MA43344A - Composition et procédés de régulation des interactions inhibitrices dans les cellules génétiquement modifiées - Google Patents

Composition et procédés de régulation des interactions inhibitrices dans les cellules génétiquement modifiées

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Publication number
MA43344A
MA43344A MA043344A MA43344A MA43344A MA 43344 A MA43344 A MA 43344A MA 043344 A MA043344 A MA 043344A MA 43344 A MA43344 A MA 43344A MA 43344 A MA43344 A MA 43344A
Authority
MA
Morocco
Prior art keywords
cells
cell
inhibitoring
interactions
regulating
Prior art date
Application number
MA043344A
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English (en)
Inventor
Valerie Odegard
Original Assignee
Juno Therapeutics Inc
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Publication date
Application filed by Juno Therapeutics Inc filed Critical Juno Therapeutics Inc
Publication of MA43344A publication Critical patent/MA43344A/fr

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
    • A61K40/4211—CD19 or B4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
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    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • C07K2319/81—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding
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    • C12N2310/00—Structure or type of the nucleic acid
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Abstract

L'invention concerne des cellules conçues pour la thérapie adoptive, y compris les cellules t. L'invention concerne également des procédés et des compositions pour l'ingénierie et la production des cellules, des compositions contenant les cellules et un procédé pour leur administration à des sujets. Dans certains modes de réalisation, les cellules, telles que les cellules t, contiennent des récepteurs d'antigène génétiquement modifiés qui se lient spécifiquement aux antigènes, tels qu'un récepteur d'antigène chimérique (car). Dans certains modes de réalisation, les cellules, telles qu'une cellule t exprimant car, contiennent un agent capable de réduire un effet inhibiteur en réprimant et / ou en perturbant un gène dans une cellule manipulée, tel qu'un gène impliqué dans l'inhibition de la réponse immunitaire. . Dans certains modes de réalisation, les caractéristiques des cellules et des procédés permettent une activité, une efficacité et / ou une persistance accrues ou améliorées.
MA043344A 2015-05-29 2016-05-27 Composition et procédés de régulation des interactions inhibitrices dans les cellules génétiquement modifiées MA43344A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562168721P 2015-05-29 2015-05-29
US201562244132P 2015-10-20 2015-10-20

Publications (1)

Publication Number Publication Date
MA43344A true MA43344A (fr) 2018-04-11

Family

ID=56118053

Family Applications (1)

Application Number Title Priority Date Filing Date
MA043344A MA43344A (fr) 2015-05-29 2016-05-27 Composition et procédés de régulation des interactions inhibitrices dans les cellules génétiquement modifiées

Country Status (9)

Country Link
US (1) US20180161368A1 (fr)
EP (1) EP3303586A1 (fr)
JP (2) JP6949728B2 (fr)
CN (1) CN108174607A (fr)
AU (1) AU2016271147B2 (fr)
CA (1) CA2986060A1 (fr)
MA (1) MA43344A (fr)
MX (2) MX2017015239A (fr)
WO (1) WO2016196388A1 (fr)

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