MA50630A - Procédé de préparation de dérivés d'alpha-carboxamide de pyrrolidine - Google Patents

Procédé de préparation de dérivés d'alpha-carboxamide de pyrrolidine

Info

Publication number
MA50630A
MA50630A MA050630A MA50630A MA50630A MA 50630 A MA50630 A MA 50630A MA 050630 A MA050630 A MA 050630A MA 50630 A MA50630 A MA 50630A MA 50630 A MA50630 A MA 50630A
Authority
MA
Morocco
Prior art keywords
pyrrolidine
alpha
preparation
carboxamide derivatives
carboxamide
Prior art date
Application number
MA050630A
Other languages
English (en)
Inventor
Weirong Chen
Vinny Couming
Erwin Irdam
William F Kiesman
Daw-Long A Kwok
Wenli Liang
Tamera L Mack
Suzanne M Opalka
Daniel B Patience
Donald G Walker
Original Assignee
Biogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Inc filed Critical Biogen Inc
Publication of MA50630A publication Critical patent/MA50630A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
MA050630A 2017-10-05 2018-10-05 Procédé de préparation de dérivés d'alpha-carboxamide de pyrrolidine MA50630A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762568651P 2017-10-05 2017-10-05

Publications (1)

Publication Number Publication Date
MA50630A true MA50630A (fr) 2021-03-31

Family

ID=65995302

Family Applications (1)

Application Number Title Priority Date Filing Date
MA050630A MA50630A (fr) 2017-10-05 2018-10-05 Procédé de préparation de dérivés d'alpha-carboxamide de pyrrolidine

Country Status (12)

Country Link
US (2) US11192856B2 (fr)
EP (1) EP3691634A4 (fr)
JP (1) JP2020536870A (fr)
KR (1) KR20200061381A (fr)
CN (1) CN112153968A (fr)
AU (2) AU2018346763A1 (fr)
CA (1) CA3076823A1 (fr)
IL (1) IL273639B2 (fr)
MA (1) MA50630A (fr)
MX (1) MX2020003811A (fr)
SG (2) SG11202002706XA (fr)
WO (1) WO2019071162A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11192856B2 (en) 2017-10-05 2021-12-07 Biogen Inc. Process for preparing alpha-carboxamide pyrrolidine derivatives

Family Cites Families (42)

* Cited by examiner, † Cited by third party
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CH674205A5 (fr) * 1988-05-11 1990-05-15 Lonza Ag
IL94466A (en) 1989-05-25 1995-01-24 Erba Carlo Spa Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation
US6201016B1 (en) 1994-06-27 2001-03-13 Cytomed Incorporated Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
GB9618349D0 (en) 1996-09-03 1996-10-16 Pharmacia Spa N-substituted 2-amino-4-phenyl-4-oxo-butanoic acid derivatives with kynurenine-3-hydroxylase inhibitory activity
IT1290910B1 (it) 1997-02-03 1998-12-14 Sigma Tau Ind Farmaceuti 2-amminotetralina otticamente attiva, procedimento per la sua preparazione e composizioni farmaceutiche che la contengono, attive
GB9727523D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Alpha-aminoamide derivatives useful as analgesic agents
TW502019B (en) 1999-03-26 2002-09-11 Cocensys Inc Aryl substituted pyrazoles, imidazoles, oxazoles, thiazoles and pyrroles, and the use thereof
GB9923748D0 (en) 1999-10-07 1999-12-08 Glaxo Group Ltd Chemical compounds
IT1317049B1 (it) 2000-06-23 2003-05-26 Sigma Tau Ind Farmaceuti Composti utili per la preparazione di medicamenti ad attivita'inibitrice della fosfodiesterasi iv.
GB0115517D0 (en) 2001-06-25 2001-08-15 Ferring Bv Novel antidiabetic agents
PE20050077A1 (es) 2002-09-20 2005-03-01 Hoffmann La Roche Derivados de 4-pirrolidino-fenil-bencil-eter
MY142651A (en) 2003-03-18 2010-12-15 Merck Sharp & Dohme Biaryl substituted triazoles as sodium channel blockers
US7589116B2 (en) 2003-04-03 2009-09-15 Merck & Co. Inc. Biaryl substituted pyrazoles as sodium channel blockers
CA2522476A1 (fr) 2003-04-18 2004-11-04 Merck & Co., Inc. Thiazoles, oxazoles et imidazoles a substitution biaryle utilises comme bloqueurs du canal sodique
WO2005000309A2 (fr) 2003-06-27 2005-01-06 Ionix Pharmaceuticals Limited Composes chimiques
EP1524265A1 (fr) 2003-10-15 2005-04-20 Newron Pharmaceuticals S.p.A. Dérivés de prolinamide en tant que bloqueurs du canal sodium et/ou calcium ou inhibiteurs sélectifs de MAO-B
WO2005110982A2 (fr) 2004-04-07 2005-11-24 Neurogen Corporation Analogues substitues 1-benzyl-4-substitues piperazine
WO2005100334A1 (fr) 2004-04-14 2005-10-27 Pfizer Products Inc. Inhibiteurs de dipeptidyl peptidase-iv
JP2008540443A (ja) 2005-05-04 2008-11-20 バーテックス ファーマシューティカルズ インコーポレイテッド イオンチャネルのモジュレーターとして有用なピリミジンおよびピラジン
WO2006119390A1 (fr) 2005-05-04 2006-11-09 Vertex Pharmaceuticals Incorporated Pyridines utiles en tant que modulateurs de canaux ioniques
JP2008540665A (ja) 2005-05-19 2008-11-20 バーテックス ファーマシューティカルズ インコーポレイテッド イオンチャネルのモジュレーターとして有用なビアリール
EA013909B1 (ru) 2005-09-09 2010-08-30 Смитклайн Бичам Корпорейшн Пиридиновые производные и их применение для лечения психотических расстройств
TW200728258A (en) 2005-10-10 2007-08-01 Glaxo Group Ltd Novel compounds
TW200730494A (en) * 2005-10-10 2007-08-16 Glaxo Group Ltd Novel compounds
EP1943216B1 (fr) 2005-10-10 2010-06-30 Glaxo Group Limited Dérivés de prolinamide en tant que modulateurs des canaux sodiques
JP5182088B2 (ja) * 2006-04-19 2013-04-10 アステラス製薬株式会社 アゾールカルボキサミド誘導体
JP2007290973A (ja) * 2006-04-21 2007-11-08 Univ Nagoya 亜鉛−マグネシウムアート錯体を含む求核試薬及びそれを使用する求核付加体の製造方法
GB0701366D0 (en) 2007-01-24 2007-03-07 Glaxo Group Ltd Novel pharmaceutical compositions
EP2117538A1 (fr) 2007-01-24 2009-11-18 Glaxo Group Limited Compositions pharmaceutiques contenant du 2-méthoxy-5- (5-trifluorométhyl-tétrazol-i-yl-benzyl) - (2s-phényl-pipéridin-3s-yl-)
GB0701365D0 (en) 2007-01-24 2007-03-07 Glaxo Group Ltd Novel pharmaceutical compositions
GB0706630D0 (en) 2007-04-04 2007-05-16 Glaxo Group Ltd Novel compounds
DK2477964T5 (en) 2009-09-14 2015-05-26 Convergence Pharmaceuticals A process for the preparation of alpha-carboxamide
US20110144081A1 (en) * 2009-12-15 2011-06-16 Henner Knust Pyrrolidine derivatives
WO2011155337A1 (fr) 2010-06-11 2011-12-15 シャープ株式会社 Dispositif à cristaux liquides
ES2428439T1 (es) * 2010-11-11 2013-11-07 Aarti Healthcare Limited Un procedimiento para la preparación de Ramipril
ES2912881T3 (es) * 2014-12-23 2022-05-30 Convergence Pharmaceuticals Procedimiento para preparar derivados de alfa-carboxamida pirrolidina
WO2016160574A2 (fr) 2015-03-27 2016-10-06 Scifluor Life Sciences, Inc. Composés d'aryl-et hétéroaryl-pyrrolidine-2-carboxamide
CN106467513A (zh) * 2016-09-30 2017-03-01 陕西科技大学 一种制备Niraparib的合成方法
US11192856B2 (en) 2017-10-05 2021-12-07 Biogen Inc. Process for preparing alpha-carboxamide pyrrolidine derivatives
WO2020210486A1 (fr) 2019-04-10 2020-10-15 Biogen Inc. Procédés de préparation de dérivés de pyrrolidine alpha-carboxamide
CN114026066A (zh) 2019-04-10 2022-02-08 生物基因麻省公司 制备α-甲酰胺吡咯烷衍生物的方法

Also Published As

Publication number Publication date
AU2023204011A1 (en) 2023-07-13
WO2019071162A2 (fr) 2019-04-11
IL273639B1 (en) 2023-03-01
IL273639A (en) 2020-05-31
CA3076823A1 (fr) 2019-04-11
US11192856B2 (en) 2021-12-07
EP3691634A2 (fr) 2020-08-12
SG11202002706XA (en) 2020-04-29
JP2020536870A (ja) 2020-12-17
CN112153968A (zh) 2020-12-29
MX2020003811A (es) 2021-01-15
IL273639B2 (en) 2023-07-01
EP3691634A4 (fr) 2021-03-31
US20200270206A1 (en) 2020-08-27
SG10202112966SA (en) 2021-12-30
WO2019071162A3 (fr) 2020-03-26
AU2018346763A1 (en) 2020-04-16
KR20200061381A (ko) 2020-06-02
US20220356154A1 (en) 2022-11-10

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