MA46024A - Vaccin contre le virus de l'herpès simplex - Google Patents

Vaccin contre le virus de l'herpès simplex

Info

Publication number
MA46024A
MA46024A MA046024A MA46024A MA46024A MA 46024 A MA46024 A MA 46024A MA 046024 A MA046024 A MA 046024A MA 46024 A MA46024 A MA 46024A MA 46024 A MA46024 A MA 46024A
Authority
MA
Morocco
Prior art keywords
herpes simplex
simplex vaccine
vaccine
herpes
simplex
Prior art date
Application number
MA046024A
Other languages
English (en)
Inventor
Andrew J Bett
Danilo R Casimiro
Giuseppe Ciaramella
Shinu John
Original Assignee
Modernatx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Modernatx Inc filed Critical Modernatx Inc
Publication of MA46024A publication Critical patent/MA46024A/fr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/7105Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/245Herpetoviridae, e.g. herpes simplex virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/7115Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53DNA (RNA) vaccination
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55516Proteins; Peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55555Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6018Lipids, e.g. in lipopeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/70Multivalent vaccine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/16011Herpesviridae
    • C12N2710/16611Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16634Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
MA046024A 2015-10-22 2016-10-21 Vaccin contre le virus de l'herpès simplex MA46024A (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562245159P 2015-10-22 2015-10-22
US201562245031P 2015-10-22 2015-10-22
US201562247576P 2015-10-28 2015-10-28
US201562248252P 2015-10-29 2015-10-29

Publications (1)

Publication Number Publication Date
MA46024A true MA46024A (fr) 2019-07-03

Family

ID=58558127

Family Applications (1)

Application Number Title Priority Date Filing Date
MA046024A MA46024A (fr) 2015-10-22 2016-10-21 Vaccin contre le virus de l'herpès simplex

Country Status (19)

Country Link
US (2) US20180303929A1 (fr)
EP (1) EP3365009A4 (fr)
JP (2) JP2018536023A (fr)
KR (1) KR20180096593A (fr)
CN (1) CN108472355A (fr)
AU (2) AU2016342049B2 (fr)
BR (1) BR112018008090A2 (fr)
CA (1) CA3002822A1 (fr)
CL (1) CL2018001056A1 (fr)
CO (1) CO2018005258A2 (fr)
EA (1) EA201890999A1 (fr)
IL (1) IL258833A (fr)
MA (1) MA46024A (fr)
MX (1) MX2018004918A (fr)
PE (1) PE20181531A1 (fr)
PH (1) PH12018500855A1 (fr)
SG (1) SG11201803365RA (fr)
TN (1) TN2018000155A1 (fr)
WO (1) WO2017070623A1 (fr)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
PL4023249T3 (pl) 2014-04-23 2025-03-10 Modernatx, Inc. Szczepionki z kwasem nukleinowym
US11364292B2 (en) 2015-07-21 2022-06-21 Modernatx, Inc. CHIKV RNA vaccines
MA42502A (fr) 2015-07-21 2018-05-30 Modernatx Inc Vaccins contre une maladie infectieuse
MA42543A (fr) 2015-07-30 2018-06-06 Modernatx Inc Arn épitope peptidiques concatémériques
US11564893B2 (en) 2015-08-17 2023-01-31 Modernatx, Inc. Methods for preparing particles and related compositions
EP4011451A1 (fr) 2015-10-22 2022-06-15 ModernaTX, Inc. Vaccins contre le virus respiratoire
WO2017070601A1 (fr) 2015-10-22 2017-04-27 Modernatx, Inc. Vaccins à base d'acide nucléique contre le virus varicelle-zona (vzv)
WO2017070624A1 (fr) 2015-10-22 2017-04-27 Modernatx, Inc. Vaccins contre des maladies tropicales
AU2016342376A1 (en) 2015-10-22 2018-06-07 Modernatx, Inc. Sexually transmitted disease vaccines
AU2016341309A1 (en) 2015-10-22 2018-06-07 Modernatx, Inc. Cancer vaccines
AU2016342045A1 (en) 2015-10-22 2018-06-07 Modernatx, Inc. Human cytomegalovirus vaccine
PL3386484T3 (pl) 2015-12-10 2022-07-25 Modernatx, Inc. Kompozycje i sposoby dostarczania środków terapeutycznych
US10465190B1 (en) 2015-12-23 2019-11-05 Modernatx, Inc. In vitro transcription methods and constructs
WO2017201342A1 (fr) 2016-05-18 2017-11-23 Modernatx, Inc. Polynucléotides codant pour jagged1 pour le traitement du syndrome d'alagille
IL263079B2 (en) 2016-05-18 2024-05-01 Modernatx Inc Polynucleotides encoding relaxin
CA3036831A1 (fr) 2016-09-14 2018-03-22 Modernatx, Inc. Compositions d'arn de haute purete et procedes pour leur preparation
EP3528821A4 (fr) 2016-10-21 2020-07-01 ModernaTX, Inc. Vaccin contre le cytomégalovirus humain
MA46766A (fr) 2016-11-11 2019-09-18 Modernatx Inc Vaccin antigrippal
WO2018107088A2 (fr) 2016-12-08 2018-06-14 Modernatx, Inc. Vaccins à acide nucléique contre des virus respiratoires
US11384352B2 (en) 2016-12-13 2022-07-12 Modernatx, Inc. RNA affinity purification
MA47515A (fr) 2017-02-16 2019-12-25 Modernatx Inc Compositions immunogènes très puissantes
WO2018170245A1 (fr) 2017-03-15 2018-09-20 Modernatx, Inc. Vaccin à large spectre contre le virus de la grippe
EP3595713A4 (fr) 2017-03-15 2021-01-13 ModernaTX, Inc. Vaccin contre le virus respiratoire syncytial
WO2018170270A1 (fr) 2017-03-15 2018-09-20 Modernatx, Inc. Vaccin contre le virus varicelle-zona
WO2018170256A1 (fr) * 2017-03-15 2018-09-20 Modernatx, Inc. Vaccin contre le virus de l'herpès simplex
EP3595676A4 (fr) 2017-03-17 2021-05-05 Modernatx, Inc. Vaccins à base d'arn contre des maladies zoonotiques
US11905525B2 (en) 2017-04-05 2024-02-20 Modernatx, Inc. Reduction of elimination of immune responses to non-intravenous, e.g., subcutaneously administered therapeutic proteins
WO2018200737A1 (fr) * 2017-04-26 2018-11-01 Modernatx, Inc. Vaccin contre le virus de l'herpès simplex
WO2018200613A1 (fr) * 2017-04-26 2018-11-01 Merck Sharp & Dohme Corp. Peptides antigéniques de vhs et vaccins protéiques de vhs
MA49421A (fr) 2017-06-15 2020-04-22 Modernatx Inc Formulations d'arn
AU2018316811B2 (en) * 2017-08-17 2023-07-13 The Trustees Of The University Of Pennsylvania Modified mRNA vaccines encoding herpes simplex virus glycoproteins and uses thereof
WO2019036682A1 (fr) 2017-08-18 2019-02-21 Modernatx, Inc. Variants d'arn polymérase
EP3668979A4 (fr) 2017-08-18 2021-06-02 Modernatx, Inc. Procédés pour analyse par clhp
MA49914A (fr) 2017-08-18 2021-04-21 Modernatx Inc Procédés analytiques par hplc
EP3675817A1 (fr) 2017-08-31 2020-07-08 Modernatx, Inc. Procédés de fabrication de nanoparticules lipidiques
WO2019055807A1 (fr) 2017-09-14 2019-03-21 Modernatx, Inc. Vaccins à arn contre le virus zika
EP3746090A4 (fr) 2018-01-29 2021-11-17 ModernaTX, Inc. Vaccins à base d'arn contre le vrs
CA3113025A1 (fr) 2018-09-19 2020-03-26 Modernatx, Inc. Lipides peg et leurs utilisations
WO2020061295A1 (fr) 2018-09-19 2020-03-26 Modernatx, Inc. Lipides peg de haute pureté et leurs utilisations
WO2020061457A1 (fr) 2018-09-20 2020-03-26 Modernatx, Inc. Préparation de nanoparticules lipidiques et leurs méthodes d'administration
US11351242B1 (en) 2019-02-12 2022-06-07 Modernatx, Inc. HMPV/hPIV3 mRNA vaccine composition
CN109701008B (zh) * 2019-02-18 2022-06-21 山东兴瑞生物科技有限公司 针对单纯疱疹病毒的治疗性dc复合疫苗及其制备方法
AU2020224103A1 (en) 2019-02-20 2021-09-16 Modernatx, Inc. Rna polymerase variants for co-transcriptional capping
US11851694B1 (en) 2019-02-20 2023-12-26 Modernatx, Inc. High fidelity in vitro transcription
CN113874502A (zh) 2019-03-11 2021-12-31 摩登纳特斯有限公司 补料分批体外转录方法
US12070495B2 (en) 2019-03-15 2024-08-27 Modernatx, Inc. HIV RNA vaccines
WO2021015987A1 (fr) * 2019-07-19 2021-01-28 Merck Sharp & Dohme Corp. Polypeptides de glycoprotéines e antigéniques, compositions et leurs procédés d'utilisation
US20220273789A1 (en) * 2019-07-21 2022-09-01 Glaxosmithkline Biologicals Sa Therapeutic viral vaccine
BR112022017852A2 (pt) 2020-03-09 2022-11-01 Dynavax Tech Corp Vacinas para herpes zoster compreendendo um agonista de tlr9
WO2021197589A1 (fr) * 2020-03-31 2021-10-07 BioNTech SE Traitement faisant appel à un arn non immunogène pour la vaccination d'antigènes
IL297419B2 (en) 2020-04-22 2025-02-01 BioNTech SE Coronavirus vaccine
KR20230034333A (ko) 2020-07-02 2023-03-09 라이프 테크놀로지스 코포레이션 트리뉴클레오티드 캡 유사체, 제조 및 이의 용도
US11406703B2 (en) 2020-08-25 2022-08-09 Modernatx, Inc. Human cytomegalovirus vaccine
EP4274607A1 (fr) 2021-01-11 2023-11-15 ModernaTX, Inc. Vaccins contre le virus de la grippe à arn saisonnière
US11524023B2 (en) 2021-02-19 2022-12-13 Modernatx, Inc. Lipid nanoparticle compositions and methods of formulating the same
AU2022233957A1 (en) * 2021-03-11 2023-10-12 Redbiotec Ag Vaccine compositions and methods for treating hsv
US20220363937A1 (en) 2021-05-14 2022-11-17 Armstrong World Industries, Inc. Stabilization of antimicrobial coatings
US20240398940A1 (en) 2021-09-03 2024-12-05 CureVac SE Novel lipid nanoparticles for delivery of nucleic acids
EP4422698A1 (fr) 2021-10-29 2024-09-04 CureVac SE Arn circulaire amélioré pour exprimer des protéines thérapeutiques
US12186387B2 (en) 2021-11-29 2025-01-07 BioNTech SE Coronavirus vaccine
US20250360194A1 (en) 2021-12-08 2025-11-27 Modernatx, Inc. Herpes simplex virus mrna vaccines
US12529047B1 (en) 2021-12-21 2026-01-20 Modernatx, Inc. mRNA quantification methods
US20250345416A1 (en) * 2022-01-27 2025-11-13 BioNTech SE Pharmaceutical compositions for delivery of herpes simplex virus antigens and related methods
US20250099614A1 (en) 2022-01-28 2025-03-27 CureVac SE Nucleic acid encoded transcription factor inhibitors
US20250345407A1 (en) 2022-05-25 2025-11-13 CureVac SE Nucleic acid based vaccine encoding an escherichia coli fimh antigenic polypeptide
WO2024002985A1 (fr) 2022-06-26 2024-01-04 BioNTech SE Vaccin contre le coronavirus
EP4608442A1 (fr) 2022-10-28 2025-09-03 GlaxoSmithKline Biologicals S.A. Vaccin à base d'acide nucléique
WO2024125597A1 (fr) 2022-12-14 2024-06-20 Providence Therapeutics Holdings Inc. Compositions et procédés pour des maladies infectieuses
WO2024131664A1 (fr) * 2022-12-19 2024-06-27 南京奥罗生物科技有限公司 Vaccin contre le virus de l'herpès simplex et son utilisation
WO2024163465A1 (fr) 2023-01-30 2024-08-08 Modernatx, Inc. Vaccins à arnm du virus d'epstein-barr
WO2024184500A1 (fr) 2023-03-08 2024-09-12 CureVac SE Nouvelles formulations de nanoparticules lipidiques pour l'administration d'acides nucléiques
WO2024215721A1 (fr) 2023-04-10 2024-10-17 Modernatx, Inc. Vaccins contre la maladie de lyme
WO2024230934A1 (fr) 2023-05-11 2024-11-14 CureVac SE Acide nucléique thérapeutique pour le traitement de maladies ophtalmiques
WO2025030097A2 (fr) * 2023-08-03 2025-02-06 BioNTech SE Compositions pharmaceutiques pour l'administration d'antigènes du virus de l'herpès simplex et méthodes associées
WO2025171082A1 (fr) * 2024-02-06 2025-08-14 Board Of Regents, The University Of Texas System Protéines gb de hsv2 stabilisées par préfusion
WO2025259931A1 (fr) 2024-06-14 2025-12-18 Orbital Therapeutics, Inc. Compositions et procédés de circularisation d'arn
WO2026006203A2 (fr) 2024-06-24 2026-01-02 Orbital Therapeutics, Inc. Compositions et procédés de production d'arn circulaire
WO2026015882A1 (fr) * 2024-07-12 2026-01-15 BioNTech SE Fragments d'antigène hsv et procédés associés
WO2026080379A1 (fr) 2024-10-07 2026-04-16 Modernatx, Inc. Vaccins à arnm contre la maladie de lyme

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703055A (en) * 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
WO1993001301A1 (fr) * 1991-07-05 1993-01-21 The Penn State Research Foundation Proteines de regulation antivirales mutantes
GB9406498D0 (en) * 1994-03-31 1994-05-25 Smithkline Beecham Biolog Novel compounds
US7094767B2 (en) * 1994-07-22 2006-08-22 Merck & Co., Inc. Polynucleotide herpes virus vaccine
US5795587A (en) 1995-01-23 1998-08-18 University Of Pittsburgh Stable lipid-comprising drug delivery complexes and methods for their production
US6214966B1 (en) 1996-09-26 2001-04-10 Shearwater Corporation Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution
CA2270282A1 (fr) * 1996-11-04 1998-05-14 Smithkline Beecham Corporation Nouvelles sequences codantes pour le virus herpes simplex de type 2
EP1222281B1 (fr) * 1999-09-30 2006-11-15 University of Washington Antigenes du virus herpes simplex immunologiquement importants
AU2001275423B2 (en) * 2000-06-09 2007-01-11 Regulon, Inc. Encapsulation of polynucleotides and drugs into targeted liposomes
US6998115B2 (en) 2000-10-10 2006-02-14 Massachusetts Institute Of Technology Biodegradable poly(β-amino esters) and uses thereof
US7708915B2 (en) 2004-05-06 2010-05-04 Castor Trevor P Polymer microspheres/nanospheres and encapsulating therapeutic proteins therein
ES2340499T3 (es) 2001-06-05 2010-06-04 Curevac Gmbh Arnm de antigeno tumoral estabilizado con un contenido de g/c aumentado.
EP1412065A2 (fr) 2001-07-27 2004-04-28 President And Fellows Of Harvard College Appareil et procedes de melange de flux laminaires
WO2003028657A2 (fr) 2001-10-03 2003-04-10 The Johns Hopkins University Compositions pour therapie genique orale et procedes d'utilisation associes
WO2003092665A2 (fr) 2002-05-02 2003-11-13 Massachusetts Eye And Ear Infirmary Systemes oculaires de distribution de medicament et utilisation associee
JP2007512355A (ja) * 2003-11-21 2007-05-17 アルザ コーポレイション 開裂性のpegで表面修飾されたリポソーム−dna複合体で媒介される遺伝子送達
EP1713514B1 (fr) 2004-01-28 2021-11-24 Johns Hopkins University Medicaments et particules de transport de genes se depla ant rapidement a travers les barrieres muqueuses
CA2563533C (fr) 2004-04-15 2013-10-01 Shmuel A. Ben-Sasson Compositions capables de faciliter la penetration a travers une barriere biologique
WO2006063249A2 (fr) 2004-12-10 2006-06-15 Justin Hanes Copolymeres sequences de poly(ether-anhydride) fonctionnalises
MX2007012157A (es) 2005-04-01 2008-03-14 Intezyne Technologies Llc Micelas polimericas para suministro de farmacos.
WO2006110776A2 (fr) 2005-04-12 2006-10-19 Nektar Therapeutics Al, Corporation Compositions a base de polymere et conjugues d'agents antimicrobiens
HUE025208T2 (en) 2005-06-16 2016-03-29 Nektar Therapeutics Conjugates with degradable binding and polymer reagents useful in the preparation of such conjugates
WO2007070705A2 (fr) * 2005-12-15 2007-06-21 The Trustees Of The University Of Pennsylvania Nouveaux procedes et modeles d'administration rapide et large de materiel genetique au systeme nerveux central a l'aide de vecteurs non viraux medies par lipides cationiques
US8309680B2 (en) 2006-02-21 2012-11-13 Nektar Therapeutics Segmented degradable polymers and conjugates made therefrom
JP5630998B2 (ja) 2006-05-15 2014-11-26 マサチューセッツ インスティテュート オブ テクノロジー 機能的粒子のためのポリマー
US20090304735A1 (en) * 2006-05-19 2009-12-10 Gabrielle Therese Belz Immunogenic Compositions
CA2658484A1 (fr) * 2006-07-20 2008-01-24 Vical Incorporated Compositions et methodes de vaccination contre le hsv-2
EP2061433B1 (fr) 2006-09-08 2011-02-16 Johns Hopkins University Compositions destinées à améliorer le transport à travers le mucus
AU2007339280B2 (en) 2006-12-21 2013-12-05 Stryker Corporation Sustained-release formulations comprising crystals, macromolecular gels, and particulate suspensions of biologic agents
US8877206B2 (en) * 2007-03-22 2014-11-04 Pds Biotechnology Corporation Stimulation of an immune response by cationic lipids
EP2436376B1 (fr) 2007-09-28 2014-07-09 BIND Therapeutics, Inc. Ciblage de cellules de cancer utilisant des nanoparticules
JP2011525180A (ja) 2008-06-16 2011-09-15 バインド バイオサイエンシズ インコーポレイテッド 治療的標的化ナノ粒子の製作に用いるためのジブロックコポリマーで官能化された標的薬の製造方法
WO2010005726A2 (fr) 2008-06-16 2010-01-14 Bind Biosciences Inc. Nanoparticules polymères thérapeutiques avec inhibiteurs de mtor et procédés de fabrication et d’utilisation associés
US8318211B2 (en) 2008-06-16 2012-11-27 Bind Biosciences, Inc. Therapeutic polymeric nanoparticles comprising vinca alkaloids and methods of making and using same
EA020954B1 (ru) 2008-06-16 2015-03-31 Бинд Терапьютикс, Инк. Загруженные лекарственным средством полимерные наночастицы, фармацевтическая композиция и способ лечения рака
US20100087337A1 (en) 2008-09-10 2010-04-08 Bind Biosciences, Inc. High Throughput Fabrication of Nanoparticles
JP2012512175A (ja) 2008-12-15 2012-05-31 バインド バイオサイエンシズ インコーポレイテッド 治療薬を徐放するための長時間循環性ナノ粒子
JP5622254B2 (ja) 2009-03-31 2014-11-12 国立大学法人東京大学 二本鎖リボ核酸ポリイオンコンプレックス
US8287910B2 (en) 2009-04-30 2012-10-16 Intezyne Technologies, Inc. Polymeric micelles for polynucleotide encapsulation
CN107028886A (zh) 2009-11-04 2017-08-11 不列颠哥伦比亚大学 含有核酸的脂质粒子及相关的方法
EA201290497A1 (ru) 2009-12-15 2013-01-30 Байнд Байосайенсиз, Инк. Терапевтические полимерные наночастицы, включающие кортикостероиды, и способы получения таковых
WO2011084521A2 (fr) 2009-12-15 2011-07-14 Bind Biosciences, Inc. Nanoparticules polymères thérapeutiques comportant de l'épothilone et leurs procédés de fabrication et d'utilisation
EP2515942B1 (fr) 2009-12-15 2020-02-12 Pfizer Inc. Compositions de nanoparticules polymères à visée thérapeutique à base de copolymères à température de transition vitreuse élevée ou poids moléculaires élevés
EP2525815B1 (fr) 2010-01-24 2015-02-25 Novartis AG Microparticles polymériques biodégradables irradiées
WO2011106607A2 (fr) * 2010-02-26 2011-09-01 Juvaris Biotherapeutics, Inc. Vaccins à virus fractionné pour les herpesvirus et procédés d'utilisation
WO2011119262A1 (fr) 2010-03-26 2011-09-29 Cerulean Pharma Inc. Procédés et systèmes de production de nanoparticules
US20110262491A1 (en) 2010-04-12 2011-10-27 Selecta Biosciences, Inc. Emulsions and methods of making nanocarriers
US8802863B2 (en) 2010-05-24 2014-08-12 Sirna Therapeutics, Inc. Amino alcohol cationic lipids for oligonucleotide delivery
WO2011163483A2 (fr) 2010-06-25 2011-12-29 Massachusetts Institute Of Technology Polymères pour des biomatériaux et des agents thérapeutiques
MX342608B (es) * 2010-07-06 2016-10-06 Novartis Ag * Particulas de suministro similares a viriones para moleculas de arn de autorreplicacion.
US10307372B2 (en) 2010-09-10 2019-06-04 The Johns Hopkins University Rapid diffusion of large polymeric nanoparticles in the mammalian brain
WO2012051211A2 (fr) * 2010-10-11 2012-04-19 Novartis Ag Plateformes de délivrance d'antigènes
US20150056300A1 (en) 2010-10-22 2015-02-26 Bind Therapeutics, Inc. Therapeutic nanoparticles with high molecular weight copolymers
WO2012061703A1 (fr) 2010-11-05 2012-05-10 The Johns Hopkins University Compositions et procédés visant à une réduction de la mucoadhérence
WO2012099805A2 (fr) 2011-01-19 2012-07-26 Ocean Nanotech, Llc Stimulation immunologique à base de nanoparticules
EA033467B1 (ru) * 2011-01-31 2019-10-31 Univ Pennsylvania Молекула нуклеиновой кислоты для индукции иммунного ответа против герпесвируса и ее применение
WO2012109121A1 (fr) 2011-02-07 2012-08-16 Purdue Research Foundation Nanoparticules glucidiques pour une efficacité prolongée d'un peptide antimicrobien
DK2691079T3 (da) 2011-03-31 2020-09-28 Ingell Tech Holding B V Bionedbrydelige sammensætninger, der er egnet til kontrolleret udløsning
CA2831471C (fr) 2011-03-31 2020-02-25 Ingell Technologies Holding B.V. Compositions biodegradables appropriees pour une liberation controlee
US8691750B2 (en) 2011-05-17 2014-04-08 Axolabs Gmbh Lipids and compositions for intracellular delivery of biologically active compounds
US20140308363A1 (en) 2011-05-31 2014-10-16 Bind Therapeutics, Inc. Drug loaded polymeric nanoparticles and methods of making and using same
EP4115875A1 (fr) * 2011-07-06 2023-01-11 GlaxoSmithKline Biologicals S.A. Liposomes ayant un rapport n:p utile pour délivrance de molécules d'arn
WO2013012476A2 (fr) 2011-07-21 2013-01-24 Arizona Chemical Company, Llc Copolymères à blocs de polyéther-polyamide ramifiés et leurs procédés de fabrication et d'utilisation
WO2013032829A1 (fr) 2011-08-26 2013-03-07 Arrowhead Research Corporation Polymères poly(ester vinyliques) pour administration d'acide nucléique in vivo
JP2014527071A (ja) 2011-08-31 2014-10-09 マリンクロッド エルエルシー H−ホスホネートによるナノ粒子pegの改変
EP2747761A1 (fr) 2011-09-22 2014-07-02 Bind Therapeutics, Inc. Méthodes de traitement de cancers au moyen de nanoparticules thérapeutiques
WO2013072929A2 (fr) 2011-09-23 2013-05-23 Indian Institute Of Technology Composition cosmétique à base d'articles nanoparticulaires
RU2014118727A (ru) * 2011-10-11 2015-11-20 Новартис Аг Рекомбинантные самореплицирующиеся полицистронные молекулы рнк
CN107266391B (zh) 2011-10-18 2020-04-17 迪克纳制药公司 胺阳离子脂质及其用途
PE20181541A1 (es) 2011-10-27 2018-09-26 Massachusetts Inst Technology Derivados de aminoacidos funcionalizados en la terminal n capaces de formar microesferas encapsuladoras de farmaco
WO2013078199A2 (fr) 2011-11-23 2013-05-30 Children's Medical Center Corporation Méthodes pour une administration in vivo améliorée d'arn synthétiques modifiés
CA3018046A1 (fr) * 2011-12-16 2013-06-20 Moderna Therapeutics, Inc. Nucleoside, nucleotide, et compositions d'acide nucleique modifies
EP2804632B1 (fr) 2012-01-19 2019-09-18 The Johns Hopkins University Nanoparticules présentant une pénétration mucosale améliorée
WO2013113326A1 (fr) * 2012-01-31 2013-08-08 Curevac Gmbh Composition pharmaceutique comprenant un complexe support polymère - charge et au moins un antigène de protéine ou de peptide
CA3069030C (fr) 2012-02-03 2021-11-16 Rutgers, The State University Of New Jersey Biomateriaux polymeres derives de monomeres phenoliques et leurs utilisations a des fins medicales
JP2015513788A (ja) 2012-02-10 2015-05-14 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーE.I.Du Pont De Nemours And Company 高度xジブロックコポリマーの製造、精製及び使用
WO2013143555A1 (fr) * 2012-03-26 2013-10-03 Biontech Ag Formulation d'arn pour immunothérapie
WO2013151665A2 (fr) * 2012-04-02 2013-10-10 modeRNA Therapeutics Polynucléotides modifiés destinés à la production de protéines associées à une maladie humaine
EP2858679B2 (fr) * 2012-06-08 2024-06-05 Translate Bio, Inc. Administration pulmonaire d'arnm à des cellules cibles autres que pulmonaires
WO2014093924A1 (fr) * 2012-12-13 2014-06-19 Moderna Therapeutics, Inc. Molécules d'acide nucléique modifiées et leurs utilisations
EP4331620A3 (fr) * 2012-12-07 2024-12-04 Translate Bio, Inc. Nanoparticules lipidiques pour l'administration d'arnm
BR112015022855A2 (pt) * 2013-03-14 2017-11-07 Shire Human Genetic Therapies composições e método para produção de um anticorpo in vitro
US10590161B2 (en) 2013-03-15 2020-03-17 Modernatx, Inc. Ion exchange purification of mRNA
US20160017313A1 (en) 2013-03-15 2016-01-21 Moderna Therapeutics, Inc. Analysis of mrna heterogeneity and stability
EP3388834B1 (fr) * 2013-03-15 2020-04-15 Translate Bio, Inc. Amélioration synergique de l'administration d'acides nucléiques par l'intermédiaire de formulations mélangées
WO2014152027A1 (fr) 2013-03-15 2014-09-25 Moderna Therapeutics, Inc. Procédés de fabrication pour la production de transcrits d'arn
EP2971165A4 (fr) 2013-03-15 2016-11-23 Moderna Therapeutics Inc Elimination de fragments d'adn dans des procédés de production d'arnm
WO2014144039A1 (fr) 2013-03-15 2014-09-18 Moderna Therapeutics, Inc. Caractérisation de molécules d'arnm
WO2014152031A1 (fr) 2013-03-15 2014-09-25 Moderna Therapeutics, Inc. Purification d'acide ribonucléique
TW201534578A (zh) * 2013-07-08 2015-09-16 Daiichi Sankyo Co Ltd 新穎脂質
PL4023249T3 (pl) * 2014-04-23 2025-03-10 Modernatx, Inc. Szczepionki z kwasem nukleinowym
WO2018226638A1 (fr) * 2017-06-05 2018-12-13 The Brigham And Women's Hospital, Inc. Lignées cellulaires vero exprimant de manière stable la protéine icp0 du vhs

Also Published As

Publication number Publication date
EP3365009A4 (fr) 2019-07-03
TN2018000155A1 (en) 2019-10-04
CL2018001056A1 (es) 2018-10-19
PE20181531A1 (es) 2018-09-26
WO2017070623A1 (fr) 2017-04-27
US20240173400A1 (en) 2024-05-30
IL258833A (en) 2018-06-28
SG11201803365RA (en) 2018-05-30
CA3002822A1 (fr) 2017-04-27
CO2018005258A2 (es) 2018-11-22
BR112018008090A2 (pt) 2018-11-13
EA201890999A1 (ru) 2018-12-28
CN108472355A (zh) 2018-08-31
AU2016342049A1 (en) 2018-06-07
KR20180096593A (ko) 2018-08-29
AU2023216825A1 (en) 2023-09-07
EP3365009A1 (fr) 2018-08-29
JP2022037134A (ja) 2022-03-08
PH12018500855A1 (en) 2018-10-29
US20180303929A1 (en) 2018-10-25
MX2018004918A (es) 2019-04-01
AU2016342049B2 (en) 2023-05-18
JP2018536023A (ja) 2018-12-06

Similar Documents

Publication Publication Date Title
MA46024A (fr) Vaccin contre le virus de l'herpès simplex
MA49463A (fr) Vaccin contre le virus de l'herpès simplex
EP3364981A4 (fr) Vaccin contre le cytomégalovirus humain
MA46584A (fr) Vaccin contre le cytomégalovirus humain
MA47787A (fr) Vaccin contre le virus respiratoire syncytial
MA50813A (fr) Vaccins contre le virus d'epstein-barr
MA46317A (fr) Vaccin contre le virus respiratoire syncytial
MA43762A (fr) Vaccin contre le rsv
MA47016A (fr) Vaccins contre les virus respiratoires
LT3371316T (lt) Vakcinos nuo hepatito b viruso
HUE053078T2 (hu) Aril-szubsztituált pirimidinek influenza vírus fertõzésben való alkalmazásra
EP3194595A4 (fr) Segments d'arn viral utilisés en tant qu'agents immunomodulateurs et composants de vaccin
BR112017013009A2 (pt) formulação de vírus herpes simplex congelada estável
ZA201704596B (en) Foot-and-mouth disease vaccine
DK3355933T3 (da) Adeninkonjugatforbindelser og deres anvendelse som vaccineadjuvanser
EP3515929A4 (fr) Vaccins thérapeutiques contre le virus de l'hépatite b
GB201520345D0 (en) Herpes simplex viruses
EP3866847A4 (fr) Vaccin antiviral
DK2941269T3 (da) Terapeutiske vacciner til behandling af herpes simplex-virus type 2-infektioner
EP3139745B8 (fr) Vaccins contre les infections de l'herpès simplex génital
GB201702193D0 (en) Hepatitis E virus vaccine
EP3706787A4 (fr) Vaccin
EP3383428A4 (fr) Vaccin contre le virus respiratoire syncytial
HK1259850A1 (en) Herpes simplex virus vaccine
HK40010574A (en) Viral vaccines