MA43135A - Compositions et méthodes pour le du traitement du cancer - Google Patents

Compositions et méthodes pour le du traitement du cancer

Info

Publication number
MA43135A
MA43135A MA043135A MA43135A MA43135A MA 43135 A MA43135 A MA 43135A MA 043135 A MA043135 A MA 043135A MA 43135 A MA43135 A MA 43135A MA 43135 A MA43135 A MA 43135A
Authority
MA
Morocco
Prior art keywords
cancer
compositions
treatment
methods
Prior art date
Application number
MA043135A
Other languages
English (en)
Inventor
Roy Lobb
Paul Rennert
Original Assignee
Aleta Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aleta Biotherapeutics Inc filed Critical Aleta Biotherapeutics Inc
Publication of MA43135A publication Critical patent/MA43135A/fr

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    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
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    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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MA043135A 2015-10-30 2016-10-28 Compositions et méthodes pour le du traitement du cancer MA43135A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562249144P 2015-10-30 2015-10-30
US201662331010P 2016-05-03 2016-05-03
US201662396783P 2016-09-19 2016-09-19

Publications (1)

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MA43135A true MA43135A (fr) 2018-09-05

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MA043135A MA43135A (fr) 2015-10-30 2016-10-28 Compositions et méthodes pour le du traitement du cancer

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US (3) US10508143B1 (fr)
EP (1) EP3368559A4 (fr)
JP (1) JP7115982B2 (fr)
KR (1) KR102868293B1 (fr)
CN (1) CN108602872A (fr)
AU (1) AU2016343809B2 (fr)
BR (1) BR112018008326A2 (fr)
CA (1) CA3002674A1 (fr)
CL (1) CL2018001152A1 (fr)
IL (1) IL258955B1 (fr)
MA (1) MA43135A (fr)
MX (1) MX2018005315A (fr)
WO (1) WO2017075537A1 (fr)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL320860A (en) * 2014-12-19 2025-07-01 Dana Farber Cancer Inst Inc Chimeric antigen receptors and methods of using them
WO2017075537A1 (fr) 2015-10-30 2017-05-04 Aleta Biotherapeutics Inc. Compositions et méthodes pour le du traitement du cancer
CN108472365A (zh) 2015-10-30 2018-08-31 艾丽塔生物治疗剂公司 用于肿瘤转导的组合物和方法
US11020429B2 (en) * 2015-11-05 2021-06-01 Juno Therapeutics, Inc. Vectors and genetically engineered immune cells expressing metabolic pathway modulators and uses in adoptive cell therapy
WO2018071873A2 (fr) 2016-10-13 2018-04-19 Juno Therapeutics, Inc. Méthodes et compositions d'immunothérapie impliquant des modulateurs de la voie métabolique du tryptophane
CN108395482B (zh) * 2017-02-08 2021-02-05 西比曼生物科技(香港)有限公司 一种靶向cd20抗原嵌合抗原受体的构建及其工程化t细胞的活性鉴定
US20210130494A1 (en) * 2017-02-22 2021-05-06 Aleta Biotherapeutics Inc. Compositions and methods for treatment of cancer
JP2020517259A (ja) 2017-04-19 2020-06-18 ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム 操作された抗原受容体を発現する免疫細胞
US11166985B2 (en) 2017-05-12 2021-11-09 Crispr Therapeutics Ag Materials and methods for engineering cells and uses thereof in immuno-oncology
IL270415B2 (en) 2017-05-12 2024-08-01 Crispr Therapeutics Ag Materials and methods for cell engineering and their uses in immuno-oncology
CN107177632B (zh) * 2017-05-27 2020-02-07 上海优卡迪生物医药科技有限公司 一种基于octs技术的髓系白血病car-t治疗载体及其构建方法和应用
EP3638300A4 (fr) * 2017-06-16 2021-06-23 Protelica, Inc. Récepteurs d'antigène chimériques à domaine de liaison de la fibronectine et leurs méthodes d'utilisation
JP7097636B2 (ja) * 2017-06-20 2022-07-08 ナノマブ テクノロジー リミテッド 抗Her2ナノボディ及びそのコード序列と用途
EP3651781A4 (fr) * 2017-07-12 2021-04-21 Refuge Biotechnologies, Inc. Procédés et systèmes de régulation conditionnelle de l'expression génique
WO2019025800A1 (fr) * 2017-08-02 2019-02-07 Autolus Limited Cellules exprimant un récepteur antigénique chimérique ou un tcr manipulé et comprenant une séquence de nucléotides exprimée de manière sélective
US12171783B2 (en) 2017-11-13 2024-12-24 The Broad Institute, Inc. Methods and compositions for targeting developmental and oncogenic programs in H3K27M gliomas
WO2019099483A1 (fr) * 2017-11-14 2019-05-23 Memorial Sloan-Kettering Cancer Center Cellules immunoréactives sécrétant l'il-36 et utilisations associées
KR102847676B1 (ko) * 2017-12-15 2025-08-21 알레타 바이오쎄라퓨틱스, 인크. Cd19 변이체
CN109988242A (zh) * 2018-01-02 2019-07-09 武汉波睿达生物科技有限公司 联合嵌合抗原受体、表达载体、慢病毒及t细胞
CA3086832A1 (fr) 2018-01-03 2019-07-11 Qu Biologics Inc. Ciblage inne de therapies cellulaires adoptives
US11851475B2 (en) 2018-01-03 2023-12-26 Xi'an Jiaotong-Liverpool University Membrane-type metalloprotease inhibitory protein and pharmaceutical and pharmaceutical composition containing same, and respective uses thereof
WO2020113403A1 (fr) * 2018-12-04 2020-06-11 Beijing Percans Oncology Co. Ltd. Protéines de fusion de cytokines
CN112105632A (zh) 2018-01-24 2020-12-18 北京智康博药肿瘤医学研究有限公司 细胞因子融合蛋白
CN110157675B (zh) * 2018-02-12 2022-05-27 深圳宾德生物技术有限公司 一种靶向性t淋巴细胞及其制备方法和应用
JP7273421B2 (ja) 2018-02-21 2023-05-15 ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム ナチュラルキラー細胞の活性化および拡大のための方法ならびにその使用
JP7474702B2 (ja) 2018-03-28 2024-04-25 ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム エキソソームから単離されたdnaにおけるエピジェネティック変化の同定法
US10869888B2 (en) 2018-04-17 2020-12-22 Innovative Cellular Therapeutics CO., LTD. Modified cell expansion and uses thereof
EP3561053A1 (fr) * 2018-04-26 2019-10-30 Baylor College of Medicine Cellules effectrices immunes et adaptateurs moléculaires avec un complexe antigène cytokine pour immunothérapie anticancéreuse efficace
US20210228629A1 (en) * 2018-04-27 2021-07-29 Crispr Therapeutics Ag Anti-bcma car-t-cells for plasma cell depletion
WO2019210293A1 (fr) * 2018-04-27 2019-10-31 Baylor College Of Medicine Lymphocytes t car comprenant une ou plusieurs interleukines
WO2019215500A1 (fr) 2018-05-11 2019-11-14 Crispr Therapeutics Ag Procédés et compositions pour le traitement du cancer
CN110623977A (zh) * 2018-06-25 2019-12-31 深圳宾德生物技术有限公司 靶向bcma的嵌合抗原受体t细胞在自身免疫性疾病中的应用
SG11202101284UA (en) 2018-08-14 2021-03-30 Sotio Llc Chimeric antigen receptor polypeptides in combination with trans metabolism molecules modulating krebs cycle and therapeutic uses thereof
CN110856751B (zh) 2018-08-24 2024-12-03 杭州康万达医药科技有限公司 包含核酸及tcr修饰的免疫细胞的治疗剂及其应用
US12240915B2 (en) 2018-08-30 2025-03-04 Innovative Cellular Therapeutics Holdings, Ltd. Chimeric antigen receptor cells for treating solid tumor
CN113416251B (zh) * 2018-09-26 2022-05-17 重庆精准生物技术有限公司 抗cd123人源化单链抗体及其应用
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
JP7486479B2 (ja) * 2018-10-13 2024-05-17 メモリアル スローン ケタリング キャンサー センター Car t細胞療法応答不良のリスクがある対象を識別および処置するための方法および組成物
AU2019384145A1 (en) * 2018-11-20 2021-06-10 Innovative Cellular Therapeutics Holdings, Ltd. Modified cell expressing therapeutic agent and uses thereof
KR20210135475A (ko) * 2018-11-30 2021-11-15 다나-파버 캔서 인스티튜트 인크. 키메라 항원 수용체 팩토리 및 이의 사용 방법
CN109468283A (zh) * 2018-11-30 2019-03-15 北京美康基免生物科技有限公司 一种基于cd19和bcma的双重嵌合抗原受体基因修饰的免疫细胞及其应用
CN109536444B (zh) * 2018-12-11 2022-06-28 吉林省拓华生物科技有限公司 一种适用于恶性实体瘤肿瘤浸润t淋巴细胞的分离诱导方法
WO2020127376A2 (fr) * 2018-12-17 2020-06-25 Alligator Bioscience Ab Nouveaux polypeptides
CN111378046B (zh) * 2018-12-27 2024-03-15 上海细胞治疗集团有限公司 一种免疫效应细胞转换受体
CN111378623B (zh) * 2018-12-29 2023-10-20 深圳市第三人民医院 一种靶向性抗肿瘤t细胞及其制备方法和应用
CN114502188B (zh) * 2019-02-21 2025-04-04 艾贝乐医药科技有限公司 人工免疫监视嵌合抗原受体及其表达细胞
CN113891718B (zh) * 2019-02-21 2025-01-28 杭州天康麦生物技术有限公司 人工免疫监视嵌合抗原受体(ai-car)及其表达细胞
US20220144917A1 (en) 2019-03-01 2022-05-12 Universität Für Bodenkultur Wien Stabilized extracellular domain of cd19
KR20210148228A (ko) * 2019-03-27 2021-12-07 내셔날 리서치 카운실 오브 캐나다 항-EGFRvIII 항체 및 그의 항원-결합 단편
CN114007626A (zh) * 2019-04-26 2022-02-01 艾丽塔生物治疗剂公司 用于治疗癌症的组合物和方法
US20220249558A1 (en) 2019-04-30 2022-08-11 Crispr Therapeutics Ag Allogeneic cell therapy of b cell malignancies using genetically engineered t cells targeting cd19
CN114585377A (zh) * 2019-06-21 2022-06-03 沙塔克实验室有限公司 表达嵌合蛋白的t细胞
EP3986426A4 (fr) * 2019-06-21 2023-10-18 Board of Regents, The University of Texas System Ciblage de l'intégrine alpha3bêta1 pour le traitement du cancer et d'autres maladies
CA3149754A1 (fr) * 2019-08-29 2021-03-04 National Institute For Biotechnology In The Negev Ltd. Anticorps a domaine unique pour le ciblage d'un antigene membranaire specifique de la prostate (psma)
EP4036222A4 (fr) * 2019-09-26 2023-10-25 Oricell Therapeutics Co., Ltd. Cellule immunitaire modifiée et son utilisation
KR102402276B1 (ko) * 2019-11-15 2022-05-26 주식회사 제넥신 변형된 인터루킨-7 및 tgf 베타 수용체 ii를 포함하는 융합단백질 및 이의 용도
WO2021147886A1 (fr) * 2020-01-21 2021-07-29 张晋宇 Composition pharmaceutique et son utilisation
US12076343B2 (en) 2020-02-19 2024-09-03 Innovative Cellular Therapeutics Holdings, Ltd. Engineered safety in cell therapy
CN113402612A (zh) 2020-03-17 2021-09-17 西比曼生物科技(香港)有限公司 靶向cd19和cd20的联合嵌合抗原受体及其应用
JP2023526282A (ja) * 2020-05-13 2023-06-21 ボナム セラピューティクス,インク. タンパク質複合体の組成物及びその使用方法
EP3915578A1 (fr) * 2020-05-28 2021-12-01 Miltenyi Biotec B.V. & Co. KG Récepteur d'antigène chimérique doté d'un espaceur comprenant des domaines d'ensemble c2 de type ig
US12043654B2 (en) 2020-06-02 2024-07-23 Innovative Cellular Therapeutics Holdings, Ltd. Anti-GCC antibody and CAR thereof for treating digestive system cancer
CN115701999A (zh) * 2020-07-09 2023-02-14 南京传奇生物科技有限公司 用白介素-36工程化γδT细胞用于免疫疗法
GB202011993D0 (en) 2020-07-31 2020-09-16 Adc Therapeutics Sa ANTI-IL 13Ra2 antibodies
CN116348604A (zh) * 2020-08-10 2023-06-27 克莱格医学有限公司 多功能的免疫效应细胞及其应用
CN111944063A (zh) * 2020-08-20 2020-11-17 深圳市因诺转化医学研究院 特异性识别人cd19嵌合抗原受体的融合蛋白、核酸分子及其应用
KR20230061486A (ko) 2020-09-04 2023-05-08 밀테니 비오텍 비.브이. & 씨오. 케이지 면역 세포 내 어댑터의 유도성 발현을 위한 시스템
JP2023541455A (ja) 2020-09-14 2023-10-02 ブイオーアール バイオファーマ インコーポレーテッド Cd33に対する単一ドメイン抗体
EP4232052A4 (fr) * 2020-10-22 2025-08-20 Actinium Pharmaceuticals Inc Combinaison de radioimmunothérapie et de blocage de cd47 dans le traitement du cancer
CN112225822B (zh) * 2020-12-14 2021-03-23 北京基因启明生物科技有限公司 高扩增、存续能力和杀瘤作用的CAR-iNKT及应用
CN114163511B (zh) * 2021-03-24 2025-02-25 深圳市新靶向生物科技有限公司 一种与肝癌驱动基因突变相关的抗原肽组合及其应用
WO2022246041A2 (fr) * 2021-05-20 2022-11-24 Achelois Biopharma, Inc. Compositions et procédés pour un affichage de surface multivalent sur des particules enveloppées
CN113238061B (zh) * 2021-07-09 2021-10-01 中南大学湘雅医院 以cd180阴性b细胞指示重症肌无力病情的试剂盒及应用
US12077607B2 (en) 2021-09-23 2024-09-03 University Of Utah Research Foundation Functional and therapeutic effects of PAR4 cleavage by cathepsin G
CN116338196A (zh) * 2021-12-15 2023-06-27 上海佳文英莉生物技术有限公司 老年痴呆症诊断及治疗的新靶点及其应用
KR102732913B1 (ko) * 2021-12-29 2024-11-20 의료법인 명지의료재단 K-ras 특이적 활성화 T 세포를 포함하는 흑색종의 예방 및 치료용 약제학적 조성물 및 이의 제조방법
KR102732910B1 (ko) * 2021-12-29 2024-11-20 의료법인 명지의료재단 K-ras 특이적 활성화 T 세포를 포함하는 대장암의 예방 및 치료용 약제학적 조성물 및 이의 제조방법
KR102732909B1 (ko) * 2021-12-29 2024-11-20 의료법인 명지의료재단 K-ras 특이적 활성화 T 세포를 포함하는 폐 유두상 선암종의 예방 및 치료용 약제학적 조성물 및 이의 제조방법
KR102732911B1 (ko) * 2021-12-29 2024-11-20 의료법인 명지의료재단 K-ras 특이적 활성화 T 세포를 포함하는 유방암의 예방 및 치료용 약제학적 조성물 및 이의 제조방법
KR102732912B1 (ko) * 2021-12-29 2024-11-20 의료법인 명지의료재단 K-ras 특이적 활성화 T 세포를 포함하는 폐 선암종의 예방 및 치료용 약제학적 조성물 및 이의 제조방법
US20250333515A1 (en) 2022-04-11 2025-10-30 Vor Biopharma Inc. Binding agents and methods of use thereof
AU2024244733B2 (en) 2023-03-31 2025-12-11 AbelZeta Inc. Bispecific chimeric antigen receptors targeting cd20 and bcma
WO2024238565A1 (fr) 2023-05-15 2024-11-21 Vor Biopharma Inc. Module de type egf contenant des agents liants l'hormone type 2 de type mucine (erm2) et procédés d'utilisation associés
EP4470555A1 (fr) 2023-05-31 2024-12-04 Miltenyi Biotec B.V. & Co. KG Récepteurs antigéniques chimériques anti-tag présentant une spécificité pour des peptides mutés dérivés de fgfr2 humain

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5807715A (en) 1984-08-27 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
US6352694B1 (en) 1994-06-03 2002-03-05 Genetics Institute, Inc. Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
ZA932522B (en) 1992-04-10 1993-12-20 Res Dev Foundation Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens
US5614191A (en) 1995-03-15 1997-03-25 The United States Of America As Represented By The Department Of Health And Human Services IL-13 receptor specific chimeric proteins and uses thereof
AU732125B2 (en) 1996-07-17 2001-04-12 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Infectious papillomavirus pseudoviral particles
GB9703369D0 (en) 1997-02-18 1997-04-09 Lindqvist Bjorn H Process
US6852703B1 (en) 1997-06-04 2005-02-08 Oxford Biomedica (Uk) Limited Tumor targeted vector
ES2268787T3 (es) 1997-09-05 2007-03-16 Medimmune, Inc. Metodo in vitro de desmontaje/embalaje de particulas similares a virus (vlp) de papilomavirus.
US5994136A (en) 1997-12-12 1999-11-30 Cell Genesys, Inc. Method and means for producing high titer, safe, recombinant lentivirus vectors
WO2001029058A1 (fr) 1999-10-15 2001-04-26 University Of Massachusetts Genes de voies d'interference d'arn en tant qu'outils d'interference genetique ciblee
US6326193B1 (en) 1999-11-05 2001-12-04 Cambria Biosciences, Llc Insect control agent
AU2001275474A1 (en) 2000-06-12 2001-12-24 Akkadix Corporation Materials and methods for the control of nematodes
AU6541801A (en) 2000-06-22 2002-01-02 Idec Pharma Corp Bispecific fusion protein and method of use for enhancing effector cell killing of target cells
CA2425862C (fr) * 2000-11-07 2013-01-22 City Of Hope Cellules immunitaires specifiques a cd19 redirigees
CN1114690C (zh) 2001-05-15 2003-07-16 乔良 乳头瘤假病毒及其制备方法
US7235641B2 (en) 2003-12-22 2007-06-26 Micromet Ag Bispecific antibodies
EP1865985B1 (fr) 2005-03-02 2010-08-25 Biogen Idec MA Inc. Anticorps kim-1 utilisés dans le traitement des états induits par th2
US20070071759A1 (en) * 2005-06-29 2007-03-29 University Of Miami Antibody-immune cell ligand fusion protein for cancer therapy
CN101460055A (zh) 2006-04-07 2009-06-17 得克萨斯大学体系董事会 和腺伴随病毒-噬菌体颗粒相关的方法和组合物
US8394411B2 (en) 2007-05-08 2013-03-12 The United States of America as represented by the Secretary, Dept. of Health and Human Services National Institutes of Health Papillomavirus pseudoviruses for detection and therapy of tumors
WO2009018500A1 (fr) * 2007-07-31 2009-02-05 The Johns Hopkins University Conjugué d'acide nucléique de polypeptide destiné à l'immunoprophylaxie ou à l'immunothérapie des troubles néoplasiques ou infectieux
CA3128656A1 (fr) 2007-08-22 2009-02-26 The Regents Of The University Of California Polypeptides de liaison activables et procedes d'identification et utilisation de ceux-ci
WO2009117117A1 (fr) * 2008-03-19 2009-09-24 Altor Bioscience Corporation Protéines hybrides et conjugués de récepteurs de lymphocytes t et procédés d'utilisation de ceux-ci
EP2328920A2 (fr) 2008-08-25 2011-06-08 Amplimmune, Inc. Polypeptides co-stimulateurs ciblés et leurs procédés d'utilisation dans le traitement du cancer
WO2010051635A1 (fr) * 2008-11-06 2010-05-14 University Of Guelph Procédés d'amélioration de l'efficacité thérapeutique et utilisation de fragments d'anticorps
EP3543256A1 (fr) 2009-01-12 2019-09-25 Cytomx Therapeutics Inc. Compositions d anticorps modifiées et leurs procédés de production et d'utilisation
BRPI1011384A2 (pt) 2009-02-23 2016-03-15 Cytomx Therapeutics Inc pro-proteinas e seus metodos de uso
WO2010144295A1 (fr) * 2009-06-09 2010-12-16 University Of Miami Aptamère ligand co-stimulateur ciblé par un aptamère
CA3253628A1 (en) * 2010-03-05 2025-11-29 The Johns Hopkins University Compositions and methods for targeted immunomodulatory antibodies and fusion proteins
AU2011319727B2 (en) * 2010-10-27 2016-06-30 Baylor College Of Medicine Chimeric CD27 receptors for redirecting T cells to CD70-positive malignancies
US10195253B2 (en) 2011-09-26 2019-02-05 Philogen S.P.A. Immunocytokine combination therapy
GB201203442D0 (en) * 2012-02-28 2012-04-11 Univ Birmingham Immunotherapeutic molecules and uses
MX2014013041A (es) 2012-04-27 2015-03-19 Cytomx Therapeutics Inc Anticuerpos activables que se ligan al receptor del factor de crecimiento epidermico y metodos de uso de los mismos.
WO2013192550A2 (fr) 2012-06-22 2013-12-27 Cytomx Therapeutics, Inc. Anticorps à réaction croisée anti-jagged 1/jagged 2, anticorps anti-jagged activables et leurs procédés d'utilisation
US9487590B2 (en) 2012-09-25 2016-11-08 Cytomx Therapeutics, Inc. Activatable antibodies that bind interleukin-6 receptor and methods of use thereof
WO2014055657A1 (fr) 2012-10-05 2014-04-10 The Trustees Of The University Of Pennsylvania Utilisation d'une approche trans-signalisation dans des récepteurs d'antigènes chimériques
PL2997141T3 (pl) * 2013-05-13 2023-02-06 Cellectis Chimeryczny receptor antygenowy swoisty względem cd19 i jego zastosowania
US9932409B2 (en) 2013-07-19 2018-04-03 Vib Vzw Targeted modified IL-1 family members
EP3057994B1 (fr) * 2013-10-15 2020-09-23 The Scripps Research Institute Commutateurs de cellules t à récepteur d'antigène chimère peptidique et leurs utilisations
SG11201605046YA (en) * 2013-12-20 2016-07-28 Hutchinson Fred Cancer Res Tagged chimeric effector molecules and receptors thereof
JP2017513818A (ja) 2014-03-15 2017-06-01 ノバルティス アーゲー キメラ抗原受容体を使用する癌の処置
EP3119425B1 (fr) 2014-03-15 2020-09-23 Novartis AG Récepteur d'antigène chimèrique régulable
US20180002435A1 (en) * 2015-01-26 2018-01-04 Cellectis mAb-DRIVEN CHIMERIC ANTIGEN RECEPTOR SYSTEMS FOR SORTING/DEPLETING ENGINEERED IMMUNE CELLS
EP3283113A4 (fr) * 2015-04-15 2018-12-05 The California Institute for Biomedical Research Commutateurs de lymphocytes t à récepteurs d'antigènes chimères à base de pne optimisés et leurs utilisations
MX2018001776A (es) * 2015-08-11 2018-06-06 Cellectis Celulas para inmunoterapia modificadas geneticamente para dirigirse al antigeno cd38 y para la inactivacion del gen cd38.
CN108472365A (zh) 2015-10-30 2018-08-31 艾丽塔生物治疗剂公司 用于肿瘤转导的组合物和方法
WO2017075537A1 (fr) 2015-10-30 2017-05-04 Aleta Biotherapeutics Inc. Compositions et méthodes pour le du traitement du cancer
EA201891641A1 (ru) * 2016-01-21 2019-01-31 Пфайзер Инк. Химерные антигенные рецепторы, нацеленные на вариант iii рецептора эпидермального фактора роста
JP6952706B2 (ja) * 2016-03-08 2021-10-20 ヴェンタナ メディカル システムズ, インク. エピトープタグを有する組換え抗体を使用する多重化免疫組織化学
JP7114490B2 (ja) * 2016-06-24 2022-08-08 アイセル・ジーン・セラピューティクス・エルエルシー キメラ抗体受容体(CARs)の構成およびその使用方法

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