MA46996A - Conjugués comprenant un agoniste double de glp-1/glucagon, un lieur et de l'acide hyaluronique - Google Patents

Conjugués comprenant un agoniste double de glp-1/glucagon, un lieur et de l'acide hyaluronique

Info

Publication number
MA46996A
MA46996A MA046996A MA46996A MA46996A MA 46996 A MA46996 A MA 46996A MA 046996 A MA046996 A MA 046996A MA 46996 A MA46996 A MA 46996A MA 46996 A MA46996 A MA 46996A
Authority
MA
Morocco
Prior art keywords
lieur
hyaluronic acid
including double
glucagon agonist
conjugates including
Prior art date
Application number
MA046996A
Other languages
English (en)
Inventor
Martin Bossart
Pradeep Dhal
Andreas Evers
Dieter Kadereit
Paul Konowicz
Nino Meyer
Thomas Olpp
Nils Poth
Peyman Sakhaii
James Stefano
Michael Wagner
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57542941&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA46996(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of MA46996A publication Critical patent/MA46996A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6903—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being semi-solid, e.g. an ointment, a gel, a hydrogel or a solidifying gel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Toxicology (AREA)
  • Inorganic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
MA046996A 2016-12-02 2017-12-01 Conjugués comprenant un agoniste double de glp-1/glucagon, un lieur et de l'acide hyaluronique MA46996A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP16306613 2016-12-02

Publications (1)

Publication Number Publication Date
MA46996A true MA46996A (fr) 2019-10-09

Family

ID=57542941

Family Applications (1)

Application Number Title Priority Date Filing Date
MA046996A MA46996A (fr) 2016-12-02 2017-12-01 Conjugués comprenant un agoniste double de glp-1/glucagon, un lieur et de l'acide hyaluronique

Country Status (23)

Country Link
US (2) US10792367B2 (fr)
EP (1) EP3548090A1 (fr)
JP (1) JP2020503278A (fr)
KR (1) KR20190091482A (fr)
CN (1) CN110022902A (fr)
AR (1) AR110299A1 (fr)
AU (1) AU2017369723A1 (fr)
BR (1) BR112019011139A8 (fr)
CA (1) CA3045483A1 (fr)
CL (1) CL2019001466A1 (fr)
CO (1) CO2019006912A2 (fr)
CR (1) CR20190312A (fr)
DO (1) DOP2019000038A (fr)
EA (1) EA201991316A1 (fr)
EC (1) ECSP19046865A (fr)
IL (1) IL266973A (fr)
MA (1) MA46996A (fr)
MX (1) MX2019006432A (fr)
PE (1) PE20191472A1 (fr)
PH (1) PH12019501215A1 (fr)
TW (1) TW201832783A (fr)
UY (1) UY37505A (fr)
WO (1) WO2018100174A1 (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR105319A1 (es) 2015-06-05 2017-09-27 Sanofi Sa Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico
IL317744A (en) 2016-03-01 2025-02-01 Ascendis Pharma Bone Diseases As PTH drug agonists
RS64440B1 (sr) 2016-09-29 2023-09-29 Ascendis Pharma Bone Diseases As Režim doziranja za pth jedinjenje sa kontrolisanim oslobađanjem
PL3518961T3 (pl) 2016-09-29 2023-08-14 Ascendis Pharma Bone Diseases A/S Związki pth o niskim stosunku wartości maksymalnej do minimalnej
FI3518982T3 (fi) 2016-09-29 2025-02-11 Ascendis Pharma Bone Diseases As Säädellysti vapautuvia PTH-yhdisteitä
TW201832783A (zh) 2016-12-02 2018-09-16 法商賽諾菲公司 包含ｇｌｐ－１／胰高血糖素雙重激動劑、連接子和透明質酸的接合物
IL269506B2 (en) 2017-03-22 2024-04-01 Genentech Inc Hydrogel cross-linked hyaluronic acid prodrug compositions and methods
CA3072118A1 (fr) 2017-08-09 2019-02-14 Sanofi Agonistes du recepteur de glp-1/glucagon dans le traitement de la steatose hepatique et de la steatohepatite
TW202015735A (zh) 2018-05-30 2020-05-01 法商賽諾菲公司 包含ｇｌｐ－１／升糖素／ｇｉｐ三重受體促效劑、連接子及透明質酸之接合物
FR3084586B1 (fr) * 2018-08-03 2020-11-06 Adocia Compositions sous forme d'une solution aqueuse injectable comprenant de l'amyline, un agoniste au recepteur de l'amyline ou un analogue d'amyline et un compose amphiphile porteur de radicaux hydrophobes
US12403182B2 (en) 2019-02-11 2025-09-02 Ascendis Pharma Bone Diseases A/S Liquid pharmaceutical formulations of PTH conjugates
ES3029282T3 (en) * 2019-05-07 2025-06-23 Genzyme Corp Methods for quantifying drug concentration in a prodrug composition
ES2962935T3 (es) * 2019-06-03 2024-03-21 Symborg S L Nueva cepa de Methylobacterium sp., composiciones que la comprenden, y su uso como bioestimulante y bacteria fijadora del nitrógeno endófito
KR20220117256A (ko) * 2019-12-02 2022-08-23 엔리티사 (상하이) 파마슈티컬 컴퍼니 리미티드 펩타이드 및 염증 치료에서의 이의 용도
KR20230005289A (ko) 2020-04-24 2023-01-09 베링거 인겔하임 인터내셔날 게엠베하 지방 간 질환 및 지방간염의 치료에서 장시간-작용성 glp-1/글루카곤 수용체 작용제로서 글루카곤 유사체
KR102225971B1 (ko) * 2020-05-19 2021-03-10 주식회사 차메디텍 펩타이드 가교제를 이용한 히알루론산 기반의 하이드로겔 및 이의 제조 방법
CA3226846A1 (fr) 2021-07-30 2023-02-02 Boehringer Ingelheim International Gmbh Schema posologique pour agonistes du recepteur glp1/glucagon a action prolongee
CN114470170B (zh) * 2022-02-22 2023-09-19 广州新济药业科技有限公司 一种司美格鲁肽可溶性微针组合物及其制备方法
WO2024165571A2 (fr) 2023-02-06 2024-08-15 E-Therapeutics Plc Inhibiteurs d'expression et/ou de fonction
WO2025125576A2 (fr) 2023-12-15 2025-06-19 E-Therapeutics Plc Inhibiteurs d'expression et/ou de fonction
EP4686757A1 (fr) 2024-07-31 2026-02-04 e-therapeutics PLC Inhibiteurs d expression et/ou de fonction
WO2025133348A1 (fr) 2023-12-22 2025-06-26 E-Therapeutics Plc Inhibiteurs d'expression et/ou de fonction
WO2025191342A2 (fr) * 2024-03-15 2025-09-18 (주)앰틱스바이오 Composition pharmaceutique à libération prolongée comprenant un agoniste du récepteur de glp-1
WO2025196502A1 (fr) 2024-03-20 2025-09-25 North Carolina Agricultural & Technical State University Inhibiteurs de choline kinase utilisés en tant que traitement thérapeutique contre l'obésité

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005066215A1 (fr) * 2003-12-30 2005-07-21 Genzyme Corporation Gels cohesifs de hyaluronane et/ou hylane reticules, preparation et utilisation
TW200612991A (en) * 2004-09-07 2006-05-01 Chugai Pharmaceutical Co Ltd Process for producing water-soluble hyaluronic acid modification
EP2494983B1 (fr) 2004-11-12 2019-04-24 Novo Nordisk A/S Formulation stable de glp-1
CN101107270B (zh) * 2004-11-24 2011-11-23 诺维信生物制药丹麦公司 用二乙烯基砜交联透明质酸的方法
CA2612063A1 (fr) 2005-06-13 2006-12-21 Imperial Innovations Limited Nouveaux composes et leurs effets sur le comportement alimentaire
CA2628241C (fr) 2005-11-07 2016-02-02 Indiana University Research And Technology Corporation Analogues de glucagon a solubilite et a stabilite physiologiques ameliorees
TWI428346B (zh) 2006-12-13 2014-03-01 Imp Innovations Ltd 新穎化合物及其等對進食行為影響
MX2009008241A (es) 2007-02-15 2009-10-08 Univ Indiana Res & Tech Corp Co-agonistas de receptor de glucagon/glp-1.
WO2008148839A2 (fr) 2007-06-08 2008-12-11 Ascendis Pharma As Conjugués polymères transitoires longue durée de l'exendine
JP5385266B2 (ja) 2007-06-15 2014-01-08 ジーランド ファーマ アクティーゼルスカブ グルカゴン類似体
CA2707861A1 (fr) 2007-10-30 2009-05-07 Indiana University Research And Technology Corporation Antagonistes du glucagon
CA2712224C (fr) 2008-02-01 2016-03-08 Ascendis Pharma As Promedicament comprenant un conjugue medicament-lieur
HUE054585T2 (hu) 2008-04-29 2021-09-28 Ascendis Pharma Endocrinology Div A/S Pegilezett rekombináns humán növekedési hormon vegyületek
EP2300037B1 (fr) 2008-06-17 2016-03-30 Indiana University Research and Technology Corporation Co-agonistes du récepteur glucagon/glp-1
PT3228320T (pt) 2008-10-17 2020-03-26 Sanofi Aventis Deutschland Combinação de uma insulina e de um agonista do glp-1
PL2370462T3 (pl) 2008-12-15 2015-01-30 Zealand Pharma As Analogi glukagonu
EA020537B1 (ru) 2008-12-15 2014-11-28 Зилэнд Фарма А/С Аналоги глюкагона
AU2008365557A1 (en) 2008-12-15 2011-07-21 Zealand Pharma A/S Glucagon analogues
MX2011006314A (es) 2008-12-15 2011-09-22 Zealand Pharma As Analogos de glucagon.
WO2010096052A1 (fr) 2009-02-19 2010-08-26 Merck Sharp & Dohme Corp. Analogues d'oxyntomoduline
AP3329A (en) 2009-07-13 2015-06-30 Zealand Pharma As Acylated glucagon analogues
SG178193A1 (en) 2009-07-31 2012-03-29 Sanofi Aventis Deutschland Prodrugs comprising an insulin linker conjugate
FR2952695B1 (fr) 2009-11-13 2012-03-30 Commissariat Energie Atomique Reservoir de stockage d'hydrogene a hydrures metalliques
KR101337322B1 (ko) 2009-11-13 2013-12-06 사노피-아벤티스 도이칠란트 게엠베하 Ｇｌｐ-1 효능제 및 메티오닌을 포함하는 약제학적 조성물
US8703701B2 (en) 2009-12-18 2014-04-22 Indiana University Research And Technology Corporation Glucagon/GLP-1 receptor co-agonists
AR079344A1 (es) 2009-12-22 2012-01-18 Lilly Co Eli Analogo peptidico de oxintomodulina, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para tratar diabetes no insulinodependiente y/u obesidad
JO2976B1 (en) 2009-12-22 2016-03-15 ايلي ليلي اند كومباني Axentomodulin polypeptide
EP2552950A1 (fr) 2010-03-26 2013-02-06 Novo Nordisk A/S Nouveaux analogues du glucagon
CA2797133C (fr) 2010-04-27 2019-08-06 Zealand Pharma A/S Conjugues peptidiques d'antagonistes du recepteur de glp-1 et de gastrine, et leur utilisation
AU2011202239C1 (en) 2010-05-19 2017-03-16 Sanofi Long-acting formulations of insulins
EP2578726B1 (fr) 2010-05-31 2018-10-17 JTEKT Corporation Procédé de fabrication d'un élément revêtu
JP5702376B2 (ja) 2010-06-01 2015-04-15 本田技研工業株式会社 Ｄｃ／ｄｃコンバータの制御装置
UY33462A (es) 2010-06-23 2012-01-31 Zealand Pharma As Analogos de glucagon
EP2438930A1 (fr) * 2010-09-17 2012-04-11 Sanofi-Aventis Deutschland GmbH Promédicaments comprenant un conjugué de liaison d'exendine
PL2721062T3 (pl) 2011-06-17 2019-05-31 Hanmi Science Co Ltd Koniugat zawierający oksyntomodulinę oraz fragment immunoglobuliny i jego zastosowanie
US20150316188A1 (en) 2012-06-29 2015-11-05 University Of South Australia Fluid connection ports
UA116217C2 (uk) * 2012-10-09 2018-02-26 Санофі Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
JP2016506401A (ja) 2012-12-21 2016-03-03 サノフイ 二重ｇｌｐ１／ｇｉｐまたは三方ｇｌｐ１／ｇｉｐ／グルカゴンアゴニストとしてのエキセンジン−４誘導体
KR102310392B1 (ko) 2013-11-06 2021-10-13 질랜드 파마 에이/에스 글루카곤-ｇｌｐ-1-ｇｉｐ 삼원 효능제 화합물
WO2015086732A1 (fr) 2013-12-13 2015-06-18 Sanofi Analogues peptidiques de l'exendine 4
WO2015086733A1 (fr) 2013-12-13 2015-06-18 Sanofi Agonistes mixtes des récepteurs du glp-1/glucagon
WO2015086731A1 (fr) 2013-12-13 2015-06-18 Sanofi Analogues peptidiques de l'exendine-4 en tant qu'agonistes mixtes des récepteurs glp-1/glucagon
TW201625669A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑
US10188759B2 (en) * 2015-01-07 2019-01-29 Endocyte, Inc. Conjugates for imaging
AR105319A1 (es) 2015-06-05 2017-09-27 Sanofi Sa Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico
TW201832783A (zh) 2016-12-02 2018-09-16 法商賽諾菲公司 包含ｇｌｐ－１／胰高血糖素雙重激動劑、連接子和透明質酸的接合物

Also Published As

Publication number Publication date
AR110299A1 (es) 2019-03-13
US11141489B2 (en) 2021-10-12
MX2019006432A (es) 2019-08-21
KR20190091482A (ko) 2019-08-06
DOP2019000038A (es) 2019-05-31
EA201991316A1 (ru) 2019-10-31
ECSP19046865A (es) 2019-07-31
CR20190312A (es) 2019-09-11
IL266973A (en) 2019-07-31
CA3045483A1 (fr) 2018-06-07
PH12019501215A1 (en) 2019-08-19
CO2019006912A2 (es) 2020-04-24
TW201832783A (zh) 2018-09-16
CL2019001466A1 (es) 2019-10-11
US10792367B2 (en) 2020-10-06
AU2017369723A1 (en) 2019-07-18
US20200155688A1 (en) 2020-05-21
JP2020503278A (ja) 2020-01-30
EP3548090A1 (fr) 2019-10-09
CN110022902A (zh) 2019-07-16
US20180154005A1 (en) 2018-06-07
WO2018100174A1 (fr) 2018-06-07
UY37505A (es) 2018-06-29
PE20191472A1 (es) 2019-10-16
BR112019011139A8 (pt) 2020-03-24
BR112019011139A2 (pt) 2019-10-01

Similar Documents

Publication Publication Date Title
IL266973A (en) Conjugates comprising an glp-1/glucagon dual agonist, a linker and hyaluronic acid
IL272232A (en) Glp-1 compositions and uses thereof
LT3283521T (lt) Vaistų konjugatai, apimantys antikūnus prieš klaudiną 18.2
EP3730152A4 (fr) Médicament combiné comprenant un agoniste de tlr7
EP3398961A4 (fr) Triple activateur activant le récepteur du glucagon, du glp-1 et du gip
EP3353213A4 (fr) Nouvel anticorps anti-mésothéline et composition le comprenant
EP3322437A4 (fr) Dérivé de glucagon et composition comprenant un conjugué à action prolongée de celui-ci
MX2020011100A (es) Compuestos, composiciones farmaceuticas y metodos de uso de agonistas de ppar.
EP3530828A4 (fr) Raccord d'articulation
JP2016526891A5 (fr)
FR3023072B1 (fr) Borne de connecteur et connecteur comprenant celle-ci
EP3390739A4 (fr) Connecteur fendu et bâti modulaire comprenant ledit connecteur
WO2017074798A3 (fr) Co-agonistes à action longue durée des récepteurs du glucagon et du glp-1
FR3048272B1 (fr) Longe d'assurage equipee d'un emerillon perfectionne.
ITUA20163694A1 (it) "ciclocomputer con dispositivo di elaborazione delle immagini"
EP3406264A4 (fr) Composition comprenant un agoniste du récepteur de glp-1 et un agoniste du récepteur du glucagon et application associée
EP3819439A4 (fr) Raccord, structure de raccordement et cadre
DK3817775T3 (da) Forbedringer i immunogene konjugater
EP3454851A4 (fr) Compositions comprenant de la benzofuroquinolizine substituée et un médicament psychoactif
EP3397132A4 (fr) Dispositif d'intubation
ITUA20163609A1 (it) "micro-cogeneratore".
FR3032870B1 (fr) Structure de mobilier repliable, en particulier de mobilier d'enseignement
Ariba About SAP Ariba
Kru Kannumuchchaale-A Na Kru
Kru Kidi-A Na Kru