MA50095A - Micro-organismes et méthodes pour la fermentation d'alcaloïdes de benzylisoquinoline - Google Patents

Micro-organismes et méthodes pour la fermentation d'alcaloïdes de benzylisoquinoline

Info

Publication number
MA50095A
MA50095A MA050095A MA50095A MA50095A MA 50095 A MA50095 A MA 50095A MA 050095 A MA050095 A MA 050095A MA 50095 A MA50095 A MA 50095A MA 50095 A MA50095 A MA 50095A
Authority
MA
Morocco
Prior art keywords
organisms
fermentation
micro
methods
benzylisoquinoline alkaloids
Prior art date
Application number
MA050095A
Other languages
English (en)
Inventor
Maria Enquist-Newman
Kata Zsuzsanna Hetenyi
Genevieve Vidanes
Original Assignee
Intrexon Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intrexon Corp filed Critical Intrexon Corp
Publication of MA50095A publication Critical patent/MA50095A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B60—VEHICLES IN GENERAL
    • B60G—VEHICLE SUSPENSION ARRANGEMENTS
    • B60G17/00—Resilient suspensions having means for adjusting the spring or vibration-damper characteristics, for regulating the distance between a supporting surface and a sprung part of vehicle or for locking suspension during use to meet varying vehicular or surface conditions, e.g. due to speed or load
    • B60G17/015—Resilient suspensions having means for adjusting the spring or vibration-damper characteristics, for regulating the distance between a supporting surface and a sprung part of vehicle or for locking suspension during use to meet varying vehicular or surface conditions, e.g. due to speed or load the regulating means comprising electric or electronic elements
    • B60G17/016—Resilient suspensions having means for adjusting the spring or vibration-damper characteristics, for regulating the distance between a supporting surface and a sprung part of vehicle or for locking suspension during use to meet varying vehicular or surface conditions, e.g. due to speed or load the regulating means comprising electric or electronic elements characterised by their responsiveness, when the vehicle is travelling, to specific motion, a specific condition, or driver input
    • B60G17/0162—Resilient suspensions having means for adjusting the spring or vibration-damper characteristics, for regulating the distance between a supporting surface and a sprung part of vehicle or for locking suspension during use to meet varying vehicular or surface conditions, e.g. due to speed or load the regulating means comprising electric or electronic elements characterised by their responsiveness, when the vehicle is travelling, to specific motion, a specific condition, or driver input mainly during a motion involving steering operation, e.g. cornering, overtaking
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B60—VEHICLES IN GENERAL
    • B60G—VEHICLE SUSPENSION ARRANGEMENTS
    • B60G17/00—Resilient suspensions having means for adjusting the spring or vibration-damper characteristics, for regulating the distance between a supporting surface and a sprung part of vehicle or for locking suspension during use to meet varying vehicular or surface conditions, e.g. due to speed or load
    • B60G17/015—Resilient suspensions having means for adjusting the spring or vibration-damper characteristics, for regulating the distance between a supporting surface and a sprung part of vehicle or for locking suspension during use to meet varying vehicular or surface conditions, e.g. due to speed or load the regulating means comprising electric or electronic elements
    • B60G17/0195—Resilient suspensions having means for adjusting the spring or vibration-damper characteristics, for regulating the distance between a supporting surface and a sprung part of vehicle or for locking suspension during use to meet varying vehicular or surface conditions, e.g. due to speed or load the regulating means comprising electric or electronic elements characterised by the regulation being combined with other vehicle control systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B60—VEHICLES IN GENERAL
    • B60G—VEHICLE SUSPENSION ARRANGEMENTS
    • B60G21/00—Interconnection systems for two or more resiliently-suspended wheels, e.g. for stabilising a vehicle body with respect to acceleration, deceleration or centrifugal forces
    • B60G21/02—Interconnection systems for two or more resiliently-suspended wheels, e.g. for stabilising a vehicle body with respect to acceleration, deceleration or centrifugal forces permanently interconnected
    • B60G21/04—Interconnection systems for two or more resiliently-suspended wheels, e.g. for stabilising a vehicle body with respect to acceleration, deceleration or centrifugal forces permanently interconnected mechanically
    • B60G21/05—Interconnection systems for two or more resiliently-suspended wheels, e.g. for stabilising a vehicle body with respect to acceleration, deceleration or centrifugal forces permanently interconnected mechanically between wheels on the same axle but on different sides of the vehicle, i.e. the left and right wheel suspensions being interconnected
    • B60G21/055—Stabiliser bars
    • B60G21/0551—Mounting means therefor
    • B60G21/0553—Mounting means therefor adjustable
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01248—Salutaridine reductase (NADPH) (1.1.1.248)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/0115—Salutaridinol 7-O-acetyltransferase (2.3.1.150)
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16F—SPRINGS; SHOCK-ABSORBERS; MEANS FOR DAMPING VIBRATION
    • F16F1/00—Springs
    • F16F1/02—Springs made of steel or other material having low internal friction; Wound, torsion, leaf, cup, ring or the like springs, the material of the spring not being relevant
    • F16F1/14—Torsion springs consisting of bars or tubes
    • F16F1/145—Torsion springs consisting of bars or tubes with means for modifying the spring characteristics
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16F—SPRINGS; SHOCK-ABSORBERS; MEANS FOR DAMPING VIBRATION
    • F16F9/00—Springs, vibration-dampers, shock-absorbers, or similarly-constructed movement-dampers using a fluid or the equivalent as damping medium
    • F16F9/06—Springs, vibration-dampers, shock-absorbers, or similarly-constructed movement-dampers using a fluid or the equivalent as damping medium using both gas and liquid
    • F16F9/064—Units characterised by the location or shape of the expansion chamber
    • F16F9/065—Expansion chamber provided on the upper or lower end of a damper, separately there from or laterally on the damper
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16F—SPRINGS; SHOCK-ABSORBERS; MEANS FOR DAMPING VIBRATION
    • F16F9/00—Springs, vibration-dampers, shock-absorbers, or similarly-constructed movement-dampers using a fluid or the equivalent as damping medium
    • F16F9/32—Details
    • F16F9/44—Means on or in the damper for manual or non-automatic adjustment; such means combined with temperature correction
    • F16F9/46—Means on or in the damper for manual or non-automatic adjustment; such means combined with temperature correction allowing control from a distance, i.e. location of means for control input being remote from site of valves, e.g. on damper external wall
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16F—SPRINGS; SHOCK-ABSORBERS; MEANS FOR DAMPING VIBRATION
    • F16F9/00—Springs, vibration-dampers, shock-absorbers, or similarly-constructed movement-dampers using a fluid or the equivalent as damping medium
    • F16F9/32—Details
    • F16F9/56—Means for adjusting the length of, or for locking, the spring or damper, e.g. at the end of the stroke
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B60—VEHICLES IN GENERAL
    • B60G—VEHICLE SUSPENSION ARRANGEMENTS
    • B60G2202/00—Indexing codes relating to the type of spring, damper or actuator
    • B60G2202/10—Type of spring
    • B60G2202/13—Torsion spring
    • B60G2202/135—Stabiliser bar and/or tube
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B60—VEHICLES IN GENERAL
    • B60G—VEHICLE SUSPENSION ARRANGEMENTS
    • B60G2202/00—Indexing codes relating to the type of spring, damper or actuator
    • B60G2202/30—Spring/Damper and/or actuator Units
    • B60G2202/32—The spring being in series with the damper and/or actuator
    • B60G2202/322—The spring being in series with the damper and/or actuator the damper being controllable
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B60—VEHICLES IN GENERAL
    • B60G—VEHICLE SUSPENSION ARRANGEMENTS
    • B60G2204/00—Indexing codes related to suspensions per se or to auxiliary parts
    • B60G2204/10—Mounting of suspension elements
    • B60G2204/12—Mounting of springs or dampers
    • B60G2204/122—Mounting of torsion springs
    • B60G2204/1224—End mounts of stabiliser on wheel suspension
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B60—VEHICLES IN GENERAL
    • B60G—VEHICLE SUSPENSION ARRANGEMENTS
    • B60G2204/00—Indexing codes related to suspensions per se or to auxiliary parts
    • B60G2204/10—Mounting of suspension elements
    • B60G2204/12—Mounting of springs or dampers
    • B60G2204/128—Damper mount on vehicle body or chassis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B60—VEHICLES IN GENERAL
    • B60G—VEHICLE SUSPENSION ARRANGEMENTS
    • B60G2204/00—Indexing codes related to suspensions per se or to auxiliary parts
    • B60G2204/40—Auxiliary suspension parts; Adjustment of suspensions
    • B60G2204/422—Links for mounting suspension elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B60—VEHICLES IN GENERAL
    • B60G—VEHICLE SUSPENSION ARRANGEMENTS
    • B60G2204/00—Indexing codes related to suspensions per se or to auxiliary parts
    • B60G2204/40—Auxiliary suspension parts; Adjustment of suspensions
    • B60G2204/46—Means for locking the suspension
    • B60G2204/4605—Means for locking the suspension hydraulically, e.g. interrupting communication between the chambers of a hydraulic cylinder
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B60—VEHICLES IN GENERAL
    • B60G—VEHICLE SUSPENSION ARRANGEMENTS
    • B60G2204/00—Indexing codes related to suspensions per se or to auxiliary parts
    • B60G2204/62—Adjustable continuously, e.g. during driving
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B60—VEHICLES IN GENERAL
    • B60G—VEHICLE SUSPENSION ARRANGEMENTS
    • B60G2206/00—Indexing codes related to the manufacturing of suspensions: constructional features, the materials used, procedures or tools
    • B60G2206/01—Constructional features of suspension elements, e.g. arms, dampers, springs
    • B60G2206/10—Constructional features of arms
    • B60G2206/11—Constructional features of arms the arm being a radius or track or torque or steering rod or stabiliser end link
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B60—VEHICLES IN GENERAL
    • B60G—VEHICLE SUSPENSION ARRANGEMENTS
    • B60G2206/00—Indexing codes related to the manufacturing of suspensions: constructional features, the materials used, procedures or tools
    • B60G2206/01—Constructional features of suspension elements, e.g. arms, dampers, springs
    • B60G2206/40—Constructional features of dampers and/or springs
    • B60G2206/41—Dampers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B60—VEHICLES IN GENERAL
    • B60G—VEHICLE SUSPENSION ARRANGEMENTS
    • B60G2300/00—Indexing codes relating to the type of vehicle
    • B60G2300/07—Off-road vehicles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B60—VEHICLES IN GENERAL
    • B60G—VEHICLE SUSPENSION ARRANGEMENTS
    • B60G2500/00—Indexing codes relating to the regulated action or device
    • B60G2500/20—Spring action or springs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B60—VEHICLES IN GENERAL
    • B60G—VEHICLE SUSPENSION ARRANGEMENTS
    • B60G2800/00—Indexing codes relating to the type of movement or to the condition of the vehicle and to the end result to be achieved by the control action
    • B60G2800/21—Traction, slip, skid or slide control

Landscapes

  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Mechanical Engineering (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Automation & Control Theory (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Vehicle Body Suspensions (AREA)
MA050095A 2017-09-08 2018-09-06 Micro-organismes et méthodes pour la fermentation d'alcaloïdes de benzylisoquinoline MA50095A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762556022P 2017-09-08 2017-09-08

Publications (1)

Publication Number Publication Date
MA50095A true MA50095A (fr) 2020-07-15

Family

ID=65634403

Family Applications (1)

Application Number Title Priority Date Filing Date
MA050095A MA50095A (fr) 2017-09-08 2018-09-06 Micro-organismes et méthodes pour la fermentation d'alcaloïdes de benzylisoquinoline

Country Status (6)

Country Link
US (2) US20200325509A1 (fr)
EP (1) EP3678667A4 (fr)
AU (1) AU2018329823A1 (fr)
CA (1) CA3078818A1 (fr)
MA (1) MA50095A (fr)
WO (1) WO2019051046A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018000089A1 (fr) 2016-06-27 2018-01-04 Serturner Corp. Polynucléotides et polypeptides utiles pour la fabrication de composés alcaloïdes
JP7483617B2 (ja) * 2018-02-08 2024-05-15 アンテイア インコーポレイテッド モルフィナンアルカロイドおよび誘導体を生成する方法
CA3116502A1 (fr) 2018-10-17 2020-04-23 River Stone Biotech Llc Cellule microbienne a conversion in vivo amelioree de thebaine/oripavine
US11173767B2 (en) 2019-10-22 2021-11-16 Christopher Cox Creative Hydraulic anti-roll bar link
US12502923B2 (en) 2022-02-23 2025-12-23 Fox Factory, Inc. Hydraulic cross-linked suspension
US20240198753A1 (en) * 2022-04-26 2024-06-20 Fox Factory, Inc. E-sway algorithm
US12522042B1 (en) * 2024-10-24 2026-01-13 Fox Factory, Inc. Linked gas chambers for e-sway disconnect

Family Cites Families (143)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1060722B (de) 1953-12-21 1959-07-02 Andre Citroeen Sa Vorrichtung zum Verhueten des Schlingerns von Fahrzeugen
DE1043101B (de) 1955-06-24 1958-11-06 Daimler Benz Ag Abfederung eines Fahrzeuges, insbesondere Kraftfahrzeuges
US3357512A (en) 1965-09-15 1967-12-12 Curtis L Wilson Vehicle stabilizer
US3602470A (en) 1969-05-28 1971-08-31 Fmc Corp Hydropneumatic suspension unit
US3871635A (en) 1974-01-23 1975-03-18 Caterpillar Tractor Co Suspension hydraulic roll stabilizer with leveling
US3986118A (en) 1975-05-02 1976-10-12 Goodyear Aerospace Corporation Simplified wheel speed transducer
JPS53117170A (en) 1977-03-22 1978-10-13 Honda Motor Co Ltd Regulator of damping force changing mechanism for rolling stock
GB2006131A (en) 1977-10-21 1979-05-02 Vauxhall Motors Ltd Motor vehicle roll control system
US4159756A (en) 1978-01-17 1979-07-03 Kayaba K.K. Adjusting device for damping force of rear shock-absorbers of motorcycles
DE2849015A1 (de) 1978-11-11 1980-05-22 Daimler Benz Ag Stabilisatoranordnung fuer kraftfahrzeuge
DE3231739A1 (de) 1982-08-26 1984-03-01 Fichtel & Sachs Ag, 8720 Schweinfurt Zweirohr-schwingungsdaempfer oder federbein mit veraenderbarer daempfkraft
JPH0771888B2 (ja) 1984-12-19 1995-08-02 日本電装株式会社 車両用姿勢制御装置
JPS62194921A (ja) 1986-02-21 1987-08-27 Honda Motor Co Ltd 緩衝器の減衰力制御方法
US4984819A (en) 1988-04-14 1991-01-15 Atsugi Motor Parts Company, Limited Automotive suspension system and shock absorber therefor
JP2639396B2 (ja) 1988-07-11 1997-08-13 ダイムラー―ベンツ・アクチエンゲゼルシヤフト 液圧入れ子式緩衝器
GB2227547B (en) 1988-12-14 1992-10-28 Tokico Ltd Adjustable damping force hydraulic shock absorber
US4921080A (en) 1989-05-08 1990-05-01 Lin Chien H Hydraulic shock absorber
US5027303A (en) 1989-07-17 1991-06-25 Witte Don C Measuring apparatus for pedal-crank assembly
US5105918A (en) 1989-10-23 1992-04-21 Nippondenso Co., Ltd. Detection of damping force for shock absorber control
JPH0419210A (ja) 1990-05-14 1992-01-23 Nissan Motor Co Ltd 車両の揺動減衰装置
US5236520A (en) 1990-10-24 1993-08-17 Consolidated Metal Products, Inc. High strength steel sway bars and method of making
JPH04191115A (ja) 1990-11-27 1992-07-09 Nhk Spring Co Ltd 車両用スタビライザ装置
US5172794A (en) 1991-04-03 1992-12-22 Maremont Corporation Adjustable damping shock absorber
DE4123141C1 (fr) 1991-07-12 1992-07-30 Boge Ag, 5208 Eitorf, De
US5186486A (en) 1991-07-19 1993-02-16 General Motors Corporation Active link for a stabilizer bar
US5171036A (en) 1991-08-27 1992-12-15 The Boler Company Rebound strap
JP3049136B2 (ja) 1991-12-09 2000-06-05 マツダ株式会社 車両のサスペンション装置
US5390949A (en) 1993-03-08 1995-02-21 The University Of Toledo Active suspension systems and components using piezoelectric sensing and actuation devices
US5362094A (en) 1993-06-09 1994-11-08 General Motors Corporation Hydraulically controlled stabilizer bar system
DE4335528A1 (de) 1993-10-19 1995-04-20 Anton Pfeifer Veränderliche Zug- und Druckstangen für KFZ-Stabilisatoren
US5522280A (en) 1993-12-23 1996-06-04 United Technologies Motor Systems, Inc. Connecting links for windshield wipers and method for fabricating the link
US5597180A (en) 1994-08-15 1997-01-28 Ganzel; Blaise J. Vehicle roll control apparatus
US5630623A (en) 1994-08-15 1997-05-20 Kelsey Hayes Vehicle roll control system
KR970034283A (ko) 1995-12-27 1997-07-22 전성원 스테이빌라이저 바의 댐핑 제어장치
US5952823A (en) 1996-03-22 1999-09-14 Mts Systems Corporation Magnetostrictive linear displacement transducer for a shock absorber
US5749596A (en) 1996-09-16 1998-05-12 General Motors Corporation Latchable stabilizer bar actuator
US6244398B1 (en) 1997-05-15 2001-06-12 K2 Bike Inc. Shock absorber with variable bypass damping
US6193029B1 (en) 1997-07-08 2001-02-27 Active Control Experts, Inc. Damper and valve
JPH11165521A (ja) 1997-12-01 1999-06-22 Showa Corp スタビライザー用ダンパ装置
US6073536A (en) 1998-03-02 2000-06-13 Campbell; A. Keith Automotive hydraulic system and method for driving a hydraulic accessory in parallel with a power steering unit
US6276693B1 (en) 1998-11-16 2001-08-21 Delphi Technologies, Inc. Roll control system for a motor vehicle
GB2343663B (en) 1998-11-16 2002-03-20 Delphi France Automotive Sys A roll control system for a motor vehicle
GB2351951A (en) 1999-07-13 2001-01-17 Delphi Tech Inc A roll control system for a motor vehicle
EP1022169B1 (fr) 1999-01-22 2008-03-12 Delphi Technologies, Inc. Système de réglage du roulis d'un véhicule automobile
JP3624759B2 (ja) 1999-10-07 2005-03-02 トヨタ自動車株式会社 スタビライザ装置
EP1103396B1 (fr) 1999-11-26 2009-04-22 Delphi Technologies, Inc. Système de réglage de roulis de véhicule
US6543799B2 (en) 2000-01-13 2003-04-08 Shimano Inc. Bicycle suspension
US6352143B1 (en) 2000-03-09 2002-03-05 Bridgestone/Firestone, Inc. Vibration damping system using a hydraulic damper with a field responsive fluid control
US6457730B1 (en) 2001-02-16 2002-10-01 Trw Inc. Anti-roll bar with link actuator for controlling torsional rigidity
US6659475B2 (en) 2001-03-06 2003-12-09 Meritor Light Vehicle, Llc Decouplable link for a stabilizer bar
JP2002264625A (ja) 2001-03-13 2002-09-18 Nhk Spring Co Ltd 車両用スタビライザ装置
EP1270727A1 (fr) * 2001-06-11 2003-01-02 Institut für Pflanzenbiochemie Salutaridinol 7-0-acétyltransférase et ses derivés
GB2377415B (en) 2001-06-22 2003-09-03 Delphi Tech Inc A roll control system for a motor vehicle
GB0117210D0 (en) 2001-07-14 2001-09-05 Delphi Tech Inc A roll control system for a motor vehicle
DE10134715A1 (de) 2001-07-17 2003-02-06 Daimler Chrysler Ag Vorrichtung zur Wankabstützung von Fahrzeugen
US7128192B2 (en) 2001-08-30 2006-10-31 Fox Factory, Inc. Inertia valve shock absorber
JP3951728B2 (ja) 2002-02-06 2007-08-01 トヨタ自動車株式会社 スタビライザ装置
US6935157B2 (en) 2002-10-11 2005-08-30 Larry D. Miller Anti-bob system for cycles
US7240906B2 (en) 2002-12-04 2007-07-10 Daimlerchrysler Corporation Hydro-pneumatic suspension system
US20040231904A1 (en) 2003-02-21 2004-11-25 Beck Michael S. System and method for actively controlling traction in an articulated vehicle
US7374028B2 (en) 2003-07-08 2008-05-20 Fox Factory, Inc. Damper with pressure-sensitive compression damping
DE20313665U1 (de) 2003-09-03 2004-01-29 Trw Fahrwerksysteme Gmbh & Co Kg System zur Wankwinkelverringerung bei Kraftfahrzeugen
CN101061004B (zh) 2004-07-30 2010-10-06 凯耐提克控股有限公司 车辆的液压悬架系统
JP4351983B2 (ja) 2004-10-12 2009-10-28 アイシン精機株式会社 スタビライザ用液圧制御装置
US7472914B2 (en) 2005-02-28 2009-01-06 Anderson Brian K Suspension system
EP1853442B1 (fr) 2005-03-01 2018-11-14 Kinetic Pty Ltd. Système hydraulique pour suspension de véhicule
DE112005003567T5 (de) 2005-05-04 2008-03-20 Kelsey-Hayes Company, Livonia Elektromagnetisches Fahrzeug-Wanksteuerungssystem
DE102005045177A1 (de) 2005-09-21 2007-03-22 Zf Friedrichshafen Ag Fahrzeug
JP4909763B2 (ja) 2007-02-23 2012-04-04 カヤバ工業株式会社 ステアリングダンパ
FR2926249B1 (fr) 2008-01-10 2010-02-05 Hutchinson Dispositif antiroulis passif pour suspension de vehicule automobile, et suspension l'incorporant
FR2927020A1 (fr) 2008-02-04 2009-08-07 Renault Sas Systeme anti-roulis pour vehicule automobile.
US20100244340A1 (en) 2008-03-19 2010-09-30 Wootten Dennis K Methods and apparatus for combined variable damping and variable spring rate suspension
JP5212794B2 (ja) 2008-04-25 2013-06-19 日立オートモティブシステムズ株式会社 シリンダ装置及びこれを用いたスタビライザ装置。
US10060499B2 (en) 2009-01-07 2018-08-28 Fox Factory, Inc. Method and apparatus for an adjustable damper
US20100170760A1 (en) 2009-01-07 2010-07-08 John Marking Remotely Operated Bypass for a Suspension Damper
US8857580B2 (en) 2009-01-07 2014-10-14 Fox Factory, Inc. Remotely operated bypass for a suspension damper
US8550223B2 (en) 2008-05-09 2013-10-08 Fox Factory, Inc. Methods and apparatus for position sensitive suspension dampening
US8627932B2 (en) 2009-01-07 2014-01-14 Fox Factory, Inc. Bypass for a suspension damper
US9033122B2 (en) 2009-01-07 2015-05-19 Fox Factory, Inc. Method and apparatus for an adjustable damper
US9239090B2 (en) 2009-01-07 2016-01-19 Fox Factory, Inc. Suspension damper with remotely-operable valve
US10047817B2 (en) 2009-01-07 2018-08-14 Fox Factory, Inc. Method and apparatus for an adjustable damper
US9452654B2 (en) 2009-01-07 2016-09-27 Fox Factory, Inc. Method and apparatus for an adjustable damper
JP5145575B2 (ja) 2008-05-19 2013-02-20 ヤマハ発動機株式会社 ショックアブソーバ及びそれを備える車両
US10036443B2 (en) 2009-03-19 2018-07-31 Fox Factory, Inc. Methods and apparatus for suspension adjustment
US9140325B2 (en) 2009-03-19 2015-09-22 Fox Factory, Inc. Methods and apparatus for selective spring pre-load adjustment
US20100225084A1 (en) 2008-12-30 2010-09-09 Darco Trust Vehicle suspension system
US9556925B2 (en) 2009-01-07 2017-01-31 Fox Factory, Inc. Suspension damper with by-pass valves
US8807542B2 (en) 2009-06-05 2014-08-19 Fox Factory, Inc. Apparatus and methods for a vehicle shock absorber
US8955653B2 (en) 2009-10-13 2015-02-17 Fox Factory, Incorporated Methods and apparatus for controlling a fluid damper
EP2530355B1 (fr) 2011-05-31 2019-09-04 Fox Factory, Inc. Appareil pour amortissement de suspension sensible au positionnement et/ou réglable
EP3567272B1 (fr) 2011-09-12 2021-05-26 Fox Factory, Inc. Procédés et appareil de réglage de suspension
US8770592B2 (en) 2012-02-03 2014-07-08 Fox Factory, Inc. Suspension with hydraulic preload adjust
DE102012006928A1 (de) 2012-04-05 2012-11-22 Daimler Ag Fahrwerksanordnung eines Kraftfahrzeugs mit einer zwei Federvorrichtungen aufweisenden Querstabilisierungsvorrichtung
DE102014019822B3 (de) * 2013-02-14 2017-09-28 Ford Global Technologies, Llc Radaufhängung mit Stabilisatoranordnung
DE202013100681U1 (de) 2013-02-14 2013-04-09 Ford Global Technologies, Llc. Radaufhängung mit Stabilisatoranordnung
US9884533B2 (en) 2013-02-28 2018-02-06 Tenneco Automotive Operating Company Inc. Autonomous control damper
US9702349B2 (en) 2013-03-15 2017-07-11 ClearMotion, Inc. Active vehicle suspension system
DE202013007733U1 (de) 2013-08-30 2013-10-15 Piotr Kubinski Erweiterte Vorrichtung zur Selbsterhärtung der Dämpfung eines Wankbewegungsdämpfers für ein Kraftfahrzeug
US10457918B2 (en) * 2014-09-26 2019-10-29 The Regents Of The University Of California Tyrosine hydroxylase variants and methods of use thereof
JP6363934B2 (ja) 2014-10-17 2018-07-25 Ｋｙｂ株式会社 シリンダ装置
WO2016149821A1 (fr) * 2015-03-23 2016-09-29 Valorbec Société en Commandite Procédés de fabrication d'alcaloïdes de type morphinane et enzymes associées
CA2983419A1 (fr) * 2015-05-04 2016-11-10 The Board Of Trustees Of The Leland Stanford Junior University Precuseur d'alcaloide de benzylisoquinoline (bia) produisant des microbes, et ses procedes de fabrication et d'utilisation
CN107960102A (zh) * 2015-05-08 2018-04-24 小利兰·斯坦福大学托管委员会 产生差向异构酶和苄基异喹啉生物碱的方法
JP2016211676A (ja) 2015-05-11 2016-12-15 株式会社Ihi ダンパー
EP3303025B1 (fr) 2015-06-03 2021-04-21 Clearmotion, Inc. Procédés et systèmes de commande de mouvement de carrosserie de véhicule et d'expérience d'occupant
US9491788B1 (en) 2015-06-17 2016-11-08 Shimano Inc. Bicycle wireless system
FR3040331B1 (fr) 2015-09-02 2017-10-06 Peugeot Citroen Automobiles Sa Systeme de suspension et biellette de barre anti-devers d'un vehicule
US9834057B2 (en) 2015-11-04 2017-12-05 Ford Global Technologies, Llc Suspension stabilization system and related methods
AU2016253643A1 (en) 2015-11-06 2017-05-25 Jackson, Wayne Peter MR Hydraulic Anti-Sway Bar Disconnect System
US10737546B2 (en) 2016-04-08 2020-08-11 Fox Factory, Inc. Electronic compression and rebound control
WO2018005553A1 (fr) * 2016-06-27 2018-01-04 Intrexon Corporation Compositions et procédés de fabrication d'alcaloïdes de benzylisoquinoline, d'alcaloïdes de morphinane, de thébaïne et de dérivés de ceux-ci
WO2018000089A1 (fr) * 2016-06-27 2018-01-04 Serturner Corp. Polynucléotides et polypeptides utiles pour la fabrication de composés alcaloïdes
US11110913B2 (en) * 2016-11-18 2021-09-07 Polaris Industries Inc. Vehicle having adjustable suspension
EP3580075A4 (fr) 2017-02-12 2021-01-20 Clearmotion, Inc. Actionneur hydraulique à rapport de pression relative dépendant de la fréquence
DE102017111157B3 (de) 2017-05-22 2018-06-21 Kendrion (Villingen) Gmbh Regelbarer Schwingungsdämpfer
US10358010B2 (en) 2017-06-05 2019-07-23 Tenneco Automotive Operating Company Inc. Interlinked active suspension
BR112020002050A2 (pt) * 2017-08-03 2020-09-08 Antheia, Inc. epimerases engenheiradas alcaloides benzilisoquinolina e métodos de produção de alcaloides benzilisoquinolina
US10981429B2 (en) 2017-09-29 2021-04-20 Fox Factory, Inc. Electronically controlled sway bar damping link
US10933710B2 (en) 2017-09-29 2021-03-02 Fox Factory, Inc. Modular electronic damping control
JP7483617B2 (ja) * 2018-02-08 2024-05-15 アンテイア インコーポレイテッド モルフィナンアルカロイドおよび誘導体を生成する方法
JP6956266B2 (ja) 2018-05-29 2021-11-02 日立Astemo株式会社 サスペンション装置
JP7147528B2 (ja) * 2018-12-11 2022-10-05 トヨタ自動車株式会社 スタビライザ装置、および、それを備えたスタビライザシステム
DE112020001989T5 (de) 2019-04-15 2022-01-20 Tenneco Automotive Operating Company Inc. Aufhängungssystem mit mehreren arbeitsmodi
KR102186855B1 (ko) 2019-08-30 2020-12-07 현대모비스 주식회사 스태빌라이저 바 제어 장치 및 방법
US11446975B2 (en) 2019-09-20 2022-09-20 Shock Therapy Suspension, Inc. Convertible link for an anti-sway bar
FR3101809B1 (fr) 2019-10-09 2022-08-12 Hutchinson Dispositif antiroulis pour véhicule automobile.
US11951792B2 (en) 2020-02-24 2024-04-09 Ford Global Technologies, Llc Suspension component damage detection with marker
US20210309063A1 (en) 2020-04-02 2021-10-07 Fox Factory, Inc. Vehicle suspension management via an in-vehicle infotainment (ivi) system
US11904648B2 (en) 2020-07-17 2024-02-20 Polaris Industries Inc. Adjustable suspensions and vehicle operation for off-road recreational vehicles
US11865891B2 (en) 2020-10-30 2024-01-09 GM Global Technology Operations LLC Method and system for active roll control
US12168379B2 (en) 2020-11-19 2024-12-17 Fox Factory, Inc. Shock absorber with a bearing housing bypass assembly
US12138977B2 (en) 2020-11-19 2024-11-12 Fox Factory, Inc. Energy harvesting switch
US11634003B2 (en) 2020-12-17 2023-04-25 Fox Factory, Inc. Automated control system for an electronically controlled sway bar link
US12330459B2 (en) 2021-02-01 2025-06-17 Fox Factory, Inc. Three-port adjuster
US20220355638A1 (en) 2021-05-04 2022-11-10 Suspension Direct Inc. Electronically controlled adjustment system for sway bars
US11865887B2 (en) 2021-10-12 2024-01-09 DRiV Automotive Inc. Suspension system with incremental roll and pitch stiffness control
US12097739B2 (en) 2021-10-12 2024-09-24 DRiV Automotive Inc. Pump rinsing systems and methods
US11938772B2 (en) 2021-10-12 2024-03-26 DRiV Automotive Inc. System for grading filling of a hydraulic suspension system
US11904841B2 (en) 2021-10-12 2024-02-20 DRiV Automotive Inc. Suspension system integration with advanced driver assistance system
US12083850B2 (en) * 2021-12-20 2024-09-10 Fox Factory, Inc. Electronically controlled sway bar damping link
US20230249702A1 (en) 2022-02-04 2023-08-10 Fox Factory, Inc. Range sharing of vehicle setup iformation
US12157341B2 (en) 2022-02-11 2024-12-03 Daniel J Worley Electronically adjustable sway bar link
US20230294603A1 (en) 2022-03-18 2023-09-21 Oshkosh Corporation Braking system for a military vehicle

Also Published As

Publication number Publication date
WO2019051046A1 (fr) 2019-03-14
US20240375474A1 (en) 2024-11-14
AU2018329823A1 (en) 2020-04-23
EP3678667A1 (fr) 2020-07-15
CA3078818A1 (fr) 2019-03-14
US20200325509A1 (en) 2020-10-15
US12270062B2 (en) 2025-04-08
EP3678667A4 (fr) 2021-10-20

Similar Documents

Publication Publication Date Title
MA50095A (fr) Micro-organismes et méthodes pour la fermentation d'alcaloïdes de benzylisoquinoline
MA50632A (fr) Micro-organismes et procédés pour la fermentation de cannabinoïdes
EP3679141C0 (fr) Méthodes et compositions pour inhiber l'expression de la ldha
MA49403A (fr) Compositions de pde5 et méthodes d'immunothérapie
EP3510152A4 (fr) Méthodes et compositions pour moduler l'expression génique
EP3421009A4 (fr) Endoprothèse nue de l'aorte et endoprothèse pour dissection aortique
EP2490530A4 (fr) Composés et méthodes pour le traitement d'infections bactériennes
EP3500355A4 (fr) Bioréacteur et ses procédés d'utilisation
EP3328986A4 (fr) Fermenteur portatif horizontal multi-agité modulaire à usage unique pouvant être mis sous pression pour la culture de microorganismes
EP3464645A4 (fr) Méthodes de diagnostic d'infections bactériennes et virales
EP3402549A4 (fr) Compositions pour micro-aiguilles et méthodes d'utilisation de celles-ci
MA48579A (fr) Anticorps anti-pd1 et méthodes d'utilisation de ceux-ci
EP3383917A4 (fr) Nouveaux anticorps anti-claudine et méthodes d'utilisation
EP3682009A4 (fr) Système d'expression génique pour microorganismes probiotiques
EP3405191A4 (fr) Méthodes et compositions pour le traitement de l'hyperhidrose
EP3458079A4 (fr) Compositions et méthodes pour le traitement de l'acné
EP3508586A4 (fr) Procédé et kit de détection de micro-organismes pathogènes
EP3407925A4 (fr) Produits tissulaires f taux de support et méthodes d'utilisation
EP3641746A4 (fr) Méthodes et compositions pour le traitement d'une infection microbienne
EP3634431A4 (fr) Compositions et méthodes thérapeutiques pour le traitement de l'hépatite b
EP3651801A4 (fr) Compositions et méthodes pour le traitement d'infections fongiques
EP3843793A4 (fr) Système et procédé pour la réduction de micro-organismes
EP3746058A4 (fr) Compositions et méthodes d'amélioration de la biodisponibilité de 5-hydroxytryptophane
EP4058062A4 (fr) Compositions et méthodes pour l'immunothérapie
MA48743A (fr) Composés et méthodes de traitement d'infections bactériennes