MA42915A - Pyridines et leur utilisation dans le traitement du cancer - Google Patents

Pyridines et leur utilisation dans le traitement du cancer

Info

Publication number
MA42915A
MA42915A MA042915A MA42915A MA42915A MA 42915 A MA42915 A MA 42915A MA 042915 A MA042915 A MA 042915A MA 42915 A MA42915 A MA 42915A MA 42915 A MA42915 A MA 42915A
Authority
MA
Morocco
Prior art keywords
pyridines
cancer treatment
cancer
treatment
Prior art date
Application number
MA042915A
Other languages
English (en)
Inventor
Elias Set Jenö Arnér
Nathan Patrick Coussens
Thomas S Dexheimer
Ajit Jadhav
Diane Karen Luci
David Joseph Maloney
Anton Simeonov
William Chester Stafford
Original Assignee
Arner Elias Set Jenoe
Us Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arner Elias Set Jenoe, Us Health filed Critical Arner Elias Set Jenoe
Publication of MA42915A publication Critical patent/MA42915A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C07D213/71—Sulfur atoms to which a second hetero atom is attached
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
MA042915A 2015-08-07 2016-08-05 Pyridines et leur utilisation dans le traitement du cancer MA42915A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1514021.3A GB201514021D0 (en) 2015-08-07 2015-08-07 Novel Pyridines and their use in the treatment of cancer

Publications (1)

Publication Number Publication Date
MA42915A true MA42915A (fr) 2018-08-01

Family

ID=54200423

Family Applications (1)

Application Number Title Priority Date Filing Date
MA042915A MA42915A (fr) 2015-08-07 2016-08-05 Pyridines et leur utilisation dans le traitement du cancer

Country Status (12)

Country Link
US (1) US10899710B2 (fr)
EP (1) EP3331858A1 (fr)
JP (1) JP6636153B2 (fr)
KR (1) KR102180934B1 (fr)
CN (1) CN108026044A (fr)
AU (1) AU2016306276B2 (fr)
CA (1) CA2995077C (fr)
GB (1) GB201514021D0 (fr)
MA (1) MA42915A (fr)
MX (1) MX391999B (fr)
RU (1) RU2730505C2 (fr)
WO (1) WO2017027359A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201514021D0 (en) 2015-08-07 2015-09-23 Arner Elias Set Jeno Novel Pyridines and their use in the treatment of cancer
MY197583A (en) * 2016-05-24 2023-06-26 Basf Se Herbicidal uracilpyrid
KR20190115012A (ko) 2017-02-07 2019-10-10 오블리크 세러퓨틱스 에이비 헤테로사이클릴설포닐-치환된 피리딘 및 암의 치료에서 이의 용도
KR20190115013A (ko) 2017-02-07 2019-10-10 오블리크 세러퓨틱스 에이비 헤테로아릴설포닐-치환된 피리딘 및 암의 치료에서 이의 용도
EP3580203A1 (fr) * 2017-02-07 2019-12-18 Oblique Therapeutics AB Pyridines à substitution hydrocarbylsulfonyle et leur utilisation dans le traitement du cancer
MX2019009356A (es) 2017-02-07 2019-09-19 Oblique Therapeutics Ab Sulfinilpiridinas y su uso en el tratamiento del cancer.
CA3091085A1 (fr) * 2018-02-12 2019-08-15 Cinda Pharma Ab Inhibiteurs de la thioredoxine reductase a utiliser dans le traitement du cancer
EP3959199A4 (fr) * 2019-04-24 2023-06-28 Memorial Sloan Kettering Cancer Center Compositions et méthodes de traitement de cancers à mutation de ras

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0031173B1 (fr) 1979-12-19 1983-09-14 Duphar International Research B.V Nitrothiophènes, procédé pour leur préparation, ainsi que compositions fongicides et/ou bactéricides les contenant
AU543161B2 (en) 1980-03-07 1985-04-04 E.I. Du Pont De Nemours And Company Pyrimidine or s.triazine derivatives
US4456469A (en) 1980-03-07 1984-06-26 E. I. Du Pont De Nemours And Company Pyridyl sulfone herbicides
US4791127A (en) 1985-10-07 1988-12-13 Nippon Kayaku Kabushiki Kaisha Alkanesulfonate derivatives and their use as insecticides, acaricides or nematicides
DE3812177A1 (de) 1988-04-13 1989-10-26 Bayer Ag 2-phenylsulfinyl-nitro-pyridine, verfahren zu ihrer herstellung und ihre verwendung
US5945425A (en) 1994-04-29 1999-08-31 G.D. Searle & Co. Method of using (H+ /K+)ATPase inhibitors as antiviral agents
DE19531148A1 (de) 1995-08-24 1997-02-27 Basf Ag Fungizide Pyridin-2-yl-Derivate
EP0850223A1 (fr) 1995-08-24 1998-07-01 Basf Aktiengesellschaft Composes n-heterocycliques, produits intermediaires utilises pour les preparer, agents les contenant et utilisation pour lutter contre des champignons nuisibles
US6191280B1 (en) 1997-05-30 2001-02-20 Basf Aktiengesellschaft Method for producing substituted thiopyridines
US6284923B1 (en) 1997-08-22 2001-09-04 Tularik Inc Substituted benzene compounds as antiproliferative and cholesterol lowering action
WO1999018096A1 (fr) 1997-10-02 1999-04-15 Merck & Co., Inc. Inhibiteurs de la prenyl-proteine transferase
US6297239B1 (en) 1997-10-08 2001-10-02 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
US6191170B1 (en) * 1998-01-13 2001-02-20 Tularik Inc. Benzenesulfonamides and benzamides as therapeutic agents
ATE236136T1 (de) 1998-01-16 2003-04-15 Hoffmann La Roche Benzosulfonderivate
ES2254385T3 (es) 2000-02-29 2006-06-16 Millennium Pharmaceuticals, Inc. Benzamidas e inhibidores relacionados del factor xa.
US20030187026A1 (en) 2001-12-13 2003-10-02 Qun Li Kinase inhibitors
WO2003068744A1 (fr) 2002-02-18 2003-08-21 Ishihara Sangyo Kaisha, Ltd. Derives de la pyridine ou leurs sels, et inhibiteurs de production de citokine renfermant ces derives
US20030236287A1 (en) 2002-05-03 2003-12-25 Piotrowski David W. Positive allosteric modulators of the nicotinic acetylcholine receptor
US7037902B2 (en) 2002-07-03 2006-05-02 Receptron, Inc. Affinity small molecules for the EPO receptor
WO2005007621A2 (fr) 2003-05-30 2005-01-27 Rigel Pharmaceuticals, Inc. Inhibiteurs de ligase d'ubiquitine
HRP20090093T3 (en) 2004-06-04 2009-03-31 Arena Pharmaceuticals Inc. Substituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto
US20060019967A1 (en) * 2004-07-21 2006-01-26 Su-Ying Wu SARS CoV main protease inhibitors
GB0426313D0 (en) 2004-12-01 2005-01-05 Merck Sharp & Dohme Therapeutic agents
WO2006083692A2 (fr) 2005-01-28 2006-08-10 Mount Sinai Schoool Of Medicine Procédés d'identification de modulateurs de bromodomaines
GB0504828D0 (en) 2005-03-09 2005-04-13 Merck Sharp & Dohme Therapeutic agents
EP1976495A2 (fr) 2006-01-06 2008-10-08 Aarhus Universitet Composes agissant sur le transporteur de la serotonine
CA2647338A1 (fr) 2006-04-28 2007-11-08 Avexa Limited Inhibiteurs de l'integrase-3
US20100190777A1 (en) 2007-07-17 2010-07-29 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
CN101723932B (zh) 2008-10-31 2013-11-20 北京以岭生物工程技术有限公司 硝基吡啶乙烯亚胺化合物、其药物组合物及其制备方法和用途
US9421211B2 (en) 2009-05-28 2016-08-23 President And Fellows Of Harvard College N,N′-diarylurea compounds and N,N′-diarylthiourea compounds as inhibitors of translation initiation
NZ598262A (en) 2009-08-17 2014-05-30 Sloan Kettering Inst Cancer Heat shock protein binding compounds, compositions, and methods for making and using same
WO2011099502A1 (fr) 2010-02-10 2011-08-18 公立大学法人横浜市立大学 Utilisation d'un composé se liant à msin3b qui se lie, de façon spécifique, au facteur silenceur de la spécification neuronale nrsf
CN102206172B (zh) 2010-03-30 2015-02-25 中国医学科学院医药生物技术研究所 一组取代双芳基化合物及其制备方法和抗病毒应用
WO2012025638A1 (fr) 2010-08-27 2012-03-01 Universität des Saarlandes Inhibiteurs sélectifs de la 17-bêta-hydroxystéroïde déshydrogénase de type 1
AU2013216885B2 (en) 2012-02-10 2017-08-03 The Board Of Regents Of The University Of Texas System Modulators of exchange proteins directly activated by cAMP (EPACs)
US8946418B1 (en) 2013-07-10 2015-02-03 Boehringer Ingelheim International Gmbh Chiral nitrogen-phosphorus ligands and their use for asymmetric hydrogenation of alkenes
CN104672214B (zh) 2013-12-03 2019-04-12 上海翰森生物医药科技有限公司 具有alk抑制活性的化合物及其制备与用途
CN105503827B (zh) 2014-10-11 2019-09-24 上海翰森生物医药科技有限公司 Egfr抑制剂及其制备方法和用途
CN105085483B (zh) 2015-06-04 2019-01-01 湖北生物医药产业技术研究院有限公司 激酶抑制剂及其应用
CN104987324B (zh) 2015-06-04 2018-05-04 湖北生物医药产业技术研究院有限公司 作为alk抑制剂的嘧啶衍生物
GB201514021D0 (en) 2015-08-07 2015-09-23 Arner Elias Set Jeno Novel Pyridines and their use in the treatment of cancer
MX2019009356A (es) 2017-02-07 2019-09-19 Oblique Therapeutics Ab Sulfinilpiridinas y su uso en el tratamiento del cancer.
EP3580203A1 (fr) 2017-02-07 2019-12-18 Oblique Therapeutics AB Pyridines à substitution hydrocarbylsulfonyle et leur utilisation dans le traitement du cancer
KR20190115013A (ko) 2017-02-07 2019-10-10 오블리크 세러퓨틱스 에이비 헤테로아릴설포닐-치환된 피리딘 및 암의 치료에서 이의 용도
KR20190115012A (ko) 2017-02-07 2019-10-10 오블리크 세러퓨틱스 에이비 헤테로사이클릴설포닐-치환된 피리딘 및 암의 치료에서 이의 용도

Also Published As

Publication number Publication date
JP2018525443A (ja) 2018-09-06
CA2995077C (fr) 2020-04-21
JP6636153B2 (ja) 2020-01-29
WO2017027359A1 (fr) 2017-02-16
AU2016306276B2 (en) 2019-08-01
EP3331858A1 (fr) 2018-06-13
MX391999B (es) 2025-03-21
CN108026044A (zh) 2018-05-11
US20200087260A1 (en) 2020-03-19
GB201514021D0 (en) 2015-09-23
RU2018107879A (ru) 2019-09-09
KR20180035904A (ko) 2018-04-06
MX2018001576A (es) 2018-11-09
US10899710B2 (en) 2021-01-26
KR102180934B1 (ko) 2020-11-20
RU2730505C2 (ru) 2020-08-24
RU2018107879A3 (fr) 2019-09-09
AU2016306276A1 (en) 2018-02-22
CA2995077A1 (fr) 2017-02-16
WO2017027359A8 (fr) 2017-04-20

Similar Documents

Publication Publication Date Title
MA43163A (fr) Polypeptides à domaine extracellulaire cd80 et leur utilisation dans le traitement du cancer
MA45122A (fr) Inhibiteurs hétérocycliques de cbp/ep300 et leur utilisation dans le traitement du cancer
IL257105A (en) Modified cells and methods of therapy
PL3303632T3 (pl) Terapeutyczne i diagnostyczne sposoby stosowane w nowotworze
IL259795A (en) Methods and compositions for treating a serpinc1-associated disorder
MA39960A (fr) Composés imidazo[4,5c]quinoline-2-one et leur utilisation dans le traitement du cancer
SI3240554T1 (sl) Blautia stercosis in wexlerae za uporabo v zdravljenju vnetnih in avtoimunskih bolezni
IL256687B (en) Isolated tau-binding antibody and use thereof in therapy and diagnosis
SI3328419T1 (sl) PD-1-vezavne molekule in postopki uporabe le-teh
IL251774A0 (en) Methods and compositions for dosing in adoptive cell therapy
EP3265113A4 (fr) Anticorps anti-lilrb et leur utilisation pour détecter et traiter un cancer
SI3215601T1 (sl) Postopki za transdukcijo in obdelavo celic
DK3294770T4 (da) Terapeutiske og diagnostiske fremgangsmåder til cancer
DK3256218T3 (da) Kdm1a-hæmmer og anvendelse deraf i terapi
EP2948188A4 (fr) Imagerie neuronale et traitement
EP2991600A4 (fr) Micro-fermetures et procédés associés pour le traitement de la peau
EP2831278A4 (fr) Aptamères dirigés contre pdgf et vegf et leur utilisation dans le traitement d'états à médiation par pdgf et vegf
SI3179991T1 (sl) Terapevtske kombinacije zaviralca BTK in zaviralca BCL-2
EP3448263A4 (fr) Traitement électrothérapeutique
MA41316A (fr) Gènes de détermination du sexe et leur utilisation en reproduction
SI3303394T1 (sl) Protitelesa proti-CTLA-4 in postopki njihove uporabe
MA47452A (fr) Pyridines à substitution hétérocyclylsulfonyle et leur utilisation dans le traitement du cancer
IL251759B (en) Compositions and methods for treating insomnia
SI3319612T1 (sl) Oksisteroli in postopki za uporabo le-teh
MA47451A (fr) Pyridines à substitution hétéroarylsulfonyle et leur utilisation dans le traitement du cancer