MA50056A - Procédés de traitement de tumeur - Google Patents

Procédés de traitement de tumeur

Info

Publication number
MA50056A
MA50056A MA050056A MA50056A MA50056A MA 50056 A MA50056 A MA 50056A MA 050056 A MA050056 A MA 050056A MA 50056 A MA50056 A MA 50056A MA 50056 A MA50056 A MA 50056A
Authority
MA
Morocco
Prior art keywords
treatment processes
tumor treatment
tumor
processes
treatment
Prior art date
Application number
MA050056A
Other languages
English (en)
Inventor
Prabhu Seshaiyer Bhagavatheeswaran
Nicholas Allan John Botwood
Han Chang
Yali Fu
William J Geese
George A Green Iv
Diane Healey
Sabine Maier
Faith E Nathan
Abderrahim Oukessou
Giovanni Selvaggi
Joseph Daniel Szustakowski
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MA50056A publication Critical patent/MA50056A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hospice & Palliative Care (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
MA050056A 2017-03-31 2018-03-30 Procédés de traitement de tumeur MA50056A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762479817P 2017-03-31 2017-03-31
US201762582146P 2017-11-06 2017-11-06

Publications (1)

Publication Number Publication Date
MA50056A true MA50056A (fr) 2020-02-05

Family

ID=62067782

Family Applications (1)

Application Number Title Priority Date Filing Date
MA050056A MA50056A (fr) 2017-03-31 2018-03-30 Procédés de traitement de tumeur

Country Status (13)

Country Link
US (3) US20210101980A1 (fr)
EP (1) EP3601355A1 (fr)
JP (2) JP7458188B2 (fr)
KR (2) KR20250036268A (fr)
CN (1) CN110494450A (fr)
AU (2) AU2018243754B2 (fr)
BR (1) BR112019019795A2 (fr)
CA (1) CA3058175A1 (fr)
IL (3) IL269026B2 (fr)
MA (1) MA50056A (fr)
MX (2) MX2019010958A (fr)
SG (2) SG11201908396PA (fr)
WO (1) WO2018183928A1 (fr)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9856320B2 (en) 2012-05-15 2018-01-02 Bristol-Myers Squibb Company Cancer immunotherapy by disrupting PD-1/PD-L1 signaling
WO2016176503A1 (fr) 2015-04-28 2016-11-03 Bristol-Myers Squibb Company Traitement du mélanome pd-l1 négatif à l'aide d'un anticorps anti-pd-1 et d'un anticorps anti-ctla-4
EP3288980B1 (fr) 2015-04-28 2021-03-10 Bristol-Myers Squibb Company Traitement du mélanome pd-l1 positif à l'aide d'un anticorps anti-pd-1
MX383464B (es) 2015-07-13 2025-03-14 Cytomx Therapeutics Inc Anticuerpos anti-pd-1, anticuerpos anti-pd-1 activables, y métodos de uso de los mismos.
MX392711B (es) 2015-08-11 2025-03-24 Wuxi Biologics Ireland Ltd Anticuerpos anti-pd-1 novedosos.
EP3694884A1 (fr) * 2017-10-15 2020-08-19 Bristol-Myers Squibb Company Procédés de traitement de tumeur
US12668635B1 (en) 2017-11-21 2026-06-30 Arcus Biosciences, Inc. Methods of treating solid tumors using an anti-PD-1 antibody or a fragment thereof
JP7351845B2 (ja) * 2018-03-23 2023-09-27 ブリストル-マイヤーズ スクイブ カンパニー Micaおよび/またはmicbに対する抗体ならびにそれらの使用
EP3774911A1 (fr) * 2018-03-30 2021-02-17 Bristol-Myers Squibb Company Méthodes de traitement de tumeur
MX2020009824A (es) 2018-07-25 2021-01-15 Alteogen Inc Nuevas variantes de hialuronidasa y composicion farmaceutica que comprende la misma.
ES3069978T3 (en) * 2018-10-17 2026-06-11 Tempus Ai Inc Data based cancer research and treatment systems and methods
MX2021004356A (es) 2018-10-18 2021-05-31 Merck Sharp & Dohme Llc Formulaciones de anticuerpos anti-rsv y metodos de uso de las mismas.
JP2022505647A (ja) 2018-10-23 2022-01-14 ブリストル-マイヤーズ スクイブ カンパニー 腫瘍の処置方法
MA54089A (fr) 2018-10-31 2022-02-09 Merck Sharp & Dohme Anticorps anti-pd-1 humain et procédés d'utilisation associés
JP7503056B6 (ja) 2018-11-07 2024-07-16 メルク・シャープ・アンド・ドーム・エルエルシー 抗lag3抗体および抗pd-1抗体の共-製剤
CA3120200A1 (fr) 2018-11-15 2020-05-22 Personal Genome Diagnostics Inc. Procede d'amelioration de la prediction de la reponse pour des patients cancereux traites par immunotherapie
WO2020121226A1 (fr) * 2018-12-12 2020-06-18 Medimmune, Llc Charge de mutation de tumeur basée sur le sang permettant de prédire la survie globale dans le cancer du poumon non à petites cellules
WO2020136133A1 (fr) 2018-12-23 2020-07-02 F. Hoffmann-La Roche Ag Classification de tumeur basée sur une charge mutationnelle tumorale prédite
CN112203642B (zh) 2019-03-25 2025-03-07 阿特根公司 用于皮下注射的包含人透明质酸酶ph20变体和药物的药物组合物
WO2020198676A1 (fr) * 2019-03-28 2020-10-01 Bristol-Myers Squibb Company Méthodes de traitement de tumeur
GB201904555D0 (en) * 2019-04-01 2019-05-15 Univ Manchester Biomarkers and uses thereof
CN110229894B (zh) * 2019-05-21 2020-09-08 武汉大学 一种基因组合及其在制备预测接受免疫检查点抑制剂治疗患者预后的试剂中的应用
EP3982954A4 (fr) 2019-06-14 2024-01-03 The Trustees of Columbia University in the City of New York Inhibiteurs de nt5c2 pour le traitement de la leucémie lymphoblastique aiguë résistante à la chimiothérapie
US11705226B2 (en) 2019-09-19 2023-07-18 Tempus Labs, Inc. Data based cancer research and treatment systems and methods
US20220280609A1 (en) * 2019-07-17 2022-09-08 The Regents Of The University Of California Combination cancer therapy agents and methods
WO2021030358A1 (fr) 2019-08-12 2021-02-18 Regeneron Pharmaceuticals, Inc. Variants du récepteur 1 de la stimulation des macrophages (mst1r) et leurs utilisations
EP4042161A4 (fr) * 2019-10-09 2023-12-20 The University of North Carolina at Chapel Hill Altérations du nombre de copies (cna) d'adn pour déterminer des phénotypes de cancer
CN110927389B (zh) * 2019-11-29 2021-07-16 中国科学院苏州生物医学工程技术研究所 一种癌症生物标志物、用途
TW202615652A (zh) 2020-01-23 2026-04-16 南韓商阿特根公司 新穎的具有改善的穩定性的玻尿酸酶變異體及含有其的醫藥組合物
CN110923329B (zh) * 2020-02-06 2020-05-12 至本医疗科技(上海)有限公司 Fgfr4点突变在预测非小细胞肺癌患者对免疫检查点抑制剂疗法敏感性中的应用
CN111269979A (zh) * 2020-02-06 2020-06-12 至本医疗科技(上海)有限公司 Arid1b基因变异在预测肺腺癌患者对免疫检查点抑制剂疗法敏感性中的应用
JP2023526400A (ja) * 2020-05-21 2023-06-21 アストラゼネカ・アクチエボラーグ 局所進行性又は転移性尿路上皮がんにおける免疫療法に対する感受性に関連する遺伝子変異量
TWI788188B (zh) * 2020-06-09 2022-12-21 南韓商阿特根公司 用於皮下注射之包含人類玻尿酸酶ph20變異體及藥物的醫藥組合物
WO2022031093A1 (fr) 2020-08-07 2022-02-10 (주)알테오젠 Procédé de production d'hyaluronidase recombinant
CN112143810B (zh) * 2020-09-29 2023-11-21 南方医科大学中西医结合医院 一组用于预测癌症免疫治疗效果的基因标志物及其应用
JP2024504002A (ja) * 2020-12-22 2024-01-30 アイエフエム デュー インコーポレイテッド がんを処置する方法
WO2022135402A1 (fr) * 2020-12-24 2022-06-30 信达生物制药(苏州)有限公司 Utilisation d'un biomarqueur pd-l1 et/ou cmh-2 dans la prédiction de l'efficacité thérapeutique chez des patients atteints d'un cancer du poumon
KR102371762B1 (ko) * 2020-12-29 2022-03-07 중앙대학교 산학협력단 Brca1 매개 nsd2 유비퀴틴화를 통한 세포 분화 및 세포사멸 조절 용도
CN113005146A (zh) * 2021-03-10 2021-06-22 香港理工大学深圳研究院 一种重组质粒及其构建方法、重组影像系统与应用
US20240254230A1 (en) * 2021-03-19 2024-08-01 Shanghai Junshi Biosciences Co., Ltd. Method of treating urothelial carcinoma
US20240247065A1 (en) * 2021-05-19 2024-07-25 Merck Sharp & Dohme Llc Methods of treatment of cancer patients having altered setd2 biomarker with a pd-1 antagonist
JP7806990B2 (ja) * 2021-08-10 2026-01-27 国立大学法人 新潟大学 内胚葉嚢胞の悪性化に関連する遺伝子の検出方法
WO2023049859A1 (fr) * 2021-09-24 2023-03-30 The Regents Of The University Of California Procédés de prédiction de l'efficacité de la thérapie anti-pd-1 néoadjuvante dans le carcinome épidermoïde de la cavité buccale résécable et les rechutes post-chirurgicales cibles
CN113981080A (zh) * 2021-10-15 2022-01-28 复旦大学附属肿瘤医院 晚期三阴性乳腺癌铂类治疗敏感性的预测指标生成分析方法
EP4430614A4 (fr) * 2021-11-12 2025-12-17 Found Medicine Inc Fraction d'adn tumoral circulant et ses utilisations
CN114213542B (zh) * 2021-12-24 2023-06-23 郑州大学第三附属医院(河南省妇幼保健院) Cps-i抗体及其用途
US20250146078A1 (en) * 2022-02-11 2025-05-08 Foundation Medicine, Inc. Use of tumor mutational burden as a predictive biomarker for immune checkpoint inhibitor versus chemotherapy effectiveness in cancer treatment
WO2023209035A1 (fr) * 2022-04-26 2023-11-02 F. Hoffmann-La Roche Ag Procédés et compositions pour prédire une réponse à une thérapie anticancéreuse
CN114736967B (zh) * 2022-05-07 2024-06-11 北京大学肿瘤医院 预测免疫检查点抑制剂疗法原发耐药的标志物及方法
EP4310197A1 (fr) 2022-07-21 2024-01-24 Fundación para la Investigación Biomédica del Hospital Universitario Puerta de Hierro Majadahonda Procédé pour identifier des patients atteints de cancer du poumon pour un traitement combiné d'immunothérapie et de chimiothérapie
CN117587122A (zh) * 2022-08-11 2024-02-23 中山大学孙逸仙纪念医院 Prkn作为预测肿瘤对化疗敏感性的标志物的应用
EP4361288A1 (fr) * 2022-10-25 2024-05-01 Fundación Instituto de Investigación Sanitaria De Santiago de Compostela (FIDIS) Immunothérapie personnalisée dans le carcinome rénal
CN115449555B (zh) * 2022-10-26 2023-10-13 山东大学 Adgra2作为乳腺癌化疗疗效和预后评价生物标志物的应用
CN115825441B (zh) * 2023-01-30 2023-05-26 上海秤信生物科技有限公司 预测肺癌三期患者的免疫新辅助疗效的自身抗体标志物
WO2024203348A1 (fr) * 2023-03-31 2024-10-03 ソニーグループ株式会社 Procédé d'analyse de tumeurs, système d'analyse de tumeurs et procédé de génération de données d'analyse de tumeurs

Family Cites Families (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6362325B1 (en) 1988-11-07 2002-03-26 Advanced Research And Technology Institute, Inc. Murine 4-1BB gene
US6303121B1 (en) 1992-07-30 2001-10-16 Advanced Research And Technology Method of using human receptor protein 4-1BB
US6355476B1 (en) 1988-11-07 2002-03-12 Advanced Research And Technologyinc Nucleic acid encoding MIP-1α Lymphokine
EP0590058B1 (fr) 1991-06-14 2003-11-26 Genentech, Inc. ANTICORP HUMANISE specifique pour heregulin
US5851795A (en) 1991-06-27 1998-12-22 Bristol-Myers Squibb Company Soluble CTLA4 molecules and uses thereof
US6051227A (en) 1995-07-25 2000-04-18 The Regents Of The University Of California, Office Of Technology Transfer Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
IL129138A0 (en) 1996-10-11 2000-02-17 Bristol Myers Squibb Co Methods and compositions for immunomodulation
US6682736B1 (en) 1998-12-23 2004-01-27 Abgenix, Inc. Human monoclonal antibodies to CTLA-4
ES2706547T3 (es) 1998-12-23 2019-03-29 Pfizer Anticuerpos monoclonales humanos para CTLA-4
EP2977063A1 (fr) 1999-06-25 2016-01-27 Genentech, Inc. Procédés de traitement utilisant des conjugués maytansinoïdes-anticorps anti-ErbB
ES2539411T3 (es) 1999-08-23 2015-06-30 Dana-Farber Cancer Institute, Inc. PD-1, receptor para la B7-4 y su utilización
NZ517202A (en) 1999-08-24 2004-05-28 Medarex Inc Human CTLA-4 antibodies and their uses
AU2001233027A1 (en) 2000-01-27 2001-08-07 Genetics Institute, Llc Antibodies against ctla4 (cd152), conjugates comprising same, and uses thereof
JP2006500921A (ja) 2002-07-30 2006-01-12 ブリストル−マイヤーズ スクイブ カンパニー ヒト4−1bbに対するヒト化抗体
ES2367430T3 (es) 2002-12-23 2011-11-03 Wyeth Llc Anticuerpos contra pd-1 y sus usos.
EP2330213A1 (fr) 2003-03-05 2011-06-08 Halozyme, Inc. Glycoprotéine d'hyaluronidase soluble (sHASEGP), son procédé de préparation, utilisations et compositions pharmaceutiques le comportant
HRP20120845T1 (hr) 2003-07-02 2012-11-30 Innate Pharma Protutijela za pan-kir2dl nk-receptor i njihova uporaba u dijagnostici i lijeäśenju
HUE033129T2 (en) 2003-07-24 2017-11-28 Innate Pharma Sa Methods and compositions for increasing the efficacy of therapeutic antibodies using compounds that potentiate NK cells
US7288638B2 (en) 2003-10-10 2007-10-30 Bristol-Myers Squibb Company Fully human antibodies against human 4-1BB
WO2006003179A2 (fr) 2004-07-01 2006-01-12 Novo Nordisk A/S Anticorps anti-kir humains
US20090196850A1 (en) 2005-01-06 2009-08-06 Novo Nordisk A/S Anti-Kir Combination Treatments and Methods
JP5295568B2 (ja) 2005-01-06 2013-09-18 ノヴォ ノルディスク アー/エス Kir結合剤およびその使用方法
JP5238936B2 (ja) 2005-03-25 2013-07-17 ジーアイティーアール,インク. Gitr結合分子およびその使用
EP3530736A3 (fr) 2005-05-09 2019-11-06 ONO Pharmaceutical Co., Ltd. Anticorps monoclonaux humains pour mort programmée 1 (pd-1) et procédés de traitement du cancer à l'aide d'anticorps anti-pd-1 seuls ou combinés à d'autres formulations immunothérapeutiques
KR101704734B1 (ko) 2005-07-01 2017-02-09 이. 알. 스퀴부 앤드 선즈, 엘.엘.씨. 예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날 항체
EP1934260B1 (fr) 2005-10-14 2017-05-17 Innate Pharma Compositions et procedes pour traiter des troubles de proliferation
WO2007113648A2 (fr) 2006-04-05 2007-10-11 Pfizer Products Inc. Polythérapie à base d'un anticorps anti-ctla4
AU2008204433B2 (en) 2007-01-11 2014-03-13 Novo Nordisk A/S Anti-KIR antibodies, formulations, and uses thereof
JP2008278814A (ja) 2007-05-11 2008-11-20 Igaku Seibutsugaku Kenkyusho:Kk アゴニスティック抗ヒトgitr抗体による免疫制御の解除とその応用
PT2170959E (pt) 2007-06-18 2014-01-07 Merck Sharp & Dohme Anticorpos para o receptor humano de morte programada pd-1
PT2175884T (pt) 2007-07-12 2016-09-21 Gitr Inc Terapias de combinação empregando moléculas de ligação a gitr
HRP20150074T1 (hr) 2007-10-01 2015-03-13 Bristol-Myers Squibb Company Humana antitijela koja se vežu za mezotelin i njihove uporabe
AR069747A1 (es) 2007-11-30 2010-02-17 Medarex Inc Conjugado anticuerpo monoclonal anti-b7h4- farmaco y metodos de utilizacion
US8168757B2 (en) 2008-03-12 2012-05-01 Merck Sharp & Dohme Corp. PD-1 binding proteins
AR072999A1 (es) 2008-08-11 2010-10-06 Medarex Inc Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
US8709411B2 (en) 2008-12-05 2014-04-29 Novo Nordisk A/S Combination therapy to enhance NK cell mediated cytotoxicity
MX356367B (es) 2008-12-09 2018-05-25 Genentech Inc Anticuerpos anti-pd-l1 y su uso para mejorar la funcion de celulas t.
IN2015DN02826A (fr) 2009-09-03 2015-09-11 Merck Sharp & Dohme
EP3279215B1 (fr) 2009-11-24 2020-02-12 MedImmune Limited Agents de liaison ciblés contre b7-h1
JP6002659B2 (ja) 2010-04-13 2016-10-05 セルデックス・セラピューティクス・インコーポレイテッド ヒトcd27に結合する抗体およびその使用
CA2818684C (fr) 2010-11-22 2023-02-21 Innate Pharma Sa Traitements modulant les cellules tueuses naturelles et methodes de traitement d'hemopathies malignes
ES2699965T3 (es) 2011-03-10 2019-02-13 Provectus Pharmatech Inc Una combinación de rosa de bengala y anticuerpo anti-CTLA4 para su uso en el tratamiento del cáncer
CA2833636A1 (fr) 2011-04-20 2012-10-26 Amplimmune, Inc. Anticorps et autres molecules qui se lient a b7-h1 et a pd-1
US9067997B2 (en) 2011-05-25 2015-06-30 Innate Pharma Sa Anti-KIR antibodies for the treatment of inflammatory and autoimmune disorders
US20130108641A1 (en) 2011-09-14 2013-05-02 Sanofi Anti-gitr antibodies
DK2760471T3 (en) 2011-09-30 2017-05-08 Dana Farber Cancer Inst Inc THERAPEUTIC PEPTIDES
HUE043001T2 (hu) 2011-11-09 2019-07-29 Bristol Myers Squibb Co Hematológiai malignómák kezelése anti-CXCR4 antitesttel
BR112014012819B1 (pt) 2011-11-28 2022-08-16 Merck Patent Gmbh Anticorpo anti-pd-l1 ou fragmento de ligação ao antígeno do mesmo e composição
US9856320B2 (en) 2012-05-15 2018-01-02 Bristol-Myers Squibb Company Cancer immunotherapy by disrupting PD-1/PD-L1 signaling
US9175082B2 (en) 2012-05-31 2015-11-03 Sorrento Therapeutics, Inc. Antigen binding proteins that bind PD-L1
KR101566539B1 (ko) 2012-06-08 2015-11-05 국립암센터 신규한 Th2 세포 전환용 에피토프 및 이의 용도
AR091649A1 (es) 2012-07-02 2015-02-18 Bristol Myers Squibb Co Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos
BR112015007184A2 (pt) 2012-10-02 2017-08-08 Bristol Myers Squibb Co combinação de anticorpos anti-kir e anticorpos anti-pd-1 para tratar câncer
WO2014144791A2 (fr) 2013-03-15 2014-09-18 Dana-Farber Cancer Institute, Inc. Peptides thérapeutiques
KR20150131269A (ko) 2013-03-15 2015-11-24 제넨테크, 인크. Pd-1 및 pd-l1 관련 상태를 치료하기 위한 바이오마커 및 방법
RS61400B1 (sr) 2013-05-02 2021-02-26 Anaptysbio Inc Antitela usmerena protiv programirane smrti-1 (pd-1)
CA3175360C (fr) 2013-05-31 2024-05-28 Sorrento Therapeutics, Inc. Proteines de liaison a l'antigene qui se lient a pd-1
CN104250302B (zh) 2013-06-26 2017-11-14 上海君实生物医药科技股份有限公司 抗pd‑1抗体及其应用
AR097306A1 (es) 2013-08-20 2016-03-02 Merck Sharp & Dohme Modulación de la inmunidad tumoral
TW201605896A (zh) 2013-08-30 2016-02-16 安美基股份有限公司 Gitr抗原結合蛋白
SMT202300039T1 (it) 2013-09-13 2023-03-17 Beigene Switzerland Gmbh Anticorpi anti-pd1 e loro uso come terapia e per diagnostica
RS64268B1 (sr) 2013-09-20 2023-07-31 Bristol Myers Squibb Co Kombinacija anti-lag-3 antitela i anti-pd-1 antitela za lečenje tumora
MX371187B (es) 2013-12-06 2020-01-22 Dana Farber Cancer Inst Inc Péptidos terapéuticos.
CR20160319A (es) 2013-12-12 2016-11-08 Jiangsu Hengrui Medicine Co Anticuerpo pd-1, fragmento de union al antigeno de este y uso médico de este
SG11201605432RA (en) * 2014-01-02 2016-07-28 Sloan Kettering Inst Cancer Determinants of cancer response to immunotherapy
TWI681969B (zh) 2014-01-23 2020-01-11 美商再生元醫藥公司 針對pd-1的人類抗體
UA122479C2 (uk) 2014-01-24 2020-11-25 Дана-Фарбер Кенсер Інстітьют, Інк. Виділена молекула антитіла, яка зв’язується з людським білком програмованої смерті-1 (pd-1)
LT3148579T (lt) 2014-05-28 2021-05-25 Agenus Inc. Anti-gitr antikūnai ir jų panaudojimo būdai
KR20170080697A (ko) * 2014-11-13 2017-07-10 더 존스 홉킨스 유니버시티 관문 차단 및 미소부수체 불안정성
MA40737A (fr) * 2014-11-21 2017-07-04 Memorial Sloan Kettering Cancer Center Déterminants de la réponse d'un cancer à une immunothérapie par blocage de pd-1
CA2971734C (fr) 2014-12-22 2025-11-18 Pd-1 Acquisition Group, Llc Anticorps anti-pd-1
MA42971A (fr) 2015-03-13 2018-08-15 Cytomx Therapeutics Inc Anticorps anti-pdl1, anticorps anti-pld1 activables, et leurs procédés d'utilisation
EP3288980B1 (fr) 2015-04-28 2021-03-10 Bristol-Myers Squibb Company Traitement du mélanome pd-l1 positif à l'aide d'un anticorps anti-pd-1
DK3303394T3 (da) 2015-05-29 2020-07-06 Agenus Inc Anti-ctla-4-antistoffer og fremgangsmåder til anvendelse deraf
WO2016197367A1 (fr) 2015-06-11 2016-12-15 Wuxi Biologics (Shanghai) Co. Ltd. Nouveaux anticorps anti-pd-l1
PE20231958A1 (es) 2015-07-30 2023-12-06 Macrogenics Inc Moleculas de union a pd-1 y metodos de uso de las mismas
WO2017020291A1 (fr) 2015-08-06 2017-02-09 Wuxi Biologics (Shanghai) Co. Ltd. Nouveaux anticorps anti-pd-l1
WO2017024465A1 (fr) 2015-08-10 2017-02-16 Innovent Biologics (Suzhou) Co., Ltd. Anticorps anti-pd-1
WO2017024515A1 (fr) 2015-08-11 2017-02-16 Wuxi Biologics (Cayman) Inc. Nouveaux anticorps anti-pd-1
MX392711B (es) 2015-08-11 2025-03-24 Wuxi Biologics Ireland Ltd Anticuerpos anti-pd-1 novedosos.
AR105654A1 (es) 2015-08-24 2017-10-25 Lilly Co Eli Anticuerpos pd-l1 (ligando 1 de muerte celular programada)
JP6869987B2 (ja) 2015-09-01 2021-05-12 アジェナス インコーポレイテッド 抗pd−1抗体及びその使用方法
CN108367069B (zh) 2015-12-14 2022-08-23 宏观基因有限公司 对于pd-1和ctla-4具有免疫反应性的双特异性分子及其使用方法
JP7082051B2 (ja) 2016-01-11 2022-06-07 アルモ・バイオサイエンシーズ・インコーポレイテッド 抗原特異的cd8+t細胞の産生におけるインターロイキン-10及びその使用方法
WO2017132827A1 (fr) 2016-02-02 2017-08-10 Innovent Biologics (Suzhou) Co., Ltd. Anticorps anti-pd-1
EP3402255B1 (fr) 2016-02-02 2021-03-31 Huawei Technologies Co., Ltd. Procédé de vérification de puissance d'émission, équipement utilisateur et station de base
US11725247B2 (en) * 2016-02-29 2023-08-15 Foundation Medicine, Inc. Methods of treating cancer
US20190248893A1 (en) 2016-07-14 2019-08-15 Bristol-Myers Squibb Company Antibodies against tim3 and uses thereof
KR102804118B1 (ko) * 2016-10-06 2025-05-09 제넨테크, 인크. 암에 대한 치료 및 진단 방법
EP3694884A1 (fr) * 2017-10-15 2020-08-19 Bristol-Myers Squibb Company Procédés de traitement de tumeur

Also Published As

Publication number Publication date
SG10202110594UA (en) 2021-11-29
CA3058175A1 (fr) 2018-10-04
IL269026B2 (en) 2024-12-01
KR20250036268A (ko) 2025-03-13
AU2018243754B2 (en) 2025-04-10
SG11201908396PA (en) 2019-10-30
IL313939B2 (en) 2026-05-01
IL269026A (en) 2019-10-31
JP7458188B2 (ja) 2024-03-29
US20210101980A1 (en) 2021-04-08
IL325195A (en) 2026-02-01
US20250059610A1 (en) 2025-02-20
MX2024007719A (es) 2024-09-10
KR102775647B1 (ko) 2025-03-06
JP2024096701A (ja) 2024-07-17
MX2019010958A (es) 2019-10-17
EP3601355A1 (fr) 2020-02-05
IL269026B1 (en) 2024-08-01
AU2018243754A1 (en) 2019-10-17
IL313939B1 (en) 2026-01-01
JP2020512982A (ja) 2020-04-30
BR112019019795A2 (pt) 2020-04-22
IL313939A (en) 2024-08-01
WO2018183928A1 (fr) 2018-10-04
CN110494450A (zh) 2019-11-22
US20230295737A1 (en) 2023-09-21
AU2025205056A1 (en) 2025-07-24
KR20190133213A (ko) 2019-12-02

Similar Documents

Publication Publication Date Title
EP3426250A4 (fr) Procédés de traitement
EP3601536A4 (fr) Procédés de traitement
IL269026A (en) Methods of treating tumor
EP3500289A4 (fr) Procédés de traitement de la trachéobronchomalacie
EP3294065A4 (fr) Procédés de traitement du cancer
EP3488001A4 (fr) Traitement du cancer
EP3448263A4 (fr) Traitement électrothérapeutique
EP3388004A4 (fr) Instrument de traitement
EP3399861A4 (fr) Procédés de traitement du cancer par interféron
EP3409744A4 (fr) Agent de traitement de surface
EP3431566A4 (fr) Agent de traitement de surface
MA47408A (fr) Traitement du cancer
PL3197456T3 (pl) Leczenie nowotworów
EP3914235A4 (fr) Procédés de traitement de la dépendance
EP3606531A4 (fr) Méthodes de traitement du cancer
EP3375108A4 (fr) Traitement dewlan
EP3442946A4 (fr) Procédés de traitement du cancer
EP3705545A4 (fr) Composition de traitement de surface
EP3894561A4 (fr) Procédés de traitement du cancer
EP3658153A4 (fr) Procédés de traitement de métastase tumorale
MA52627A (fr) Traitement du cancer
DK3576740T3 (da) Cancerbehandling
EP3697767A4 (fr) Composés et procédés de traitement du cancer
EP3733175A4 (fr) Traitement du cancer
EP3684342A4 (fr) Procédé de traitement