MA44863A - Modulateurs bicycliques de la voie de réponse intégrée au stress - Google Patents

Modulateurs bicycliques de la voie de réponse intégrée au stress

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Publication number
MA44863A
MA44863A MA044863A MA44863A MA44863A MA 44863 A MA44863 A MA 44863A MA 044863 A MA044863 A MA 044863A MA 44863 A MA44863 A MA 44863A MA 44863 A MA44863 A MA 44863A
Authority
MA
Morocco
Prior art keywords
stress response
response path
integrated stress
bicyclic
modulators
Prior art date
Application number
MA044863A
Other languages
English (en)
Inventor
Lawrence A Black
Seungwon Chung
Michael J Dart
Jennifer M Frost
Charles W Hutchins
Marina Pliuschev
Lei Shi
Carmela Sidrauski
Ramzi Farah Sweis
Yunsong Tong
Xiangdong Xu
Qingwei I Zhang
Original Assignee
Abbvie Inc
Calico Life Sciences Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc, Calico Life Sciences Llc filed Critical Abbvie Inc
Publication of MA44863A publication Critical patent/MA44863A/fr

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    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
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    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/44—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing eight carbon atoms

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AU2017261336B2 (en) 2021-11-04
CN109641854A (zh) 2019-04-16
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JP6899063B2 (ja) 2021-07-07
JP2019530649A (ja) 2019-10-24
US20190135772A1 (en) 2019-05-09
EP3452456A1 (fr) 2019-03-13
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