MA42641A1 - Protéines de liaison trispécifiques et/ou trivalentes pour la prévention ou le traitement d'une infection par le vih - Google Patents

Protéines de liaison trispécifiques et/ou trivalentes pour la prévention ou le traitement d'une infection par le vih

Info

Publication number
MA42641A1
MA42641A1 MA42641A MA42641A MA42641A1 MA 42641 A1 MA42641 A1 MA 42641A1 MA 42641 A MA42641 A MA 42641A MA 42641 A MA42641 A MA 42641A MA 42641 A1 MA42641 A1 MA 42641A1
Authority
MA
Morocco
Prior art keywords
trispecific
binding proteins
prevention
treatment
hiv infection
Prior art date
Application number
MA42641A
Other languages
English (en)
Inventor
Huawei Qiu
Christian Beil
Jochen Beninga
Christian Lange
Ercole Rao
Jochen Kruip
Zhi-Yong Yang
Gary Nabel
Ling Xu
Ronnie Wei
Wulf Leuschner
Mark Connors
John Mascola
Richard Koup
Jinghe Huang
Nicole Doria-Rose
Tongqing Zhou
Peter Kwong
Young Kwon
Amarendra Pegu
Mangaiarkarasi Asokan
Original Assignee
Sanofi Sa
Us Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa, Us Health filed Critical Sanofi Sa
Publication of MA42641A1 publication Critical patent/MA42641A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6881—Cluster-antibody conjugates, i.e. the modifying agent consists of a plurality of antibodies covalently linked to each other or of different antigen-binding fragments covalently linked to each other
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/112—Retroviridae (F), e.g. leukemia viruses
    • C07K16/114—Lentivirus (G), e.g. human immunodeficiency virus [HIV], feline immunodeficiency virus [FIV] or simian immunodeficiency virus [SIV]
    • C07K16/1145—Env proteins, e.g. gp41, gp110/120, gp160, V3, principal neutralising domain [PND] or CD4-binding site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne des compositions comprenant des protéines de liaison trispecifiques et/ou trivalentes comprenant quatre chaînes polypeptidiques qui forment trois sites de liaison à l'antigène qui se lient spécifiquement à une ou plusieurs protéines cibles du vih ou un ou plusieurs récepteurs des lymphocytes t, une première paire de polypeptides qui forme la protéine de liaison possédant des domaines variables doubles ayant une orientation croisée et une seconde paire de polypeptides qui forme la prot
MA42641A 2016-02-24 2016-10-24 Protéines de liaison trispécifiques et/ou trivalentes pour la prévention ou le traitement d'une infection par le vih MA42641A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16305211 2016-02-24
PCT/US2016/058540 WO2017074878A1 (fr) 2015-10-25 2016-10-24 Protéines de liaison trispécifiques et/ou trivalentes pour la prévention ou le traitement d'une infection par le vih

Publications (1)

Publication Number Publication Date
MA42641A1 true MA42641A1 (fr) 2019-03-29

Family

ID=55588187

Family Applications (1)

Application Number Title Priority Date Filing Date
MA42641A MA42641A1 (fr) 2016-02-24 2016-10-24 Protéines de liaison trispécifiques et/ou trivalentes pour la prévention ou le traitement d'une infection par le vih

Country Status (30)

Country Link
US (4) US20190054182A1 (fr)
EP (2) EP3819310A1 (fr)
JP (3) JP7169190B2 (fr)
KR (1) KR102687212B1 (fr)
CN (4) CN116789841A (fr)
AR (1) AR106466A1 (fr)
AU (2) AU2016347058B2 (fr)
BR (1) BR112018008011A2 (fr)
CA (1) CA3002664A1 (fr)
CL (1) CL2018001065A1 (fr)
CO (1) CO2018005337A2 (fr)
CR (1) CR20180288A (fr)
DO (1) DOP2018000102A (fr)
EA (1) EA201891028A1 (fr)
ES (1) ES2894304T3 (fr)
HR (1) HRP20211528T1 (fr)
HU (1) HUE056608T2 (fr)
IL (2) IL301140A (fr)
MA (1) MA42641A1 (fr)
MX (2) MX2018005048A (fr)
MY (1) MY192278A (fr)
PE (1) PE20181167A1 (fr)
PH (1) PH12018500873A1 (fr)
PL (1) PL3365366T3 (fr)
RS (1) RS62437B1 (fr)
SG (1) SG11201803324VA (fr)
SI (1) SI3365366T1 (fr)
TW (3) TWI750139B (fr)
UY (1) UY36965A (fr)
WO (1) WO2017074878A1 (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015048770A2 (fr) 2013-09-30 2015-04-02 Beth Israel Deaconess Medical Center, Inc. Traitements par anticorps pour le virus de l'immunodéficience humaine (vih)
US10308707B2 (en) 2013-12-02 2019-06-04 Aaron Diamond Aids Research Center Bispecific HIV-1-neutralizing antibodies
EP3778630A1 (fr) * 2014-02-28 2021-02-17 The U.S.A. As Represented By The Secretary, Department Of Health And Human Services Anticorps monoclonaux largement neutralisant contre la région env vih-1 v1v2
RS62437B1 (sr) 2015-10-25 2021-11-30 Sanofi Sa Trispecifični i/ili trivalentni vezujući proteini za prevenciju ili lečenje hiv infekcije
WO2017079479A1 (fr) 2015-11-03 2017-05-11 The United States Of America, As Represented By The Secretary, Department Of Health And Human Anticorps neutralisants dirigés contre la protéine gp41 du vih-1 et leur utilisation
LT3443006T (lt) 2016-04-13 2023-10-25 Sanofi Trispecifiniai ir (arba) trivalenčiai rišantieji baltymai
CA3020633A1 (fr) * 2016-04-13 2017-10-19 Sanofi Proteines de liaison trispecifiques et/ou trivalentes
US11299751B2 (en) 2016-04-29 2022-04-12 Voyager Therapeutics, Inc. Compositions for the treatment of disease
EP3448874A4 (fr) 2016-04-29 2020-04-22 Voyager Therapeutics, Inc. Compositions pour le traitement de maladies
WO2018151841A1 (fr) 2017-02-17 2018-08-23 Sanofi Molécules de liaison multispécifiques ayant une spécificité vis-à-vis du dystroglycane et de la laminine-2
KR102654105B1 (ko) 2017-02-17 2024-04-04 사노피 디스트로글리칸 및 라미닌-2에 대한 특이성을 갖는 다중특이적 결합 분자
US11845787B2 (en) * 2017-03-27 2023-12-19 The Wistar Institute Of Anatomy And Biology DNA antibody constructs for use against HIV
AR112257A1 (es) 2017-06-21 2019-10-09 Gilead Sciences Inc Anticuerpos multiespecíficos dirigidos al vih-1 gp120 y cd3 humana, composiciones que los comprende, ácido nucleico, vector y célula huésped relacionados, método para producirlos, método para detectar células que expresan gp120 y cd3, kit de anticuerpos, fragmentos de anticuerpo que se une a gp120 y método para producirlos
BR112020007002A2 (pt) 2017-10-10 2020-11-17 Sanofi anticorpos anti-cd38 e métodos de uso
US20240239877A1 (en) * 2017-12-18 2024-07-18 Viiv Healthcare Uk (No. 5) Limited Antigen binding polypeptides
JP7345861B2 (ja) * 2017-12-21 2023-09-19 ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク 二重特異性ｈｉｖ－１中和抗体
CN119291194A (zh) 2018-01-12 2025-01-10 建新公司 用于定量多肽的方法
EP3797118A4 (fr) 2018-05-22 2022-06-29 Beth Israel Deaconess Medical Center, Inc. Traitements par anticorps pour le virus de l'immunodéficience humaine (vih)
JP7462621B2 (ja) * 2018-10-09 2024-04-05 サノフイ 三重特異性抗ｃｄ３８、抗ｃｄ２８、および抗ｃｄ３結合タンパク質ならびにウイルス感染を処置するための使用方法
US12459989B2 (en) * 2018-11-21 2025-11-04 Beth Israel Deaconess Medical Center, Inc. Antibody therapies for human immunodeficiency virus (HIV)
US11613576B2 (en) 2019-04-09 2023-03-28 Sanofi Trispecific binding proteins, methods, and uses thereof
TW202104274A (zh) 2019-04-09 2021-02-01 法商賽諾菲公司 用於治療ｈｉｖ感染之三特異性及／或三價結合蛋白
EP3953388A1 (fr) 2019-04-09 2022-02-16 Sanofi Protéines de liaison trispécifiques, procédés et utilisations connexes
WO2021080649A1 (fr) 2019-10-25 2021-04-29 Sanofi Procédés d'analyse du mésappariement de chaîne dans des protéines de liaison multispécifiques
US20230203466A1 (en) * 2020-04-03 2023-06-29 Medgenome Inc. Ace2 receptor polymorphisms and varying susceptibility to sars-cov-2, methods for diagnosis and treatment
JP7518286B2 (ja) * 2020-08-25 2024-07-17 ギリアード サイエンシーズ， インコーポレイテッド Ｈｉｖを標的とする多重特異性抗原結合分子及び使用方法
TW202330594A (zh) * 2021-09-29 2023-08-01 美商莫德斯醫療公司 抗原結合多肽、抗原結合多肽複合物及其使用方法
CN118251411A (zh) * 2021-09-29 2024-06-25 摩德斯医疗股份有限公司 抗原结合多肽、抗原结合多肽复合物及其使用方法
CA3232365A1 (fr) * 2021-09-29 2023-04-06 Ronnie Rong Wei Polypeptides de liaison a l'antigene, complexes polypeptidiques de liaison a l'antigene et leurs methodes d'utilisation dans le vih
WO2025109206A1 (fr) 2023-11-22 2025-05-30 Mabylon Ag Anticorps anti-allergènes multispécifiques et leurs utilisations
WO2025108551A1 (fr) 2023-11-23 2025-05-30 Mabylon Ag Anticorps anti-allergènes multispécifiques et leurs utilisations
US20250376537A1 (en) 2024-05-17 2025-12-11 Sanofi Methods of treating cancer using trispecific binding proteins targeting her2-expressing tumors

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3850542T2 (de) 1987-09-23 1994-11-24 Bristol Myers Squibb Co Antikörper-Heterokonjugate zur Töting von HIV-infizierten Zellen.
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
ATE375365T1 (de) 1998-04-02 2007-10-15 Genentech Inc Antikörper varianten und fragmente davon
RU2420537C2 (ru) 2001-01-17 2011-06-10 Трабьон Фармасьютикалз Инк. Слитые белки связывающий домен-иммуноглобулин
CN1294148C (zh) 2001-04-11 2007-01-10 中国科学院遗传与发育生物学研究所 环状单链三特异抗体
NZ544924A (en) 2003-06-27 2009-03-31 Biogen Idec Inc Modified binding molecules comprising connecting peptides
US9200061B2 (en) 2004-02-06 2015-12-01 Morpho Sys AG Generation and profiling of fully human HuCAL gold®-derived therapeutic antibodies specific for human CD3i
CN100376599C (zh) 2004-04-01 2008-03-26 北京安波特基因工程技术有限公司 基因工程重组抗cea抗cd3抗cd28线性单链三特异抗体
EP2014680A1 (fr) * 2007-07-10 2009-01-14 Friedrich-Alexander-Universität Erlangen-Nürnberg Dérivés d'anticorps bi-spécifiques ou tri-spécifiques trivalents, recombinants, à simple chaîne
EP2050764A1 (fr) 2007-10-15 2009-04-22 sanofi-aventis Nouveau format d'anticorps bispécifique polyvalent
CA2726087A1 (fr) 2008-06-03 2009-12-10 Tariq Ghayur Immunoglobulines a deux domaines variables et leurs utilisations
CA2774636C (fr) 2009-09-25 2019-05-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps neutralisants diriges contre le vih-1 et utilisation associee
SMT202000031T1 (it) 2010-06-09 2020-03-13 Genmab As Anticorpi contro cd38 umano
US8637024B2 (en) 2010-11-12 2014-01-28 The Rockefeller University Fusion antibodies for HIV therapy
JOP20210044A1 (ar) 2010-12-30 2017-06-16 Takeda Pharmaceuticals Co الأجسام المضادة لـ cd38
TWI743461B (zh) 2011-03-28 2021-10-21 法商賽諾菲公司 具有交叉結合區定向之雙重可變區類抗體結合蛋白
WO2012154312A1 (fr) 2011-05-09 2012-11-15 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Anticorps neutralisants anti-vih-1 et leur utilisation
WO2012158818A2 (fr) 2011-05-16 2012-11-22 Fabion Pharmaceuticals, Inc. Protéines de fusion contenant un fab multi-spécifique et procédé d'utilisation
CN103797029B (zh) * 2011-05-17 2016-08-17 洛克菲勒大学 人类免疫缺陷病毒中和抗体及其使用方法
BR112014010823B1 (pt) 2011-11-07 2021-02-17 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services anticorpos que se ligam a gp41 e neutralizam o vírus da imunodeficiência humana tipo 1 (hiv-1), seus usos, molécula de ácido nucleico, vetor de expressão, composição, kit, bem como métodos de detecção de infecção pelo hiv-1 e de teste de imunógeno potencial
US9580509B2 (en) * 2011-11-07 2017-02-28 Medimmune, Llc Multispecific and multivalent binding proteins and uses thereof
EP2788376B1 (fr) 2011-12-08 2018-10-03 The United States of America, as represented by The Secretary, Department of Health and Human Services Anticorps neutralisants dirigés contre le vih-1 et leur utilisation
WO2013163427A1 (fr) * 2012-04-25 2013-10-31 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Anticorps pour traiter les infections par le vih-1
JOP20200236A1 (ar) 2012-09-21 2017-06-16 Regeneron Pharma الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها
AU2013322710A1 (en) * 2012-09-25 2015-04-16 Glenmark Pharmaceuticals S.A. Purification of hetero-dimeric immunoglobulins
WO2014089152A1 (fr) 2012-12-04 2014-06-12 University Of Maryland, Baltimore Anticorps liant la protéine env du vih-1, protéines de fusion et leurs méthodes d'utilisation
WO2014093894A2 (fr) 2012-12-13 2014-06-19 The Trustees Of The University Of Pennsylvania Constructions d'adn d'anticorps et procédé pour les utiliser
US20140213772A1 (en) * 2012-12-28 2014-07-31 Abbvie, Inc. Cross-over dual variable domain immunoglobulin constructs
US10487155B2 (en) 2013-01-14 2019-11-26 Xencor, Inc. Heterodimeric proteins
WO2014116846A2 (fr) * 2013-01-23 2014-07-31 Abbvie, Inc. Procédés et compositions pour moduler une réponse immunitaire
LT2961771T (lt) 2013-02-26 2020-03-10 Roche Glycart Ag Bispecifinės t ląstelę aktyvinančios antigeną surišančios molekulės, specifinės cd3 ir cea antigenams
US20140302037A1 (en) 2013-03-15 2014-10-09 Amgen Inc. BISPECIFIC-Fc MOLECULES
CN105209491A (zh) 2013-03-15 2015-12-30 艾伯维公司 针对TNFα的双重特异性结合蛋白
EP3027755B1 (fr) 2013-08-02 2019-10-09 The Regents of The University of California Modification d'une immunité antivirale médiée par les cellules t par des cellules souches et des récepteurs d'antigène chimériques
JP2016538275A (ja) 2013-11-04 2016-12-08 グレンマーク ファーマシューティカルズ， エセ．アー． Ｔ細胞再標的化ヘテロ二量体免疫グロブリン（ｈｅｔｅｒｏ−ｄｉｍｅｒｉｃ ｉｍｍｕｎｏｇｌｏｂｕｌｉｎ）の製造
EP3699195A3 (fr) 2014-03-28 2020-11-04 Xencor, Inc. Anticorps bispécifiques se liant à cd38 et cd3
CN106687584B (zh) 2014-09-04 2021-08-13 干细胞技术公司 用于t细胞或nk细胞活化和扩增的可溶性抗体复合物
CN120988137A (zh) 2015-01-23 2025-11-21 赛诺菲 抗cd3抗体、抗cd123抗体和与cd3和/或cd123特异性结合的双特异性抗体
WO2016187580A1 (fr) 2015-05-20 2016-11-24 Quantum-Si Incorporated Procédé de détermination de la séquence d'un acide nucléique au moyen de la luminescence à résolution temporelle
WO2016196740A1 (fr) 2015-06-02 2016-12-08 The Rockefeller University Anticorps tri-spécifiques pour traitement anti-vih
MX2018003463A (es) 2015-09-22 2018-09-06 Univ Pennsylvania Método de redireccionamiento de células t para tratar la infección por virus de inmunodeficiencia humana (vih).
RS62437B1 (sr) 2015-10-25 2021-11-30 Sanofi Sa Trispecifični i/ili trivalentni vezujući proteini za prevenciju ili lečenje hiv infekcije
CN105837688B (zh) 2015-11-20 2019-02-26 北京大学深圳研究生院 单域抗体及其编码基因，免疫毒素及其编码基因、制备方法、表达载体、应用，及宿主细胞
JP6732915B2 (ja) 2015-12-15 2020-07-29 ギリアード サイエンシーズ， インコーポレイテッド ヒト免疫不全ウイルス中和抗体
LT3443006T (lt) 2016-04-13 2023-10-25 Sanofi Trispecifiniai ir (arba) trivalenčiai rišantieji baltymai
CA3020633A1 (fr) 2016-04-13 2017-10-19 Sanofi Proteines de liaison trispecifiques et/ou trivalentes
WO2018120842A1 (fr) 2016-12-30 2018-07-05 上海欣百诺生物科技有限公司 Molécule bifonctionnelle et son utilisation
WO2018151841A1 (fr) 2017-02-17 2018-08-23 Sanofi Molécules de liaison multispécifiques ayant une spécificité vis-à-vis du dystroglycane et de la laminine-2
KR102654105B1 (ko) 2017-02-17 2024-04-04 사노피 디스트로글리칸 및 라미닌-2에 대한 특이성을 갖는 다중특이적 결합 분자
US11845787B2 (en) 2017-03-27 2023-12-19 The Wistar Institute Of Anatomy And Biology DNA antibody constructs for use against HIV
BR112020007002A2 (pt) 2017-10-10 2020-11-17 Sanofi anticorpos anti-cd38 e métodos de uso
JP7462621B2 (ja) 2018-10-09 2024-04-05 サノフイ 三重特異性抗ｃｄ３８、抗ｃｄ２８、および抗ｃｄ３結合タンパク質ならびにウイルス感染を処置するための使用方法
US11613576B2 (en) 2019-04-09 2023-03-28 Sanofi Trispecific binding proteins, methods, and uses thereof

Also Published As

Publication number Publication date
CL2018001065A1 (es) 2018-11-23
SG11201803324VA (en) 2018-05-30
CR20180288A (es) 2018-09-11
JP2021072847A (ja) 2021-05-13
IL258822B1 (en) 2023-04-01
CA3002664A1 (fr) 2017-05-04
AR106466A1 (es) 2018-01-17
CN116789841A (zh) 2023-09-22
AU2016347058B2 (en) 2023-11-09
NZ781602A (en) 2025-07-25
UY36965A (es) 2017-05-31
EP3365366B1 (fr) 2021-07-14
TW202442675A (zh) 2024-11-01
KR20180063336A (ko) 2018-06-11
WO2017074878A1 (fr) 2017-05-04
JP7169190B2 (ja) 2022-11-10
CN116675776A (zh) 2023-09-01
MX2022014631A (es) 2023-01-11
US20220226495A1 (en) 2022-07-21
US20200054765A1 (en) 2020-02-20
US20250312475A1 (en) 2025-10-09
HK1253385A1 (zh) 2019-06-14
PH12018500873A1 (en) 2018-11-12
IL258822A (en) 2018-06-28
AU2016347058A1 (en) 2018-06-14
EA201891028A1 (ru) 2019-02-28
US11779651B2 (en) 2023-10-10
US20190054182A1 (en) 2019-02-21
JP2018537966A (ja) 2018-12-27
JP7328267B2 (ja) 2023-08-16
RS62437B1 (sr) 2021-11-30
MX2018005048A (es) 2018-09-06
EP3819310A1 (fr) 2021-05-12
CO2018005337A2 (es) 2018-07-10
MY192278A (en) 2022-08-16
NZ742825A (en) 2024-04-26
JP7724814B2 (ja) 2025-08-18
TW201730210A (zh) 2017-09-01
HRP20211528T1 (hr) 2021-12-24
TW202219064A (zh) 2022-05-16
CN117069855A (zh) 2023-11-17
AU2024200395A1 (en) 2024-04-11
PE20181167A1 (es) 2018-07-19
CN109311966A (zh) 2019-02-05
SI3365366T1 (sl) 2022-02-28
HUE056608T2 (hu) 2022-02-28
TWI750139B (zh) 2021-12-21
JP2023085476A (ja) 2023-06-20
IL301140A (en) 2023-05-01
DOP2018000102A (es) 2018-11-30
PL3365366T3 (pl) 2022-01-31
IL258822B2 (en) 2023-08-01
EP3365366A1 (fr) 2018-08-29
ES2894304T3 (es) 2022-02-14
KR102687212B1 (ko) 2024-07-19
BR112018008011A2 (en) 2018-10-30
CN109311966B (zh) 2023-03-10
US11129905B2 (en) 2021-09-28
WO2017074878A8 (fr) 2018-05-24

Similar Documents

Publication Publication Date Title
MA42641A1 (fr) Protéines de liaison trispécifiques et/ou trivalentes pour la prévention ou le traitement d'une infection par le vih
MA44670B1 (fr) Protéines de liaison trispécifiques et/ou trivalentes
EA202190138A1 (ru) Анти-sirp-бета1 антитела и способы их использования
MA40476A (fr) Anticorps et fragments de fixation à l'antigène anti-lag3
MY194290A (en) CD123 Binding Proteins and Related Compositions and Methods
MY208876A (en) Trispecific binding proteins, methods, and uses thereof
MA55609A (fr) Protéines de liaison trispécifiques et/ou trivalentes utilisant un format de domaine croisé à double variable (codv) pour le traitement d'une infection par le vih
WO2019005817A3 (fr) Clones d'hybridomes, anticorps monoclonaux dirigés contre vsig-4, et leurs procédés de fabrication et d'utilisation
MA39342B2 (fr) Anticorps il -21
MA38161A1 (fr) Anticorps anti-bmp-6
EP3930852A4 (fr) Protéines de liaison à l'antigène se liant à bcma
WO2017079443A8 (fr) Compositions comprenant des anticorps il6r pour le traitement de l'uvéite et l'oedème maculaire et leurs procédés d'utilisation
EA202092593A1 (ru) Белки, связывающие каннабиноидный рецептор 1-го типа (cb1), и их применение
EP4640282A3 (fr) Protéines et fragments immunodominants dans la sclérose en plaques
MA61946B1 (fr) Anticorps capables de se lier à la protéine spike du coronavirus sars-cov-2
MX2023004804A (es) Proteinas de union triespecificas y/o trivalentes.
EA202092229A1 (ru) Мутеины cd4 и способы их применения
PH12022550277A1 (en) Biopharmacuetical compositions and related methods
EP3808842A4 (fr) Composition pharmaceutique pour le traitement d'une immunodéficience complexe sévère comprenant une protéine de fusion d'un peptide de pénétration cellulaire et de l'adénosine désaminase
TN2018000137A1 (en) Trispecific and/or trivalent binding proteins for prevention or treatment of hiv infection
EA202191078A2 (ru) Триспецифические и/или тривалентные связывающие белки для предупреждения или лечения инфекции, вызываемой hiv
EA202190836A1 (ru) Антитела и антигенсвязывающие фрагменты против гликопротеина шипов sars-cov-2
MX2018016413A (es) Ensayos farmacocineticos mejorados para dominios variables unicos de inmunoglobulina.
TN2018000345A1 (en) Trispecific and/or trivalent binding proteins
MA48870B1 (fr) Anticorps anti-sortiline et leurs méthodes d'utilisation