MA47401A - Vaccins anticancéreux à arn - Google Patents

Vaccins anticancéreux à arn

Info

Publication number
MA47401A
MA47401A MA047401A MA47401A MA47401A MA 47401 A MA47401 A MA 47401A MA 047401 A MA047401 A MA 047401A MA 47401 A MA47401 A MA 47401A MA 47401 A MA47401 A MA 47401A
Authority
MA
Morocco
Prior art keywords
cancer vaccines
rna anti
rna
vaccines
cancer
Prior art date
Application number
MA047401A
Other languages
English (en)
Inventor
Ted Ashburn
Kristen Hopson
Nicholas Valiante
Original Assignee
Modernatx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Modernatx Inc filed Critical Modernatx Inc
Publication of MA47401A publication Critical patent/MA47401A/fr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
    • A61K40/4244Enzymes
    • A61K40/4253GTPases, e.g. Ras or Rho
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/7105Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/7115Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001154Enzymes
    • A61K39/001164GTPases, e.g. Ras or Rho
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53DNA (RNA) vaccination
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55516Proteins; Peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55555Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/58Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A61K2039/585Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
MA047401A 2017-02-01 2017-10-26 Vaccins anticancéreux à arn MA47401A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762453465P 2017-02-01 2017-02-01
US201762453444P 2017-02-01 2017-02-01
US201762558238P 2017-09-13 2017-09-13

Publications (1)

Publication Number Publication Date
MA47401A true MA47401A (fr) 2021-05-05

Family

ID=63040027

Family Applications (1)

Application Number Title Priority Date Filing Date
MA047401A MA47401A (fr) 2017-02-01 2017-10-26 Vaccins anticancéreux à arn

Country Status (12)

Country Link
US (2) US20190351040A1 (fr)
EP (1) EP3576751A4 (fr)
JP (2) JP7731656B2 (fr)
KR (2) KR20190120233A (fr)
CN (1) CN110505877A (fr)
AU (1) AU2017397458B2 (fr)
CA (1) CA3052255A1 (fr)
MA (1) MA47401A (fr)
NZ (1) NZ793715A (fr)
RU (2) RU2022106357A (fr)
SG (2) SG11201906895WA (fr)
WO (1) WO2018144082A1 (fr)

Families Citing this family (121)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
PL4023249T3 (pl) 2014-04-23 2025-03-10 Modernatx, Inc. Szczepionki z kwasem nukleinowym
US11364292B2 (en) 2015-07-21 2022-06-21 Modernatx, Inc. CHIKV RNA vaccines
MA42502A (fr) 2015-07-21 2018-05-30 Modernatx Inc Vaccins contre une maladie infectieuse
MA42543A (fr) 2015-07-30 2018-06-06 Modernatx Inc Arn épitope peptidiques concatémériques
US11564893B2 (en) 2015-08-17 2023-01-31 Modernatx, Inc. Methods for preparing particles and related compositions
AU2016342045A1 (en) 2015-10-22 2018-06-07 Modernatx, Inc. Human cytomegalovirus vaccine
AU2016342376A1 (en) 2015-10-22 2018-06-07 Modernatx, Inc. Sexually transmitted disease vaccines
AU2016341309A1 (en) 2015-10-22 2018-06-07 Modernatx, Inc. Cancer vaccines
EP4011451A1 (fr) 2015-10-22 2022-06-15 ModernaTX, Inc. Vaccins contre le virus respiratoire
WO2017070601A1 (fr) 2015-10-22 2017-04-27 Modernatx, Inc. Vaccins à base d'acide nucléique contre le virus varicelle-zona (vzv)
WO2017070624A1 (fr) 2015-10-22 2017-04-27 Modernatx, Inc. Vaccins contre des maladies tropicales
PL3386484T3 (pl) 2015-12-10 2022-07-25 Modernatx, Inc. Kompozycje i sposoby dostarczania środków terapeutycznych
US10465190B1 (en) 2015-12-23 2019-11-05 Modernatx, Inc. In vitro transcription methods and constructs
NZ746112A (en) 2016-03-18 2023-01-27 Immune Sensor Llc Cyclic di-nucleotide compounds and methods of use
EP3445392A1 (fr) * 2016-04-22 2019-02-27 CureVac AG Arn codant pour un antigène tumoral
IL263079B2 (en) 2016-05-18 2024-05-01 Modernatx Inc Polynucleotides encoding relaxin
WO2017201342A1 (fr) 2016-05-18 2017-11-23 Modernatx, Inc. Polynucléotides codant pour jagged1 pour le traitement du syndrome d'alagille
CA3036831A1 (fr) 2016-09-14 2018-03-22 Modernatx, Inc. Compositions d'arn de haute purete et procedes pour leur preparation
EP3528821A4 (fr) 2016-10-21 2020-07-01 ModernaTX, Inc. Vaccin contre le cytomégalovirus humain
MA46766A (fr) 2016-11-11 2019-09-18 Modernatx Inc Vaccin antigrippal
WO2018107088A2 (fr) 2016-12-08 2018-06-14 Modernatx, Inc. Vaccins à acide nucléique contre des virus respiratoires
US11384352B2 (en) 2016-12-13 2022-07-12 Modernatx, Inc. RNA affinity purification
AU2018219862B2 (en) * 2017-02-07 2020-09-17 Nant Holding IP, LLC Maximizing T-cell memory and compositions and methods therefor
MA47515A (fr) 2017-02-16 2019-12-25 Modernatx Inc Compositions immunogènes très puissantes
WO2018170256A1 (fr) * 2017-03-15 2018-09-20 Modernatx, Inc. Vaccin contre le virus de l'herpès simplex
WO2018170245A1 (fr) 2017-03-15 2018-09-20 Modernatx, Inc. Vaccin à large spectre contre le virus de la grippe
WO2018170270A1 (fr) 2017-03-15 2018-09-20 Modernatx, Inc. Vaccin contre le virus varicelle-zona
EP3595713A4 (fr) 2017-03-15 2021-01-13 ModernaTX, Inc. Vaccin contre le virus respiratoire syncytial
EP3595676A4 (fr) 2017-03-17 2021-05-05 Modernatx, Inc. Vaccins à base d'arn contre des maladies zoonotiques
US11905525B2 (en) 2017-04-05 2024-02-20 Modernatx, Inc. Reduction of elimination of immune responses to non-intravenous, e.g., subcutaneously administered therapeutic proteins
MA49421A (fr) 2017-06-15 2020-04-22 Modernatx Inc Formulations d'arn
MA49914A (fr) 2017-08-18 2021-04-21 Modernatx Inc Procédés analytiques par hplc
WO2019036682A1 (fr) 2017-08-18 2019-02-21 Modernatx, Inc. Variants d'arn polymérase
EP3668979A4 (fr) 2017-08-18 2021-06-02 Modernatx, Inc. Procédés pour analyse par clhp
EP3675817A1 (fr) 2017-08-31 2020-07-08 Modernatx, Inc. Procédés de fabrication de nanoparticules lipidiques
WO2019055807A1 (fr) 2017-09-14 2019-03-21 Modernatx, Inc. Vaccins à arn contre le virus zika
EP3746090A4 (fr) 2018-01-29 2021-11-17 ModernaTX, Inc. Vaccins à base d'arn contre le vrs
WO2019227106A1 (fr) * 2018-05-25 2019-11-28 The Wistar Institute Néo-antigènes spécifiques d'une tumeur et leurs méthodes d'utilisation
AU2019293244B2 (en) * 2018-06-27 2026-04-02 Modernatx, Inc. Personalized cancer vaccine epitope selection
US20220349010A1 (en) 2018-07-26 2022-11-03 Frame Pharmaceuticals B.V. Method of preparing subject-specific immunogenic compositions based on a neo open-reading-frame peptide database
CA3106564A1 (fr) 2018-07-26 2020-01-30 Frame Pharmaceuticals B.V. Vaccins contre le cancer pour le cancer du sein
CA3113025A1 (fr) 2018-09-19 2020-03-26 Modernatx, Inc. Lipides peg et leurs utilisations
WO2020061295A1 (fr) 2018-09-19 2020-03-26 Modernatx, Inc. Lipides peg de haute pureté et leurs utilisations
WO2020061457A1 (fr) 2018-09-20 2020-03-26 Modernatx, Inc. Préparation de nanoparticules lipidiques et leurs méthodes d'administration
BR112021006941A2 (pt) 2018-10-19 2021-08-31 The Francis Crick Institute Limited Antígenos de câncer inovadores e métodos
MA54192A (fr) * 2018-11-07 2021-09-15 Modernatx Inc Vaccins à arn contre le cancer
TWI852977B (zh) 2019-01-10 2024-08-21 美商健生生物科技公司 前列腺新抗原及其用途
AU2020208193A1 (en) * 2019-01-14 2021-07-29 BioNTech SE Methods of treating cancer with a PD-1 axis binding antagonist and an RNA vaccine
US11351242B1 (en) 2019-02-12 2022-06-07 Modernatx, Inc. HMPV/hPIV3 mRNA vaccine composition
US11851694B1 (en) 2019-02-20 2023-12-26 Modernatx, Inc. High fidelity in vitro transcription
AU2020224103A1 (en) 2019-02-20 2021-09-16 Modernatx, Inc. Rna polymerase variants for co-transcriptional capping
CN113874502A (zh) 2019-03-11 2021-12-31 摩登纳特斯有限公司 补料分批体外转录方法
US20220184191A1 (en) * 2019-03-11 2022-06-16 Evaxion Biotech A/S Nucleic acid vaccination using neo-epitope encoding constructs
US12070495B2 (en) 2019-03-15 2024-08-27 Modernatx, Inc. HIV RNA vaccines
WO2020198338A1 (fr) * 2019-03-25 2020-10-01 Ohio State Innovation Foundation Immunorégulation combinée et utilisations associées
EP3962521A1 (fr) 2019-05-02 2022-03-09 University of Florida Research Foundation, Inc. Compositions pour le traitement de gliome diffus pontique intrinsèque
US20220236253A1 (en) * 2019-05-31 2022-07-28 Modernatx, Inc. Expanded t cell assay
US12577278B2 (en) * 2019-06-07 2026-03-17 Emory University KRAS G12V mutant binds to JAK1, inhibitors, pharmaceutical compositions, and methods related thereto
CN110172089B (zh) * 2019-06-11 2020-01-07 北京鼎成肽源生物技术有限公司 一种kras突变多抗原组合、靶向kras突变肿瘤ctl及其应用
CN110172480B (zh) * 2019-06-11 2020-01-07 北京鼎成肽源生物技术有限公司 双抗原表位融合基因重组慢病毒载体、抗原提呈细胞和ctl细胞及其构建方法和应用
US20220307017A1 (en) * 2019-08-29 2022-09-29 Universität Zürich Minimal Messenger RNAs and uses thereof
CR20220220A (es) 2019-11-18 2022-09-20 Janssen Biotech Inc Vacunas basadas en calr y jak2 mutantes y sus usos
WO2021119418A1 (fr) * 2019-12-11 2021-06-17 Vanderbilt University Procédés de synthèse d'arnm et de protéines fonctionnelles à partir d'adn double brin synthétique
EP4096720A2 (fr) * 2020-01-30 2022-12-07 ModernaTX, Inc. Arnm codant des polypeptides de reprogrammation métabolique et leurs utilisations
MX2022009391A (es) * 2020-01-31 2022-09-26 Genentech Inc Metodos para inducir linfocitos t especificos para neoepitopo con un antagonista de union al eje de pd-1 y una vacuna de arn.
US20230096704A1 (en) * 2020-02-05 2023-03-30 University Of Florida Research Foundation, Incorporated Rna-loaded nanoparticles and use thereof for the treatment of cancer
IL296234A (en) * 2020-03-11 2022-11-01 Advansix Resins & Chemicals Llc Surfactants for healthcare products
JP2023517664A (ja) 2020-03-11 2023-04-26 アドバンシックス・レジンズ・アンド・ケミカルズ・リミテッド・ライアビリティ・カンパニー 油及びガス生産のための界面活性剤
JP2023517666A (ja) 2020-03-11 2023-04-26 アドバンシックス・レジンズ・アンド・ケミカルズ・リミテッド・ライアビリティ・カンパニー 農業用製品のための界面活性剤
JP2023522193A (ja) * 2020-04-17 2023-05-29 ザ フランシス クリック インスティチュート リミティッド 抗原プール
IL297419B2 (en) 2020-04-22 2025-02-01 BioNTech SE Coronavirus vaccine
US11130787B2 (en) * 2020-06-11 2021-09-28 MBF Therapeutics, Inc. Alphaherpesvirus glycoprotein d-encoding nucleic acid constructs and methods
KR20230034333A (ko) 2020-07-02 2023-03-09 라이프 테크놀로지스 코포레이션 트리뉴클레오티드 캡 유사체, 제조 및 이의 용도
EP4175664A2 (fr) 2020-07-06 2023-05-10 Janssen Biotech, Inc. Néo-antigènes prostatiques et leurs utilisations
US20230346924A1 (en) * 2020-08-04 2023-11-02 Progeneer Inc. Mrna vaccine comprising adjuvant capable of kinetic control
IL300447A (en) 2020-08-12 2023-04-01 Actym Therapeutics Inc Bacteria-based ingredients that stimulate the immune system, treatments and platforms for delivering RNA
US11406703B2 (en) 2020-08-25 2022-08-09 Modernatx, Inc. Human cytomegalovirus vaccine
CA3198727A1 (fr) 2020-10-20 2022-04-28 St Pharm Co., Ltd. Oligonucleotide pour la synthese d'arn a coiffe en 5'
WO2022087424A1 (fr) * 2020-10-22 2022-04-28 The Regents Of The University Of California Thérapie de blocage de monoamine oxydase pour le traitement du cancer par régulation de macrophages associés à une tumeur (tam)
WO2022120560A1 (fr) * 2020-12-08 2022-06-16 深圳市瑞吉生物科技有限公司 Immunosuppresseur sous forme posologique d'arnm et son application dans la préparation d'un médicament pour le traitement de tumeurs
US20240299516A1 (en) * 2020-12-21 2024-09-12 University Of Florida Research Foundaton, Inc. Multilamellar rna nanoparticle vaccine against cancer
CN114717229B (zh) * 2021-01-05 2024-09-10 麦塞拿治疗(香港)有限公司 治疗性mRNA的无细胞和无载体体外RNA转录方法和核酸分子
EP4274607A1 (fr) 2021-01-11 2023-11-15 ModernaTX, Inc. Vaccins contre le virus de la grippe à arn saisonnière
US20240299520A1 (en) * 2021-02-09 2024-09-12 Virginia Commonwealth University Mini circular rna therapeutics and vaccines and methods of use thereof
US11524023B2 (en) 2021-02-19 2022-12-13 Modernatx, Inc. Lipid nanoparticle compositions and methods of formulating the same
EP4313072A1 (fr) * 2021-03-26 2024-02-07 ModernaTX, Inc. Vaccin contre la coqueluche
NL2028681B1 (en) * 2021-04-02 2022-10-17 Nutcracker Therapeutics Inc Materials and methods for generating antigen-specific t cells and treating diseases
CN113186285B (zh) * 2021-05-10 2022-05-24 深圳市展行生物有限公司 一种辅助诊断胃癌的方法及其使用的miRNA组合
US20220363937A1 (en) 2021-05-14 2022-11-17 Armstrong World Industries, Inc. Stabilization of antimicrobial coatings
CN113577258B (zh) * 2021-07-31 2024-04-16 山东兴瑞生物科技有限公司 一种双靶点mRNA疫苗及其制备方法
CN115703714B (zh) * 2021-08-13 2025-06-10 广州谷森制药有限公司 阳离子脂质化合物
WO2023030635A1 (fr) * 2021-09-02 2023-03-09 BioNTech SE Test d'activité pour potentiel thérapeutique d'acide nucléique codant
CA3230564A1 (fr) 2021-09-13 2023-03-16 Jean-Pol DETIFFE Procede de generation de neo-antigenes personnalises d'une tumeur d'un patient
EP4147713A1 (fr) * 2021-09-13 2023-03-15 OncoDNA Vaccin arn comprenant un groupe d'arn généré à partir d'un groupe d'adn à double brin
EP4147712A1 (fr) 2021-09-13 2023-03-15 OncoDNA Procédé pour générer un groupe d'adn à double brin codant pour des néo-antigènes d'une tumeur d'un patient
WO2023086796A2 (fr) 2021-11-09 2023-05-19 Actym Therapeutics, Inc. Bactéries immunostimulatrices pour convertir des macrophages en un phénotype pouvant être traité, et diagnostic compagnon pour identifier des sujets pour un traitement
US12186387B2 (en) 2021-11-29 2025-01-07 BioNTech SE Coronavirus vaccine
US12529047B1 (en) 2021-12-21 2026-01-20 Modernatx, Inc. mRNA quantification methods
CN116376942A (zh) * 2021-12-31 2023-07-04 广州国家实验室 mRNA疫苗
WO2024002985A1 (fr) 2022-06-26 2024-01-04 BioNTech SE Vaccin contre le coronavirus
WO2024026490A1 (fr) * 2022-07-28 2024-02-01 Sqz Biotechnologies Company Polynucléotides codant pour des antigènes liés et leurs utilisations
CN115992152A (zh) * 2022-09-22 2023-04-21 浙江大学医学院附属第一医院 一种用于乙型肝炎病毒治疗性mRNA疫苗及其制备方法与应用
CN120019151A (zh) * 2022-10-07 2025-05-16 国立大学法人筑波大学 核酸构建物及蛋白复合体的设计方法及制造方法
EP4604981A2 (fr) * 2022-10-19 2025-08-27 KaliVir Immunotherapeutics, Inc. Acides nucléiques codant pour pd-1 et il-12 solubles et leurs utilisations
EP4611918A1 (fr) * 2022-10-31 2025-09-10 Gritstone bio, Inc. Surveillance d'adn acellulaire de panel de combinaison
WO2024097874A1 (fr) * 2022-11-03 2024-05-10 Modernatx, Inc. Stabilité chimique de l'arnm
EP4364752A1 (fr) 2022-11-07 2024-05-08 OncoDNA Vaccin ameliore
CN116970614A (zh) * 2022-12-29 2023-10-31 达冕疫苗(广州)有限公司 编码ny-eso-1的核糖核酸疫苗的组合物和方法
US20240238408A1 (en) * 2023-01-17 2024-07-18 The University Of Hong Kong CANCER IMMUNOTHERAPY BY DELIVERY OF mRNA
CN119055669A (zh) * 2023-05-23 2024-12-03 源生生物科技(青岛)有限责任公司 包含miRNA的活性成分及其应用
WO2025054383A1 (fr) * 2023-09-06 2025-03-13 Modernatx, Inc. Stabilité chimique de l'arnm
WO2025080869A1 (fr) * 2023-10-11 2025-04-17 The Regents Of The University Of California Immunothérapie du cancer du pancréas à l'aide de nanovecteurs lipidiques et polymères cationiques pour la co-administration de néoantigènes kras et de sting et/ou d'autres immunomodulateurs pour augmenter le cycle d'immunité contre le cancer et traiter des métastases hépatiques
WO2025117816A1 (fr) * 2023-12-01 2025-06-05 Recode Therapeutics, Inc. Compositions de nanoparticules lipidiques et leurs utilisations
CN121464216A (zh) * 2024-01-17 2026-02-03 艾博生物科技(上海)有限公司 用于诱导针对kras突变细胞的抗原特异性免疫的组合物和方法
WO2025158069A1 (fr) * 2024-01-25 2025-07-31 Rheinische Friedrich-Wilhelms-Universität Bonn Construction contenant un brin arnm et le(s) ligand(s) du gène 1 inductible à l'acide rétinoïque (rig-1), composition pharmaceutique et kit comportant ces éléments
CN118389553A (zh) * 2024-03-01 2024-07-26 中国科学技术大学 免疫增效rna分子及其组合物、疫苗与试剂盒
CN117883558B (zh) * 2024-03-15 2024-06-14 山东兴瑞生物科技有限公司 靶向肝肿瘤个性化mRNA疫苗的制备方法
WO2025235990A1 (fr) * 2024-05-10 2025-11-13 Metrohealth Ventures Llc Vaccin à arnm oncogène contre le cancer
WO2026005647A2 (fr) * 2024-06-29 2026-01-02 федеральное государственное бюджетное учреждение "Национальный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации Agent immunobiologique pour traiter des maladies oncologiques sur la base d'un vecteur arn
CN119874872B (zh) * 2025-01-17 2025-11-25 武汉大学 一种mita铰链区突变多肽及其在自身免疫性疾病中的应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010037408A1 (fr) * 2008-09-30 2010-04-08 Curevac Gmbh Composition comprenant un arnm complexé et un arnm nu pour déclencher ou augmenter une réponse immunostimulante chez un mammifère et utilisations de ladite composition
EP2569633B1 (fr) * 2010-05-14 2016-02-10 The General Hospital Corporation Compositions et procédés d'identification de néoantigènes spécifiques à une tumeur
PL3892295T3 (pl) * 2011-05-24 2023-07-24 BioNTech SE Zindywidualizowane szczepionki przeciwnowotworowe
WO2012159643A1 (fr) * 2011-05-24 2012-11-29 Biontech Ag Vaccins individualisés pour le cancer
US9371380B2 (en) * 2011-08-16 2016-06-21 Taiho Pharmaceutical Co., Ltd. Antitumor agent and therapeutic effect prediction method for patients with KRAS-mutated colorectal cancer
MX366055B (es) * 2011-08-31 2019-06-26 Novartis Ag Liposomas pegilados para admistracion de acido ribonucleico (arn) que codifica para inmunogeno.
WO2013151665A2 (fr) * 2012-04-02 2013-10-10 modeRNA Therapeutics Polynucléotides modifiés destinés à la production de protéines associées à une maladie humaine
KR20150130283A (ko) 2013-03-15 2015-11-23 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 생체분자 보조제를 갖는 백신
US20160367651A1 (en) * 2013-10-01 2016-12-22 Mie University T cell inducing vaccine containing an interepitope sequence that promotes antigen presentation
PL4023249T3 (pl) 2014-04-23 2025-03-10 Modernatx, Inc. Szczepionki z kwasem nukleinowym
US20170204152A1 (en) * 2014-07-16 2017-07-20 Moderna Therapeutics, Inc. Chimeric polynucleotides
WO2016128060A1 (fr) * 2015-02-12 2016-08-18 Biontech Ag Prédiction des épitopes de lymphocytes t utiles pour la vaccination
CN108064176A (zh) 2015-04-22 2018-05-22 库瑞瓦格股份公司 用于治疗肿瘤疾病的含有rna的组合物
WO2016201377A1 (fr) * 2015-06-10 2016-12-15 Moderna Therapeutics, Inc. Vaccins adaptatifs ciblés
MA42543A (fr) * 2015-07-30 2018-06-06 Modernatx Inc Arn épitope peptidiques concatémériques
AU2016341309A1 (en) * 2015-10-22 2018-06-07 Modernatx, Inc. Cancer vaccines
CN110402145A (zh) * 2016-10-26 2019-11-01 莫得纳特斯公司 用于增强免疫应答的信使核糖核酸及其使用方法

Also Published As

Publication number Publication date
AU2017397458A1 (en) 2019-08-15
KR20190120233A (ko) 2019-10-23
US20250134978A1 (en) 2025-05-01
CA3052255A1 (fr) 2018-08-09
JP2020506189A (ja) 2020-02-27
KR20240117650A (ko) 2024-08-01
RU2019127381A3 (fr) 2021-06-17
SG11201906895WA (en) 2019-08-27
AU2017397458B2 (en) 2025-07-10
SG10202108307YA (en) 2021-08-30
EP3576751A4 (fr) 2021-08-04
NZ793715A (en) 2026-02-27
NZ755780A (en) 2023-10-27
CN110505877A (zh) 2019-11-26
RU2022106357A (ru) 2022-03-24
WO2018144082A1 (fr) 2018-08-09
RU2019127381A (ru) 2021-03-02
EP3576751A1 (fr) 2019-12-11
JP7731656B2 (ja) 2025-09-01
JP2023164537A (ja) 2023-11-10
US20190351040A1 (en) 2019-11-21
RU2768829C2 (ru) 2022-03-24

Similar Documents

Publication Publication Date Title
MA47401A (fr) Vaccins anticancéreux à arn
MA54192A (fr) Vaccins à arn contre le cancer
MA50253A (fr) Vaccins à arn contre le virus zika
MA46255A (fr) Vaccins anticancéreux
MA47680A (fr) Arn thérapeutique
MA44479A (fr) Arn transrepliquant
DK3393510T3 (da) Zikavirusvaccine
EP3538146A4 (fr) Vaccin antigrippal
EP3324979A4 (fr) Vaccins contre une maladie infectieuse
EP3478312A4 (fr) Vaccin contre le cancer nant
EP3356371A4 (fr) Vaccins à conjugués de polymère
EP3585803A4 (fr) Formulations de vaccin pneumococcique conjugué
DK3262066T4 (da) Genterapi
EP3700565A4 (fr) Vaccins avec adjuvant
DK3313436T3 (da) Multivalent pneumokok-konjugatvaccine
EP3773649A4 (fr) Vaccins anticancéreux personnalisés
PL3534945T3 (pl) Szczepionka przeciwko parwowirusowi świń
PL3373959T3 (pl) Cząstki arenawirusa jako szczepionki przeciwrakowe
EP3385286A4 (fr) Antigène vaccinal à immunogénicité accrue
EP3273989C0 (fr) Vaccin streptococcique
EP3560512A4 (fr) Composition de vaccin contre le zona
IL266237A (en) Tolerogenic DNA composition
EP3344286A4 (fr) Vaccins contre le cancer de l'ovaire
EP3638297A4 (fr) Vaccin bactérien
EP3511016A4 (fr) Immunostimulant