MA49634A - Arnm modifié codant pour une propionyl-coa-carboxylase et utilisations associées - Google Patents

Arnm modifié codant pour une propionyl-coa-carboxylase et utilisations associées

Info

Publication number
MA49634A
MA49634A MA049634A MA49634A MA49634A MA 49634 A MA49634 A MA 49634A MA 049634 A MA049634 A MA 049634A MA 49634 A MA49634 A MA 49634A MA 49634 A MA49634 A MA 49634A
Authority
MA
Morocco
Prior art keywords
carboxylase
propionyl
coa
modified rna
rna coding
Prior art date
Application number
MA049634A
Other languages
English (en)
Inventor
Judith L Campagnari
Zhiliang Cheng
Susan Sobolov-Jaynes
Romesh R Subramanian
Haren Vasavada
Original Assignee
Modernatx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Modernatx Inc filed Critical Modernatx Inc
Publication of MA49634A publication Critical patent/MA49634A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01041—Methylmalonyl-CoA decarboxylase (4.1.1.41)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y604/00—Ligases forming carbon-carbon bonds (6.4)
    • C12Y604/01—Ligases forming carbon-carbon bonds (6.4.1)
    • C12Y604/01003—Propionyl-CoA carboxylase (6.4.1.3)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MA049634A 2017-07-21 2018-07-20 Arnm modifié codant pour une propionyl-coa-carboxylase et utilisations associées MA49634A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762535289P 2017-07-21 2017-07-21

Publications (1)

Publication Number Publication Date
MA49634A true MA49634A (fr) 2020-05-27

Family

ID=63165470

Family Applications (1)

Application Number Title Priority Date Filing Date
MA049634A MA49634A (fr) 2017-07-21 2018-07-20 Arnm modifié codant pour une propionyl-coa-carboxylase et utilisations associées

Country Status (4)

Country Link
US (1) US20200165593A1 (fr)
EP (1) EP3655040A1 (fr)
MA (1) MA49634A (fr)
WO (1) WO2019018765A1 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK4023249T3 (da) 2014-04-23 2025-01-13 Modernatx Inc Nukleinsyrevacciner
MA42543A (fr) 2015-07-30 2018-06-06 Modernatx Inc Arn épitope peptidiques concatémériques
CA3003090A1 (fr) 2015-10-22 2017-04-27 Modernatx, Inc. Vaccins anticancereux
ES2928475T3 (es) 2016-09-14 2022-11-18 Modernatx Inc Composiciones de ARN de alta pureza y métodos para su preparación
CN110167587A (zh) 2016-11-11 2019-08-23 摩登纳特斯有限公司 流感疫苗
MA49913A (fr) 2017-08-18 2021-05-05 Modernatx Inc Variants d'arn polymérase
JP7424976B2 (ja) * 2017-11-22 2024-01-30 モダーナティエックス・インコーポレイテッド プロピオン酸血症の治療用のプロピオニルＣｏＡカルボキシラーゼアルファ及びベータサブユニットをコードするポリヌクレオチド
EP3746090A4 (fr) 2018-01-29 2021-11-17 ModernaTX, Inc. Vaccins à base d'arn contre le vrs
EP3853305B1 (fr) 2018-09-19 2024-10-02 ModernaTX, Inc. Lipides peg de haute pureté et leurs utilisations
WO2020061284A1 (fr) 2018-09-19 2020-03-26 Modernatx, Inc. Lipides peg et leurs utilisations
CA3132975A1 (fr) 2019-03-11 2020-09-17 Modernatx, Inc. Procede de transcription in vitro a alimentation semi-discontinue
EP4274607A1 (fr) 2021-01-11 2023-11-15 ModernaTX, Inc. Vaccins contre le virus de la grippe à arn saisonnière
US20220363937A1 (en) 2021-05-14 2022-11-17 Armstrong World Industries, Inc. Stabilization of antimicrobial coatings
EP4525830A1 (fr) * 2022-05-17 2025-03-26 ModernaTX, Inc. Préparation d'arnm hautement concentré
CN118166004B (zh) * 2024-05-14 2024-12-03 北京剂泰医药科技有限公司 用于编码人PCCA或PCCB蛋白的mRNA及其用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
TR201909609T4 (tr) 2005-08-23 2019-07-22 Univ Pennsylvania Modifiye edilmiş nükleosidleri içeren rna ve kullanım yöntemleri.
CA2634131C (fr) 2005-12-21 2014-02-11 Wyeth Formulations de proteines a viscosite reduite et leurs utilisations
WO2009030254A1 (fr) * 2007-09-04 2009-03-12 Curevac Gmbh Complexes d'arn et de peptides cationiques pour transfection et immunostimulation
RS58405B1 (sr) 2009-12-01 2019-04-30 Translate Bio Inc Stereoidni derivati za isporuku irnk u humanim genetskim oboljenjima
US8853377B2 (en) 2010-11-30 2014-10-07 Shire Human Genetic Therapies, Inc. mRNA for use in treatment of human genetic diseases
WO2012129648A1 (fr) 2011-03-25 2012-10-04 University Of Guelph Activation d'expression de protéines de vecteurs de virus adéno-associés
RU2649364C2 (ru) 2011-12-16 2018-04-02 Модерна Терапьютикс, Инк. Составы на основе модифицированного нуклеозида, нуклеотида и нуклеиновой кислоты
AU2013243954A1 (en) 2012-04-02 2014-10-30 Moderna Therapeutics, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
CA2876155C (fr) 2012-06-08 2022-12-13 Ethris Gmbh Administration pulmonaire d'arnm a des cellules cibles autres que pulmonaires
HRP20220607T1 (hr) 2012-11-26 2022-06-24 Modernatx, Inc. Terminalno modificirana rna
US20160032316A1 (en) * 2013-03-14 2016-02-04 The Trustees Of The University Of Pennsylvania Purification and Purity Assessment of RNA Molecules Synthesized with Modified Nucleosides
US11219634B2 (en) * 2015-01-21 2022-01-11 Genevant Sciences Gmbh Methods, compositions, and systems for delivering therapeutic and diagnostic agents into cells
EP3291829A1 (fr) * 2015-05-03 2018-03-14 The Regents of the University of Colorado, a body corporate Compositions de propionyl-coa carboxylase et utilisations de celles-ci
WO2017100551A1 (fr) * 2015-12-09 2017-06-15 Alexion Pharmaceuticals, Inc. Séquences utr hétérologues pour l'amplification de l'expression d'arnm

Also Published As

Publication number Publication date
US20200165593A1 (en) 2020-05-28
WO2019018765A1 (fr) 2019-01-24
EP3655040A1 (fr) 2020-05-27

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