MA44238B1 - Procédés d'augmentation de l'efficacité d'un vaccin par administration d'un antagoniste d'il-4r - Google Patents
Procédés d'augmentation de l'efficacité d'un vaccin par administration d'un antagoniste d'il-4rInfo
- Publication number
- MA44238B1 MA44238B1 MA44238A MA44238A MA44238B1 MA 44238 B1 MA44238 B1 MA 44238B1 MA 44238 A MA44238 A MA 44238A MA 44238 A MA44238 A MA 44238A MA 44238 B1 MA44238 B1 MA 44238B1
- Authority
- MA
- Morocco
- Prior art keywords
- methods
- antagonist
- administration
- vaccine
- vaccine efficacy
- Prior art date
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Abstract
La présente invention concerne des procédés d'amélioration de l'efficacité et/ou la sécurité d'un vaccin. Dans certains modes de réalisation, l'invention concerne des procédés d'augmentation ou de potentialisation de la réponse immunitaire à un vaccin chez un sujet en ayant besoin. Les procédés de la présente invention comprennent l'administration à un sujet en ayant besoin d'un antagoniste de récepteur d'interleukine 4 (IL-4R) tel qu'un anticorps anti-IL-4R en combinaison avec ledit vaccin. Dans certains modes de réalisation, les procédés de la présente invention sont utilisés pour obtenir une protection améliorée contre une maladie infectieuse telle que la coqueluche.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662297257P | 2016-02-19 | 2016-02-19 | |
| US201662409936P | 2016-10-19 | 2016-10-19 | |
| EP17708398.7A EP3416685B1 (fr) | 2016-02-19 | 2017-02-17 | Procédés d'augmentation de l'efficacité d'un vaccin par administration d'un antagoniste d'il-4r |
| PCT/US2017/018487 WO2017143270A1 (fr) | 2016-02-19 | 2017-02-17 | Procédés d'augmentation de l'efficacité d'un vaccin par administration d'un antagoniste d'il-4r |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA44238A MA44238A (fr) | 2018-12-26 |
| MA44238B1 true MA44238B1 (fr) | 2024-07-31 |
Family
ID=58192407
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA44238A MA44238B1 (fr) | 2016-02-19 | 2017-02-17 | Procédés d'augmentation de l'efficacité d'un vaccin par administration d'un antagoniste d'il-4r |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US10314904B2 (fr) |
| EP (2) | EP3416685B1 (fr) |
| JP (3) | JP7597500B2 (fr) |
| KR (1) | KR102868264B1 (fr) |
| CN (1) | CN109069625A (fr) |
| AU (2) | AU2017220184B2 (fr) |
| CA (1) | CA3014202A1 (fr) |
| ES (1) | ES2983475T3 (fr) |
| HU (1) | HUE067673T2 (fr) |
| IL (1) | IL261025A (fr) |
| MA (1) | MA44238B1 (fr) |
| MX (2) | MX2018009990A (fr) |
| PL (1) | PL3416685T3 (fr) |
| PT (1) | PT3416685T (fr) |
| RU (1) | RU2753869C2 (fr) |
| WO (1) | WO2017143270A1 (fr) |
| ZA (1) | ZA201805295B (fr) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7608693B2 (en) | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
| US9574004B2 (en) | 2012-08-21 | 2017-02-21 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an IL-4R antagonist |
| PT3889181T (pt) | 2012-09-07 | 2024-05-29 | Regeneron Pharma | Um anticorpo antagonista de il-4r para utilização no tratamento da dermatite atópica por administração |
| TWI633891B (zh) | 2013-06-04 | 2018-09-01 | 再生元醫藥公司 | 藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法 |
| TWI682781B (zh) | 2013-07-11 | 2020-01-21 | 美商再生元醫藥公司 | 藉由投與il-4r抑制劑治療嗜酸性食道炎的方法 |
| WO2015130975A1 (fr) | 2014-02-28 | 2015-09-03 | Regeneron Pharmaceuticals, Inc. | Procédés de traitement de l'infection cutanée par l'administration d'un antagoniste de l'il-4r |
| AU2015346150B2 (en) | 2014-11-14 | 2021-08-19 | Regeneron Pharmaceuticals, Inc. | Methods for treating chronic sinusitis with nasal polyps by administering an IL-4R antagonist |
| WO2017196943A1 (fr) * | 2016-05-10 | 2017-11-16 | Minneapolis Medical Research Foundation | Immunomodulateurs et procédés de signalisation de cytokine |
| HUE067888T2 (hu) * | 2016-09-01 | 2024-11-28 | Regeneron Pharma | Módszerek az allergia megelõzésére vagy kezelésére egy IL-4R antagonista adagolásával |
| WO2018057776A1 (fr) | 2016-09-22 | 2018-03-29 | Regeneron Pharmaceuticals, Inc. | Méthodes de traitement d'une dermatite atopique sévère par administration d'un inhibiteur des il-4r |
| US11053309B2 (en) | 2017-08-04 | 2021-07-06 | Regeneron Pharmaceuticals, Inc. | Methods for treating active eosinophilic esophagitis |
| CA3079946A1 (fr) | 2017-10-30 | 2019-05-09 | Sanofi Biotechnology | Methodes de traitement ou de prevention de l'asthme par administration d'un antagoniste d'il-4r |
| US11292847B2 (en) | 2018-05-13 | 2022-04-05 | Regeneron Pharmaceuticals, Inc. | Methods for treating atopic dermatitis by administering an IL-4R inhibitor |
| WO2020092015A1 (fr) | 2018-11-02 | 2020-05-07 | University Of Rochester | Atténuation thérapeutique d'une infection épithéliale |
| MX2021010560A (es) * | 2019-03-06 | 2021-11-12 | Regeneron Pharma | Inhibidores de la via il-4/il-13 para una eficacia aumentada en el tratamiento de cancer. |
| CA3132587A1 (fr) | 2019-03-21 | 2020-09-24 | Regeneron Pharmaceuticals, Inc. | Combinaison d'inhibiteurs de la voie il-4/il-13 et d'ablation de plasmocytes pour traiter une allergie |
| BR112022000740A2 (pt) | 2019-07-16 | 2022-07-05 | Sanofi Biotechnology | Métodos para tratamento ou prevenção de asma por administração de um antagonista de il-4r |
| US11504426B2 (en) | 2019-08-05 | 2022-11-22 | Regeneron Pharmaceuticals, Inc. | Methods for treating allergy and enhancing allergen-specific immunotherapy by administering an IL-4R antagonist |
| WO2021026205A1 (fr) | 2019-08-05 | 2021-02-11 | Regeneron Pharmaceuticals, Inc. | Méthodes de traitement de la dermatite atopique par administration d'un antagoniste de l'il-4r |
| IL293487A (en) | 2019-12-09 | 2022-08-01 | Sanofi Biotechnology | Methods for the treatment of digitally identified il-4/il-13-related disorders |
| EP3992974A1 (fr) | 2020-11-02 | 2022-05-04 | Sanofi Biotechnology | Procédés pour le traitement de troubles liés à l'il-13/il-4 identifiés numériquement |
| MX2022011730A (es) * | 2020-03-27 | 2022-10-13 | Regeneron Pharma | Metodos para el tratamiento de dermatitis atopica mediante la administracion de un antagonista de il-4r. |
| US20240336688A1 (en) * | 2021-07-22 | 2024-10-10 | Icahn School Of Medicine At Mount Sinai | Dual-blockade of il-4 signaling and immune checkpoint proteins for treating cancer |
| IL310962A (en) * | 2021-08-23 | 2024-04-01 | Regeneron Pharma | Methods for treating atopic dermatitis by administering an IL-4R antagonist |
| CN118717989A (zh) * | 2024-05-27 | 2024-10-01 | 中国人民解放军军事科学院军事医学研究院 | Il-4r拮抗剂在制备预防和/或治疗流感病毒感染的药物中的应用 |
Family Cites Families (16)
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| DK2990420T3 (en) | 2000-05-26 | 2017-04-03 | Immunex Corp | USE OF INTERLEUKIN-4 RECEPTOR ANTIBODIES AND COMPOSITIONS THEREOF |
| US20030139364A1 (en) * | 2001-10-12 | 2003-07-24 | University Of Iowa Research Foundation | Methods and products for enhancing immune responses using imidazoquinoline compounds |
| GB0217920D0 (en) * | 2002-04-23 | 2002-09-11 | Aventis Pharm Prod Inc | Interleukin-4 Gene Expression inhibitors |
| BRPI0416603A (pt) | 2003-11-07 | 2007-01-30 | Immunex Corp | anticorpo que se liga ao receptor interleucina-4 (il-4) humano |
| MY149079A (en) | 2006-10-02 | 2013-07-15 | Regeneron Pharma | High affinity human antibodies to human il-4 receptor |
| US7608693B2 (en) * | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
| KR101759457B1 (ko) | 2007-12-21 | 2017-07-31 | 메디뮨 리미티드 | 인터루킨-4 수용체 알파(IL-4Rα)에 대한 결합 구성원-173 |
| US8092804B2 (en) | 2007-12-21 | 2012-01-10 | Medimmune Limited | Binding members for interleukin-4 receptor alpha (IL-4Rα)-173 |
| US20120088814A1 (en) * | 2009-03-31 | 2012-04-12 | Isis Pharmaceuticals, Inc. | Methods of modulating an immune response to a viral infection |
| NZ609557A (en) | 2010-10-06 | 2014-12-24 | Regeneron Pharma | Stabilized formulations containing anti-interleukin-4 receptor (il-4r) antibodies |
| EP3530283A1 (fr) * | 2012-06-05 | 2019-08-28 | The Australian National University | Vaccination avec des antagonistes interleukine-4 |
| PT3889181T (pt) * | 2012-09-07 | 2024-05-29 | Regeneron Pharma | Um anticorpo antagonista de il-4r para utilização no tratamento da dermatite atópica por administração |
| TWI633891B (zh) | 2013-06-04 | 2018-09-01 | 再生元醫藥公司 | 藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法 |
| CN111437387B (zh) | 2013-06-21 | 2024-10-01 | 赛诺菲生物技术公司 | 通过施用il-4r拮抗剂治疗鼻息肉症的方法 |
| KR20190062142A (ko) * | 2017-11-28 | 2019-06-05 | (주)비티엔 | 면역 증강 활성을 가지는 아미노산 미네랄 복합체 및 이를 포함하는 식품, 약학 또는 사료용 조성물 |
| US20210361700A1 (en) * | 2020-05-22 | 2021-11-25 | Trustees Of Tufts College | Nutritional supplement to combat covid-19 and aid vaccination |
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