MA51075A - Procédés et compositions pour traiter des troubles à l'aide de polypeptides de follistatine - Google Patents

Procédés et compositions pour traiter des troubles à l'aide de polypeptides de follistatine

Info

Publication number
MA51075A
MA51075A MA051075A MA51075A MA51075A MA 51075 A MA51075 A MA 51075A MA 051075 A MA051075 A MA 051075A MA 51075 A MA51075 A MA 51075A MA 51075 A MA51075 A MA 51075A
Authority
MA
Morocco
Prior art keywords
compositions
methods
treating disorders
follistatin polypeptides
follistatin
Prior art date
Application number
MA051075A
Other languages
English (en)
Inventor
Asya Grinberg
Ravindra Kumar
Original Assignee
Acceleron Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acceleron Pharma Inc filed Critical Acceleron Pharma Inc
Publication of MA51075A publication Critical patent/MA51075A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4707—Muscular dystrophy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/06—Anabolic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
MA051075A 2014-06-04 2015-06-04 Procédés et compositions pour traiter des troubles à l'aide de polypeptides de follistatine MA51075A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462007908P 2014-06-04 2014-06-04

Publications (1)

Publication Number Publication Date
MA51075A true MA51075A (fr) 2020-10-14

Family

ID=54767384

Family Applications (2)

Application Number Title Priority Date Filing Date
MA051074A MA51074A (fr) 2014-06-04 2015-06-04 Procédés et compositions pour traiter des troubles à l'aide de polypeptides de follistatine
MA051075A MA51075A (fr) 2014-06-04 2015-06-04 Procédés et compositions pour traiter des troubles à l'aide de polypeptides de follistatine

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MA051074A MA51074A (fr) 2014-06-04 2015-06-04 Procédés et compositions pour traiter des troubles à l'aide de polypeptides de follistatine

Country Status (12)

Country Link
US (2) US10023621B2 (fr)
EP (2) EP3721892B1 (fr)
JP (3) JP6568110B2 (fr)
KR (4) KR102132144B1 (fr)
CN (2) CN113583104A (fr)
AU (2) AU2015269333B2 (fr)
BR (1) BR112016028520A2 (fr)
CA (1) CA2950754C (fr)
EA (2) EA202090632A1 (fr)
MA (2) MA51074A (fr)
MX (2) MX382908B (fr)
WO (1) WO2015187977A1 (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2781222B1 (fr) 2005-11-23 2017-08-02 Acceleron Pharma, Inc. Antagonistes de l'activine-actriia destinés à être utilisés pour la promotion de la croissance osseuse
CN102131822A (zh) 2008-06-26 2011-07-20 阿塞勒隆制药公司 进行激活素-ActRIIa拮抗剂给药和监测受治疗患者的方法
EA201590719A1 (ru) 2013-01-25 2015-12-30 Шир Хьюман Дженетик Терапис, Инк. Фоллистатин в лечении мышечной дистрофии дюшенна
US10010498B2 (en) 2014-06-04 2018-07-03 Acceleron Pharma Inc. Methods for treatment of amyotrophic lateral sclerosis with follistatin fusion proteins
KR102132144B1 (ko) 2014-06-04 2020-07-09 악셀레론 파마 인코포레이티드 폴리스타틴 폴리펩티드를 이용한 장애의 치료방법 및 치료를 위한 조성물
MA40008A (fr) 2014-06-13 2021-05-05 Acceleron Pharma Inc Antagoniste actrii pour le traitement et la prevention d'un ulcere cutane chez un sujet ayant l'anemie
CN107636154A (zh) 2015-03-26 2018-01-26 阿塞勒隆制药公司 促滤泡素抑制素相关的融合蛋白及其用途
MA43588A (fr) * 2016-03-04 2021-06-02 Takeda Pharmaceuticals Co Protéines de fusion follistatine-fc recombinantes et leur utilisation dans le traitement de la dystrophie musculaire de duchenne
US10905766B2 (en) 2017-03-23 2021-02-02 Oregon State University Therapeutic compositions and methods for treatment of muscle wasting diseases
KR101822633B1 (ko) * 2017-08-22 2018-01-26 (주)진셀팜 폴리스타틴 유래 생리활성 펩타이드, 및 이의 용도
WO2019046903A1 (fr) * 2017-09-08 2019-03-14 Baker Heart and Diabetes Institute Procédé thérapeutique pour augmenter la masse musculaire chez un sujet
CN108218985B (zh) * 2017-12-12 2021-04-30 山西农业大学 一种利用特征多肽制备fst蛋白特异性抗体的方法及其应用
CN111936617A (zh) * 2018-03-16 2020-11-13 益缪索夫特公司 经遗传工程化以分泌卵泡抑素的b细胞以及使用所述b细胞来治疗卵泡抑素相关的疾病、病况、病症及增强肌肉生长和力量的方法
CN111902157B (zh) * 2018-03-21 2023-08-04 松阳生技股份有限公司 促进局部肌肉增长、减缓或防止局部肌肉萎缩的组合物及其用途
WO2019191204A1 (fr) * 2018-03-28 2019-10-03 Acceleron Pharma Inc. Polypeptides de follistatine pour le traitement de la contracture musculaire
US20210207135A1 (en) * 2018-05-17 2021-07-08 Housey Pharmaceutical Research Laboratories, L.L.C. Inhibition of follistatin
US12246042B2 (en) 2018-08-29 2025-03-11 Myos Corp. Methods for alleviating, inhibiting or reversing muscle disuse atrophy in mammals
WO2021222875A1 (fr) 2020-04-30 2021-11-04 Keros Therapeutics, Inc. Procédés d'utilisation d'inhibiteurs d'alk2
WO2022098812A1 (fr) 2020-11-04 2022-05-12 Keros Therapeutics, Inc. Méthodes de traitement d'une surcharge en fer
AU2022214780A1 (en) * 2021-01-26 2023-09-07 Immunis, Inc. Molecular superstructure and methods of use thereof
AU2023291634C9 (en) 2022-06-15 2026-01-22 UCB Biopharma SRL Follistatin fusion proteins
KR20250036807A (ko) 2022-06-15 2025-03-14 유씨비 바이오파마 에스알엘 신장 질환의 예방, 치료 또는 완화를 위한 융합 단백질
JP2026500221A (ja) * 2022-12-07 2026-01-06 カミノ エーピーエス 治療薬または診断薬の局所的ローディングのための細胞外マトリックス結合化合物
TW202530250A (zh) * 2024-01-25 2025-08-01 大陸商四川至善唯新生物科技有限公司 編碼卵泡抑素的核酸及其用途

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987005330A1 (fr) 1986-03-07 1987-09-11 Michel Louis Eugene Bergh Procede pour ameliorer la stabilite des glycoproteines
US5182375A (en) 1987-08-28 1993-01-26 The Salk Institute For Biological Studies DNA encoding follistatin
US5041538A (en) 1987-08-28 1991-08-20 The Salk Institute For Biological Studies Mammalian follistatin
CA2080226C (fr) * 1991-02-08 2004-05-04 Gary A. Beaudry Chimeres cd4-gamma2 et cd4-igg2
DE69310525T2 (de) 1992-09-16 1997-10-02 Genentech Inc Schutz gegen leberschäden mit hgf
US6686198B1 (en) 1993-10-14 2004-02-03 President And Fellows Of Harvard College Method of inducing and maintaining neuronal cells
AU701623B2 (en) 1993-10-14 1999-02-04 President And Fellows Of Harvard College Method of inducing and maintaining neuronal cells
US5541087A (en) 1994-09-14 1996-07-30 Fuji Immunopharmaceuticals Corporation Expression and export technology of proteins as immunofusins
US5545616A (en) 1994-09-22 1996-08-13 Genentech, Inc. Method for predicting and/or preventing preterm labor
GB2306481A (en) 1995-10-21 1997-05-07 Univ Manchester Pharmaceutical comprising a stimulator of activin and/or inhibin
US6891082B2 (en) 1997-08-01 2005-05-10 The Johns Hopkins University School Of Medicine Transgenic non-human animals expressing a truncated activintype II receptor
US6656475B1 (en) 1997-08-01 2003-12-02 The Johns Hopkins University School Of Medicine Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same
AU8666398A (en) 1997-08-01 1999-02-22 Johns Hopkins University School Of Medicine, The Methods to identify growth differentiation factor (gdf) receptors
US6004937A (en) 1998-03-09 1999-12-21 Genetics Institute, Inc. Use of follistatin to modulate growth and differentiation factor 8 [GDF-8] and bone morphogenic protein 11 [BMP-11]
NZ513642A (en) 1999-01-21 2004-02-27 Metamorphix Inc Growth differentiation factor inhibitors and uses therefor
AU777783B2 (en) 1999-04-19 2004-10-28 Kyowa Hakko Kogyo Co. Ltd. Proliferation inhibitor for androgen-independent tumor
WO2001009368A1 (fr) 1999-07-30 2001-02-08 The General Hospital Corporation Antagonistes de la follistatine
JP4487376B2 (ja) 2000-03-31 2010-06-23 味の素株式会社 腎疾患治療剤
AUPR638101A0 (en) 2001-07-13 2001-08-09 Bioa Pty Limited Composition and method for treatment of disease
JP4429728B2 (ja) 2002-02-21 2010-03-10 ワイス エルエルシー フォリスタチン（ｆｏｌｌｉｓｔａｔｉｎ）ドメイン含有タンパク質
CN1993048A (zh) * 2002-02-21 2007-07-04 惠氏公司 包含促滤泡素抑制素结构域的蛋白质
BR0307907A2 (pt) 2002-02-21 2011-07-05 Wyeth Corp gasp1: proteìna contendo domìnio de folistatina
ATE474593T1 (de) 2003-03-21 2010-08-15 Celldex Therapeutics Ltd Behandlung von allergischen erkrankungen unter verwendung eines modulators des notch signaling pathway
JP5110877B2 (ja) 2003-06-02 2012-12-26 ワイス・エルエルシー 神経筋障害を処置するための、コルチコステロイドと組み合わせたミオスタチン（ｇｄｆ８）インヒビターの使用
US20070135336A1 (en) 2003-09-15 2007-06-14 De Kretser David Follistatin isoforms and uses thereof
US7355018B2 (en) * 2003-09-30 2008-04-08 Regeneron Pharmaceuticals, Inc. Modified IGF1 polypeptides with increased stability and potency
JP2007507429A (ja) 2003-10-06 2007-03-29 モナシュ ユニバーシティー 治療方法
JP4688483B2 (ja) 2004-04-15 2011-05-25 株式会社テクノネットワーク四国 フォリスタチン変異体ポリペプチド
EP3489257A1 (fr) * 2004-07-23 2019-05-29 Acceleron Pharma Inc. Polypeptides du récepteur actrii, procédés et compositions
MX2007000976A (es) 2004-08-12 2007-04-10 Wyeth Corp Tratamiento combinado para diabetes, obesidad y enfermedades cardiovasculares utilizando inhibidores del factor 8 de crecimiento y diferenciacion.
NZ538097A (en) 2005-02-07 2006-07-28 Ovita Ltd Method and compositions for improving wound healing
PL2407486T3 (pl) 2005-08-19 2018-05-30 Wyeth Llc Przeciwciała antagonistyczne względem GDF-8 i zastosowania w leczeniu ALS i innych zaburzeń związanych z GDF-8
EP1968621A2 (fr) * 2005-12-06 2008-09-17 Amgen Inc. Utilisations d'antagonistes de la myostatine
WO2008030367A2 (fr) 2006-09-01 2008-03-13 The General Hospital Corporation Inhibiteurs sélectifs de la myostatine
ES2569365T3 (es) 2006-11-29 2016-05-10 Nationwide Children's Hospital Inhibición de miostatina para la potenciación de músculo y/o la mejora de la función muscular
US20100028332A1 (en) 2006-12-18 2010-02-04 Acceleron Pharma Inc. Antagonists of actriib and uses for increasing red blood cell levels
US8895016B2 (en) 2006-12-18 2014-11-25 Acceleron Pharma, Inc. Antagonists of activin-actriia and uses for increasing red blood cell levels
WO2008076437A2 (fr) 2006-12-18 2008-06-26 Acceleron Pharma Inc. Antagonistes de l'activine-actrii et ses utilisations pour accroître les niveaux de globules rouges
EP3663318A1 (fr) 2008-01-07 2020-06-10 Amgen Inc. Procédé de fabrication de molécules hétérodimères fc d'anticorps utilisant les effets de conduite électrostatique
KR20110031951A (ko) * 2008-06-26 2011-03-29 악셀레론 파마 인코포레이티드 액티빈-ａｃｔｒｉｉａ의 길항물질 및 적혈구 수준을 증가시키기 위한 이들의 용도
CN102131822A (zh) * 2008-06-26 2011-07-20 阿塞勒隆制药公司 进行激活素-ActRIIa拮抗剂给药和监测受治疗患者的方法
JP6211767B2 (ja) * 2009-09-09 2017-10-11 アクセルロン ファーマ， インコーポレイテッド ＡｃｔＲＩＩｂアンタゴニストならびにその投薬および使用
AR082518A1 (es) * 2010-08-25 2012-12-12 Hoffmann La Roche Anticuerpos contra il-18r1 y usos de los mismos
PL2635607T3 (pl) 2010-11-05 2020-05-18 Zymeworks Inc. Projekt stabilnego przeciwciała heterodimerowego z mutacjami w domenie FC
WO2013151663A1 (fr) 2012-04-02 2013-10-10 modeRNA Therapeutics Polynucléotides modifiés pour la production de protéines membranaires
US10034920B2 (en) 2012-05-17 2018-07-31 Paranta Biosciences Limited Method of treatment and agents useful for same
AU2013281328B2 (en) * 2012-06-27 2017-11-23 MeiraGTx Gene Regulation Limited Combination for treating an inflammatory disorder
EA201590719A1 (ru) 2013-01-25 2015-12-30 Шир Хьюман Дженетик Терапис, Инк. Фоллистатин в лечении мышечной дистрофии дюшенна
WO2014187807A1 (fr) 2013-05-21 2014-11-27 Arcarios B.V. Dérivés de follistatine
KR102132144B1 (ko) * 2014-06-04 2020-07-09 악셀레론 파마 인코포레이티드 폴리스타틴 폴리펩티드를 이용한 장애의 치료방법 및 치료를 위한 조성물
US10010498B2 (en) 2014-06-04 2018-07-03 Acceleron Pharma Inc. Methods for treatment of amyotrophic lateral sclerosis with follistatin fusion proteins
CN107636154A (zh) 2015-03-26 2018-01-26 阿塞勒隆制药公司 促滤泡素抑制素相关的融合蛋白及其用途
JP2020519291A (ja) 2017-05-12 2020-07-02 シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド 組み換えフォリスタチン−ｆｃ融合タンパク質およびデュシェンヌ型筋ジストロフィーの治療における使用

Also Published As

Publication number Publication date
MX382908B (es) 2025-03-13
KR102132144B1 (ko) 2020-07-09
KR20210119546A (ko) 2021-10-05
CN113583104A (zh) 2021-11-02
JP6568110B2 (ja) 2019-08-28
MX2021006017A (es) 2021-07-06
AU2015269333A1 (en) 2016-12-15
BR112016028520A2 (pt) 2017-10-24
JP2019203017A (ja) 2019-11-28
US10023621B2 (en) 2018-07-17
EP3152237B1 (fr) 2020-04-01
KR102077286B1 (ko) 2020-02-13
JP2021095416A (ja) 2021-06-24
EP3721892B1 (fr) 2024-05-22
EA202090632A1 (ru) 2020-07-31
CN106795224A (zh) 2017-05-31
MX2016015868A (es) 2017-04-05
AU2015269333B2 (en) 2020-05-07
US10954279B2 (en) 2021-03-23
KR20200017548A (ko) 2020-02-18
US20180340013A1 (en) 2018-11-29
CA2950754A1 (fr) 2015-12-10
MA51074A (fr) 2020-10-14
EP3152237A4 (fr) 2017-11-01
EA201692529A1 (ru) 2017-05-31
WO2015187977A1 (fr) 2015-12-10
CA2950754C (fr) 2021-10-26
KR102305109B1 (ko) 2021-09-27
EP3721892A1 (fr) 2020-10-14
AU2020210315A1 (en) 2020-08-27
KR20170005891A (ko) 2017-01-16
JP6856716B2 (ja) 2021-04-07
JP2017518303A (ja) 2017-07-06
US20160185836A1 (en) 2016-06-30
CN106795224B (zh) 2021-05-18
KR20200084064A (ko) 2020-07-09
EA035455B1 (ru) 2020-06-18
EP3152237A1 (fr) 2017-04-12

Similar Documents

Publication Publication Date Title
MA51074A (fr) Procédés et compositions pour traiter des troubles à l'aide de polypeptides de follistatine
IL291533A (en) Compounds and preparations including them for the treatment of diseases of the central nervous system
EP3481387A4 (fr) Methodes et compositions pour le traitement de troubles épileptiques
EP3364993A4 (fr) Procédés pour traiter le syndrome d'angelman et des troubles associés
EP3324960A4 (fr) Procédés permettant de traiter des troubles associés à l'angiogenèse et à une néovascularisation
EP3319976A4 (fr) Compositions et procédés pour traiter des maladies pulmonaires et des lésions pulmonaires
SMT202000414T1 (it) Composizioni e metodi per trattare disturbi del snc
ME03749B (fr) Compositions et procédés pour traiter des troubles du snc
EP3353278A4 (fr) Préparation d'échantillons pour des types d'échantillons compliqués
EP3390642A4 (fr) Compositions et procédés pour le traitement de rétinite pigmentaire 18 et de rétinite pigmentaire 13
PL3250210T3 (pl) Kompozycje i sposoby leczenia zaburzeń OUN
EP3331527A4 (fr) Procédés de traitement de troubles du développement à l'aide de pipradrol
EP3180022A4 (fr) Cassette d'expression améliorée pour le conditionnement et l'expression de variantes du facteur viii pour le traitement des troubles de l'hémostase
MA44886A (fr) Compositions et méthode pour traiter des troubles acide-base
EP3331542A4 (fr) Compositions et procédés pour traiter des cancers associés à l'activation d'etbr
EP3692151A4 (fr) Thérapies géniques pour troubles lysosomaux
EP3358929A4 (fr) Procédés et appareils pour le traitement d'une matière agricole
EP3703706A4 (fr) Compositions et méthode pour traiter des troubles acide-base
EP3204028A4 (fr) Composition synergique pour l'arthrose
EP3442554A4 (fr) Compositions et méthodes pour le traitement de troubles associés à la néovascularisation
EP3661492A4 (fr) Procédés et compositions pour traiter des troubles neurologiques
EP3506927A4 (fr) Compositions de reeline pour le traitement des troubles neurologiques
FR3020758B1 (fr) Composition pour ameliorer l'hygiene buco-dentaire
MA44747A (fr) Méthodes et compositions pour le traitement de troubles associés à une accumulation du glycogène cytoplasmique
EP3294339A4 (fr) Méthodes et compositions pour le traitement de l'arthrite