MA44381A - Format d'anticorps hétérodimères multispécifiques - Google Patents

Format d'anticorps hétérodimères multispécifiques

Info

Publication number
MA44381A
MA44381A MA044381A MA44381A MA44381A MA 44381 A MA44381 A MA 44381A MA 044381 A MA044381 A MA 044381A MA 44381 A MA44381 A MA 44381A MA 44381 A MA44381 A MA 44381A
Authority
MA
Morocco
Prior art keywords
antibody format
heterodimeric antibody
multispecific heterodimeric
multispecific
format
Prior art date
Application number
MA044381A
Other languages
English (en)
Inventor
Sebastian Meyer
David Urech
Original Assignee
Numab Innovation Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Numab Innovation Ag filed Critical Numab Innovation Ag
Publication of MA44381A publication Critical patent/MA44381A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/626—Diabody or triabody

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
MA044381A 2015-06-15 2016-06-15 Format d'anticorps hétérodimères multispécifiques MA44381A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP15001758 2015-06-15

Publications (1)

Publication Number Publication Date
MA44381A true MA44381A (fr) 2019-01-23

Family

ID=53434175

Family Applications (1)

Application Number Title Priority Date Filing Date
MA044381A MA44381A (fr) 2015-06-15 2016-06-15 Format d'anticorps hétérodimères multispécifiques

Country Status (13)

Country Link
US (2) US11236150B2 (fr)
EP (2) EP4047020A1 (fr)
JP (3) JP6839101B2 (fr)
KR (2) KR20250091329A (fr)
CN (2) CN107922486B (fr)
AU (3) AU2016278586B2 (fr)
CA (1) CA2989474C (fr)
EA (1) EA201890041A1 (fr)
HK (1) HK1245805A1 (fr)
IL (2) IL293435B1 (fr)
MA (1) MA44381A (fr)
MX (2) MX395604B (fr)
WO (1) WO2016202457A1 (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL293435B1 (en) * 2015-06-15 2026-04-01 Numab Therapeutics AG Heterodimeric multispecific antibody format
EP3156417A1 (fr) * 2015-10-13 2017-04-19 Affimed GmbH Anticorps fv multivalents
MA49249A (fr) 2017-06-05 2021-04-14 Numab Therapeutics AG Nouveaux anticorps anti-hsa
WO2018224441A1 (fr) 2017-06-05 2018-12-13 Numab Innovation Ag Nouveaux anticorps anti-cd3
EP3634998B8 (fr) 2017-06-05 2025-04-09 Numab Therapeutics AG Anticorps anti cd3 epsilon
WO2018224439A1 (fr) 2017-06-05 2018-12-13 Numab Innovation Ag Nouveaux anticorps anti-hsa
SG11201911527QA (en) * 2017-06-05 2020-01-30 Numab Therapeutics AG Hetero-dimeric multi-specific antibody format targeting at least cd3 and hsa
EP3459968A1 (fr) 2017-09-20 2019-03-27 Numab Innovation AG Nouvelles combinaisons de structure de domaines variables d'anticorps stables
AU2018348431B2 (en) 2017-10-10 2025-10-02 Numab Therapeutics AG Antibodies targeting CD137 and methods of use thereof
EP3470428A1 (fr) 2017-10-10 2019-04-17 Numab Innovation AG Anticorps dirigés contre cd137 et leurs procédés d'utilisation
EP3470426A1 (fr) 2017-10-10 2019-04-17 Numab Therapeutics AG Anticorps multi-spécifique
CN120248120A (zh) 2017-10-10 2025-07-04 努玛治疗有限公司 靶向pdl1的抗体及其使用方法
EP3470429A1 (fr) 2017-10-10 2019-04-17 Numab Innovation AG Anticorps dirigés contre pdl1 et leurs procédés d'utilisation
US12202911B2 (en) 2017-10-10 2025-01-21 Numab Therapeutics AG Multispecific antibody comprising CD137 binding domain and PDL1 binding domain
EP3735254A4 (fr) * 2018-01-05 2021-11-03 City of Hope Liants de ligands multi-spécifiques
TWI839395B (zh) 2018-10-09 2024-04-21 瑞士商Ｎｕｍａｂ治療公司 靶向cd137的抗體及其使用方法
EP3636320A1 (fr) 2018-10-09 2020-04-15 Numab Therapeutics AG Anticorps dirigés contre cd137 et leurs procédés d'utilisation
EP3689907A1 (fr) 2019-01-31 2020-08-05 Numab Therapeutics AG Anticorps dirigés contre il-17a et leurs procédés d'utilisation
EP4591879A3 (fr) 2019-01-31 2025-10-22 Numab Therapeutics AG Anticorps multispécifiques ayant une spécificité pour tnfa et il-17a, anticorps ciblant il-17a, et leurs procédés d'utilisation
EP3816185A1 (fr) 2019-11-04 2021-05-05 Numab Therapeutics AG Anticorps multi-spécifique contra pd-l1 et antigène associé à une tumeur
EP3915580A1 (fr) 2020-05-29 2021-12-01 Numab Therapeutics AG Anticorps multi-spécifique
US20230235090A1 (en) * 2020-06-30 2023-07-27 Harbour Biomed US, Inc. Bispecific antibody and use thereof
US20230303698A1 (en) * 2020-06-30 2023-09-28 Harbour Biomed (Shanghai) Co., Ltd Multispecific binding protein of immune cell engager, preparation therefor and application thereof
EP3988568A1 (fr) 2020-10-21 2022-04-27 Numab Therapeutics AG Traitement combiné
WO2022136693A1 (fr) 2020-12-23 2022-06-30 Numab Therapeutics AG Domaines variables d'anticorps et anticorps ayant une immunogénicité réduite
EP4019546A1 (fr) 2020-12-23 2022-06-29 Numab Therapeutics AG Domaines variables d'anticorps qui se lient à il-31
KR20230123981A (ko) 2020-12-23 2023-08-24 누맙 세러퓨틱스 아게 Il-4r에 결합하는 항체 가변 도메인
EP4019090A1 (fr) 2020-12-23 2022-06-29 Numab Therapeutics AG Domaines variables d'anticorps liant il-4r
JP2024504471A (ja) * 2021-02-02 2024-01-31 ヌマブ セラピューティックス アーゲー Ｒｏｒ１およびｃｄ３に対する特異性を有する多重特異性抗体
CN115536749A (zh) 2021-06-29 2022-12-30 三生国健药业（上海）股份有限公司 三特异性抗体、其制备方法和用途
EP4183800A1 (fr) 2021-11-19 2023-05-24 Medizinische Hochschule Hannover Nouveaux anticorps neutralisants du sars-cov-2
AU2023265474A1 (en) 2022-05-06 2024-10-31 Numab Therapeutics AG Antibody variable domains and antibodies having decreased immunogenicity
EP4273162A1 (fr) 2022-05-06 2023-11-08 Numab Therapeutics AG Domaines variables d'anticorps et anticorps présentant une immunogénicité réduite
WO2024038095A1 (fr) 2022-08-16 2024-02-22 Iome Bio Nouveaux anticorps anti-rgmb
AU2024275787A1 (en) 2023-05-19 2025-11-27 Numab Therapeutics AG Antibody variable domains and antibodies having decreased immunogenicity

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2410551A1 (fr) * 2000-06-30 2002-01-10 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw (Vib) Proteines de fusion heterodimeres
EP1293514B1 (fr) 2001-09-14 2006-11-29 Affimed Therapeutics AG Multimères d'anticorps Fv monocaténaires en tandem
WO2004094613A2 (fr) * 2003-04-22 2004-11-04 Ibc Pharmaceuticals Complexe proteinique polyvalent
WO2010132872A1 (fr) 2009-05-15 2010-11-18 Novimmune S.A Polythérapies et méthodes utilisant des agents de modulation anti-cd3 et des antagonistes anti-tnf
MY192182A (en) 2009-06-26 2022-08-04 Regeneron Pharma Readily isolated bispecific antibodies with native immunoglobulin format
GB201000467D0 (en) * 2010-01-12 2010-02-24 Ucb Pharma Sa Antibodies
UY33826A (es) * 2010-12-22 2012-07-31 Abbott Lab Proteínas de unión con dominios trivariables y sus usos
TWI743461B (zh) 2011-03-28 2021-10-21 法商賽諾菲公司 具有交叉結合區定向之雙重可變區類抗體結合蛋白
WO2013003647A2 (fr) * 2011-06-28 2013-01-03 Sea Lane Biotechnologies, Llc Protéines de liaison à domaines variables empilés polyvalentes
US20150203591A1 (en) * 2012-08-02 2015-07-23 Regeneron Pharmaceuticals, Inc. Mutivalent antigen-binding proteins
CN105229034B (zh) * 2013-02-05 2019-12-10 赛诺菲 用于与抗体药物偶联物疗法一起使用的免疫成像剂
WO2014180754A1 (fr) 2013-05-07 2014-11-13 F. Hoffmann-La Roche Ag Molécules trimériques de liaison à l'antigène
EP3415534A1 (fr) * 2013-05-10 2018-12-19 Numab Therapeutics AG Constructions bispécifiques et leur utilisation dans le traitement de plusieurs maladies
IL243311B (en) 2013-06-26 2022-07-01 Numab Therapeutics AG New frameworks for antibodies
GB2518221A (en) * 2013-09-16 2015-03-18 Sergej Michailovic Kiprijanov Tetravalent antigen-binding protein molecule
EP2930188A1 (fr) * 2014-04-13 2015-10-14 Affimed Therapeutics AG Molécule de liaison à l'antigène trifonctionnel
IL293435B1 (en) * 2015-06-15 2026-04-01 Numab Therapeutics AG Heterodimeric multispecific antibody format
EP3156417A1 (fr) 2015-10-13 2017-04-19 Affimed GmbH Anticorps fv multivalents

Also Published As

Publication number Publication date
AU2022218544B2 (en) 2025-09-11
US20220332797A1 (en) 2022-10-20
WO2016202457A1 (fr) 2016-12-22
JP2018522545A (ja) 2018-08-16
AU2025238141A1 (en) 2025-10-23
JP2021087436A (ja) 2021-06-10
CN107922486A (zh) 2018-04-17
US20180355024A1 (en) 2018-12-13
JP2022177097A (ja) 2022-11-30
MX2022011472A (es) 2023-03-01
KR20180012860A (ko) 2018-02-06
CA2989474A1 (fr) 2016-12-22
IL293435A (en) 2022-07-01
HK1245805A1 (zh) 2018-08-31
JP7457764B2 (ja) 2024-03-28
IL293435B1 (en) 2026-04-01
AU2016278586A1 (en) 2018-01-04
EA201890041A1 (ru) 2018-07-31
MX395604B (es) 2025-03-25
US11236150B2 (en) 2022-02-01
JP6839101B2 (ja) 2021-03-03
IL256314A (en) 2018-02-28
NZ738221A (en) 2024-10-25
AU2022218544A1 (en) 2022-09-15
EP3307776A1 (fr) 2018-04-18
MX2017016188A (es) 2018-07-06
CN107922486B (zh) 2022-05-31
IL256314B (en) 2022-06-01
WO2016202457A8 (fr) 2017-11-30
KR20250091329A (ko) 2025-06-20
EP4047020A1 (fr) 2022-08-24
CN115057936A (zh) 2022-09-16
AU2016278586B2 (en) 2022-05-19
JP7140861B2 (ja) 2022-09-21
CN115057936B (zh) 2025-05-30
US11879005B2 (en) 2024-01-23
CA2989474C (fr) 2023-09-05

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