MA44038B1 - Activites antitumorales d'une nouvelle famille des derives de l'acide ethacrynique - Google Patents

Activites antitumorales d'une nouvelle famille des derives de l'acide ethacrynique

Info

Publication number
MA44038B1
MA44038B1 MA44038A MA44038A MA44038B1 MA 44038 B1 MA44038 B1 MA 44038B1 MA 44038 A MA44038 A MA 44038A MA 44038 A MA44038 A MA 44038A MA 44038 B1 MA44038 B1 MA 44038B1
Authority
MA
Morocco
Prior art keywords
ethacrynic acid
acid derivatives
new family
antitumor activities
vitro
Prior art date
Application number
MA44038A
Other languages
English (en)
Other versions
MA44038A1 (fr
Inventor
Kazzouli Said El
Abdelmajid Zyad
Brahmi Nabil El
Abbouchi Abdelmoula El
Khalid Boujdi
Mostapha Bousmina
Mouse Hassan Ait
Mounir Tilaoui
Original Assignee
Univ Euromed De Fes
Univ Sultan Moulay Slimane Beni Mellal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Euromed De Fes, Univ Sultan Moulay Slimane Beni Mellal filed Critical Univ Euromed De Fes
Priority to MA44038A priority Critical patent/MA44038B1/fr
Priority to US17/297,252 priority patent/US20220024957A1/en
Priority to EP19839176.5A priority patent/EP3887380A1/fr
Priority to PCT/MA2019/000013 priority patent/WO2020111921A1/fr
Publication of MA44038A1 publication Critical patent/MA44038A1/fr
Publication of MA44038B1 publication Critical patent/MA44038B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des nouveaux analogues de l’acide ethacrynique ont été synthétisés puis, leurs activités cytotoxiques in vitro ont été évaluées sur la lignée cellulaire tumorale p815 en utilisant le test mtt. Le dérivé de l’acide ethacrynique, qui a présenté la meilleur cytotoxité in vitro, a été ensuite testé in vivo en utilisant le modèle de souries dba2/p815 (h2d). A 30 mg/kg, la dose effective, les animaux ont montré une tolérance générale avec un pourcentage de survie aux alentours de 80%, et aucune perte de poids significative n’a été observée.
MA44038A 2018-11-29 2018-11-29 Activites antitumorales d'une nouvelle famille des derives de l'acide ethacrynique MA44038B1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
MA44038A MA44038B1 (fr) 2018-11-29 2018-11-29 Activites antitumorales d'une nouvelle famille des derives de l'acide ethacrynique
US17/297,252 US20220024957A1 (en) 2018-11-29 2019-11-29 Anticancer activities of a novel family of ethacrynic acid derivatives
EP19839176.5A EP3887380A1 (fr) 2018-11-29 2019-11-29 Activités anticancéreuses d'une nouvelle famille des dérivés de l'acide ethacrynique
PCT/MA2019/000013 WO2020111921A1 (fr) 2018-11-29 2019-11-29 Activités anticancéreuses d'une nouvelle famille des dérivés de l'acide ethacrynique

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MA44038A MA44038B1 (fr) 2018-11-29 2018-11-29 Activites antitumorales d'une nouvelle famille des derives de l'acide ethacrynique

Publications (2)

Publication Number Publication Date
MA44038A1 MA44038A1 (fr) 2020-06-30
MA44038B1 true MA44038B1 (fr) 2020-10-28

Family

ID=69174565

Family Applications (1)

Application Number Title Priority Date Filing Date
MA44038A MA44038B1 (fr) 2018-11-29 2018-11-29 Activites antitumorales d'une nouvelle famille des derives de l'acide ethacrynique

Country Status (4)

Country Link
US (1) US20220024957A1 (fr)
EP (1) EP3887380A1 (fr)
MA (1) MA44038B1 (fr)
WO (1) WO2020111921A1 (fr)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR100E (fr) 1901-10-14 1902-10-24 Legrand Sa Un appareil dénommé "marquette manille"
US20110306671A1 (en) * 2008-12-17 2011-12-15 The Regents of the The University of California Amide derivatives of ethacrynic acid

Also Published As

Publication number Publication date
EP3887380A1 (fr) 2021-10-06
US20220024957A1 (en) 2022-01-27
WO2020111921A1 (fr) 2020-06-04
MA44038A1 (fr) 2020-06-30

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