MA46543A - Variants de l'endonucléase tgfbéta r2, compositions et procédés d'utilisation - Google Patents

Variants de l'endonucléase tgfbéta r2, compositions et procédés d'utilisation

Info

Publication number: MA46543A
Authority: MA; Morocco
Prior art keywords: tgfbeta; compositions; methods; endonuclease variants; endonuclease
Prior art date: 2016-10-17

Application number

MA046543A

Other languages

English (en)

Inventor

Kyle Havens

Jordan Jarjour

Original Assignee

Bluebird Bio Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2016-10-17

Filing date

2017-10-17

Publication date

2019-08-21

2017-10-17 Application filed by Bluebird Bio Inc filed Critical Bluebird Bio Inc

2019-08-21 Publication of MA46543A publication Critical patent/MA46543A/fr

Links

102000004533 Endonucleases Human genes 0.000 title 1
108010042407 Endonucleases Proteins 0.000 title 1
239000000203 mixture Substances 0.000 title 1
ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/31—Chimeric antigen receptors [CAR]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4225—Growth factors
- A61K40/4229—Transforming growth factor [TGF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4256—Tumor associated carbohydrates
- A61K40/4258—Gangliosides, e.g. GM2, GD2 or GD3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Wood Science & Technology (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Immunology (AREA)
Biochemistry (AREA)
Epidemiology (AREA)
Biophysics (AREA)
Microbiology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Cell Biology (AREA)
Crystallography & Structural Chemistry (AREA)
Oncology (AREA)
Transplantation (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Hematology (AREA)
Communicable Diseases (AREA)

MA046543A 2016-10-17 2017-10-17 Variants de l'endonucléase tgfbéta r2, compositions et procédés d'utilisation MA46543A (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201662409163P	2016-10-17	2016-10-17
US201662414260P	2016-10-28	2016-10-28

Publications (1)

Publication Number	Publication Date
MA46543A true MA46543A (fr)	2019-08-21

Family

ID=62018976

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA046543A MA46543A (fr)	2016-10-17	2017-10-17	Variants de l'endonucléase tgfbéta r2, compositions et procédés d'utilisation

Country Status (8)

Country	Link
US (1)	US11530395B2 (fr)
EP (1)	EP3526334A4 (fr)
JP (2)	JP7060591B2 (fr)
CN (1)	CN110050066A (fr)
AU (1)	AU2017346683B2 (fr)
CA (1)	CA3040157A1 (fr)
MA (1)	MA46543A (fr)
WO (1)	WO2018075541A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US11708572B2 (en)	2015-04-29	2023-07-25	Flodesign Sonics, Inc.	Acoustic cell separation techniques and processes
US11214789B2 (en)	2016-05-03	2022-01-04	Flodesign Sonics, Inc.	Concentration and washing of particles with acoustics
KR102451510B1 (ko)	2016-09-08	2022-10-07	2세븐티 바이오, 인코포레이티드	Pd-1 호밍 엔도뉴클레아제 변이체, 조성물 및 사용 방법
US20190284553A1 (en)	2018-03-15	2019-09-19	KSQ Therapeutics, Inc.	Gene-regulating compositions and methods for improved immunotherapy
CN110904045A (zh) *	2018-09-17	2020-03-24	中国科学院动物研究所	经修饰的t细胞、其制备方法及用途
JP2022513750A (ja)	2018-12-10	2022-02-09	２セブンティバイオインコーポレイテッド	ホーミングエンドヌクレアーゼバリアント
IL283724B1 (en) *	2018-12-10	2026-02-01	Genetix Biotherapeutics Inc	pdcd-1 homing endonuclease variants
WO2020223535A1 (fr) *	2019-05-01	2020-11-05	Juno Therapeutics, Inc.	Cellules exprimant un récepteur recombinant à base d'un locus modifié du tgfbr2, et polynucléotides et méthodes associés
CA3136742A1 (fr) *	2019-05-01	2020-11-05	Juno Therapeutics, Inc.	Cellules exprimant un recepteur chimerique a partir d'un locus cd247 modifie, polynucleotides et procedes associes
WO2023081900A1 (fr) *	2021-11-08	2023-05-11	Juno Therapeutics, Inc.	Lymphocytes t modifiés exprimant un récepteur recombiné de lymphocytes t (tcr) et systèmes et procédés apparentés

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4751180A (en)	1985-03-28	1988-06-14	Chiron Corporation	Expression using fused genes providing for protein product
US4935233A (en)	1985-12-02	1990-06-19	G. D. Searle And Company	Covalently linked polypeptide cell modulators
US4873192A (en)	1987-02-17	1989-10-10	The United States Of America As Represented By The Department Of Health And Human Services	Process for site specific mutagenesis without phenotypic selection
GB8918616D0 (en)	1989-08-15	1989-09-27	Univ Glasgow	Herpes simplex virus type 1 mutant
US5804413A (en)	1992-07-31	1998-09-08	University Of Pittsburgh Of The Commonwealth System Of Higher Education	Herpes simplex virus strains for gene transfer
GB9415319D0 (en)	1994-07-29	1994-09-21	Medical Res Council	HSV viral vector
US5846782A (en)	1995-11-28	1998-12-08	Genvec, Inc.	Targeting adenovirus with use of constrained peptide motifs
US6093570A (en)	1995-06-07	2000-07-25	The University Of North Carolina At Chapel Hill	Helper virus-free AAV production
US6013516A (en)	1995-10-06	2000-01-11	The Salk Institute For Biological Studies	Vector and method of use for nucleic acid delivery to non-dividing cells
AU8605598A (en)	1997-07-31	1999-02-22	University Of Pittsburgh	Targeted hsv vectors
US5994136A (en)	1997-12-12	1999-11-30	Cell Genesys, Inc.	Method and means for producing high titer, safe, recombinant lentivirus vectors
FR2777909B1 (fr)	1998-04-24	2002-08-02	Pasteur Institut	Utilisation de sequences d'adn de structure triplex pour le tranfert de sequences de nucleotides dans des cellules, vecteurs recombinants contenant ces sequences triplex
US6692736B2 (en)	2000-03-24	2004-02-17	Cell Genesys, Inc.	Cell-specific adenovirus vectors comprising an internal ribosome entry site
ATE318923T1 (de)	2000-06-01	2006-03-15	Univ North Carolina	Doppelsträngige parvovirus-vektoren
FR2872170B1 (fr)	2004-06-25	2006-11-10	Centre Nat Rech Scient Cnrse	Lentivirus non interactif et non replicatif, preparation et utilisations
JP5136766B2 (ja)	2004-12-15	2013-02-06	ユニバーシティオブノースカロライナアットチャペルヒル	キメラベクター
CN101679959A (zh) *	2007-02-19	2010-03-24	赛莱克蒂斯公司	具有新的底物特异性的laglidadg归巢核酸内切酶变体及其用途
EP2215223B1 (fr) *	2007-10-31	2013-05-01	Precision Biosciences, Inc.	Méganucléases monocaténaires conçues rationnellement contenant des séquences de reconnaissance non palindromiques
US20110239315A1 (en)	2009-01-12	2011-09-29	Ulla Bonas	Modular dna-binding domains and methods of use
WO2010093784A2 (fr)	2009-02-11	2010-08-19	The University Of North Carolina At Chapel Hill	Vecteurs viraux modifiés et procédés de fabrication et d'utilisation de ceux-ci
WO2010093966A2 (fr)	2009-02-12	2010-08-19	Fred Hutchinson Cancer Research Center	Génération d'une enzyme de césure de l'adn stimulant la conversion d'un gène spécifique d'un site à partir d'une endonucléase de ciblage
EP2524037B1 (fr)	2010-01-12	2018-05-16	The University Of North Carolina At Chapel Hill	Répétitions terminales inversées restrictives pour vecteurs viraux
US9169492B2 (en)	2010-02-05	2015-10-27	The University Of North Carolina At Chapel Hill	Compositions and methods for enhanced parvovirus transduction
US20140148361A1 (en) *	2010-06-07	2014-05-29	Barry L. Stoddard	Generation and Expression of Engineered I-ONUI Endonuclease and Its Homologues and Uses Thereof
US8673557B2 (en)	2011-02-28	2014-03-18	Seattle Children's Research Institute	Coupling endonucleases with end-processing enzymes drives high efficiency gene disruption
US8450107B1 (en)	2011-11-30	2013-05-28	The Broad Institute Inc.	Nucleotide-specific recognition sequences for designer TAL effectors
US10584158B2 (en) *	2013-04-17	2020-03-10	Baylor College Of Medicine	Immunosuppressive TGF-β signal converter
ES2883131T3 (es)	2013-05-29	2021-12-07	Cellectis	Métodos para la modificación de células T para inmunoterapia utilizando el sistema de nucleasa CAS guiado por ARN
CA2913871C (fr)	2013-05-31	2021-07-13	Cellectis	Endonuclease de homing de la famille laglidadg clivant le gene du recepteur aux chimiokines c-c de type 5 (ccr5) et utilisations associees
ES2716867T3 (es)	2013-05-31	2019-06-17	Cellectis Sa	Endonucleasa de asentamiento LAGLIDADG que escinde el gen de receptor de células T alfa y usos de la misma
EP3925618A1 (fr)	2013-07-29	2021-12-22	2seventy bio, Inc.	Protéines de signalisation multipartites et leurs utilisations
WO2018022619A1 (fr)	2016-07-25	2018-02-01	Bluebird Bio, Inc.	Variants d'endonucléase de homing bcl11a, compositions et procédés d'utilisation
MA45996A (fr)	2016-08-16	2021-06-02	Bluebird Bio Inc	Variants d'endonucléase de homing du récepteur alpha de l'il-10, compositions et méthodes d'utilisation associées
WO2018039333A1 (fr)	2016-08-23	2018-03-01	Bluebird Bio, Inc.	Variants de l'endonucléase homing tim3, compositions et procédés d'utilisation
KR102451510B1 (ko)	2016-09-08	2022-10-07	2세븐티 바이오, 인코포레이티드	Pd-1 호밍 엔도뉴클레아제 변이체, 조성물 및 사용 방법
US11591582B2 (en)	2016-10-11	2023-02-28	2Seventy Bio, Inc.	TCRα homing endonuclease variants

2017
- 2017-10-17 MA MA046543A patent/MA46543A/fr unknown
- 2017-10-17 CN CN201780076229.5A patent/CN110050066A/zh active Pending
- 2017-10-17 WO PCT/US2017/057014 patent/WO2018075541A1/fr not_active Ceased
- 2017-10-17 US US16/341,228 patent/US11530395B2/en active Active
- 2017-10-17 JP JP2019520527A patent/JP7060591B2/ja active Active
- 2017-10-17 EP EP17861537.3A patent/EP3526334A4/fr not_active Withdrawn
- 2017-10-17 AU AU2017346683A patent/AU2017346683B2/en active Active
- 2017-10-17 CA CA3040157A patent/CA3040157A1/fr active Pending
2022
- 2022-04-14 JP JP2022066868A patent/JP2022103174A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
JP2022103174A (ja)	2022-07-07
CA3040157A1 (fr)	2018-04-26
CN110050066A (zh)	2019-07-23
EP3526334A1 (fr)	2019-08-21
US20200123515A1 (en)	2020-04-23
US11530395B2 (en)	2022-12-20
JP2019535240A (ja)	2019-12-12
EP3526334A4 (fr)	2020-09-30
AU2017346683A1 (en)	2019-05-09
AU2017346683B2 (en)	2024-04-18
WO2018075541A1 (fr)	2018-04-26
JP7060591B2 (ja)	2022-04-26

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