MA46164B1 - Combinaison de facteurs epignetique et de composes bispecifiques ciblant cd33 et cd3 dans le traitement de la leucémie myéloïde - Google Patents

Combinaison de facteurs epignetique et de composes bispecifiques ciblant cd33 et cd3 dans le traitement de la leucémie myéloïde

Info

Publication number
MA46164B1
MA46164B1 MA46164A MA46164A MA46164B1 MA 46164 B1 MA46164 B1 MA 46164B1 MA 46164 A MA46164 A MA 46164A MA 46164 A MA46164 A MA 46164A MA 46164 B1 MA46164 B1 MA 46164B1
Authority
MA
Morocco
Prior art keywords
myeloid leukemia
treatment
epigenetic
compound targeting
factor
Prior art date
Application number
MA46164A
Other languages
English (en)
Other versions
MA46164A1 (fr
Inventor
Christina Krupka
Roland B Walter
Marion Subklewe
Original Assignee
Amgen Inc
Amgen Res Munich Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc, Amgen Res Munich Gmbh filed Critical Amgen Inc
Publication of MA46164A1 publication Critical patent/MA46164A1/fr
Publication of MA46164B1 publication Critical patent/MA46164B1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne une composition de facteurs épigénétiques et de composés bispécifiques ciblant cd33 et cd3 dans le traitement de la leucémie myéloïde, le facteur épigénétique étant sélectionné parmi les inhibiteurs d'histone désacétylase (hdac), les inhibiteurs d'adn méthyltransférase (dnmt) i, l'hydroxyurée, le facteur de croissance des granulocytes (g-csf), les inhibiteurs d'histone déméthylase et l'atra (acide rétinoïque totalement trans). L'invention concerne donc une composition pharmaceutique contenant un composé ciblant cd33 et au moins un facteur épigénétique, la composition pharmaceutique servant à améliorer et/ou à traiter une leucémie myéloïde, le facteur épigénétique augmentant la sensibilité d'un patient à un composé ciblant cd33. De plus, l'invention concerne l'utilisation d'au moins un facteur épigénétique pour augmenter la sensibilité d'un patient souffrant d'une leucémie myéloïde à un traitement avec un composé ciblant cd33, un procédé de traitement d'une leucémie myéloïde, le procédé comprenant l'administration d'au moins un facteur épigénétique et d'un composé ciblant cd33 à un patient ayant besoin d'un tel traitement et un kit comprenant une composition pharmaceutique de l'invention ou un facteur épigénétique de l'invention et un composé bispécifique ciblant cd33.
MA46164A 2013-09-13 2014-09-15 Combinaison de facteurs epignetique et de composes bispecifiques ciblant cd33 et cd3 dans le traitement de la leucémie myéloïde MA46164B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361877714P 2013-09-13 2013-09-13
PCT/EP2014/069575 WO2015036583A2 (fr) 2013-09-13 2014-09-15 Combinaison de facteurs épigénétiques et de composés bispécifiques ciblant cd33 et cd3 dans le traitement de la leucémie myéloïde

Publications (2)

Publication Number Publication Date
MA46164A1 MA46164A1 (fr) 2020-12-31
MA46164B1 true MA46164B1 (fr) 2021-04-30

Family

ID=51690351

Family Applications (2)

Application Number Title Priority Date Filing Date
MA46164A MA46164B1 (fr) 2013-09-13 2014-09-15 Combinaison de facteurs epignetique et de composes bispecifiques ciblant cd33 et cd3 dans le traitement de la leucémie myéloïde
MA38898A MA38898A1 (fr) 2013-09-13 2016-03-09 Combinaison de facteurs épigénétiques et de composés bispécifiques ciblant cd33 et cd3 dans le traitement de la leucémie myéloïde

Family Applications After (1)

Application Number Title Priority Date Filing Date
MA38898A MA38898A1 (fr) 2013-09-13 2016-03-09 Combinaison de facteurs épigénétiques et de composés bispécifiques ciblant cd33 et cd3 dans le traitement de la leucémie myéloïde

Country Status (27)

Country Link
US (1) US10933132B2 (fr)
EP (1) EP3043794B1 (fr)
JP (1) JP6530409B2 (fr)
KR (1) KR102366470B1 (fr)
CN (2) CN111888474A (fr)
AP (1) AP2016009132A0 (fr)
AR (1) AR097648A1 (fr)
AU (2) AU2014320246B2 (fr)
CA (1) CA2923354C (fr)
CL (1) CL2016000564A1 (fr)
DK (1) DK3043794T3 (fr)
EA (1) EA036476B1 (fr)
HU (1) HUE056867T2 (fr)
IL (1) IL278527B (fr)
JO (1) JO3597B1 (fr)
LT (1) LT3043794T (fr)
MA (2) MA46164B1 (fr)
MX (1) MX381852B (fr)
MY (1) MY185611A (fr)
NZ (1) NZ716448A (fr)
PH (1) PH12016500434B1 (fr)
SG (2) SG10201801777YA (fr)
SI (1) SI3043794T1 (fr)
TW (1) TWI688401B (fr)
UA (1) UA123199C2 (fr)
WO (1) WO2015036583A2 (fr)
ZA (1) ZA201600528B (fr)

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