024-01-15 Gilead Sciences Inc Compuestos moduladores de diacilglicerol quinasa.
CN117355531A (zh) 2021-06-23 2024-01-05 吉利德科学公司 二酰基甘油激酶调节化合物
JP7651018B2 (ja) 2021-06-23 2025-03-25 ギリアード サイエンシーズ, インコーポレイテッド ジアシルグリセロールキナーゼ調節化合物
EP4359413A1 (fr) 2021-06-23 2024-05-01 Gilead Sciences, Inc. Composés de modulation de la diacylglycérol kinase
EP4423078A1 (fr) 2021-10-28 2024-09-04 Gilead Sciences, Inc. Dérivés de pyridine-3(2h)-one
PE20241186A1 (es) 2021-10-29 2024-06-03 Gilead Sciences Inc Compuestos de cd73
US20240124412A1 (en) 2021-12-22 2024-04-18 Gilead Sciences, Inc. Ikaros zinc finger family degraders and uses thereof
CN118488948A (zh) 2021-12-22 2024-08-13 吉利德科学公司 Ikaros锌指家族降解剂及其用途
CA3248911A1 (fr) 2022-01-28 2023-08-03 Gilead Sciences, Inc. Inhibiteurs de poly(adénosine diphosphate-ribose) polymérase 7
PL4245756T3 (pl) 2022-03-17 2025-02-17 Gilead Sciences, Inc. Środki degradujące palec cynkowy z rodziny ikaros i ich zastosowania
AU2023240346A1 (en) 2022-03-24 2024-09-19 Gilead Sciences, Inc. Combination therapy for treating trop-2 expressing cancers
TWI876305B (zh) 2022-04-05 2025-03-11 美商基利科學股份有限公司 用於治療結腸直腸癌之組合療法
EP4511127A1 (fr) 2022-04-21 2025-02-26 Gilead Sciences, Inc. Composés modulateurs de kras g12d
WO2023235716A2 (fr) * 2022-05-31 2023-12-07 Cardiff Oncology, Inc. Traitement du cancer à l'aide d'inhibiteurs de topoisomérase i et d'inhibiteurs de plk1
WO2024006929A1 (fr) 2022-07-01 2024-01-04 Gilead Sciences, Inc. Composés cd73
US20240091351A1 (en) 2022-09-21 2024-03-21 Gilead Sciences, Inc. FOCAL IONIZING RADIATION AND CD47/SIRPa DISRUPTION ANTICANCER COMBINATION THERAPY
EP4638436A1 (fr) 2022-12-22 2025-10-29 Gilead Sciences, Inc. Inhibiteurs de prmt5 et leurs utilisations
WO2024215754A1 (fr) 2023-04-11 2024-10-17 Gilead Sciences, Inc. Composés modulateurs de kras
PE20260121A1 (es) 2023-04-21 2026-01-16 Gilead Sciences Inc Inhibidores de prmt5 y usos de los mismos
JP2026522894A (ja) 2023-06-30 2026-07-09 ギリアード サイエンシーズ, インコーポレイテッド Kras調節化合物
AU2024297978A1 (en) 2023-07-26 2026-02-05 Gilead Sciences, Inc. Parp7 inhibitors
CN121568935A (zh) 2023-07-26 2026-02-24 吉利德科学公司 Parp7抑制剂
US20250109147A1 (en) 2023-09-08 2025-04-03 Gilead Sciences, Inc. Kras g12d modulating compounds
EP4774280A1 (fr) 2023-09-08 2026-07-15 Gilead Sciences, Inc. Composés de modulation de kras g12d
WO2025096589A1 (fr) 2023-11-03 2025-05-08 Gilead Sciences, Inc. Inhibiteurs de prmt5 et leurs utilisations
US20250230168A1 (en) 2023-12-22 2025-07-17 Gilead Sciences, Inc. Azaspiro wrn inhibitors
WO2025245003A1 (fr) 2024-05-21 2025-11-27 Gilead Sciences, Inc. Inhibiteurs de prmt5 et leurs utilisations
US20260098049A1 (en) 2024-08-12 2026-04-09 Gilead Sciences, Inc. Kras modulating compounds
US20260130893A1 (en) 2024-10-21 2026-05-14 Gilead Sciences, Inc. Prmt5 inhibitors and uses thereof
WO2026136515A1 (fr) 2024-12-19 2026-06-25 Gilead Sciences, Inc. Inhibiteurs de parp7

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4873192A (en) 1987-02-17 1989-10-10 The United States Of America As Represented By The Department Of Health And Human Services Process for site specific mutagenesis without phenotypic selection
US5248766A (en) 1990-08-17 1993-09-28 Baxter International Inc. Oxirane-modified hemoglobin based composition
US5295944A (en) * 1991-05-14 1994-03-22 Dana-Farber Cancer Institute Method for treating a tumor with ionizing radiation
US5776898A (en) 1991-05-14 1998-07-07 Dana-Farber Cancer Institute Method for treating a tumor with a chemotherapeutic agent
WO1992020369A1 (fr) 1991-05-14 1992-11-26 Dana Farber Cancer Institute Utilisation d'hemoglobine dans un procede de traitement de tumeurs a l'aide d'agents chimiotherapeutiques
US6054427A (en) 1997-02-28 2000-04-25 The Regents Of The University Of California Methods and compositions for optimization of oxygen transport by cell-free systems
US5981710A (en) 1997-07-21 1999-11-09 Baxter International, Inc. Therapeutic hemoglobin composition having isotropically increased size
US20020142957A1 (en) * 2000-08-07 2002-10-03 Hepler William T. Compositions and methods for the therapy and diagnosis of colon cancer
US20030153491A1 (en) 2002-01-11 2003-08-14 Winslow Robert M. Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
US20050176108A1 (en) * 2003-03-13 2005-08-11 Young-Min Kim Physiologically active polypeptide conjugate having prolonged in vivo half-life
US20080188480A1 (en) 2005-02-22 2008-08-07 Cedars-Sinai Medical Center Use of Sildenafil, Vardenafil and Other 5-Phosphodiesterase Inhibitors to Enhance Permeability of the Abnormal Blood-Brain Barrier
EP1981519B1 (fr) 2005-12-29 2017-12-27 Dyax Corp. Inhibition de protease
WO2007133811A2 (fr) 2006-05-15 2007-11-22 Viral Logic Systems Technology Corp. Compositions associées au cd47 et procédés destinés au traitement de maladies et de troubles immunologiques
EP2463295A1 (fr) 2006-05-22 2012-06-13 The Regents of The University of California Compositions et procédés de fourniture d'oxygène
US20110300113A1 (en) 2006-09-19 2011-12-08 Deutsches Krebsforschungszentrum Death Receptor CD95 Controls Neurogenesis of Adult Neural Stem Cells in Vivo and in Vitro
WO2008074865A1 (fr) 2006-12-21 2008-06-26 Novo Nordisk A/S Ligands des récepteurs de la prolactine dimères
US20110288023A1 (en) * 2007-06-08 2011-11-24 The Regents Of The University Of California Office Of Technology Transfer Cancer drug delivery using modified transferrin
US20100183545A1 (en) * 2008-10-14 2010-07-22 The United States Of America, As Represented By The Secretary, Targeted cargo protein combination therapy
JP2011168521A (ja) * 2010-02-18 2011-09-01 Eci Inc PEG化eMIP及びその製造方法並びにこれを用いた癌治療剤
US20110243849A1 (en) 2010-04-02 2011-10-06 Marletta Michael A Heme-binding photoactive polypeptides and methods of use thereof
US8742073B2 (en) 2010-05-27 2014-06-03 Bing Lou Wong Method for the preparation of a high-temperature stable oxygen-carrier-containing pharmaceutical composition and the use thereof
US7989593B1 (en) 2010-05-27 2011-08-02 Bing Lou Wong Method for the preparation of a high-temperature stable oxygen-carrier-containing pharmaceutical composition and the use thereof
WO2012094679A2 (fr) 2011-01-07 2012-07-12 Vindico NanoBio Technology Inc. Compositions et procédés pour délivrer aux tumeurs des agents se liant à l'oxygène avec une affinité élevée
US20140363496A1 (en) 2011-01-07 2014-12-11 Vindico NanoBio Technology Inc. Compositions and Methods for Inducing Nanoparticle-mediated Microvascular Embolization of Tumors
US20130052232A1 (en) 2011-08-31 2013-02-28 Bing Lou Wong Method for the preparation of a heat stable oxygen carrier-containing composition facilating beta-beta cross-linking
EP3922643A1 (fr) 2013-01-07 2021-12-15 Omniox, Inc. Formes polymères de protéines h-nox
US10094835B2 (en) * 2013-05-09 2018-10-09 Mayo Foundation For Medical Education And Research Treating patients based on immune subtypes
WO2014193898A1 (fr) * 2013-05-31 2014-12-04 Merck Sharp & Dohme Corp. Thérapies combinées contre le cancer
UA122479C2 (uk) * 2014-01-24 2020-11-25 Дана-Фарбер Кенсер Інстітьют, Інк. Виділена молекула антитіла, яка зв’язується з людським білком програмованої смерті-1 (pd-1)
AU2015301014B2 (en) 2014-08-08 2021-05-06 Poseida Therapeutics, Inc. Compositions and methods for inducing nanoparticle-mediated microvascular embolization of tumors
AU2015358413A1 (en) 2014-12-05 2017-06-29 Poseida Therapeutics, Inc. Compositions and methods for inducing nanoparticle-mediated microvascular embolization of tumors
WO2016149562A2 (fr) 2015-03-17 2016-09-22 Omniox, Inc. Modulation de l'immunité tumorale par distribution d'o2 induite par une protéine

Also Published As

Publication number Publication date
CN107580499A (zh) 2018-01-12
IL254507A0 (en) 2017-11-30
SG11201707583RA (en) 2017-10-30
RU2017134953A3 (fr) 2019-12-26
JP7049832B2 (ja) 2022-04-07
RU2731450C2 (ru) 2020-09-03
US20220160823A1 (en) 2022-05-26
JP2020183450A (ja) 2020-11-12
IL254507B (en) 2022-07-01
HK1249416A1 (zh) 2018-11-02
BR112017019862A2 (pt) 2018-05-29
US12285463B2 (en) 2025-04-29
WO2016149562A2 (fr) 2016-09-22
SG10201908269SA (en) 2019-10-30
CA2979974A1 (fr) 2016-09-22
EP3270961A2 (fr) 2018-01-24
US20180243364A1 (en) 2018-08-30
JP2018511595A (ja) 2018-04-26
RU2017134953A (ru) 2019-04-08
MX2017011847A (es) 2018-06-06
AU2016232866A1 (en) 2017-10-12
HK1250137A1 (zh) 2018-11-30
AU2016232866B2 (en) 2021-10-21
WO2016149562A3 (fr) 2016-11-03
KR20170132789A (ko) 2017-12-04

Similar Documents

Publication Publication Date Title
IL291932B2 (en) Nanoparticle compositions for sustained therapy
IL254516A0 (en) Proteins specific for cd137
EP3307378A4 (fr) Thérapie de modulation intratumorale
IL263846B (en) Formulation of a peptide vaccine
EP3317294A4 (fr) Peptides stabilisés anti-microbiens
IL254507A0 (en) Modulation of tumor immunity by protein-mediated o2 delivery
MA47323A (fr) Protéines de liaison icos
HUE053347T2 (hu) Glikopeptid-készítmények
EP3370760A4 (fr) Thérapie de substitution de plasminogène destinée au déficit en plasminogène
FR3018450B1 (fr) Procede de preparation de proteines plasmatiques humaines
HUE051184T2 (hu) Baktériumalapú fehérjeszállítás
EP3665416A4 (fr) Lampe de sécurité
EP3522947C0 (fr) Dispositif transcathéter pour la pose de dispositifs intracorporels
LT3143037T (lt) Alfa4beta7 integrino tioeterio peptidų antagonistaii
EP3589640A4 (fr) Purification de protéines avec la protéine l
HUE045024T2 (hu) Poliamid készítmények
EP3355931C0 (fr) Conjugués de protéines
HUE063435T2 (hu) Eljárások rekombináns fehérjék mannóztartalmának növelésére
DK3259358T3 (da) Forøget proteinekspression
EP3436049A4 (fr) Protéine 8 de type angiopoïétine (angptl8)
EP3405581A4 (fr) Protéines antimicrobiennes
EP3697428A4 (fr) Peptides sécréteurs artificiels pour la production de protéines hétérologues
DK3615169T3 (da) Separeringslegeme
EP3463414C0 (fr) Interfaces de protéines
EP3377633C0 (fr) Production de protéines recombinantes