MA43260A - Liants pd1 et/ou lag3 - Google Patents

Liants pd1 et/ou lag3

Info

Publication number
MA43260A
MA43260A MA043260A MA43260A MA43260A MA 43260 A MA43260 A MA 43260A MA 043260 A MA043260 A MA 043260A MA 43260 A MA43260 A MA 43260A MA 43260 A MA43260 A MA 43260A
Authority
MA
Morocco
Prior art keywords
lag3
binders
Prior art date
Application number
MA043260A
Other languages
English (en)
Inventor
Maribel Beaumont
Carlo Boutton
Edward Bowman
Marie-Ange Buyse
Bruno Dombrecht
Robert A Kastelein
David Vlerick
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of MA43260A publication Critical patent/MA43260A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Ceramic Products (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MA043260A 2015-11-18 2016-11-17 Liants pd1 et/ou lag3 MA43260A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562257009P 2015-11-18 2015-11-18

Publications (1)

Publication Number Publication Date
MA43260A true MA43260A (fr) 2018-09-26

Family

ID=57472067

Family Applications (1)

Application Number Title Priority Date Filing Date
MA043260A MA43260A (fr) 2015-11-18 2016-11-17 Liants pd1 et/ou lag3

Country Status (30)

Country Link
US (5) US10323090B2 (fr)
EP (1) EP3377531A2 (fr)
JP (3) JP6817302B2 (fr)
KR (3) KR102194188B1 (fr)
CN (1) CN108473585B (fr)
AR (1) AR106754A1 (fr)
AU (3) AU2016355570B2 (fr)
CA (3) CA3132021C (fr)
CL (3) CL2018001327A1 (fr)
CO (1) CO2018005126A2 (fr)
CR (1) CR20180278A (fr)
DO (2) DOP2018000126A (fr)
EA (1) EA201891165A1 (fr)
EC (1) ECSP18045468A (fr)
GE (1) GEP20217220B (fr)
HK (1) HK1254951A1 (fr)
IL (2) IL300122A (fr)
JO (1) JO3744B1 (fr)
MA (1) MA43260A (fr)
MX (2) MX2018006245A (fr)
MY (1) MY189018A (fr)
NI (1) NI201800061A (fr)
PE (1) PE20181532A1 (fr)
PH (1) PH12018501080A1 (fr)
SG (2) SG11201804178YA (fr)
SV (1) SV2018005694A (fr)
TN (1) TN2018000172A1 (fr)
TW (2) TWI754621B (fr)
UA (1) UA121914C2 (fr)
WO (1) WO2017087589A2 (fr)

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NI201800061A (es) 2018-07-24
PH12018501080A1 (en) 2019-01-28
JP7184866B2 (ja) 2022-12-06
CR20180278A (es) 2018-08-24
IL259224A (en) 2018-07-31
IL300122A (en) 2023-03-01
CA3004748A1 (fr) 2017-05-26
BR112018010084A2 (en) 2018-11-13
US20220041727A1 (en) 2022-02-10
UA121914C2 (uk) 2020-08-10
AU2016355570B2 (en) 2020-01-02
AR106754A1 (es) 2018-02-14
HK1254951A1 (zh) 2019-08-02
JP2020015753A (ja) 2020-01-30
DOP2018000126A (es) 2018-09-30
SV2018005694A (es) 2019-01-18
US20190330340A1 (en) 2019-10-31
TWI754621B (zh) 2022-02-11
KR20200143748A (ko) 2020-12-24
CA3132021A1 (fr) 2017-05-26
US11168135B2 (en) 2021-11-09
CN108473585A (zh) 2018-08-31
AU2016355570A1 (en) 2018-05-17
CL2020002531A1 (es) 2021-01-29
CL2018001327A1 (es) 2018-10-12
JP2019506137A (ja) 2019-03-07
WO2017087589A3 (fr) 2017-07-13
KR102220275B1 (ko) 2021-02-26
KR102194188B1 (ko) 2020-12-24
KR102317574B1 (ko) 2021-10-26
KR20180081592A (ko) 2018-07-16
IL259224B2 (en) 2023-07-01
AU2020202238B2 (en) 2022-07-28
US12351630B2 (en) 2025-07-08
CN108473585B (zh) 2022-04-05
SG11201804178YA (en) 2018-06-28
US20190338025A1 (en) 2019-11-07
EA201891165A1 (ru) 2018-11-30
US10323090B2 (en) 2019-06-18
CO2018005126A2 (es) 2018-11-30
DOP2021000005A (es) 2021-04-15
CA3131983A1 (fr) 2017-05-26
US20170137517A1 (en) 2017-05-18
AU2020202177B2 (en) 2022-07-28
US11155619B2 (en) 2021-10-26
IL259224B1 (en) 2023-03-01
JP2021058197A (ja) 2021-04-15
SG10201911035QA (en) 2020-01-30
WO2017087589A2 (fr) 2017-05-26
MY189018A (en) 2022-01-19
TW202216787A (zh) 2022-05-01
US20190330339A1 (en) 2019-10-31
MX2018006245A (es) 2018-08-01
JP6845905B2 (ja) 2021-03-24
US11168136B2 (en) 2021-11-09
PE20181532A1 (es) 2018-09-26
CL2020002521A1 (es) 2021-01-29
JP6817302B2 (ja) 2021-01-20
AU2020202177A1 (en) 2020-04-16
EP3377531A2 (fr) 2018-09-26
KR20190116546A (ko) 2019-10-14
GEP20217220B (en) 2021-02-10
TW201726740A (zh) 2017-08-01
CA3131983C (fr) 2023-12-05
JO3744B1 (ar) 2021-01-31
TN2018000172A1 (en) 2019-10-04
MX2023001356A (es) 2023-02-27
ECSP18045468A (es) 2018-10-31

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