MA42685A - Synthèse de chlorhydrate de lévométhadone ou de chlorhydrate de dextrométhadone et leurs méthodes d'utilisation - Google Patents
Synthèse de chlorhydrate de lévométhadone ou de chlorhydrate de dextrométhadone et leurs méthodes d'utilisationInfo
- Publication number
- MA42685A MA42685A MA042685A MA42685A MA42685A MA 42685 A MA42685 A MA 42685A MA 042685 A MA042685 A MA 042685A MA 42685 A MA42685 A MA 42685A MA 42685 A MA42685 A MA 42685A
- Authority
- MA
- Morocco
- Prior art keywords
- hydrochloride
- dextromethadone
- synthesis
- methods
- levomethadone
- Prior art date
Links
- FJQXCDYVZAHXNS-LMOVPXPDSA-N (6s)-6-(dimethylamino)-4,4-diphenylheptan-3-one;hydrochloride Chemical compound Cl.C=1C=CC=CC=1C(C[C@H](C)N(C)C)(C(=O)CC)C1=CC=CC=C1 FJQXCDYVZAHXNS-LMOVPXPDSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 229960002710 levomethadone Drugs 0.000 title 1
- USSIQXCVUWKGNF-QGZVFWFLSA-N levomethadone Chemical compound C=1C=CC=CC=1C(C[C@@H](C)N(C)C)(C(=O)CC)C1=CC=CC=C1 USSIQXCVUWKGNF-QGZVFWFLSA-N 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
- C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
- C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562209168P | 2015-08-24 | 2015-08-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA42685A true MA42685A (fr) | 2018-07-04 |
Family
ID=56853854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA042685A MA42685A (fr) | 2015-08-24 | 2016-08-24 | Synthèse de chlorhydrate de lévométhadone ou de chlorhydrate de dextrométhadone et leurs méthodes d'utilisation |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US10040752B2 (fr) |
| EP (1) | EP3341354A1 (fr) |
| CN (1) | CN108137483A (fr) |
| MA (1) | MA42685A (fr) |
| WO (1) | WO2017035224A1 (fr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA42685A (fr) * | 2015-08-24 | 2018-07-04 | Cody Laboratories Inc | Synthèse de chlorhydrate de lévométhadone ou de chlorhydrate de dextrométhadone et leurs méthodes d'utilisation |
| MX2019009038A (es) * | 2017-01-31 | 2019-12-09 | L Manfredi Paolo | D-metadona y sus derivados para uso en el tratamiento de trastornos del sistema nervioso. |
| CN108693272B (zh) * | 2018-06-04 | 2021-03-12 | 吉林百纯化学科技有限公司 | 一种hplc法分析及制备n-（对甲苯磺酰基）-l-丙氨酸及其对映异构体的方法 |
| US20200033307A1 (en) * | 2018-07-25 | 2020-01-30 | Honeywell International Inc. | Method of determining an amount of water in a sample using a derivative of imidazole and a hydrogen halide donor |
| US12637411B2 (en) | 2019-01-30 | 2026-05-26 | Mggm Llc | Structurally modified opioids for prevention and treatment of diseases and conditions |
| US11332434B2 (en) * | 2019-04-17 | 2022-05-17 | Javad Safaei-Ghomi | Synthesis of levomethadone hydrochloride |
| CN110818908B (zh) * | 2019-08-29 | 2021-12-17 | 杭州市富阳区浙工大银湖创新创业研究院 | 一种用于检测氧化气体的金属有机骨架材料的制备方法 |
| CN114341291A (zh) | 2019-09-09 | 2022-04-12 | 3M创新有限公司 | 共挤出聚合物粘合剂制品 |
| CN117897146A (zh) | 2021-04-09 | 2024-04-16 | 保罗·L·曼佛雷蒂 | 用于合成对映纯(s)-美沙酮、(r)-美沙酮、外消旋(r,s)-美沙酮和相关类似物质的新型方法 |
| US20240122878A1 (en) * | 2021-06-30 | 2024-04-18 | Paolo L. Manfredi | Modified release formulations of methadone and its isomers, esmethadone and levomethadone and derivatives |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2540636A (en) | 1947-11-12 | 1951-02-06 | Mallinckrodt Chemical Works | Separation of nitrile intermediates in amidone synthesis |
| US2497739A (en) | 1949-01-05 | 1950-02-14 | Merck & Co Inc | Process of separating isomers of amidone intermediates |
| US2601323A (en) | 1949-02-02 | 1952-06-24 | Upjohn Co | Process for preparing 4, 4-diphenyl-6-dimethylamino-heptanone-3 |
| GB1124682A (en) | 1966-06-21 | 1968-08-21 | Wyeth John & Brother Ltd | Preparation of amines |
| US4048211A (en) | 1976-05-10 | 1977-09-13 | Eli Lilly And Company | Modification of methadone synthesis process step |
| US4242274A (en) | 1979-06-18 | 1980-12-30 | Mallinckrodt, Inc. | Process for the preparation of 2,2-diphenyl-4-(dimethylamino)-pentane nitrile |
| GB9611041D0 (en) | 1996-05-25 | 1996-07-31 | Salford Ultrafine Chem & Res | Process for the preparation of optically active methadones in high enantiomeric purity |
| SK287446B6 (sk) | 2007-02-08 | 2010-10-07 | Zentiva, A. S. | Spôsob prípravy metadóniumchloridu |
| AU2012258618B2 (en) | 2011-05-26 | 2017-05-25 | Sunovion Pharmaceuticals Inc. | Metabotropic glutamate receptors 5 modulators and methods of use thereof |
| MY183354A (en) | 2011-11-22 | 2021-02-18 | Univ Sains Malaysia | (r)-6-(dimthylamino)-4,4-diphenylheptan-3-one |
| US9468611B2 (en) | 2012-09-27 | 2016-10-18 | Relmada Therapeutics, Inc. | d-Methadone for the treatment of psychiatric symptoms |
| MA42685A (fr) * | 2015-08-24 | 2018-07-04 | Cody Laboratories Inc | Synthèse de chlorhydrate de lévométhadone ou de chlorhydrate de dextrométhadone et leurs méthodes d'utilisation |
-
2016
- 2016-08-24 MA MA042685A patent/MA42685A/fr unknown
- 2016-08-24 US US15/245,935 patent/US10040752B2/en active Active
- 2016-08-24 CN CN201680061096.XA patent/CN108137483A/zh active Pending
- 2016-08-24 EP EP16760285.3A patent/EP3341354A1/fr not_active Withdrawn
- 2016-08-24 WO PCT/US2016/048380 patent/WO2017035224A1/fr not_active Ceased
-
2018
- 2018-06-29 US US16/024,283 patent/US20190002394A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20190002394A1 (en) | 2019-01-03 |
| WO2017035224A1 (fr) | 2017-03-02 |
| US10040752B2 (en) | 2018-08-07 |
| US20170057909A1 (en) | 2017-03-02 |
| EP3341354A1 (fr) | 2018-07-04 |
| CN108137483A (zh) | 2018-06-08 |
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