MA45087A - 3-oxo-2,6-diphényl-2,3-dihydropyridazine-4-carboxamides - Google Patents
3-oxo-2,6-diphényl-2,3-dihydropyridazine-4-carboxamidesInfo
- Publication number
- MA45087A MA45087A MA045087A MA45087A MA45087A MA 45087 A MA45087 A MA 45087A MA 045087 A MA045087 A MA 045087A MA 45087 A MA45087 A MA 45087A MA 45087 A MA45087 A MA 45087A
- Authority
- MA
- Morocco
- Prior art keywords
- dihydropyridazine
- carboxamides
- diphenyl
- oxo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
- C07D237/16—Two oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2016083308 | 2016-05-25 | ||
| CN2017074408 | 2017-02-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA45087A true MA45087A (fr) | 2021-05-26 |
Family
ID=58745251
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA045087A MA45087A (fr) | 2016-05-25 | 2017-05-23 | 3-oxo-2,6-diphényl-2,3-dihydropyridazine-4-carboxamides |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US11040035B2 (fr) |
| EP (1) | EP3464248B1 (fr) |
| JP (1) | JP6964096B2 (fr) |
| KR (1) | KR20190009369A (fr) |
| CN (1) | CN109863140B (fr) |
| AU (1) | AU2017269870A1 (fr) |
| BR (1) | BR112018074185A2 (fr) |
| CA (1) | CA3025227A1 (fr) |
| CL (1) | CL2018003345A1 (fr) |
| CO (1) | CO2018012654A2 (fr) |
| CR (1) | CR20180556A (fr) |
| CU (1) | CU20180143A7 (fr) |
| DO (1) | DOP2018000256A (fr) |
| EA (1) | EA201892666A1 (fr) |
| EC (1) | ECSP18087725A (fr) |
| IL (1) | IL263046A (fr) |
| JO (1) | JOP20170126A1 (fr) |
| MA (1) | MA45087A (fr) |
| MX (1) | MX2018014443A (fr) |
| NI (1) | NI201800124A (fr) |
| PE (1) | PE20190509A1 (fr) |
| PH (1) | PH12018502472A1 (fr) |
| SG (1) | SG11201810366WA (fr) |
| SV (1) | SV2018005787A (fr) |
| TN (1) | TN2018000392A1 (fr) |
| TW (1) | TW201742859A (fr) |
| UY (1) | UY37256A (fr) |
| WO (1) | WO2017202816A1 (fr) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI759301B (zh) | 2016-05-24 | 2022-04-01 | 美商安美基公司 | 聚乙二醇化卡非佐米化合物 |
| US12522594B2 (en) * | 2017-02-09 | 2026-01-13 | Deutsches Krebsforschungszentrum | 2-heteroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamides for the treatment of cancer |
| EP3713931B1 (fr) * | 2017-11-21 | 2025-03-05 | Deutsches Krebsforschungszentrum | 3-oxo-6-hétéroaryl-2-phényl-2,3-dihydropyridazine-4-carboxamides |
| EA037978B1 (ru) * | 2017-11-21 | 2021-06-18 | Байер Акциенгезельшафт | 2-гетероарил-3-оксо-2,3-дигидропиридазин-4-карбоксамиды для лечения злокачественного новообразования |
| US11524944B2 (en) | 2017-11-21 | 2022-12-13 | Bayer Aktiengesellschaft | 2-phenylpyrimidine-4-carboxamides as AHR inhibitors |
| WO2019101642A1 (fr) * | 2017-11-21 | 2019-05-31 | Bayer Aktiengesellschaft | 3-oxo-2,3-dihydropyridazine-4-carboxamides substitués par du soufre |
| US12221439B2 (en) | 2018-08-24 | 2025-02-11 | Jaguahr Therapeutics Pte Ltd | Tetrahydropyridopyrimidine derivatives as AhR modulators |
| US20210395242A1 (en) | 2018-08-31 | 2021-12-23 | Jaguahr Therapeutics Pte Ltd | Heterocyclic compounds as ahr modulators |
| CN109771437B (zh) * | 2019-03-28 | 2023-03-17 | 西安交通大学医学院第一附属医院 | 三氟胸苷在制备治疗三阴性乳腺癌药物中的应用 |
| EP3715471A1 (fr) * | 2019-03-29 | 2020-09-30 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Ensemble de marqueur de signature d'ahr |
| EP3721894A1 (fr) | 2019-04-10 | 2020-10-14 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Gène 1 induit par l'interleukine-4 (il4i1) en tant que biomarqueur et ses utilisations |
| JP7636326B2 (ja) * | 2019-07-29 | 2025-02-26 | 武田薬品工業株式会社 | 複素環化合物 |
| EP3835432A1 (fr) | 2019-12-10 | 2021-06-16 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Gène 1 induit par l'interleukine-4 (il4i1) et métabolites respectifs en tant que biomarqueurs pour le cancer |
| BR112022007837A2 (pt) * | 2019-12-16 | 2022-07-05 | Bayer Ag | Combinação de um inibidor de ahr e um anticorpo inibidor de pd1 e seu uso no tratamento de câncer |
| BR112022013673A2 (pt) | 2020-01-10 | 2022-09-13 | Ikena Oncology Inc | Inibidores de ahr e seus usos |
| JP2023515128A (ja) | 2020-02-26 | 2023-04-12 | ジャガー セラピューティクス ピーティーイーリミテッド | Ａｈｒシグナル伝達の調節に有用なピリドピリミジン誘導体 |
| BR112022019387A2 (pt) * | 2020-03-27 | 2022-11-16 | Dong A St Co Ltd | Derivados de aminopirimidina e seu uso como moduladores de receptores de aril hidrocarbonetos |
| US11911376B2 (en) | 2020-03-30 | 2024-02-27 | The Regents Of The University Of Colorado | Methods for preventing and treating retinal damage |
| WO2021236717A1 (fr) | 2020-05-20 | 2021-11-25 | Senda Biosciences, Inc. | Dérivés d'imidazole fusionnés utilisés en tant qu'antagonistes d'ahr |
| CN114181212B (zh) * | 2020-09-15 | 2023-06-06 | 山东轩竹医药科技有限公司 | 哒嗪酮类AhR抑制剂 |
| CN114369097B (zh) * | 2020-10-15 | 2023-07-14 | 山东轩竹医药科技有限公司 | 杂芳环类AhR抑制剂 |
| CN114685426B (zh) * | 2020-12-28 | 2026-05-26 | 苏州泽璟生物制药股份有限公司 | 磺酰胺类抑制剂及其制备方法和应用 |
| WO2023043753A1 (fr) * | 2021-09-14 | 2023-03-23 | Allianthera (Suzhou) Biopharmaceutical Co., Ltd. | Modulateurs des récepteurs d'hydrocarbures 2-aryle ou hétéroaryl-3-oxo-4-carbamide-6-cyclique-dihydropyrazine aryle et leur utilisation dans le traitement de maladies et d'affections |
| CN119948035A (zh) | 2022-10-03 | 2025-05-06 | 捷豹治疗有限公司 | 可用于调节AhR信号传导的化合物 |
| WO2025114771A1 (fr) | 2023-11-29 | 2025-06-05 | Latvian Institute Of Organic Synthesis | Nouvelle classe d'antagonistes du récepteur aryl hydrocarbone et leur optimisation |
| WO2026027421A1 (fr) | 2024-07-30 | 2026-02-05 | Leibniz-Institut Für Pflanzenbiochemie | Dérivés de 4-oxo-1,4-dihydropyridazine utilisés en tant qu'agonistes du récepteur d'hydrocarbure aryle pour le traitement du cancer |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4134467A1 (de) * | 1991-10-18 | 1993-04-22 | Thomae Gmbh Dr K | Heterobiarylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| AU756275B2 (en) * | 1998-08-14 | 2003-01-09 | Nihon Nohyaku Co., Ltd. | Pyridazinone derivatives |
| JP4233868B2 (ja) * | 2000-09-18 | 2009-03-04 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ピリダジノンおよびトリアジノン化合物類ならびにそれらの医薬用途 |
| FR2847253B1 (fr) | 2002-11-19 | 2007-05-18 | Aventis Pharma Sa | Nouveaux derives de pyridazinones a titre de medicaments et compositions pharmaceutiques les renfermant |
| FR2847235B1 (fr) | 2002-11-20 | 2005-07-08 | Essilor Int | Emballage de protection et de calage pour objets a contour circulaire |
| AR057986A1 (es) | 2005-11-21 | 2008-01-09 | Japan Tobacco Inc | Compuesto heterociclico y su uso farmaceutico |
| EP2328586A2 (fr) | 2008-05-20 | 2011-06-08 | Cephalon, Inc. | Dérivés pyridazinone substitués comme ligands des récepteurs de l'histamine-3 (h3) |
| PE20100362A1 (es) | 2008-10-30 | 2010-05-27 | Irm Llc | Derivados de purina que expanden las celulas madre hematopoyeticas |
| US10314810B2 (en) | 2010-07-27 | 2019-06-11 | Trustees Of Boston University | Aryl hydrocarbon receptor (AhR) modifiers as novel cancer therapeutics |
| WO2015143164A1 (fr) * | 2014-03-19 | 2015-09-24 | President And Fellows Of Harvard College | Agents antimicrobiens et procédés de criblage |
| US12522594B2 (en) * | 2017-02-09 | 2026-01-13 | Deutsches Krebsforschungszentrum | 2-heteroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamides for the treatment of cancer |
-
2017
- 2017-05-23 SG SG11201810366WA patent/SG11201810366WA/en unknown
- 2017-05-23 WO PCT/EP2017/062355 patent/WO2017202816A1/fr not_active Ceased
- 2017-05-23 KR KR1020187037050A patent/KR20190009369A/ko not_active Ceased
- 2017-05-23 CU CU2018000143A patent/CU20180143A7/es unknown
- 2017-05-23 EA EA201892666A patent/EA201892666A1/ru unknown
- 2017-05-23 CN CN201780046149.5A patent/CN109863140B/zh active Active
- 2017-05-23 BR BR112018074185-0A patent/BR112018074185A2/pt not_active IP Right Cessation
- 2017-05-23 CA CA3025227A patent/CA3025227A1/fr active Pending
- 2017-05-23 EP EP17724833.3A patent/EP3464248B1/fr active Active
- 2017-05-23 MX MX2018014443A patent/MX2018014443A/es unknown
- 2017-05-23 MA MA045087A patent/MA45087A/fr unknown
- 2017-05-23 US US16/303,539 patent/US11040035B2/en active Active
- 2017-05-23 CR CR20180556A patent/CR20180556A/es unknown
- 2017-05-23 AU AU2017269870A patent/AU2017269870A1/en not_active Abandoned
- 2017-05-23 JP JP2018561224A patent/JP6964096B2/ja active Active
- 2017-05-23 TN TNP/2018/000392A patent/TN2018000392A1/en unknown
- 2017-05-23 PE PE2018003109A patent/PE20190509A1/es unknown
- 2017-05-24 UY UY0001037256A patent/UY37256A/es not_active Application Discontinuation
- 2017-05-24 JO JOJO/P/2017/0126A patent/JOP20170126A1/ar unknown
- 2017-05-25 TW TW106117299A patent/TW201742859A/zh unknown
-
2018
- 2018-11-15 IL IL263046A patent/IL263046A/en unknown
- 2018-11-23 CO CONC2018/0012654A patent/CO2018012654A2/es unknown
- 2018-11-23 SV SV2018005787A patent/SV2018005787A/es unknown
- 2018-11-23 NI NI201800124A patent/NI201800124A/es unknown
- 2018-11-23 CL CL2018003345A patent/CL2018003345A1/es unknown
- 2018-11-23 EC ECSENADI201887725A patent/ECSP18087725A/es unknown
- 2018-11-23 DO DO2018000256A patent/DOP2018000256A/es unknown
- 2018-11-23 PH PH12018502472A patent/PH12018502472A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20190009369A (ko) | 2019-01-28 |
| SV2018005787A (es) | 2019-02-07 |
| SG11201810366WA (en) | 2018-12-28 |
| EP3464248A1 (fr) | 2019-04-10 |
| AU2017269870A1 (en) | 2018-12-06 |
| CO2018012654A2 (es) | 2018-12-14 |
| CU20180143A7 (es) | 2019-07-04 |
| US11040035B2 (en) | 2021-06-22 |
| TW201742859A (zh) | 2017-12-16 |
| PE20190509A1 (es) | 2019-04-10 |
| EP3464248B1 (fr) | 2021-09-08 |
| UY37256A (es) | 2018-01-02 |
| TN2018000392A1 (en) | 2020-06-15 |
| JP6964096B2 (ja) | 2021-11-10 |
| EA201892666A1 (ru) | 2019-08-30 |
| CR20180556A (es) | 2019-04-23 |
| CN109863140B (zh) | 2023-02-21 |
| JOP20170126A1 (ar) | 2017-11-25 |
| DOP2018000256A (es) | 2019-02-15 |
| IL263046A (en) | 2018-12-31 |
| WO2017202816A1 (fr) | 2017-11-30 |
| JP2019516744A (ja) | 2019-06-20 |
| US20200237757A1 (en) | 2020-07-30 |
| ECSP18087725A (es) | 2018-11-30 |
| MX2018014443A (es) | 2019-04-15 |
| PH12018502472A1 (en) | 2019-09-23 |
| BR112018074185A2 (pt) | 2019-03-06 |
| NI201800124A (es) | 2019-04-29 |
| CN109863140A (zh) | 2019-06-07 |
| CL2018003345A1 (es) | 2019-03-15 |
| CA3025227A1 (fr) | 2017-11-30 |
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