MA49634A - Arnm modifié codant pour une propionyl-coa-carboxylase et utilisations associées - Google Patents

Arnm modifié codant pour une propionyl-coa-carboxylase et utilisations associées

Info

Publication number
MA49634A
MA49634A MA049634A MA49634A MA49634A MA 49634 A MA49634 A MA 49634A MA 049634 A MA049634 A MA 049634A MA 49634 A MA49634 A MA 49634A MA 49634 A MA49634 A MA 49634A
Authority
MA
Morocco
Prior art keywords
carboxylase
propionyl
coa
modified rna
rna coding
Prior art date
Application number
MA049634A
Other languages
English (en)
Inventor
Judith L Campagnari
Zhiliang Cheng
Susan Sobolov-Jaynes
Romesh R Subramanian
Haren Vasavada
Original Assignee
Modernatx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Modernatx Inc filed Critical Modernatx Inc
Publication of MA49634A publication Critical patent/MA49634A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01041—Methylmalonyl-CoA decarboxylase (4.1.1.41)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y604/00—Ligases forming carbon-carbon bonds (6.4)
    • C12Y604/01—Ligases forming carbon-carbon bonds (6.4.1)
    • C12Y604/01003—Propionyl-CoA carboxylase (6.4.1.3)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MA049634A 2017-07-21 2018-07-20 Arnm modifié codant pour une propionyl-coa-carboxylase et utilisations associées MA49634A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762535289P 2017-07-21 2017-07-21

Publications (1)

Publication Number Publication Date
MA49634A true MA49634A (fr) 2020-05-27

Family

ID=63165470

Family Applications (1)

Application Number Title Priority Date Filing Date
MA049634A MA49634A (fr) 2017-07-21 2018-07-20 Arnm modifié codant pour une propionyl-coa-carboxylase et utilisations associées

Country Status (4)

Country Link
US (1) US20200165593A1 (fr)
EP (1) EP3655040A1 (fr)
MA (1) MA49634A (fr)
WO (1) WO2019018765A1 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL4023249T3 (pl) 2014-04-23 2025-03-10 Modernatx, Inc. Szczepionki z kwasem nukleinowym
MA42543A (fr) 2015-07-30 2018-06-06 Modernatx Inc Arn épitope peptidiques concatémériques
AU2016341309A1 (en) 2015-10-22 2018-06-07 Modernatx, Inc. Cancer vaccines
CA3036831A1 (fr) 2016-09-14 2018-03-22 Modernatx, Inc. Compositions d'arn de haute purete et procedes pour leur preparation
MA46766A (fr) 2016-11-11 2019-09-18 Modernatx Inc Vaccin antigrippal
WO2019036682A1 (fr) 2017-08-18 2019-02-21 Modernatx, Inc. Variants d'arn polymérase
EP3714045A1 (fr) * 2017-11-22 2020-09-30 Modernatx, Inc. Polynucléotides codant pour des sous-unités alpha et bêta de propionyl-coa carboxylase pour le traitement de l'acidémie propionique
EP3746090A4 (fr) 2018-01-29 2021-11-17 ModernaTX, Inc. Vaccins à base d'arn contre le vrs
CA3113025A1 (fr) 2018-09-19 2020-03-26 Modernatx, Inc. Lipides peg et leurs utilisations
WO2020061295A1 (fr) 2018-09-19 2020-03-26 Modernatx, Inc. Lipides peg de haute pureté et leurs utilisations
CN113874502A (zh) 2019-03-11 2021-12-31 摩登纳特斯有限公司 补料分批体外转录方法
EP4274607A1 (fr) 2021-01-11 2023-11-15 ModernaTX, Inc. Vaccins contre le virus de la grippe à arn saisonnière
US20220363937A1 (en) 2021-05-14 2022-11-17 Armstrong World Industries, Inc. Stabilization of antimicrobial coatings
EP4525830A1 (fr) * 2022-05-17 2025-03-26 ModernaTX, Inc. Préparation d'arnm hautement concentré
CN118166004B (zh) * 2024-05-14 2024-12-03 北京剂泰医药科技有限公司 用于编码人PCCA或PCCB蛋白的mRNA及其用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
PL2578685T3 (pl) 2005-08-23 2020-01-31 The Trustees Of The University Of Pennsylvania Rna zawierający zmodyfikowane nukleozydy i sposoby jego zastosowania
BRPI0620316A2 (pt) 2005-12-21 2011-11-08 Wyeth Corp formulações de proteìnas com viscosidades reduzida e seus usos
WO2009030254A1 (fr) * 2007-09-04 2009-03-12 Curevac Gmbh Complexes d'arn et de peptides cationiques pour transfection et immunostimulation
EP3318248B1 (fr) 2009-12-01 2019-04-10 Translate Bio, Inc. Administration d'arnm pour l'augmentation des protéines et des enzymes dans des maladies génétiques humaines
US8853377B2 (en) 2010-11-30 2014-10-07 Shire Human Genetic Therapies, Inc. mRNA for use in treatment of human genetic diseases
WO2012129648A1 (fr) 2011-03-25 2012-10-04 University Of Guelph Activation d'expression de protéines de vecteurs de virus adéno-associés
CA3018046A1 (fr) 2011-12-16 2013-06-20 Moderna Therapeutics, Inc. Nucleoside, nucleotide, et compositions d'acide nucleique modifies
WO2013151665A2 (fr) 2012-04-02 2013-10-10 modeRNA Therapeutics Polynucléotides modifiés destinés à la production de protéines associées à une maladie humaine
EP2858679B2 (fr) 2012-06-08 2024-06-05 Translate Bio, Inc. Administration pulmonaire d'arnm à des cellules cibles autres que pulmonaires
PL2922554T3 (pl) 2012-11-26 2022-06-20 Modernatx, Inc. Na zmodyfikowany na końcach
US20160032316A1 (en) * 2013-03-14 2016-02-04 The Trustees Of The University Of Pennsylvania Purification and Purity Assessment of RNA Molecules Synthesized with Modified Nucleosides
JP2018509387A (ja) * 2015-01-21 2018-04-05 フェーズアールエックス インコーポレイテッド 細胞に治療および診断剤を送達するための方法、組成物、ならびにシステム
WO2016179138A1 (fr) * 2015-05-03 2016-11-10 The Regents Of The University Of Colorado Compositions de propionyl-coa carboxylase et utilisations de celles-ci
WO2017100551A1 (fr) * 2015-12-09 2017-06-15 Alexion Pharmaceuticals, Inc. Séquences utr hétérologues pour l'amplification de l'expression d'arnm

Also Published As

Publication number Publication date
US20200165593A1 (en) 2020-05-28
WO2019018765A1 (fr) 2019-01-24
EP3655040A1 (fr) 2020-05-27

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