MA42811B1 - Dérivés d'indole monosubstitués ou disubstitués utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue - Google Patents
Dérivés d'indole monosubstitués ou disubstitués utilisés en tant qu'inhibiteurs de la réplication du virus de la dengueInfo
- Publication number
- MA42811B1 MA42811B1 MA42811A MA42811A MA42811B1 MA 42811 B1 MA42811 B1 MA 42811B1 MA 42811 A MA42811 A MA 42811A MA 42811 A MA42811 A MA 42811A MA 42811 B1 MA42811 B1 MA 42811B1
- Authority
- MA
- Morocco
- Prior art keywords
- monosubstituted
- inhibitors
- compounds
- dengue virus
- virus replication
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
La présente invention concerne des composés indoles mono- ou di-substitués, des procédés pour prévenir ou traiter les infections virales de la dengue en utilisant lesdits composés et concerne également lesdits composés à utiliser comme médicament, plus préférablement à utiliser comme médicament pour traiter ou prévenir la dengue virale infections. La présente invention concerne en outre des compositions pharmaceutiques ou des préparations combinées des composés, des compositions ou des préparations destinées à être utilisées comme médicament, plus préférablement pour la prévention ou le traitement des infections virales de la dengue. L'invention concerne également des procédés de préparation des composés.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15185522 | 2015-09-16 | ||
| EP16163465 | 2016-04-01 | ||
| PCT/EP2016/071852 WO2017046258A1 (fr) | 2015-09-16 | 2016-09-15 | Dérivés d'indole monosubstitués ou disubstitués utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA42811A MA42811A (fr) | 2018-07-25 |
| MA42811B1 true MA42811B1 (fr) | 2020-03-31 |
Family
ID=56958913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA42811A MA42811B1 (fr) | 2015-09-16 | 2016-09-15 | Dérivés d'indole monosubstitués ou disubstitués utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue |
Country Status (37)
| Country | Link |
|---|---|
| US (1) | US10786484B2 (fr) |
| EP (1) | EP3350163B1 (fr) |
| JP (2) | JP7045984B2 (fr) |
| KR (1) | KR102676442B1 (fr) |
| CN (1) | CN108368044B (fr) |
| AU (1) | AU2016323535B2 (fr) |
| CA (1) | CA2996856C (fr) |
| CL (1) | CL2018000697A1 (fr) |
| CO (1) | CO2018003369A2 (fr) |
| CR (1) | CR20180214A (fr) |
| CY (1) | CY1122792T1 (fr) |
| DK (1) | DK3350163T3 (fr) |
| EA (1) | EA035679B1 (fr) |
| EC (1) | ECSP18020039A (fr) |
| ES (1) | ES2778431T3 (fr) |
| HR (1) | HRP20200408T1 (fr) |
| IL (1) | IL258031B (fr) |
| JO (1) | JO3633B1 (fr) |
| LT (1) | LT3350163T (fr) |
| MA (1) | MA42811B1 (fr) |
| MD (1) | MD3350163T2 (fr) |
| ME (1) | ME03674B (fr) |
| MX (1) | MX381632B (fr) |
| MY (1) | MY188347A (fr) |
| NI (1) | NI201800040A (fr) |
| PE (1) | PE20181007A1 (fr) |
| PH (1) | PH12018500569B1 (fr) |
| PL (1) | PL3350163T3 (fr) |
| PT (1) | PT3350163T (fr) |
| RS (1) | RS60039B1 (fr) |
| SI (1) | SI3350163T1 (fr) |
| SM (1) | SMT202000140T1 (fr) |
| TW (1) | TWI758256B (fr) |
| UA (1) | UA123672C2 (fr) |
| UY (1) | UY36904A (fr) |
| WO (1) | WO2017046258A1 (fr) |
| ZA (1) | ZA201801764B (fr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| KR101818521B1 (ko) * | 2011-11-16 | 2018-01-16 | 대우조선해양 주식회사 | 마이크로채널 열교환기용 2상 유체 공급장치 및 그 방법 |
| GB201305376D0 (en) | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| ES2828431T3 (es) | 2015-12-16 | 2021-05-26 | Loxo Oncology Inc | Compuestos útiles como inhibidores de cinasa |
| MA44498A (fr) | 2016-03-31 | 2019-02-06 | Janssen Pharmaceuticals Inc | Dérivés d'indoline substituée utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue |
| SG11201808138YA (en) | 2016-03-31 | 2018-10-30 | Janssen Pharmaceuticals Inc | Substituted indole derivatives as dengue viral replication inhibitors |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| EP3436004B1 (fr) | 2016-04-01 | 2024-12-11 | Janssen Pharmaceuticals, Inc. | Dérivés substitués de l'indol comme inhibiteurs du virus de la dengue |
| JOP20180025B1 (ar) * | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180026A1 (ar) * | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| SI3630724T1 (sl) | 2017-05-22 | 2021-08-31 | Janssen Pharmaceuticals, Inc. | Substituirani derivati indolina kot zaviralci replikacije virusa denga |
| CA3060583C (fr) | 2017-05-22 | 2024-06-04 | Janssen Pharmaceuticals, Inc. | Derives d'indoline substitues utilises en tant qu'inhibiteurs de replication du virus de la dengue |
| WO2024178504A1 (fr) * | 2023-02-27 | 2024-09-06 | Enveric Biosciences Canada Inc. | Dérivés de tryptamine à substitution tri-halo-alcoxy et procédés d'utilisation |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0110832D0 (en) | 2001-05-03 | 2001-06-27 | Virogen Ltd | Antiviral compounds |
| JP2005520795A (ja) | 2001-12-12 | 2005-07-14 | コンフォーマ・セラピューティクス・コーポレイション | Ｈｓｐ９０阻害活性を有するプリン類似体 |
| GB0215293D0 (en) | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
| US20060211698A1 (en) | 2005-01-14 | 2006-09-21 | Genelabs, Inc. | Bicyclic heteroaryl derivatives for treating viruses |
| AU2006221080A1 (en) | 2005-02-09 | 2006-09-14 | Migenix Inc. | Compositions and methods for treating or preventing flaviviridae infections |
| FR2928645A1 (fr) * | 2008-03-14 | 2009-09-18 | Sanofi Aventis Sa | Nouveaux derives de carbazole inhibiteurs d'hsp90, compositions les contenant et utilisation |
| AU2009256390A1 (en) | 2008-06-03 | 2009-12-10 | Siga Technologies, Inc. | Small molecule inhibitors for the treatment or prevention of dengue virus infection |
| PE20110368A1 (es) * | 2008-08-18 | 2011-06-13 | Univ Yale | Moduladores de mif |
| US8143259B2 (en) | 2008-08-19 | 2012-03-27 | Janssen Pharmaceutica, Nv | Cold menthol receptor antagonists |
| TWI453207B (zh) | 2008-09-08 | 2014-09-21 | Signal Pharm Llc | 胺基三唑并吡啶，其組合物及使用其之治療方法 |
| GB0910003D0 (en) * | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
| US8993604B2 (en) | 2009-06-30 | 2015-03-31 | Siga Technologies, Inc. | Treatment and prevention of dengue virus infections |
| KR20120123678A (ko) | 2010-01-15 | 2012-11-09 | 길리애드 사이언시즈, 인코포레이티드 | 플라비비리다에 바이러스의 억제제 |
| JP5716205B2 (ja) * | 2011-03-29 | 2015-05-13 | 学校法人日本大学 | グルコシダーゼ活性阻害用組成物及びそのスクリーニング方法 |
| GB201116559D0 (en) * | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB201305376D0 (en) | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
| JP6030035B2 (ja) | 2013-09-27 | 2016-11-24 | 富士フイルム株式会社 | 蛍光観察装置、内視鏡システム及びプロセッサ装置並びに作動方法 |
| MX368158B (es) * | 2013-10-23 | 2019-09-20 | Janssen Sciences Ireland Uc | Derivados de carboxamida y su uso como medicamentos para el tratamiento de la hepatitis b. |
| KR20240017118A (ko) | 2014-01-31 | 2024-02-06 | 브리스톨-마이어스 스큅 컴퍼니 | 인자 XIa 억제제로서의 헤테로시클릭 P2' 기를 갖는 마크로사이클 |
| DK3201177T3 (en) | 2014-10-01 | 2019-03-04 | Janssen Pharmaceuticals Inc | MONO OR DISUBSTITUTED INDOLES AS INHIBITORS OF DENGUE VIRUS REPLICATION |
| PT3201176T (pt) | 2014-10-01 | 2019-03-04 | Janssen Pharmaceuticals Inc | Derivados indol mono- ou dissubstituídos como inibidores da replicação viral do dengue |
| NO2721243T3 (fr) | 2014-10-01 | 2018-10-20 | ||
| PH12017501272B1 (en) * | 2015-01-16 | 2023-01-11 | Janssen Pharmaceuticals Inc | Indole derivatives as dengue viral replication inhibitors |
| AR103680A1 (es) | 2015-02-23 | 2017-05-24 | Lilly Co Eli | Inhibidores selectivos de bace1 |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) * | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| EP3370698B1 (fr) | 2015-11-03 | 2022-01-26 | Zoetis Services LLC | Composites de polymère sol-gel et utilisation de ces derniers |
| MY194647A (en) | 2016-03-31 | 2022-12-09 | Takeda Pharmaceuticals Co | Heterocyclic compound |
| SG11201808138YA (en) | 2016-03-31 | 2018-10-30 | Janssen Pharmaceuticals Inc | Substituted indole derivatives as dengue viral replication inhibitors |
| MA44498A (fr) | 2016-03-31 | 2019-02-06 | Janssen Pharmaceuticals Inc | Dérivés d'indoline substituée utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue |
| US10603380B2 (en) | 2016-04-01 | 2020-03-31 | Kite Pharma, Inc. | Chimeric antigen and T cell receptors and methods of use |
| CA3015934A1 (fr) | 2016-04-01 | 2017-10-05 | Basf Se | Composes bicycliques |
| EP3436004B1 (fr) | 2016-04-01 | 2024-12-11 | Janssen Pharmaceuticals, Inc. | Dérivés substitués de l'indol comme inhibiteurs du virus de la dengue |
| BR112018070163A2 (pt) | 2016-04-01 | 2019-01-29 | Signal Pharm Llc | compostos de aminopurina substituída, composições e métodos de tratamento |
| KR102694879B1 (ko) | 2016-04-01 | 2024-08-16 | 암젠 인크 | Flt3에 대한 키메라 수용체 및 이의 사용 방법 |
| KR102608405B1 (ko) | 2016-04-01 | 2023-12-01 | 카이트 파마 인코포레이티드 | 키메라 수용체 및 그의 사용 방법 |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| SI3630724T1 (sl) | 2017-05-22 | 2021-08-31 | Janssen Pharmaceuticals, Inc. | Substituirani derivati indolina kot zaviralci replikacije virusa denga |
| CA3060583C (fr) | 2017-05-22 | 2024-06-04 | Janssen Pharmaceuticals, Inc. | Derives d'indoline substitues utilises en tant qu'inhibiteurs de replication du virus de la dengue |
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2016
- 2016-09-06 JO JOP/2016/0197A patent/JO3633B1/ar active
- 2016-09-13 TW TW105129691A patent/TWI758256B/zh not_active IP Right Cessation
- 2016-09-15 SM SM20200140T patent/SMT202000140T1/it unknown
- 2016-09-15 DK DK16767235.1T patent/DK3350163T3/da active
- 2016-09-15 PL PL16767235T patent/PL3350163T3/pl unknown
- 2016-09-15 RS RS20200272A patent/RS60039B1/sr unknown
- 2016-09-15 MX MX2018003256A patent/MX381632B/es unknown
- 2016-09-15 PE PE2018000391A patent/PE20181007A1/es unknown
- 2016-09-15 PT PT167672351T patent/PT3350163T/pt unknown
- 2016-09-15 CN CN201680053589.9A patent/CN108368044B/zh active Active
- 2016-09-15 JP JP2018513845A patent/JP7045984B2/ja active Active
- 2016-09-15 SI SI201630686T patent/SI3350163T1/sl unknown
- 2016-09-15 LT LTEP16767235.1T patent/LT3350163T/lt unknown
- 2016-09-15 AU AU2016323535A patent/AU2016323535B2/en active Active
- 2016-09-15 KR KR1020187009485A patent/KR102676442B1/ko active Active
- 2016-09-15 US US15/759,844 patent/US10786484B2/en active Active
- 2016-09-15 EA EA201890723A patent/EA035679B1/ru not_active IP Right Cessation
- 2016-09-15 MA MA42811A patent/MA42811B1/fr unknown
- 2016-09-15 UA UAA201804016A patent/UA123672C2/uk unknown
- 2016-09-15 MY MYPI2018000378A patent/MY188347A/en unknown
- 2016-09-15 ES ES16767235T patent/ES2778431T3/es active Active
- 2016-09-15 CA CA2996856A patent/CA2996856C/fr active Active
- 2016-09-15 MD MDE20180704T patent/MD3350163T2/ro unknown
- 2016-09-15 HR HRP20200408TT patent/HRP20200408T1/hr unknown
- 2016-09-15 EP EP16767235.1A patent/EP3350163B1/fr active Active
- 2016-09-15 PH PH1/2018/500569A patent/PH12018500569B1/en unknown
- 2016-09-15 ME MEP-2020-53A patent/ME03674B/fr unknown
- 2016-09-15 CR CR20180214A patent/CR20180214A/es unknown
- 2016-09-15 WO PCT/EP2016/071852 patent/WO2017046258A1/fr not_active Ceased
- 2016-09-16 UY UY0001036904A patent/UY36904A/es not_active Application Discontinuation
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2018
- 2018-03-12 IL IL258031A patent/IL258031B/en active IP Right Grant
- 2018-03-14 EC ECIEPI201820039A patent/ECSP18020039A/es unknown
- 2018-03-15 CL CL2018000697A patent/CL2018000697A1/es unknown
- 2018-03-15 ZA ZA2018/01764A patent/ZA201801764B/en unknown
- 2018-03-15 NI NI201800040A patent/NI201800040A/es unknown
- 2018-03-26 CO CONC2018/0003369A patent/CO2018003369A2/es unknown
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2020
- 2020-03-12 CY CY20201100216T patent/CY1122792T1/el unknown
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2021
- 2021-08-20 JP JP2021135171A patent/JP2021193092A/ja active Pending
Also Published As
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| Publication | Publication Date | Title |
|---|---|---|
| MA42811A (fr) | Dérivés d'indole monosubstitués ou disubstitués utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue | |
| MA40769B1 (fr) | Indoles mono ou di-substitués utilisés en tant qu'inhibiteurs de réplication du virus de la dengue | |
| MA40768B1 (fr) | Dérivés d'indole mono ou di-substitué en tant qu'inhibiteurs de réplication du virus de la dengue | |
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| EA201992295A1 (ru) | Производные моно- или дизамещенных индолов в качестве ингибиторов репликации вирусов денге |