MA44061A - Molécules d'anticorps multispécifiques ayant une spécificité pour tnf-alpha, il-17a et il-17f - Google Patents

Molécules d'anticorps multispécifiques ayant une spécificité pour tnf-alpha, il-17a et il-17f

Info

Publication number: MA44061A
Authority: MA; Morocco
Prior art keywords: tnf; specificity; alpha; antibody molecules; multispecific antibody
Prior art date: 2015-12-18

Application number

MA044061A

Other languages

English (en)

Inventor

Ralph Adams

Pallavi Bhatta

Emma Dave

Sam Philip Heywood

David Paul Humphreys

Daniel John Lightwood

Diane Marshall

Stevan Graham Shaw

Original Assignee

Ucb Biopharma Sprl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-12-18

Filing date

2016-12-14

Publication date

2018-10-24

2016-12-14 Application filed by Ucb Biopharma Sprl filed Critical Ucb Biopharma Sprl

2018-10-24 Publication of MA44061A publication Critical patent/MA44061A/fr

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/624—Disulfide-stabilized antibody (dsFv)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
General Chemical & Material Sciences (AREA)
Physical Education & Sports Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

MA044061A 2015-12-18 2016-12-14 Molécules d'anticorps multispécifiques ayant une spécificité pour tnf-alpha, il-17a et il-17f MA44061A (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB1522391.0A GB201522391D0 (en)	2015-12-18	2015-12-18	Antibody molecules

Publications (1)

Publication Number	Publication Date
MA44061A true MA44061A (fr)	2018-10-24

Family

ID=55311227

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
MA044061A MA44061A (fr)	2015-12-18	2016-12-14	Molécules d'anticorps multispécifiques ayant une spécificité pour tnf-alpha, il-17a et il-17f
MA42743A MA42743A1 (fr)	2015-12-18	2016-12-14	Molécules d'anticorps multispécifiques ayant une spécificité pour tnf-alpha, il-17a et il-17f

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
MA42743A MA42743A1 (fr)	2015-12-18	2016-12-14	Molécules d'anticorps multispécifiques ayant une spécificité pour tnf-alpha, il-17a et il-17f

Country Status (26)

Country	Link
US (1)	US20200277366A1 (fr)
EP (1)	EP3390445A1 (fr)
JP (1)	JP2019502380A (fr)
KR (1)	KR20180089514A (fr)
CN (1)	CN108473568A (fr)
AR (1)	AR107735A1 (fr)
AU (1)	AU2016369307A1 (fr)
BR (1)	BR112018011860A2 (fr)
CA (1)	CA3007493A1 (fr)
CL (1)	CL2018001660A1 (fr)
CO (1)	CO2018006667A2 (fr)
EA (1)	EA201891446A1 (fr)
EC (1)	ECSP18054047A (fr)
GB (1)	GB201522391D0 (fr)
IL (1)	IL259645A (fr)
MA (2)	MA44061A (fr)
MX (1)	MX2018007289A (fr)
PE (1)	PE20181625A1 (fr)
PH (1)	PH12018501141A1 (fr)
RU (1)	RU2018126318A (fr)
SG (1)	SG11201804803WA (fr)
TN (1)	TN2018000200A1 (fr)
TW (1)	TW201726731A (fr)
UY (1)	UY37035A (fr)
WO (1)	WO2017102830A1 (fr)
ZA (1)	ZA201803681B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN108350068A (zh)	2015-10-27	2018-07-31	Ucb生物制药私人有限公司	使用抗-il-17a/f抗体的治疗方法
GB201522394D0 (en)	2015-12-18	2016-02-03	Ucb Biopharma Sprl	Antibodies
RU2680011C2 (ru) *	2016-04-29	2019-02-14	Закрытое Акционерное Общество "Биокад"	Триспецифические антитела против il-17a, il-17f и другой провоспалительной молекулы
EP3824906A1 (fr)	2016-12-21	2021-05-26	Amgen Inc.	Formulations d'anticorps anti-tnf alpha
GB201719447D0 (en) *	2017-11-23	2018-01-10	Ucb Biopharma Sprl	Pharmaceutical composition
CN110551215A (zh) *	2018-05-30	2019-12-10	中山康方生物医药有限公司	抗白细胞介素-17a抗体、其药物组合物及其用途
JP7525499B2 (ja) *	2019-01-31	2024-07-30	ヌマブセラピューティクスアクチェンゲゼルシャフト	ＴＮＦα及びＩＬ－１７Ａに対する特異性を有する多重特異性抗体、ＩＬ－１７Ａを標的とする抗体、及びそれらの使用方法
CN110669137B (zh) *	2019-10-24	2021-07-16	高新	一种多特异性抗体及其制备方法和用途
GB201919061D0 (en) *	2019-12-20	2020-02-05	Ucb Biopharma Sprl	Multi-specific antibody
KR20210095781A (ko)	2020-01-24	2021-08-03	주식회사 에이프릴바이오	항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물
BR112022020256A2 (pt)	2020-04-09	2023-01-03	Aprilbio Co Ltd	anticorpo monoclonal ou um fragmento de ligação ao antígeno do mesmo, ácido nucleico, vetor de expressão, célula, composição, uso da composição e uso do anticorpo monoclonal ou fragmento de ligação ao antígeno do mesmo
CN114621354A (zh) *	2020-12-11	2022-06-14	正大天晴药业集团股份有限公司	Fab-白蛋白结合肽融合蛋白及其制备方法和应用
US20250074996A1 (en) *	2021-02-19	2025-03-06	Innovent Biologics (Suzhou) Co., Ltd.	ANTI-GPRC5DxBCMAxCD3 TRISPECIFIC ANTIBODY AND USE THEREOF
CN117642423A (zh) *	2021-09-13	2024-03-01	深圳华普药物研发有限公司	一种il17抗体及其制备方法和应用
CN114380917B (zh) *	2022-03-25	2022-06-14	南京融捷康生物科技有限公司	针对IL-17A和TNFα的双特异性单域抗体及其用途
WO2025248017A1 (fr) *	2024-05-31	2025-12-04	UCB Biopharma SRL	Procédé de purification de protéines de recombinaison

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7790163B2 (en) *	2006-03-10	2010-09-07	Zymogenetics, Inc.	Antibodies that bind both IL-17A and IL-17F and methods of using the same
BRPI0908312A2 (pt) *	2008-05-05	2015-08-18	Novimmune Sa	'' anticorpo monoclonal totalmente humano isolado, composição farmacêutica, método de alívio de um sintoma de uma indicação clínica e método de alívio de um sintoma de uma doença autoimune, distúrbio inflamatório ou distúrbio da proliferação celular''
UA117218C2 (uk) *	2011-05-05	2018-07-10	Мерк Патент Гмбх	Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f
UY34410A (es) *	2011-10-24	2013-05-31	Abbvie Inc	Inmunoligantes biespecificos dirigidos contra tnf
TW201444867A (zh) *	2013-03-08	2014-12-01	Lilly Co Eli	抗ｔｎｆ－抗ｉｌ－１７雙特異性抗體
EP3027649B1 (fr) *	2013-08-01	2020-04-01	F.Hoffmann-La Roche Ag	Anticorps bispécifiques tnfa-il-17

2015
- 2015-12-18 GB GBGB1522391.0A patent/GB201522391D0/en not_active Ceased
2016
- 2016-12-14 BR BR112018011860-5A patent/BR112018011860A2/pt not_active Application Discontinuation
- 2016-12-14 MA MA044061A patent/MA44061A/fr unknown
- 2016-12-14 WO PCT/EP2016/080979 patent/WO2017102830A1/fr not_active Ceased
- 2016-12-14 TN TNP/2018/000200A patent/TN2018000200A1/en unknown
- 2016-12-14 EP EP16822624.9A patent/EP3390445A1/fr not_active Withdrawn
- 2016-12-14 US US16/063,108 patent/US20200277366A1/en not_active Abandoned
- 2016-12-14 PE PE2018001148A patent/PE20181625A1/es unknown
- 2016-12-14 EA EA201891446A patent/EA201891446A1/ru unknown
- 2016-12-14 JP JP2018531446A patent/JP2019502380A/ja not_active Abandoned
- 2016-12-14 RU RU2018126318A patent/RU2018126318A/ru not_active Application Discontinuation
- 2016-12-14 SG SG11201804803WA patent/SG11201804803WA/en unknown
- 2016-12-14 MA MA42743A patent/MA42743A1/fr unknown
- 2016-12-14 CN CN201680079820.1A patent/CN108473568A/zh active Pending
- 2016-12-14 CA CA3007493A patent/CA3007493A1/fr not_active Abandoned
- 2016-12-14 KR KR1020187020510A patent/KR20180089514A/ko not_active Withdrawn
- 2016-12-14 MX MX2018007289A patent/MX2018007289A/es unknown
- 2016-12-14 AU AU2016369307A patent/AU2016369307A1/en not_active Abandoned
- 2016-12-16 UY UY0001037035A patent/UY37035A/es not_active Application Discontinuation
- 2016-12-16 TW TW105141750A patent/TW201726731A/zh unknown
- 2016-12-16 AR ARP160103878A patent/AR107735A1/es unknown
2018
- 2018-05-28 IL IL259645A patent/IL259645A/en unknown
- 2018-05-31 PH PH12018501141A patent/PH12018501141A1/en unknown
- 2018-06-01 ZA ZA2018/03681A patent/ZA201803681B/en unknown
- 2018-06-18 CL CL2018001660A patent/CL2018001660A1/es unknown
- 2018-06-27 CO CONC2018/0006667A patent/CO2018006667A2/es unknown
- 2018-07-18 EC ECSENADI201854047A patent/ECSP18054047A/es unknown

Also Published As

Publication number	Publication date
IL259645A (en)	2018-07-31
SG11201804803WA (en)	2018-07-30
JP2019502380A (ja)	2019-01-31
WO2017102830A1 (fr)	2017-06-22
GB201522391D0 (en)	2016-02-03
US20200277366A1 (en)	2020-09-03
PE20181625A1 (es)	2018-10-11
AU2016369307A1 (en)	2018-07-12
KR20180089514A (ko)	2018-08-08
CN108473568A (zh)	2018-08-31
RU2018126318A (ru)	2020-01-20
MX2018007289A (es)	2018-09-28
CO2018006667A2 (es)	2018-07-10
BR112018011860A2 (pt)	2018-12-04
EA201891446A1 (ru)	2018-11-30
RU2018126318A3 (fr)	2020-05-20
CL2018001660A1 (es)	2018-10-19
ECSP18054047A (es)	2018-07-31
EP3390445A1 (fr)	2018-10-24
MA42743A1 (fr)	2019-07-31
CA3007493A1 (fr)	2017-06-22
TN2018000200A1 (en)	2019-10-04
ZA201803681B (en)	2019-09-25
AR107735A1 (es)	2018-05-30
UY37035A (es)	2017-07-31
PH12018501141A1 (en)	2019-01-28
TW201726731A (zh)	2017-08-01

Publication	Publication Date	Title
ZA201803681B (en)	2019-09-25	Multi-specific antibody molecules having specificity for tnf-alpha, il-17a and il-17f
IL264142A (en)	2019-02-28	Multispecific antibodies against cd40 and cd137
IL263690A (en)	2019-01-31	Purification of multispecific antibodies
EA202092435A2 (ru)	2021-02-26	Моноклональные антитела против bcma
IL256416B (en)	2021-12-01	Multispecific antigen-binding molecules and uses thereof
DK3428194T3 (da)	2021-11-15	Forbedret polypeptidmolekyle med dobbelt specificitet
MA44381A (fr)	2019-01-23	Format d'anticorps hétérodimères multispécifiques
AR101845A1 (es)	2017-01-18	Anticuerpos anti-her2 e inmunoconjugados
IL264161A (en)	2019-02-28	Tgfb antibodies, methods, and uses
MA50352A (fr)	2020-08-19	Anticorps multispécifiques
DK3356401T3 (da)	2020-09-07	Bindingsmolekyler med modificeret j-kæde
EA201791029A1 (ru)	2017-12-29	Антитела против интерлейкина-33 и их применение
EA201300819A1 (ru)	2014-01-30	Молекулы антител, которые связываются с il-17a и il-17f
CL2016002455A1 (es)	2017-08-11	Anticuerpos multiespecíficos.
DK3355913T3 (da)	2024-12-02	Bindingsmolekyler med modificeret j-kæde
HUE051496T2 (hu)	2021-03-01	TL1A-hoz specifikusan kötõdõ ellenanyagok
EP3277711C0 (fr)	2023-06-07	Domaines de répétition d'ankyrine artificiels ayant une spécificité de liaison pour l'albumine sérique
EA201790505A1 (ru)	2017-07-31	Соединение, нацеленое на ил-23а и фно-альфа, и его применение
MX2016016883A (es)	2018-03-02	Anticuerpo anti-axl.
MX375524B (es)	2025-03-06	Anticuerpos anti-axl.
EA201890747A1 (ru)	2018-10-31	Способы лечения воспалительных заболеваний
MA45656A (fr)	2021-03-24	Nouveaux pyrimidine carboxamides utilisées comme inhibiteurs de l'enzyme vanin-1
EP3830268A4 (fr)	2023-12-13	Molécules d'arn comprenant des paires de bases non canoniques
IL269559A (en)	2019-11-28	Stable multispecific antibodies
EP3673066A4 (fr)	2021-05-26	Molécules d'arn