MA45845B1 - Combinaisons de l'imételstat et du vénétoclax destinées au traitement de la leucémie aigüe myéloblastique - Google Patents
Combinaisons de l'imételstat et du vénétoclax destinées au traitement de la leucémie aigüe myéloblastiqueInfo
- Publication number
- MA45845B1 MA45845B1 MA45845A MA45845A MA45845B1 MA 45845 B1 MA45845 B1 MA 45845B1 MA 45845 A MA45845 A MA 45845A MA 45845 A MA45845 A MA 45845A MA 45845 B1 MA45845 B1 MA 45845B1
- Authority
- MA
- Morocco
- Prior art keywords
- imetelstat
- treatment
- venetoclax
- combinations
- inhibitor
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Control Of Indicators Other Than Cathode Ray Tubes (AREA)
- Peptides Or Proteins (AREA)
- Apparatus For Radiation Diagnosis (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Developing Agents For Electrophotography (AREA)
- Glass Compositions (AREA)
- Photoreceptors In Electrophotography (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
La présente invention concerne un traitement d'association pour des cancers hématologiques. Plus spécifiquement, une combinaison d'un inhibiteur de télomérase et d'un inhibiteur de Bcl-2 est utile dans le traitement de cancers hématologiques, comprenant la LMA. Dans certains modes de réalisation, l'inhibiteur de télomérase est l'imételstat ou l'imételstat sodium et l'inhibiteur de Bcl-2 est ABT-199.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662370018P | 2016-08-02 | 2016-08-02 | |
| EP16197293.0A EP3318276A1 (fr) | 2016-11-04 | 2016-11-04 | Combinaisons d'un inhibiteur de la télomérase et d'un inhibiteur du bcl-2 destinées au traitement des cancers hématologiques |
| US201662422738P | 2016-11-16 | 2016-11-16 | |
| PCT/US2017/044348 WO2018026646A1 (fr) | 2016-08-02 | 2017-07-28 | Traitement d'association pour cancers hématologiques |
| EP17748613.1A EP3493812B1 (fr) | 2016-08-02 | 2017-07-28 | Combinaisons de l'imételstat et du vénétoclax destinées au traitement de la leucémie aigüe myéloblastique |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA45845A MA45845A (fr) | 2019-06-12 |
| MA45845B1 true MA45845B1 (fr) | 2025-08-29 |
Family
ID=57226888
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA45845A MA45845B1 (fr) | 2016-08-02 | 2017-07-28 | Combinaisons de l'imételstat et du vénétoclax destinées au traitement de la leucémie aigüe myéloblastique |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US11278561B2 (fr) |
| EP (3) | EP3318276A1 (fr) |
| JP (3) | JP7016856B2 (fr) |
| KR (3) | KR20250134002A (fr) |
| CN (2) | CN109641002B (fr) |
| AU (2) | AU2017305950B2 (fr) |
| CA (2) | CA3217021A1 (fr) |
| CL (1) | CL2019000228A1 (fr) |
| DK (1) | DK3493812T3 (fr) |
| ES (1) | ES2941462T3 (fr) |
| FI (1) | FI3493812T3 (fr) |
| HR (1) | HRP20230300T1 (fr) |
| HU (1) | HUE061471T2 (fr) |
| IL (2) | IL305332A (fr) |
| LT (1) | LT3493812T (fr) |
| MA (1) | MA45845B1 (fr) |
| MD (1) | MD3493812T2 (fr) |
| MX (2) | MX395085B (fr) |
| NZ (1) | NZ750191A (fr) |
| PL (1) | PL3493812T3 (fr) |
| PT (1) | PT3493812T (fr) |
| RS (1) | RS64074B1 (fr) |
| SG (1) | SG11201900883UA (fr) |
| SI (1) | SI3493812T1 (fr) |
| SM (1) | SMT202300108T1 (fr) |
| UA (1) | UA124935C2 (fr) |
| WO (1) | WO2018026646A1 (fr) |
| ZA (1) | ZA201900939B (fr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9375485B2 (en) | 2012-12-07 | 2016-06-28 | Geron Corporation | Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms |
| EP3318276A1 (fr) * | 2016-11-04 | 2018-05-09 | Janssen Biotech, Inc. | Combinaisons d'un inhibiteur de la télomérase et d'un inhibiteur du bcl-2 destinées au traitement des cancers hématologiques |
| WO2019023667A1 (fr) | 2017-07-28 | 2019-01-31 | Janssen Biotech, Inc. | Procédés de traitement du syndrome myélodysplasique |
| CA3087261A1 (fr) | 2018-01-10 | 2019-07-18 | Recurium Ip Holdings, Llc | Composes benzamide |
| EP3887537A4 (fr) | 2018-11-29 | 2023-04-12 | Geron Corporation | Procédés de traitement du syndrome myélodysplasique |
| WO2020223351A1 (fr) * | 2019-04-29 | 2020-11-05 | Immunogen, Inc. | Combinaisons thérapeutiques comprenant des immunoconjugués anti-cd123 |
| CN115776909A (zh) * | 2020-07-17 | 2023-03-10 | 美国杰龙生物医药公司 | 皮下端粒酶抑制剂组合物及其使用方法 |
| JP2024504367A (ja) * | 2021-01-22 | 2024-01-31 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | がんを治療及び改善するための方法 |
| TW202320802A (zh) * | 2021-07-16 | 2023-06-01 | 美商塞萊托藥品股份有限公司 | Bcl抑制劑之脂質體調配物 |
| EP4463151A4 (fr) | 2022-01-19 | 2025-10-01 | Univ Northwestern | Agents ciblant la transcriptase inverse de la télomérase (tert) pour traiter le cancer et sensibiliser des cellules cancéreuses à une thérapie génotoxique |
| CN114949230B (zh) * | 2022-06-13 | 2024-12-06 | 厦门大学附属第一医院 | 一种预防和/或治疗急性髓系白血病的联合用药物组合物及其应用 |
| CN118593709B (zh) * | 2024-05-28 | 2025-05-23 | 湖南大学 | Fasn抑制剂的新用途、化合物、化合物的新用途 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5776679A (en) | 1994-07-07 | 1998-07-07 | Geron Corporation | Assays for the DNA component of human telomerase |
| US5958680A (en) | 1994-07-07 | 1999-09-28 | Geron Corporation | Mammalian telomerase |
| US5583016A (en) | 1994-07-07 | 1996-12-10 | Geron Corporation | Mammalian telomerase |
| AU767646B2 (en) | 1999-09-10 | 2003-11-20 | Geron Corporation | Oligonucleotide N3'-P5' thiophosphoramidates: their synthesis and use |
| SI3342425T1 (sl) | 2003-09-09 | 2020-04-30 | Geron Corporation | Modificirani oligonukleotidi za inhibicijo telomeraze |
| WO2006113426A2 (fr) | 2005-04-15 | 2006-10-26 | Geron Corporation | Traitement de cancer par inhibition combinee des activites de la telomerase et de la tubuline |
| WO2006113470A2 (fr) | 2005-04-15 | 2006-10-26 | Geron Corporation | Procede pour traiter un cancer grace a l'inhibition combinee d'activites de proteasome et de telomerase |
| WO2006124904A2 (fr) | 2005-05-16 | 2006-11-23 | Geron Corporation | Traitement du cancer par inhibition combinee de telomerase et d'activites hsp90 |
| PT2101789E (pt) | 2006-10-30 | 2015-03-24 | Geron Corp | Inibidor de telomerase combinado e gencitabina para o tratamento de cancro |
| US8785409B2 (en) | 2007-01-30 | 2014-07-22 | Geron Corporation | Compounds having anti-adhesive effects on cancer cells |
| EP2134364B1 (fr) | 2007-03-09 | 2013-02-13 | Geron Corporation | Traitement de carcinomes avec une combinaison d'inhibiteurs de voie egf et de telomerase |
| PT3330383T (pt) | 2008-10-17 | 2020-05-06 | Geron Corp | Grn163l para utiliização como inibidor de telomerase no tratamento de cancro |
| US8772264B2 (en) * | 2009-08-04 | 2014-07-08 | Mayo Foundation For Medical Education And Research | Methods of treating hematologic cancers |
| EP2914263A4 (fr) * | 2012-11-02 | 2016-04-27 | Pharmacyclics Inc | Thérapie adjuvante par inhibiteur de kinase de la famille tec |
| EP2925889B1 (fr) | 2012-11-30 | 2018-09-05 | Geron Corporation | Marqueurs de diagnostic pour le traitement de troubles de la prolifération cellulaire par des inhibiteurs de télomérase |
| US9200327B2 (en) | 2012-11-30 | 2015-12-01 | Geron Corporation | Diagnostic markers for treating cell proliferative disorders with telomerase inhibitors |
| IL280144B2 (en) * | 2012-12-07 | 2025-05-01 | Geron Corp | Use of telomerase inhibitors to treat bone marrow culture disorders and bone marrow culture tumors |
| US9375485B2 (en) | 2012-12-07 | 2016-06-28 | Geron Corporation | Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms |
| WO2014160071A1 (fr) * | 2013-03-14 | 2014-10-02 | St. Jude Children's Research Hospital | Procédés et compositions pour le traitement de cancers dépendants à la glutamine |
| EA030957B1 (ru) * | 2013-03-14 | 2018-10-31 | Оникс Терапьютикс, Инк. | Дипептидные и трипептидные эпоксикетонные ингибиторы протеазы |
| RS58659B1 (sr) * | 2013-11-06 | 2019-05-31 | Mayo Found Medical Education & Res | Postupci i materijali za tretiranje hematoloških maligniteta |
| US11034757B2 (en) * | 2014-06-09 | 2021-06-15 | Biomed Valley Discoveries, Inc. | Combination therapies using agents that target tumor-associated stroma or tumor cells and tumor vasculature |
| US9635050B2 (en) | 2014-07-23 | 2017-04-25 | Cisco Technology, Inc. | Distributed supervised architecture for traffic segregation under attack |
| EA201790504A1 (ru) | 2014-09-24 | 2017-09-29 | Семм Форшунгсцентрум Фюр Молекуларе Медицин Гмбх | Монослой мононуклеарных клеток периферической крови или клеток костного мозга и его применение |
| EP3318276A1 (fr) * | 2016-11-04 | 2018-05-09 | Janssen Biotech, Inc. | Combinaisons d'un inhibiteur de la télomérase et d'un inhibiteur du bcl-2 destinées au traitement des cancers hématologiques |
| WO2019023667A1 (fr) | 2017-07-28 | 2019-01-31 | Janssen Biotech, Inc. | Procédés de traitement du syndrome myélodysplasique |
-
2016
- 2016-11-04 EP EP16197293.0A patent/EP3318276A1/fr not_active Withdrawn
-
2017
- 2017-07-28 FI FIEP17748613.1T patent/FI3493812T3/fi active
- 2017-07-28 SM SM20230108T patent/SMT202300108T1/it unknown
- 2017-07-28 IL IL305332A patent/IL305332A/en unknown
- 2017-07-28 MX MX2019001315A patent/MX395085B/es unknown
- 2017-07-28 EP EP17748613.1A patent/EP3493812B1/fr active Active
- 2017-07-28 CN CN201780048256.1A patent/CN109641002B/zh active Active
- 2017-07-28 KR KR1020257028924A patent/KR20250134002A/ko active Pending
- 2017-07-28 KR KR1020197005690A patent/KR102515378B1/ko active Active
- 2017-07-28 EP EP22216202.6A patent/EP4218768A1/fr active Pending
- 2017-07-28 AU AU2017305950A patent/AU2017305950B2/en active Active
- 2017-07-28 UA UAA201900955A patent/UA124935C2/uk unknown
- 2017-07-28 KR KR1020237010185A patent/KR102854375B1/ko active Active
- 2017-07-28 SG SG11201900883UA patent/SG11201900883UA/en unknown
- 2017-07-28 PL PL17748613.1T patent/PL3493812T3/pl unknown
- 2017-07-28 RS RS20230227A patent/RS64074B1/sr unknown
- 2017-07-28 HU HUE17748613A patent/HUE061471T2/hu unknown
- 2017-07-28 US US15/662,706 patent/US11278561B2/en active Active
- 2017-07-28 HR HRP20230300TT patent/HRP20230300T1/hr unknown
- 2017-07-28 NZ NZ750191A patent/NZ750191A/en unknown
- 2017-07-28 LT LTEPPCT/US2017/044348T patent/LT3493812T/lt unknown
- 2017-07-28 WO PCT/US2017/044348 patent/WO2018026646A1/fr not_active Ceased
- 2017-07-28 SI SI201731322T patent/SI3493812T1/sl unknown
- 2017-07-28 JP JP2019504731A patent/JP7016856B2/ja active Active
- 2017-07-28 CN CN202211230655.9A patent/CN116327954A/zh active Pending
- 2017-07-28 MD MDE20190665T patent/MD3493812T2/ro unknown
- 2017-07-28 CA CA3217021A patent/CA3217021A1/fr active Pending
- 2017-07-28 DK DK17748613.1T patent/DK3493812T3/da active
- 2017-07-28 MA MA45845A patent/MA45845B1/fr unknown
- 2017-07-28 IL IL264451A patent/IL264451B2/en unknown
- 2017-07-28 CA CA3032118A patent/CA3032118C/fr active Active
- 2017-07-28 PT PT177486131T patent/PT3493812T/pt unknown
- 2017-07-28 ES ES17748613T patent/ES2941462T3/es active Active
-
2019
- 2019-01-29 CL CL2019000228A patent/CL2019000228A1/es unknown
- 2019-01-30 MX MX2022010466A patent/MX2022010466A/es unknown
- 2019-02-13 ZA ZA2019/00939A patent/ZA201900939B/en unknown
-
2022
- 2022-02-11 US US17/670,278 patent/US20220168333A1/en active Pending
- 2022-08-12 JP JP2022128782A patent/JP2022145948A/ja not_active Withdrawn
-
2023
- 2023-09-15 AU AU2023229592A patent/AU2023229592A1/en not_active Abandoned
-
2024
- 2024-09-09 JP JP2024154746A patent/JP2024166290A/ja active Pending
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