MA43312A - Sérine protéases recombinées - Google Patents

Sérine protéases recombinées

Info

Publication number: MA43312A
Authority: MA; Morocco
Prior art keywords: recombinated; protease serine; serine; protease; recombinated protease
Prior art date: 2015-11-25

Application number

MA043312A

Other languages

English (en)

Inventor

Mettine H A Bos

Pieter H Reitsma

Daniël Verhoef

Original Assignee

Academisch Ziekenhuis Leiden

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-11-25

Filing date

2016-11-25

Publication date

2018-10-03

2016-11-25 Application filed by Academisch Ziekenhuis Leiden filed Critical Academisch Ziekenhuis Leiden

2018-10-03 Publication of MA43312A publication Critical patent/MA43312A/fr

Links

108091005804 Peptidases Proteins 0.000 title 1
239000004365 Protease Substances 0.000 title 1
102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 title 1
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6427—Chymotrypsins (3.4.21.1; 3.4.21.2); Trypsin (3.4.21.4)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6429—Thrombin (3.4.21.5)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6437—Coagulation factor VIIa (3.4.21.21)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/644—Coagulation factor IXa (3.4.21.22)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6443—Coagulation factor XIa (3.4.21.27)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21004—Trypsin (3.4.21.4)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21005—Thrombin (3.4.21.5)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21027—Coagulation factor XIa (3.4.21.27)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Biomedical Technology (AREA)
General Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Medicinal Chemistry (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Hematology (AREA)
Diabetes (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

MA043312A 2015-11-25 2016-11-25 Sérine protéases recombinées MA43312A (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP15196291		2015-11-25

Publications (1)

Publication Number	Publication Date
MA43312A true MA43312A (fr)	2018-10-03

Family

ID=54705420

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA043312A MA43312A (fr)	2015-11-25	2016-11-25	Sérine protéases recombinées

Country Status (15)

Country	Link
US (1)	US20180340163A1 (fr)
EP (1)	EP3380610A1 (fr)
JP (1)	JP2018537976A (fr)
KR (1)	KR20180089439A (fr)
CN (1)	CN108463553A (fr)
AU (1)	AU2016358796A1 (fr)
BR (1)	BR112018010603A2 (fr)
CA (1)	CA3006175A1 (fr)
EA (1)	EA201891012A1 (fr)
HK (1)	HK1255343A1 (fr)
IL (1)	IL259532A (fr)
MA (1)	MA43312A (fr)
MX (1)	MX2018006479A (fr)
SG (1)	SG11201804413XA (fr)
WO (1)	WO2017091074A1 (fr)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4703004A (en)	1984-01-24	1987-10-27	Immunex Corporation	Synthesis of protein with an identification peptide
US5304482A (en) *	1989-03-06	1994-04-19	The Board Of Regents Of The University Of Texas System	Serine protease mutants of the chymotrypsin superfamily resistant to inhibition by their cognate inhibitors
US6797492B2 (en)	1991-05-17	2004-09-28	Merck & Co., Inc.	Method for reducing the immunogenicity of antibody variable domains
EP0519596B1 (fr)	1991-05-17	2005-02-23	Merck & Co. Inc.	Procédé pour réduire l'immunogénicité des domaines variables d'anticorps
GB9216558D0 (en) *	1992-08-04	1992-09-16	British Bio Technology	Modified proteases
US7060484B1 (en) *	1993-11-12	2006-06-13	Gilead Sciences, Inc.	Polypeptides and coagulation therapy
WO2000017332A1 (fr)	1998-09-21	2000-03-30	Eli Lilly And Company	Production d'analogues de trypsinogene de recombinaison solubles
WO2011017296A1 (fr)	2009-08-04	2011-02-10	Schering Corporation	Dérivés de pyrimidine 4,5,6-trisubstituée comme inhibiteurs du facteur ixa

2016
- 2016-11-25 AU AU2016358796A patent/AU2016358796A1/en not_active Abandoned
- 2016-11-25 HK HK18114479.1A patent/HK1255343A1/zh unknown
- 2016-11-25 SG SG11201804413XA patent/SG11201804413XA/en unknown
- 2016-11-25 CN CN201680078249.1A patent/CN108463553A/zh active Pending
- 2016-11-25 BR BR112018010603A patent/BR112018010603A2/pt not_active Application Discontinuation
- 2016-11-25 EP EP16834290.5A patent/EP3380610A1/fr not_active Withdrawn
- 2016-11-25 WO PCT/NL2016/050833 patent/WO2017091074A1/fr not_active Ceased
- 2016-11-25 JP JP2018527905A patent/JP2018537976A/ja active Pending
- 2016-11-25 EA EA201891012A patent/EA201891012A1/ru unknown
- 2016-11-25 US US15/777,963 patent/US20180340163A1/en not_active Abandoned
- 2016-11-25 MX MX2018006479A patent/MX2018006479A/es unknown
- 2016-11-25 KR KR1020187017489A patent/KR20180089439A/ko not_active Withdrawn
- 2016-11-25 CA CA3006175A patent/CA3006175A1/fr not_active Abandoned
- 2016-11-25 MA MA043312A patent/MA43312A/fr unknown
2018
- 2018-05-22 IL IL259532A patent/IL259532A/en unknown

Also Published As

Publication number	Publication date
AU2016358796A1 (en)	2018-06-21
WO2017091074A1 (fr)	2017-06-01
MX2018006479A (es)	2019-01-28
HK1255343A1 (zh)	2019-08-16
BR112018010603A2 (pt)	2018-11-13
CA3006175A1 (fr)	2017-06-01
SG11201804413XA (en)	2018-06-28
US20180340163A1 (en)	2018-11-29
JP2018537976A (ja)	2018-12-27
IL259532A (en)	2018-07-31
KR20180089439A (ko)	2018-08-08
EP3380610A1 (fr)	2018-10-03
EA201891012A1 (ru)	2019-01-31
CN108463553A (zh)	2018-08-28

Publication	Publication Date	Title
DK3212780T3 (da)	2020-03-23	Serinprotease
LT3256580T (lt)	2022-10-10	Cisteino proteazė
DK3212662T3 (da)	2020-07-20	Serinproteaser
EP3374114A4 (fr)	2019-04-10	Établi
PL3496173T3 (pl)	2020-08-10	Materiał perowskitowy
DK3212781T3 (da)	2019-12-16	Serinproteaser
DK3679133T3 (da)	2025-02-10	Ydelsesforbedrede proteasevarianter
IL258532B (en)	2022-04-01	Compression garment compliance
DK3679131T3 (da)	2024-10-21	Ydelses-forbedrede proteasevarianter II
PL3648604T3 (pl)	2025-04-14	Mieszaniny grzybobójcze mefentriflukonazolu
DK3679132T3 (da)	2024-05-06	Performance-forbedrede proteasevarianter iii
EP3346135A4 (fr)	2019-04-17	Compresseur
DK3271981T3 (da)	2023-01-09	Tætning
DK3470517T3 (da)	2024-04-02	Alkalisk protease-variant
DK3365629T3 (da)	2021-02-01	H-formet vaterpas
EP3452343A4 (fr)	2019-11-20	Compresseur
EP3415756A4 (fr)	2019-10-09	Compresseur
EP3514390A4 (fr)	2019-10-30	Compresseur
EP3386329C0 (fr)	2023-12-27	Chaussures de plage
DK3121490T3 (da)	2019-07-15	Tætningsanordning
MA43312A (fr)	2018-10-03	Sérine protéases recombinées
DK3373956T3 (da)	2023-04-03	Proenzymsammensætning
UA35827S (uk)	2017-12-11	Бланк
BR112018005689A2 (pt)	2018-10-02	Material de controle de peste de inseto
UA32945S (uk)	2016-09-12	Тумба