MA43871A - Inhibition du lymphome 2 à cellules b (bcl -2) et des protéines apparentées - Google Patents

Inhibition du lymphome 2 à cellules b (bcl -2) et des protéines apparentées

Info

Publication number
MA43871A
MA43871A MA043871A MA43871A MA43871A MA 43871 A MA43871 A MA 43871A MA 043871 A MA043871 A MA 043871A MA 43871 A MA43871 A MA 43871A MA 43871 A MA43871 A MA 43871A
Authority
MA
Morocco
Prior art keywords
bcl
inhibition
cell lymphoma
related proteins
proteins
Prior art date
Application number
MA043871A
Other languages
English (en)
Inventor
Daryl C Drummond
Bolin Geng
Dmitri B Kirpotin
Alexander Koshkaryev
Suresh K Tipparaju
Original Assignee
Merrimack Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrimack Pharmaceuticals Inc filed Critical Merrimack Pharmaceuticals Inc
Publication of MA43871A publication Critical patent/MA43871A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MA043871A 2016-01-11 2017-01-11 Inhibition du lymphome 2 à cellules b (bcl -2) et des protéines apparentées MA43871A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662277248P 2016-01-11 2016-01-11
US201762444168P 2017-01-09 2017-01-09

Publications (1)

Publication Number Publication Date
MA43871A true MA43871A (fr) 2018-11-21

Family

ID=59312078

Family Applications (1)

Application Number Title Priority Date Filing Date
MA043871A MA43871A (fr) 2016-01-11 2017-01-11 Inhibition du lymphome 2 à cellules b (bcl -2) et des protéines apparentées

Country Status (5)

Country Link
EP (1) EP3402485A1 (fr)
JP (1) JP2019501225A (fr)
AU (1) AU2017206731A1 (fr)
MA (1) MA43871A (fr)
WO (1) WO2017123616A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200108301A (ko) 2018-01-10 2020-09-17 리커리엄 아이피 홀딩스, 엘엘씨 벤즈아미드 화합물
WO2020061295A1 (fr) 2018-09-19 2020-03-26 Modernatx, Inc. Lipides peg de haute pureté et leurs utilisations
CN110143941B (zh) * 2019-06-04 2021-05-25 北京四环制药有限公司 一种巴罗萨韦玛波酯中间体的合成方法
KR20220034038A (ko) * 2019-07-10 2022-03-17 리커리엄 아이피 홀딩스, 엘엘씨 Bcl-2 억제제의 나노입자 제형
CN114786654A (zh) * 2019-12-11 2022-07-22 密执安大学评议会 用于全身递送Bcl-2和Bcl-xL拮抗剂的组合物和方法
US12447163B2 (en) * 2021-07-16 2025-10-21 Jazz Pharmaceuticals Therapeutics, Inc. Liposomal formulations of Bcl inhibitors
CA3244230A1 (fr) * 2022-03-31 2025-05-06 Eisai R&D Management Co., Ltd. Composition de liposomes et composition pharmaceutique contenant des liposomes
WO2024012557A1 (fr) * 2022-07-15 2024-01-18 Berrybio (Hong Kong) Limited Agents de dégradation de protéines anti-apoptotiques de la famille bcl-2, compositions pharmaceutiques et applications thérapeutiques
KR20260049706A (ko) * 2023-07-14 2026-04-14 재즈 파마슈티컬스 테라퓨틱스, 인크. Atr 억제제를 포함하는 리포좀 조성물의 사용 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5043164A (en) * 1989-01-17 1991-08-27 The University Of Tennessee Research Corporation Blood-stable, cholesterol-free liposomes
LT3173073T (lt) * 2004-05-03 2025-01-10 Ipsen Biopharm Ltd. Liposomos, skirtos vaistų pristatymui
PL1888550T3 (pl) * 2005-05-12 2014-12-31 Abbvie Bahamas Ltd Promotory apoptozy
JP5277168B2 (ja) * 2006-09-05 2013-08-28 アボット・ラボラトリーズ 血小板過剰を治療するｂｃｌインヒビター
CA2772989A1 (fr) * 2009-09-10 2011-03-17 Novartis Ag Sulfamides utilises comme inhibiteurs des proteines de la famille de bcl-2 dans le traitement du cancer

Also Published As

Publication number Publication date
EP3402485A1 (fr) 2018-11-21
JP2019501225A (ja) 2019-01-17
WO2017123616A1 (fr) 2017-07-20
AU2017206731A1 (en) 2018-08-02

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