MA47121A - Molécules de liaison pour le traitement du cancer - Google Patents

Molécules de liaison pour le traitement du cancer

Info

Publication number
MA47121A
MA47121A MA047121A MA47121A MA47121A MA 47121 A MA47121 A MA 47121A MA 047121 A MA047121 A MA 047121A MA 47121 A MA47121 A MA 47121A MA 47121 A MA47121 A MA 47121A
Authority
MA
Morocco
Prior art keywords
binding molecules
cancer treatment
cancer
treatment
molecules
Prior art date
Application number
MA047121A
Other languages
English (en)
Inventor
Ertan Eryilmaz
Timothy Fenn
Rajkumar Ganesan
Juan Manuel Garcia-Martinez
Jason Ho
Christian Koessl
Klaus-Peter Kuenkele
Saurabh Sen
Abdulsalam Shaaban
Vladimir Voynov
Andreas Wernitznig
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of MA47121A publication Critical patent/MA47121A/fr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35Valency
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
MA047121A 2016-12-22 2017-12-21 Molécules de liaison pour le traitement du cancer MA47121A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662437770P 2016-12-22 2016-12-22
EP17155973.5A EP3360898A1 (fr) 2017-02-14 2017-02-14 Molécules bispécifiques présentant une immunoréactivité par rapport à tnf-related apoptosis-inducing ligand receptor 2 et à cadherin 17 pour le traitement du cancer

Publications (1)

Publication Number Publication Date
MA47121A true MA47121A (fr) 2019-10-30

Family

ID=58043942

Family Applications (1)

Application Number Title Priority Date Filing Date
MA047121A MA47121A (fr) 2016-12-22 2017-12-21 Molécules de liaison pour le traitement du cancer

Country Status (15)

Country Link
US (2) US10858438B2 (fr)
EP (2) EP3360898A1 (fr)
JP (1) JP7196076B2 (fr)
KR (1) KR102651761B1 (fr)
CN (1) CN110582513B (fr)
AU (1) AU2017384687B2 (fr)
BR (1) BR112019011750A2 (fr)
CA (1) CA3046591A1 (fr)
CO (1) CO2019006320A2 (fr)
EA (1) EA201991480A1 (fr)
MA (1) MA47121A (fr)
MX (1) MX391650B (fr)
PE (1) PE20191251A1 (fr)
TW (1) TWI790219B (fr)
WO (1) WO2018115231A2 (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3360898A1 (fr) 2017-02-14 2018-08-15 Boehringer Ingelheim International GmbH Molécules bispécifiques présentant une immunoréactivité par rapport à tnf-related apoptosis-inducing ligand receptor 2 et à cadherin 17 pour le traitement du cancer
US20210115152A1 (en) * 2018-05-16 2021-04-22 Arbele Limited Composition of bispecific antibodies and method of use thereof
EP3725370A1 (fr) * 2019-04-19 2020-10-21 ImmunoBrain Checkpoint, Inc. Anticorps anti-pd-l1 modifiés et procédés et utilisations pour le traitement d'une maladie neurodégénérative
JP2023526223A (ja) * 2020-05-11 2023-06-21 クリーブ セラピューティクス,インク. がん処置のためのVCP/p97阻害薬
CA3180665A1 (fr) * 2020-05-19 2021-11-25 Boehringer Ingelheim International Gmbh Molecules de liaison pour le traitement du cancer
WO2022155518A1 (fr) 2021-01-15 2022-07-21 Seagen Inc. Conjugués anticorps-médicament immunomodulateurs
MX2023009113A (es) 2021-02-03 2023-08-10 Seagen Inc Conjugados y compuestos inmunoestimulantes.
CN117813120A (zh) * 2021-06-07 2024-04-02 旗舰先锋创新Vii有限责任公司 用于靶向递送治疗剂的组合物和方法
CN113512117B (zh) * 2021-07-12 2023-08-22 武汉麦考津生物科技有限公司 一种可结合cd206的抗体及其应用
US20250270314A1 (en) * 2021-08-02 2025-08-28 Tavotek Biotech (Suzhou) Ltd Anti-cdh17 monoclonal and bispecific antibodies and uses thereof
WO2023023677A1 (fr) * 2021-08-20 2023-02-23 University Of Virginia Patent Foundation Stratégie pour l'activation de dr5 hautement supérieure, notamment dans des tumeurs et des cancers
CA3252067A1 (fr) 2022-05-06 2023-11-09 Seagen Inc. Conjugués anticorps-médicament immunomodulateurs
EP4554677A1 (fr) 2022-07-15 2025-05-21 Boehringer Ingelheim International GmbH Molécules de liaison pour le traitement du cancer
AU2023320054A1 (en) 2022-08-03 2025-02-06 Regents Of The University Of Minnesota Immunostimulatory anti-pd-l1-drug conjugates
EP4321522A1 (fr) 2022-08-12 2024-02-14 Seagen Inc. Composés cytotoxiques et conjugués de ceux-ci
CN120359047A (zh) * 2022-10-14 2025-07-22 旗舰创业创新第七有限责任公司 用于靶向递送治疗剂的组合物和方法
CN115785269B (zh) * 2022-11-01 2023-09-22 四川大学 抗pd-l1的抗体及其应用
AU2023375570A1 (en) 2022-11-10 2025-06-12 Immuvia Inc Cytotoxic bispecific antibodies binding to dr5 and muc16 and uses thereof
CN120712286A (zh) 2023-02-23 2025-09-26 翰森生物有限责任公司 抗体、抗原结合片段和使用方法
WO2025072182A2 (fr) * 2023-09-25 2025-04-03 Trio Pharmaceuticals, Inc. Activation ciblée de mort cellulaire endogène
WO2025108446A1 (fr) * 2023-11-23 2025-05-30 LaNova Medicines Limited Anticorps anti-cdh17 et leurs conjugués
WO2025242099A1 (fr) * 2024-05-21 2025-11-27 康诺亚生物医药科技(成都)有限公司 Conjugué anticorps-médicament contre cdh17 et son utilisation
WO2025261505A1 (fr) * 2024-06-21 2025-12-26 映恩生物制药(苏州)有限公司 Conjugué médicament-anticorps anti-cdh17 et son utilisation
WO2026017120A1 (fr) * 2024-07-18 2026-01-22 信达生物制药(苏州)有限公司 Anticorps trispécifique anti-cdh17/egfr/cd16a et son utilisation
WO2026020031A2 (fr) 2024-07-18 2026-01-22 Novarock Biotherapeutics, Ltd. Anticorps cdh17 et leurs utilisations
WO2026046327A1 (fr) * 2024-08-29 2026-03-05 Utc Therapeutics (Shanghai) Co., Ltd. Anticorps ciblant cdh17, récepteurs antigéniques chimériques et leurs utilisations
CN119310289A (zh) * 2024-10-31 2025-01-14 新疆维吾尔自治区人民医院 On的检测试剂在辅助诊断急性胸痛疾病中的应用

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US168A (en) 1837-04-17 Improvement in fire-arms
US5731A (en) 1848-08-22 Elisha k
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
WO1988001649A1 (fr) 1986-09-02 1988-03-10 Genex Corporation Molecules de liaison de chaines de polypeptide simples
EP0307434B2 (fr) 1987-03-18 1998-07-29 Scotgen Biopharmaceuticals, Inc. Anticorps alteres
ES2052027T5 (es) 1988-11-11 2005-04-16 Medical Research Council Clonacion de secuencias de dominio variable de inmunoglobulina.
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
WO1993008829A1 (fr) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions induisant la destruction de cellules infectees par l'hiv
PT1621554E (pt) 1992-08-21 2009-07-13 Univ Bruxelles Imunoglobtainas desprovidas de cadeias leves
JP3720353B2 (ja) 1992-12-04 2005-11-24 メディカル リサーチ カウンシル 多価および多重特異性の結合タンパク質、それらの製造および使用
DE69420137T2 (de) 1993-06-03 1999-12-23 Therapeutic Antibodies, Inc. Herstellung von antikörperfragmenten
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
GB9625640D0 (en) 1996-12-10 1997-01-29 Celltech Therapeutics Ltd Biological products
AU7266698A (en) 1997-04-30 1998-11-24 Enzon, Inc. Polyalkylene oxide-modified single chain polypeptides
US6342369B1 (en) 1997-05-15 2002-01-29 Genentech, Inc. Apo-2-receptor
EP1274720A4 (fr) 2000-04-12 2004-08-18 Human Genome Sciences Inc Proteines fusionnees a l'albumine
CN101684158A (zh) 2001-01-17 2010-03-31 特鲁比昂药品公司 结合域-免疫球蛋白融合蛋白
US20050214857A1 (en) 2001-12-11 2005-09-29 Algonomics N.V. Method for displaying loops from immunoglobulin domains in different contexts
EP1465925A4 (fr) 2001-12-20 2006-02-08 Human Genome Sciences Inc Anticorps se liant de maniere immunospecifique a des recepteurs trail
EP1600459A3 (fr) 2002-06-28 2005-12-07 Domantis Limited Ligand
EP2284192A3 (fr) 2002-11-08 2011-07-20 Ablynx N.V. Anticorps de Camelidae pour administration sublinguale
SI1639011T1 (sl) 2003-06-30 2009-04-30 Domantis Ltd Pegilirana protitelesa z enojno domeno (dAb)
US20050079184A1 (en) 2003-08-08 2005-04-14 Immunomedics, Inc. Bispecific antibodies for inducing apoptosis of tumor and diseased cells
US8029783B2 (en) 2005-02-02 2011-10-04 Genentech, Inc. DR5 antibodies and articles of manufacture containing same
US20060228352A1 (en) 2005-02-24 2006-10-12 Schoenberger Stephen P TRAIL and methods of modulating T cell activity and adaptive immune responses using TRAIL
PL2860192T3 (pl) 2005-10-12 2018-03-30 Morphosys Ag Wytwarzanie i profilowanie w pełni ludzkich, uzyskanych z HuCAL GOLD terapeutycznych przeciwciał swoistych wobec ludzkiego CD38
EP3663318A1 (fr) 2008-01-07 2020-06-10 Amgen Inc. Procédé de fabrication de molécules hétérodimères fc d'anticorps utilisant les effets de conduite électrostatique
EP3009454A3 (fr) 2009-04-20 2016-10-19 Oxford Bio Therapeutics Limited Anticorps spécifiques à la cadhérine-17
KR101508043B1 (ko) 2009-09-29 2015-04-06 로슈 글리카트 아게 이중특이적 사멸 수용체 아고니스트성 항체
NZ610091A (en) * 2010-10-20 2015-02-27 Oxford Biotherapeutics Ltd Antibodies
US20130025987A1 (en) 2011-07-18 2013-01-31 David Batterbee Methods and apparatus for controlling a fluid damper
EP2684896A1 (fr) 2012-07-09 2014-01-15 International-Drug-Development-Biotech Anticorps de la famille anti-DR5 ou bispécifique anticorps de la famille anti-DR5 multivalents et leurs procédés d'utilisation
UA118028C2 (uk) 2013-04-03 2018-11-12 Рош Глікарт Аг Біспецифічне антитіло, специфічне щодо fap і dr5, антитіло, специфічне щодо dr5, і спосіб їх застосування
NO2776305T3 (fr) 2014-04-23 2018-01-27
PE20170903A1 (es) 2014-08-12 2017-07-12 Novartis Ag Conjugados de farmacos con anticuerpos anti-cdh6
PE20170912A1 (es) 2014-11-14 2017-07-12 Novartis Ag Conjugados de anticuerpo-farmaco
JP7179464B2 (ja) * 2015-01-20 2022-11-29 アイジーエム バイオサイエンシズ インコーポレイテッド 腫瘍壊死因子 (tnf) スーパーファミリー受容体結合分子およびその使用
HK1247215A1 (zh) 2015-01-26 2018-09-21 Macrogenics, Inc. 包含dr5-结合结构域的多价分子
UA127200C2 (uk) 2016-05-18 2023-06-07 Бьорінгер Інгельхайм Інтернаціональ Гмбх Молекула антитіла до pd1
EP3360898A1 (fr) 2017-02-14 2018-08-15 Boehringer Ingelheim International GmbH Molécules bispécifiques présentant une immunoréactivité par rapport à tnf-related apoptosis-inducing ligand receptor 2 et à cadherin 17 pour le traitement du cancer

Also Published As

Publication number Publication date
BR112019011750A2 (pt) 2019-10-29
EP3360898A1 (fr) 2018-08-15
JP7196076B2 (ja) 2022-12-26
EP3559040A2 (fr) 2019-10-30
CO2019006320A2 (es) 2019-06-28
CN110582513B (zh) 2023-11-14
PE20191251A1 (es) 2019-09-18
JP2020501586A (ja) 2020-01-23
CN110582513A (zh) 2019-12-17
US20210095038A1 (en) 2021-04-01
MX2019007511A (es) 2019-09-04
KR102651761B1 (ko) 2024-03-26
MX391650B (es) 2025-03-21
TW201835102A (zh) 2018-10-01
AU2017384687A1 (en) 2019-06-13
KR20190099223A (ko) 2019-08-26
US20180179287A1 (en) 2018-06-28
AU2017384687B2 (en) 2025-01-23
WO2018115231A2 (fr) 2018-06-28
WO2018115231A3 (fr) 2018-08-02
US11851495B2 (en) 2023-12-26
TWI790219B (zh) 2023-01-21
EP3559040B1 (fr) 2026-04-08
US10858438B2 (en) 2020-12-08
EA201991480A1 (ru) 2020-01-15
CA3046591A1 (fr) 2018-06-28

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