MA42954A - Potentialisateurs cftr deutérés - Google Patents
Potentialisateurs cftr deutérésInfo
- Publication number
- MA42954A MA42954A MA042954A MA42954A MA42954A MA 42954 A MA42954 A MA 42954A MA 042954 A MA042954 A MA 042954A MA 42954 A MA42954 A MA 42954A MA 42954 A MA42954 A MA 42954A
- Authority
- MA
- Morocco
- Prior art keywords
- potentializers
- cftr
- deuterated
- deuterated cftr
- cftr potentializers
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B49/00—Grignard reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/12—Mucolytics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562232834P | 2015-09-25 | 2015-09-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA42954A true MA42954A (fr) | 2018-08-01 |
Family
ID=58387351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA042954A MA42954A (fr) | 2015-09-25 | 2016-09-23 | Potentialisateurs cftr deutérés |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10759721B2 (fr) |
| EP (1) | EP3352758A4 (fr) |
| AU (1) | AU2016327603B2 (fr) |
| CA (1) | CA2999529A1 (fr) |
| HK (1) | HK1258473A1 (fr) |
| MA (1) | MA42954A (fr) |
| WO (1) | WO2017053711A2 (fr) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12458635B2 (en) | 2008-08-13 | 2025-11-04 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administrations thereof |
| HUE047354T2 (hu) | 2011-05-18 | 2020-04-28 | Vertex Pharmaceuticals Europe Ltd | Ivacaftor deuterizált származékai |
| JP2015511583A (ja) | 2012-02-27 | 2015-04-20 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | 薬学的組成物およびその投与 |
| HK1249893A1 (zh) | 2015-03-31 | 2018-11-16 | Vertex Pharmaceuticals (Europe) Limited | 氘代vx-661 |
| EP3352758A4 (fr) | 2015-09-25 | 2018-08-01 | Vertex Pharmaceuticals (Europe) Limited | Potentialisateurs cftr deutérés |
| PT3551622T (pt) | 2016-12-09 | 2020-11-12 | Vertex Pharma | Modulador do regulador da condutância transmembrana da fibrose quística, composições farmacêuticas, métodos de tratamento e processo de fabrico do modulador |
| WO2019018395A1 (fr) | 2017-07-17 | 2019-01-24 | Vertex Pharmaceuticals Incorporated | Méthodes de traitement de la fibrose kystique |
| CN117924170A (zh) * | 2017-12-01 | 2024-04-26 | 弗特克斯药品有限公司 | 用于制备囊性纤维化跨膜传导调节因子的调节剂的方法 |
| TWI848092B (zh) | 2019-04-03 | 2024-07-11 | 美商維泰克斯製藥公司 | 囊腫纖維化跨膜傳導調節蛋白調節劑 |
| TWI899097B (zh) | 2019-08-14 | 2025-10-01 | 美商維泰克斯製藥公司 | 製備cftr調節劑之方法 |
| US11873300B2 (en) | 2019-08-14 | 2024-01-16 | Vertex Pharmaceuticals Incorporated | Crystalline forms of CFTR modulators |
| CR20230120A (es) | 2020-08-07 | 2023-09-01 | Vertex Pharma | Moduladores del regulador de la conductancia transmembrana de la fibrosis quística |
| WO2022036060A1 (fr) | 2020-08-13 | 2022-02-17 | Vertex Pharmaceuticals Incorporated | Formes cristallines de modulateurs de cftr |
| US12612416B2 (en) | 2020-10-07 | 2026-04-28 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
| US12324802B2 (en) | 2020-11-18 | 2025-06-10 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
| IL303519A (en) | 2020-12-10 | 2023-08-01 | Vertex Pharma | Cystic fibrosis treatment methods |
| WO2025166342A1 (fr) | 2024-02-04 | 2025-08-07 | Vertex Pharmaceuticals Incorporated | Combinaison de vanzacaftor, de tezacaftor et de deutivacaftor destinée à être utilisée dans le traitement de la fibrose kystique |
| DK4648753T3 (da) | 2024-02-07 | 2026-02-23 | Vertex Pharma | Sammensætninger til behandling af cftr-medierede sygdomme |
Family Cites Families (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1087725C (zh) | 1994-03-25 | 2002-07-17 | 同位素技术有限公司 | 用氘代方法增强药物效果 |
| US6221335B1 (en) | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| US6440710B1 (en) | 1998-12-10 | 2002-08-27 | The Scripps Research Institute | Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds |
| DK1104760T3 (da) | 1999-12-03 | 2003-06-30 | Pfizer Prod Inc | Sulfamoylheteroarylpyrazolforbindelser som anti-inflammatoriske/analgetiske midler |
| RS51550B (sr) | 2002-04-08 | 2011-06-30 | Pfizer Inc. | Derivati tropana kao modulatori ccr5 |
| CN100351259C (zh) | 2002-06-20 | 2007-11-28 | Icvec有限公司 | 含硫的磷脂衍生物 |
| TW200413273A (en) | 2002-11-15 | 2004-08-01 | Wako Pure Chem Ind Ltd | Heavy hydrogenation method of heterocyclic rings |
| US8354427B2 (en) | 2004-06-24 | 2013-01-15 | Vertex Pharmaceutical Incorporated | Modulators of ATP-binding cassette transporters |
| CN101891680B (zh) | 2004-06-24 | 2014-10-29 | 沃泰克斯药物股份有限公司 | Atp-结合弹夹转运蛋白的调控剂 |
| US20140343098A1 (en) | 2004-06-24 | 2014-11-20 | Vertex Pharmaceuticals Incorporated | Modulators of atp-binding cassette transporters |
| US7598273B2 (en) | 2005-10-06 | 2009-10-06 | Auspex Pharmaceuticals, Inc | Inhibitors of the gastric H+, K+-ATPase with enhanced therapeutic properties |
| CN101374849A (zh) | 2005-12-24 | 2009-02-25 | 沃泰克斯药物股份有限公司 | 作为abc转运蛋白调控剂的喹啉-4-酮衍生物 |
| AU2006331565A1 (en) | 2005-12-27 | 2007-07-05 | Vertex Pharmaceuticals Incorporated | Compounds useful in CFTR assays and methods therewith |
| DK3219705T3 (da) | 2005-12-28 | 2020-04-14 | Vertex Pharma | Farmaceutiske sammensætninger af den amorfe form af n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinolin-3-carboxamid |
| US7750168B2 (en) | 2006-02-10 | 2010-07-06 | Sigma-Aldrich Co. | Stabilized deuteroborane-tetrahydrofuran complex |
| JO2630B1 (en) | 2006-04-13 | 2012-06-17 | نوفارتيس ايه جي | Organic compounds |
| AU2007249269A1 (en) | 2006-05-12 | 2007-11-22 | Vertex Pharmaceuticals Incorporated | Compositions of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl)-1,4-dihydro-4-oxoquinoline-3-carboxamide |
| US20080103122A1 (en) | 2006-09-05 | 2008-05-01 | Schering Corporation | Pharmaceutical combinations for lipid management and in the treatment of atherosclerosis and hepatic steatosis |
| CN101765582A (zh) | 2007-04-26 | 2010-06-30 | 奥斯拜客斯制药有限公司 | 氘标记的氯胺酮 |
| JP5647519B2 (ja) | 2007-09-13 | 2014-12-24 | コンサート ファーマシューティカルズ インコーポレイテッド | 重水素化カテコールおよびベンゾ［ｄ］［１，３］ジオキソールおよびその誘導体の合成 |
| CA2699292A1 (fr) | 2007-09-14 | 2009-03-26 | Vertex Pharmaceuticals Incorporated | Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide |
| HUE031913T2 (en) | 2007-12-07 | 2017-08-28 | Vertex Pharma | Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid |
| US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
| US20100256184A1 (en) | 2008-08-13 | 2010-10-07 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administrations thereof |
| KR20110042356A (ko) | 2008-08-13 | 2011-04-26 | 버텍스 파마슈티칼스 인코포레이티드 | 제약 조성물 및 그의 투여 |
| MX2011002033A (es) | 2008-09-03 | 2011-05-02 | Teva Pharma | 2-oxo-1,2-dihidro-quinolinas moduladoras de la funcion inmune. |
| EP2358680B1 (fr) | 2008-10-23 | 2013-03-20 | Vertex Pharmaceuticals Incorporated | Formes solides de n-(4-(7-azadicyclo[2.2.1]heptan-7-yl)-2-(trifluorométhyl)phényl)-4-oxo-5-(trifluorométhyl)-1,4-dihydroquinoline-3-carboxamide |
| TWI465449B (zh) | 2008-10-23 | 2014-12-21 | Vertex Pharma | 囊腫性纖維化跨膜傳導調節因子之調控因子 |
| US8314239B2 (en) | 2008-10-23 | 2012-11-20 | Vertex Pharmaceutical Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
| US20110257223A1 (en) | 2008-10-23 | 2011-10-20 | Vertex Pharmaceuticals Incorporated | Modulators of Cystic Fibrosis Transmembrane Conductance Regulator |
| SMT201800416T1 (it) | 2009-03-20 | 2018-09-13 | Vertex Pharma | Modulatori del regolatore di conduttanza trans-membrana della fibrosi cistica |
| KR101727762B1 (ko) | 2009-03-20 | 2017-04-17 | 버텍스 파마슈티칼스 인코포레이티드 | 낭성 섬유증 막횡단 전도도 조절자의 조정자의 제조 방법 |
| EP2813227A1 (fr) * | 2009-10-22 | 2014-12-17 | Vertex Pharmaceuticals Incorporated | Compositions pour le traitement de la mucoviscidose et d'autres maladies chroniques |
| US8471029B2 (en) | 2010-03-19 | 2013-06-25 | Vertex Pharmaceutical Incorporated | Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide |
| RS62767B1 (sr) | 2010-04-07 | 2022-01-31 | Vertex Pharma | Farmaceutski sastavi 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioksol-5-il) ciklopropankarboksamido)-3-metilpiriodin-2-il)benzojeve kiseline i njihova primena |
| EP2560650A1 (fr) | 2010-04-22 | 2013-02-27 | Vertex Pharmaceuticals Incorporated | Compositions pharmaceutiques et leurs administrations |
| CA2796646A1 (fr) | 2010-04-22 | 2011-10-27 | Vertex Pharmaceuticals Incorporated | Compositions pharmaceutiques et leurs administrations |
| AU2011242452A1 (en) | 2010-04-22 | 2012-11-08 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions and administrations thereof |
| CN102234275B (zh) | 2010-04-27 | 2015-12-16 | 溧阳合誉药物科技有限公司 | 治疗失眠的氘代咪唑并[1,2-a]吡啶衍生物、制备方法及其应用 |
| AU2011255237A1 (en) | 2010-05-20 | 2012-11-29 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions and administrations thereof |
| NZ607494A (en) | 2010-08-27 | 2015-04-24 | Vertex Pharma | Pharmaceutical composition and administrations thereof |
| US8802700B2 (en) | 2010-12-10 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
| DK3235812T3 (da) | 2011-05-18 | 2019-11-25 | Vertex Pharmaceuticals Europe Ltd | Deutererede derivater af ivacaftor |
| HUE047354T2 (hu) | 2011-05-18 | 2020-04-28 | Vertex Pharmaceuticals Europe Ltd | Ivacaftor deuterizált származékai |
| WO2013067410A1 (fr) | 2011-11-02 | 2013-05-10 | Vertex Pharmaceuticals Incorporated | Utilisation de (n-[2,4-bis(1,1-diméthyléthyl)-5-hydroxyphényl]-1,4-dihydro-4-oxoquinoline-3-carboxamide) pour le traitement des maladies associées au gène cftr |
| JP2015511583A (ja) | 2012-02-27 | 2015-04-20 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | 薬学的組成物およびその投与 |
| US8674108B2 (en) | 2012-04-20 | 2014-03-18 | Vertex Pharmaceuticals Incorporated | Solid forms of N-[2,4-bis(1,1-dimethylethy)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide |
| EP2858645A1 (fr) | 2012-06-08 | 2015-04-15 | Vertex Pharmaceuticals Incorporated | Compositions pharmaceutiques pour le traitement des troubles à médiation par cftr |
| SMT202500078T1 (it) | 2012-11-02 | 2025-03-12 | Vertex Pharma | Composizioni farmaceutiche per il trattamento di malattie mediate da cftr |
| WO2014078842A1 (fr) | 2012-11-19 | 2014-05-22 | Concert Pharmaceuticals, Inc. | Potentialisateurs de cftr deutérés |
| US20140221424A1 (en) | 2013-01-30 | 2014-08-07 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions for use in the treatment of cystic fibrosis |
| JP2016535036A (ja) | 2013-10-28 | 2016-11-10 | ネステク ソシエテ アノニム | 消化不良の処置における使用のためのモノアシルグリセロール及び脂溶性栄養素 |
| CN107250113B (zh) | 2014-10-07 | 2019-03-29 | 弗特克斯药品有限公司 | 囊性纤维化跨膜传导调节蛋白的调节剂的共晶 |
| US20180353500A1 (en) | 2015-09-21 | 2018-12-13 | Vertex Pharmaceuticals (Europe) Limited | Administration of deuterated cftr potentiators |
| EP3352758A4 (fr) | 2015-09-25 | 2018-08-01 | Vertex Pharmaceuticals (Europe) Limited | Potentialisateurs cftr deutérés |
| US20180125838A1 (en) | 2016-10-27 | 2018-05-10 | Vertex Pharmaceuticals (Europe) Limited | Methods of treatment with deuterated cftr potentiators |
| AU2017352206B2 (en) | 2016-10-27 | 2022-03-03 | Vertex Pharmaceuticals (Europe) Limited | Methods of treatment with deuterated CFTR potentiators |
-
2016
- 2016-09-23 EP EP16849692.5A patent/EP3352758A4/fr not_active Withdrawn
- 2016-09-23 MA MA042954A patent/MA42954A/fr unknown
- 2016-09-23 CA CA2999529A patent/CA2999529A1/fr not_active Abandoned
- 2016-09-23 WO PCT/US2016/053323 patent/WO2017053711A2/fr not_active Ceased
- 2016-09-23 HK HK19100789.4A patent/HK1258473A1/zh unknown
- 2016-09-23 US US15/762,264 patent/US10759721B2/en active Active
- 2016-09-23 AU AU2016327603A patent/AU2016327603B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US10759721B2 (en) | 2020-09-01 |
| WO2017053711A2 (fr) | 2017-03-30 |
| US20200031776A1 (en) | 2020-01-30 |
| AU2016327603B2 (en) | 2021-04-22 |
| AU2016327603A1 (en) | 2018-04-19 |
| WO2017053711A3 (fr) | 2017-05-04 |
| EP3352758A2 (fr) | 2018-08-01 |
| CA2999529A1 (fr) | 2017-03-30 |
| HK1258473A1 (zh) | 2019-11-15 |
| EP3352758A4 (fr) | 2018-08-01 |
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