MA49809A1 - Composés utilisés comme inhibiteurs de kinase - Google Patents

Composés utilisés comme inhibiteurs de kinase

Info

Publication number
MA49809A1
MA49809A1 MA49809A MA49809A MA49809A1 MA 49809 A1 MA49809 A1 MA 49809A1 MA 49809 A MA49809 A MA 49809A MA 49809 A MA49809 A MA 49809A MA 49809 A1 MA49809 A1 MA 49809A1
Authority
MA
Morocco
Prior art keywords
kinase inhibitors
compounds used
tyrosine kinase
compounds
inhibitors
Prior art date
Application number
MA49809A
Other languages
English (en)
Inventor
Nicolas Guisot
Original Assignee
Loxo Oncology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1522245.8A external-priority patent/GB201522245D0/en
Priority claimed from GBGB1613945.3A external-priority patent/GB201613945D0/en
Application filed by Loxo Oncology Inc filed Critical Loxo Oncology Inc
Publication of MA49809A1 publication Critical patent/MA49809A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/08—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne de nouveaux composés. Les composés selon l'invention sont des inhibiteurs de tyrosine kinase. De manière spécifique, les composés selon l'invention sont utilisés comme inhibiteurs de la tyrosine kinase de bruton (btk). L'invention concerne également l'utilisation de ces composés pour le traitement d'affections pouvant être traitées en inhibant la tyrosine kinase de bruton, par exemple le cancer, le lymphome, la leucémie et les maladies immunologiques.
MA49809A 2015-12-16 2016-12-16 Composés utilisés comme inhibiteurs de kinase MA49809A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1522245.8A GB201522245D0 (en) 2015-12-16 2015-12-16 Compounds useful as kinase inhibitors
GBGB1613945.3A GB201613945D0 (en) 2016-08-15 2016-08-15 Compounds useful as kinase inhibitors
PCT/GB2016/053968 WO2017103611A1 (fr) 2015-12-16 2016-12-16 Composés utilisés comme inhibiteurs de kinase

Publications (1)

Publication Number Publication Date
MA49809A1 true MA49809A1 (fr) 2021-08-31

Family

ID=57590725

Family Applications (2)

Application Number Title Priority Date Filing Date
MA055064A MA55064A (fr) 2015-12-16 2016-12-16 Composés utilisés comme inhibiteurs de kinase
MA49809A MA49809A1 (fr) 2015-12-16 2016-12-16 Composés utilisés comme inhibiteurs de kinase

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MA055064A MA55064A (fr) 2015-12-16 2016-12-16 Composés utilisés comme inhibiteurs de kinase

Country Status (38)

Country Link
US (8) US10695323B2 (fr)
EP (2) EP3782994B1 (fr)
JP (3) JP6731483B2 (fr)
KR (2) KR102215792B1 (fr)
CN (9) CN114716381B (fr)
AU (4) AU2016373530B2 (fr)
CA (1) CA3008488C (fr)
CL (1) CL2018001591A1 (fr)
CO (1) CO2018006164A2 (fr)
CR (1) CR20180367A (fr)
CY (2) CY1123561T1 (fr)
DK (1) DK3390395T3 (fr)
EA (1) EA035132B1 (fr)
ES (2) ES3041897T3 (fr)
FI (1) FIC20240004I1 (fr)
FR (1) FR24C1009I2 (fr)
HR (1) HRP20201835T1 (fr)
HU (2) HUE051921T2 (fr)
IL (4) IL285976B2 (fr)
LT (2) LT3390395T (fr)
LU (1) LUC00330I2 (fr)
MA (2) MA55064A (fr)
MD (1) MD3390395T2 (fr)
MX (2) MX394193B (fr)
MY (2) MY200590A (fr)
NL (1) NL301262I2 (fr)
NO (1) NO2024008I1 (fr)
NZ (1) NZ743553A (fr)
PE (3) PE20181449A1 (fr)
PH (1) PH12018501268A1 (fr)
PT (1) PT3390395T (fr)
RS (1) RS60982B9 (fr)
SG (2) SG10202012498TA (fr)
SI (1) SI3390395T1 (fr)
TN (1) TN2018000213A1 (fr)
UA (2) UA127863C2 (fr)
WO (1) WO2017103611A1 (fr)
ZA (5) ZA201804137B (fr)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201410430D0 (en) 2014-06-11 2014-07-23 Redx Pharma Ltd Compounds
JP7337502B2 (ja) 2015-09-16 2023-09-04 ロクソ オンコロジー， インコーポレイテッド がんの治療のためのｂｔｋ阻害剤としてのピラゾロピリミジン誘導体
CN114716381B (zh) 2015-12-16 2025-03-11 洛克索肿瘤学股份有限公司 可用作激酶抑制剂的化合物
GB201801226D0 (en) 2018-01-25 2018-03-14 Redx Pharma Plc Modulators of Rho-associated protein kinase
WO2019195810A2 (fr) * 2018-04-06 2019-10-10 Praxis Biotech LLC Inhibiteurs d'atf6 et leurs utilisations
JP6995195B2 (ja) 2018-05-18 2022-02-04 富士フイルム株式会社 ３－ジフルオロメチルピラゾール化合物の製造方法及び３－ジフルオロメチルピラゾール－４－カルボン酸化合物の製造方法、並びに、ピラゾリジン化合物
CN117285467A (zh) * 2018-07-31 2023-12-26 罗索肿瘤学公司 喷雾干燥的分散体和制剂
EP4010333A1 (fr) 2019-08-09 2022-06-15 Kalvista Pharmaceuticals Limited Inhibiteurs de la kallicréine plasmatique
WO2021053234A1 (fr) * 2019-09-19 2021-03-25 Johann Wolfgang Goethe-Universität Frankfurt am Main Composés et compositions pour le traitement d'une maladie rénale
CN110724135B (zh) * 2019-11-18 2023-04-28 上海医药工业研究院有限公司 一种艾拉普林中间体及其制备方法
JP7142173B2 (ja) 2019-12-06 2022-09-26 ロクソ オンコロジー， インコーポレイテッド ブルトン型チロシンキナーゼ阻害剤の投薬
MX2022008148A (es) 2020-01-02 2022-07-21 Dizal Jiangsu Pharmaceutical Co Ltd Inhibidores de btk.
WO2021180107A1 (fr) * 2020-03-12 2021-09-16 Fochon Pharmaceuticals, Ltd. Composés utiles en tant qu'inhibiteurs de kinase
TW202317099A (zh) * 2020-09-10 2023-05-01 美商絡速藥業公司 用於製備(s)-5-胺基-3-(4-((5-氟-2-甲氧基苯甲醯胺基)甲基)苯基)-1-(1,1,1-三氟丙烷-2-基)-1h-吡唑-4-甲醯胺之方法及中間體
CN112386597B (zh) * 2020-10-15 2022-03-15 天津济坤医药科技有限公司 泽布替尼在制备治疗肺纤维化疾病药物中的应用
US20240100172A1 (en) 2020-12-21 2024-03-28 Hangzhou Jijing Pharmaceutical Technology Limited Methods and compounds for targeted autophagy
CN116348453B (zh) * 2021-04-25 2025-07-04 烨辉医药科技(上海)有限公司 杂芳族甲酰胺化合物及其用途
WO2022240920A1 (fr) * 2021-05-14 2022-11-17 Loxo Oncology, Inc. Formes cocristallines d'un inhibiteur de la tyrosine kinase de bruton
JP2024524480A (ja) * 2021-07-01 2024-07-05 ハンチョウ、ヘルズン、セラピューティクス、カンパニー、リミテッド ブルトン型チロシンキナーゼ及びその突然変異体の分解剤、組成物並びにそれらの応用
CN115611810B (zh) * 2021-07-16 2025-03-04 深圳市塔吉瑞生物医药有限公司 取代的吡唑类化合物及包含该化合物的组合物及其用途
KR20240157639A (ko) 2021-12-14 2024-11-01 크로스파이어 온콜로지 홀딩 비.브이. 거대고리 btk 억제제
WO2023143355A1 (fr) * 2022-01-28 2023-08-03 Hansoh Bio Llc Dérivé d'amide d'azacycle, ses procédés de préparation et ses utilisations médicinales
JP2025508964A (ja) * 2022-03-03 2025-04-10 深▲チェン▼市塔吉瑞生物医薬有限公司 シクロアルキルまたはヘテロシクリルで置換されたヘテロアリール化合物、並びにその組成物及び使用
EP4493557A4 (fr) * 2022-03-18 2026-03-18 Insilico Medicine Ip Ltd Inhibiteurs de kinase inhibitrice de cdc2 spécifique de la tyrosine et de la thréonine associés à une membrane de pyrazole (pkmyt1) et leurs utilisations
CN115894376B (zh) * 2022-12-15 2025-05-16 南京雷正医药科技有限公司 一种芳香族酰胺类化合物、药物组合物及其用途
IL322630A (en) 2023-02-22 2025-10-01 Assia Chem Ind Ltd Solid forms of pirobrutinib
WO2024245577A1 (fr) 2023-06-02 2024-12-05 Netherlands Translational Research Center Holding B.V. Combinaisons thérapeutiques d'un inhibiteur irréversible de btk et d'un inhibiteur réversible de btk
WO2024245578A1 (fr) 2023-06-02 2024-12-05 Netherlands Translational Research Center Holding B.V. Combinaisons thérapeutiques d'un inhibiteur de btk irréversible et d'un inhibiteur de btk réversible macrocyclique
WO2024246287A1 (fr) 2023-06-02 2024-12-05 Crossfire Oncology Holding B.V. Utilisation médicale d'un inhibiteur de btk réversible macrocyclique
WO2024256568A1 (fr) 2023-06-13 2024-12-19 Crossfire Oncology Holding B.V. Formes salines et formes cristallines d'un inhibiteur de btk macrocyclique
WO2024256574A1 (fr) 2023-06-13 2024-12-19 Crossfire Oncology Holding B.V. Procédé de préparation d'inhibiteurs de btk macrocycliques
KR20250046558A (ko) 2023-09-27 2025-04-03 임창섭 5g 사물인터넷 기반 하드월렛 간의 디지털자산 안심이체 시스템
WO2025124496A1 (fr) * 2023-12-13 2025-06-19 正大天晴药业集团股份有限公司 Composé contenant un cycle pyrazole et un groupe hétéroaryle bicyclique, composition pharmaceutique et utilisation associées
WO2025137329A1 (fr) * 2023-12-22 2025-06-26 Neupharma, Inc Entités chimiques particulières, compositions et procédés
CN119059974B (zh) * 2024-08-12 2025-10-28 武汉九州钰民医药科技有限公司 一种吡托布鲁替尼的制备方法
CN119059973A (zh) * 2024-08-12 2024-12-03 武汉九州钰民医药科技有限公司 一种吡托布鲁替尼的合成工艺
CN120504661B (zh) * 2025-07-14 2025-11-07 复旦大学 Alkbh8小分子抑制剂及其制备方法和用途

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6921763B2 (en) 1999-09-17 2005-07-26 Abbott Laboratories Pyrazolopyrimidines as therapeutic agents
JP2003509428A (ja) 1999-09-17 2003-03-11 アボツト・ゲー・エム・ベー・ハー・ウント・コンパニー・カーゲー 治療薬としてのピラゾロピリミジン
US6291504B1 (en) * 1999-10-20 2001-09-18 Dupont Pharmaceuticals Company Acylsemicarbazides and their uses
US20030225098A1 (en) 2002-03-21 2003-12-04 Hirst Gavin C. Kinase inhibitors
DK2526933T3 (en) 2006-09-22 2015-05-18 Pharmacyclics Inc Inhibitors of Bruton's tyrosine kinase
EP2068869A4 (fr) * 2006-10-06 2011-05-25 Abbott Lab Nouveaux imidazothiazoles et imidazoxazoles
CA2668286C (fr) 2006-11-03 2014-09-16 Pharmacyclics, Inc. Sonde d'activite de la tyrosine kinase de bruton et son procede d'utilisation
SG10202107066WA (en) 2007-03-28 2021-07-29 Pharmacyclics Llc Inhibitors of bruton's tyrosine kinase
NZ603525A (en) 2008-06-27 2015-02-27 Celgene Avilomics Res Inc Pyrimidine based compound and uses thereof
US8338439B2 (en) 2008-06-27 2012-12-25 Celgene Avilomics Research, Inc. 2,4-disubstituted pyrimidines useful as kinase inhibitors
CA2730930C (fr) 2008-07-16 2015-01-13 Pharmacyclics, Inc. Inhibiteurs de tyrosine kinase de bruton pour le traitement de tumeurs solides
PT2324008E (pt) * 2008-07-24 2012-06-25 Nerviano Medical Sciences Srl 3,4-diarilpirazoles como inibidores da proteína quinase
US8426428B2 (en) 2008-12-05 2013-04-23 Principia Biopharma, Inc. EGFR kinase knockdown via electrophilically enhanced inhibitors
US7718662B1 (en) 2009-10-12 2010-05-18 Pharmacyclics, Inc. Pyrazolo-pyrimidine inhibitors of bruton's tyrosine kinase
CA3007787C (fr) 2010-06-03 2020-03-10 Pharmacyclics Llc Utilisation d'inhibiteurs de la tyrosine kinase de bruton (btk)
EP2588465B1 (fr) 2010-06-30 2017-01-25 Ironwood Pharmaceuticals, Inc. Stimulateurs de sgc
PL2710005T3 (pl) 2011-05-17 2017-07-31 Principia Biopharma Inc. Inhibitory kinazy tyrozynowej
ES2770550T3 (es) 2011-05-17 2020-07-02 Univ California Inhibidores de quinasa
JP2014520863A (ja) 2011-07-13 2014-08-25 ファーマサイクリックス，インク． Ｂｒｕｔｏｎ型チロシンキナーゼの阻害剤
EP2548877A1 (fr) 2011-07-19 2013-01-23 MSD Oss B.V. Dérivés de 4-(pyridine condensée à 5 chaînons)benzamide comme inhibiteurs de BTK
US8377946B1 (en) 2011-12-30 2013-02-19 Pharmacyclics, Inc. Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
WO2013191965A1 (fr) 2012-06-18 2013-12-27 Principia Biopharma Inc. Pyrrolopyrimidines ou pyrazolopyrimidines covalentes réversibles utiles pour le traitement du cancer et de maladies auto-immunes
WO2014022569A1 (fr) 2012-08-03 2014-02-06 Principia Biopharma Inc. Traitement de la sécheresse oculaire
SG11201500499TA (en) * 2012-08-10 2015-03-30 Boehringer Ingelheim Int Heteroaromatic compounds as bruton's tyrosine kinase (btk) inhibitors
GB201214750D0 (en) * 2012-08-17 2012-10-03 Respivert Ltd Compounds
KR101668574B1 (ko) * 2012-11-02 2016-10-24 화이자 인코포레이티드 브루톤 티로신 키나제 억제제
CN103848810A (zh) * 2012-11-30 2014-06-11 北京赛林泰医药技术有限公司 鲁顿酪氨酸激酶抑制剂
US8957080B2 (en) 2013-04-09 2015-02-17 Principia Biopharma Inc. Tyrosine kinase inhibitors
GB201309085D0 (en) 2013-05-20 2013-07-03 Redx Pharma Ltd Compounds
KR102272792B1 (ko) * 2013-09-30 2021-07-05 광저우 이노케어 파마 테크 씨오., 엘티디. Ｂｔｋ의 치환된 니코틴이미드 저해제 및 그의 제조 방법 및 암, 염증 및 자가면역 질환에의 용도
WO2015075051A1 (fr) * 2013-11-19 2015-05-28 Universitaet Des Saarlandes Inhibiteurs allostériques de protéines kinases c atypiques
WO2015095099A1 (fr) 2013-12-20 2015-06-25 Merck Sharp & Dohme Corp. Inhibiteurs de btk
CN112353806A (zh) 2014-02-21 2021-02-12 普林斯匹亚生物制药公司 Btk抑制剂的盐和固体形式
GB201404987D0 (en) 2014-03-20 2014-05-07 Redx Pharma Ltd Compounds
CN105085474B (zh) * 2014-05-07 2018-05-18 北京赛林泰医药技术有限公司 鲁顿酪氨酸激酶抑制剂
GB201410430D0 (en) * 2014-06-11 2014-07-23 Redx Pharma Ltd Compounds
TN2017000329A1 (en) 2015-01-28 2019-01-16 Bayer Pharma AG 4h-pyrrolo[3,2-c]pyridin-4-one derivatives
GB2548542A (en) * 2015-06-16 2017-09-27 Redx Pharma Plc Compounds
JP7337502B2 (ja) 2015-09-16 2023-09-04 ロクソ オンコロジー， インコーポレイテッド がんの治療のためのｂｔｋ阻害剤としてのピラゾロピリミジン誘導体
JOP20160198B1 (ar) 2015-09-16 2022-03-14 Janssen Pharmaceuticals Inc مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JO3633B1 (ar) 2015-09-16 2020-08-27 Katholieke Univ Leuven Ku Leuven Research & Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
KR20180095871A (ko) 2015-12-16 2018-08-28 프리오스타 피티와이 엘티디 덴드리머 및 그의 배합물
LT3390390T (lt) 2015-12-16 2021-11-25 Boehringer Ingelheim International Gmbh Bipirazolilo dariniai, tinkami naudoti autoimuninių ligų gydymui
TW201725203A (zh) 2015-12-16 2017-07-16 必治妥美雅史谷比公司 作為ａｐｊ受體促效劑之雜芳基羥基嘧啶酮
CN108367243B (zh) 2015-12-16 2021-09-28 艺康美国股份有限公司 用于膜过滤清洁的过氧甲酸组合物
CN114716381B (zh) 2015-12-16 2025-03-11 洛克索肿瘤学股份有限公司 可用作激酶抑制剂的化合物

Also Published As

Publication number Publication date
CN113603645B (zh) 2024-10-29
CN114621146A (zh) 2022-06-14
AU2021201811B2 (en) 2022-01-27
ES2828431T3 (es) 2021-05-26
JP6731483B2 (ja) 2020-07-29
CY2024003I2 (el) 2024-09-20
TN2018000213A1 (en) 2019-10-04
US10464905B2 (en) 2019-11-05
RS60982B9 (sr) 2025-07-31
MY202026A (en) 2024-03-29
PE20220502A1 (es) 2022-04-07
US10918622B2 (en) 2021-02-16
US20180362512A1 (en) 2018-12-20
CO2018006164A2 (es) 2018-09-20
HUS2400003I1 (hu) 2024-03-28
US20210093611A1 (en) 2021-04-01
EP3390395B1 (fr) 2020-09-09
US20200276162A1 (en) 2020-09-03
US20190000806A1 (en) 2019-01-03
NZ743553A (en) 2022-08-26
MX2018007267A (es) 2018-11-09
EP3782994A1 (fr) 2021-02-24
NO2024008I1 (no) 2024-02-29
CY1123561T1 (el) 2022-03-24
AU2021201811A1 (en) 2021-04-22
FR24C1009I1 (fr) 2024-05-24
US20220062239A1 (en) 2022-03-03
ES3041897T3 (en) 2025-11-17
AU2021225162B2 (en) 2023-08-03
KR20180115261A (ko) 2018-10-22
EA035132B1 (ru) 2020-04-30
CL2018001591A1 (es) 2018-09-28
CN113636978B (zh) 2024-10-29
UA122258C2 (uk) 2020-10-12
AU2016373530B2 (en) 2021-01-21
LT3390395T (lt) 2020-11-25
MD3390395T2 (ro) 2021-02-28
US12220401B2 (en) 2025-02-11
AU2016373530A1 (en) 2018-07-05
MX2021003478A (es) 2022-07-25
KR102215792B1 (ko) 2021-02-16
IL285976B1 (en) 2023-06-01
AU2021225161B2 (en) 2023-08-03
LTPA2024506I1 (fr) 2024-03-25
IL259923B (en) 2020-08-31
MX394193B (es) 2025-03-21
UA127863C2 (uk) 2024-01-31
CN114573510A (zh) 2022-06-03
US20190135762A1 (en) 2019-05-09
ZA202100544B (en) 2023-06-28
PE20181449A1 (es) 2018-09-12
US20230372298A1 (en) 2023-11-23
AU2021225162A1 (en) 2021-09-30
JP2020172535A (ja) 2020-10-22
CN114634447B (zh) 2024-11-15
JP2022120013A (ja) 2022-08-17
CN108473481A (zh) 2018-08-31
CN114591242A (zh) 2022-06-07
CA3008488A1 (fr) 2017-06-22
SG11201805044WA (en) 2018-07-30
CN114605327A (zh) 2022-06-10
SI3390395T1 (sl) 2020-11-30
ZA202003176B (en) 2026-03-25
US11471441B2 (en) 2022-10-18
WO2017103611A1 (fr) 2017-06-22
CN114634447A (zh) 2022-06-17
IL276283B (en) 2021-03-25
CN114716381A (zh) 2022-07-08
FIC20240004I1 (fi) 2024-03-01
HUE051921T2 (hu) 2021-03-29
CN113603645A (zh) 2021-11-05
NL301262I2 (nl) 2024-04-24
PH12018501268A1 (en) 2019-02-18
IL281067B (en) 2022-04-01
FR24C1009I2 (fr) 2025-02-07
EP3782994B1 (fr) 2025-07-16
CN113636978A (zh) 2021-11-12
IL276283A (en) 2020-09-30
PT3390395T (pt) 2020-11-03
US10695323B2 (en) 2020-06-30
DK3390395T3 (da) 2020-09-28
CN114573510B (zh) 2025-02-25
CN114716381B (zh) 2025-03-11
SG10202012498TA (en) 2021-01-28
JP2018538307A (ja) 2018-12-27
HK1263254A1 (en) 2020-02-21
CY2024003I1 (el) 2024-09-20
EA201891268A1 (ru) 2018-11-30
MY200590A (en) 2024-01-04
IL259923A (en) 2018-07-31
US10342780B2 (en) 2019-07-09
AU2021225161A1 (en) 2021-09-30
BR112018012341A2 (pt) 2018-12-04
US11826351B2 (en) 2023-11-28
KR20210018530A (ko) 2021-02-17
JP7419437B2 (ja) 2024-01-22
CA3008488C (fr) 2023-10-10
MA55064A (fr) 2021-09-29
EP3390395A1 (fr) 2018-10-24
IL285976B2 (en) 2023-10-01
ZA201804137B (en) 2022-08-31
RS60982B1 (sr) 2020-11-30
CN114605327B (zh) 2025-03-11
ZA202107472B (en) 2023-03-29
IL285976A (en) 2021-10-31
JP7086140B2 (ja) 2022-06-17
CN114591242B (zh) 2025-01-07
LUC00330I2 (fr) 2026-03-04
CR20180367A (es) 2018-11-12
MX380907B (es) 2025-03-12
CN108473481B (zh) 2022-04-19
ZA202107471B (en) 2023-03-29
PE20220507A1 (es) 2022-04-07
US20250090500A1 (en) 2025-03-20
HRP20201835T1 (hr) 2021-01-08
IL281067A (en) 2021-04-29

Similar Documents

Publication Publication Date Title
MA49809A1 (fr) Composés utilisés comme inhibiteurs de kinase
PH12018500587A1 (en) Pyrazolopyrimidine derivatives as btk inhibitors for the treatment of cancer
WO2020160193A3 (fr) Composés et leurs utilisations
MX2023005636A (es) Inhibidores de bcl6 derivados de bencimidazolona.
EA202091709A1 (ru) Ингибиторы днк-пк
EA202091708A1 (ru) Ингибиторы днк-пк
ZA202005326B (en) Heteroaryl compounds as type ii irak inhibitors and uses hereof
MA41134A (fr) Composés substitués de 5-amino-6h-thiazolo[4,5-d]pyrimidine-2,7-dione pour le traitement et la prophylaxie des infections virales
MX383213B (es) Inhibidores de tirosina-cinasas
EP4371562A3 (fr) Dérivés de la 2-quinolone en tant qu'inhibiteurs du récepteur bcl6
MA39211B1 (fr) Composés tricycliques comme agents anti-cancers
MA43409B1 (fr) Composés polycycliques à utiliser en tant qu'inhibiteurs de la tyrosine kinase de bruton
MX2020010805A (es) Inhibidores de bcl6.
MA39170B1 (fr) Composes inhibiteurs de sérine/thréonine kinase pour leurs utilisations dans le traitement du cancer
MA34968B1 (fr) Urées asymétriques et utilisations médicales de celles-ci
PH12021550743A1 (en) Boron containing pde4 inhibitors
MX2023001296A (es) Composiciones y metodos para tratar enfermedades y trastornos.
MX2015010983A (es) Inhibidores de tirosina-cinasa de bruton.
MA42871B1 (fr) Composés utilisés comme inhibiteurs de la tyrosine kinase de bruton (btk)
MA42175B1 (fr) Dérivés de pyrazolopyrimidine comme inhibiteurs de btk pour le traitement du cancer
MX2015010820A (es) Inhibidores de tirosina cinasa de bruton.
MA38523A1 (fr) Composés triazoliques tricycliques utilisés en tant que ligands des récepteurs sigma
MA45367B1 (fr) Inhibiteurs de la tyrosine kinase
MA51297B1 (fr) Quinazolinones en tant qu'inhibiteurs de parp14
EA202092344A1 (ru) Гетероциклические соединения в качестве иммуномодуляторов