MA51568A - Composés aza-, oxa et thia-pregnan-20-one-3.alpha.-ol s'utilisant dans le traitement de troubles du système nerveux central - Google Patents
Composés aza-, oxa et thia-pregnan-20-one-3.alpha.-ol s'utilisant dans le traitement de troubles du système nerveux centralInfo
- Publication number
- MA51568A MA51568A MA051568A MA51568A MA51568A MA 51568 A MA51568 A MA 51568A MA 051568 A MA051568 A MA 051568A MA 51568 A MA51568 A MA 51568A MA 51568 A MA51568 A MA 51568A
- Authority
- MA
- Morocco
- Prior art keywords
- pregnan
- thia
- aza
- oxa
- alpha
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/003—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by oxygen as hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/006—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by sulfur as hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
- C07J75/005—Preparation of steroids by cyclization of non-steroid compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862617134P | 2018-01-12 | 2018-01-12 | |
| US201862616768P | 2018-01-12 | 2018-01-12 | |
| US201862728514P | 2018-09-07 | 2018-09-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA51568A true MA51568A (fr) | 2021-04-21 |
Family
ID=65324563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA051568A MA51568A (fr) | 2018-01-12 | 2019-01-11 | Composés aza-, oxa et thia-pregnan-20-one-3.alpha.-ol s'utilisant dans le traitement de troubles du système nerveux central |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US11718642B2 (fr) |
| EP (2) | EP4706761A3 (fr) |
| JP (3) | JP7538040B2 (fr) |
| MA (1) | MA51568A (fr) |
| TW (2) | TW202612704A (fr) |
| WO (1) | WO2019140272A1 (fr) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG10201606063RA (en) | 2012-01-23 | 2016-09-29 | Sage Therapeutics Inc | Neuroactive steroid formulations and methods of treating cns disorders |
| RS62761B1 (sr) | 2012-08-21 | 2022-01-31 | Sage Therapeutics Inc | Alopregnanolon za lečenje refraktornog epileptičkog statusa |
| SMT202100509T1 (it) | 2013-04-17 | 2021-11-12 | Sage Therapeutics Inc | Steroide di c21-n-pirazolile 19-nor c3,3-disostituito per l'uso in terapia |
| US10246482B2 (en) | 2014-06-18 | 2019-04-02 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| JOP20200195A1 (ar) | 2014-09-08 | 2017-06-16 | Sage Therapeutics Inc | سترويدات وتركيبات نشطة عصبياً، واستخداماتها |
| WO2016082789A1 (fr) | 2014-11-27 | 2016-06-02 | Sage Therapeutics, Inc. | Compositions et procédés pour traiter des troubles du snc |
| WO2018013613A1 (fr) | 2016-07-11 | 2018-01-18 | Sage Therapeutics, Inc. | Stéroïdes neuroactifs substitués en c17, c20 et c21 et leurs procédés d'utilisation |
| TW202604538A (zh) | 2016-08-23 | 2026-02-01 | 美商賽吉醫療公司 | 結晶19-去甲c3,3-二取代之c21-n-吡唑類固醇 |
| US20200291059A1 (en) | 2017-12-08 | 2020-09-17 | Sage Therapeutics, Inc. | Compositions and methods for treating cns disorders |
| JP7538040B2 (ja) | 2018-01-12 | 2024-08-21 | セージ セラピューティクス, インコーポレイテッド | CNS障害の処置における使用のためのアザ、オキサ、およびチア-プレグナン-20-オン-3α-オール化合物 |
| US10857163B1 (en) | 2019-09-30 | 2020-12-08 | Athenen Therapeutics, Inc. | Compositions that preferentially potentiate subtypes of GABAA receptors and methods of use thereof |
| US20230018765A1 (en) * | 2019-12-05 | 2023-01-19 | Sage Therapeutics, Inc. | A 19-nor c3,3-disubstituted c21-n-pyrazolyl steroid and methods of use thereof |
| CN111233815B (zh) * | 2020-01-21 | 2022-10-14 | 上海应用技术大学 | 一种异阿根廷蚁素的制备方法 |
| CN115551514A (zh) | 2020-03-25 | 2022-12-30 | 萨奇治疗股份有限公司 | 用于治疗呼吸系统病症的药物的用途 |
| CN118401539A (zh) | 2021-12-15 | 2024-07-26 | 兆维生物科技公司 | 官能化的n-乙酰半乳糖胺类似物 |
| US12116382B2 (en) | 2022-11-28 | 2024-10-15 | Hongene Biotech Corporation | Functionalized N-acetylgalactosamine analogs |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL48628A0 (en) * | 1974-12-23 | 1976-02-29 | Schering Ag | D-homo-20-keto-pregnanes and process for their manufactur |
| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| JP4008024B2 (ja) | 1993-05-24 | 2007-11-14 | パーデュー、ファーマ、リミテッド、パートナーシップ | Gabaaレセプター複合体と相互作用させるための化合物 |
| BR9509764A (pt) * | 1994-11-23 | 1998-07-07 | Cocensys Inc | Série androstano e pregnano para modulação alostérica de receptor de gaba |
| PT837874E (pt) | 1995-06-06 | 2005-03-31 | Euro Celtique Sa | Esteroides neuroactivos da serie androstano e pregnano |
| AU3967297A (en) | 1996-08-01 | 1998-02-25 | Cocensys, Inc. | Use of gaba and nmda receptor ligands for the treatment of migraine headache |
| SMT202100509T1 (it) | 2013-04-17 | 2021-11-12 | Sage Therapeutics Inc | Steroide di c21-n-pirazolile 19-nor c3,3-disostituito per l'uso in terapia |
| US20170233433A1 (en) | 2014-10-16 | 2017-08-17 | Sage Therapeutics, Inc. | Compositions and methods for treating cns disorders |
| EP3728285B1 (fr) | 2017-12-22 | 2026-04-08 | Sage Therapeutics, LLC | Compositions et méthodes permettant de traiter les troubles du snc |
| JP7538040B2 (ja) | 2018-01-12 | 2024-08-21 | セージ セラピューティクス, インコーポレイテッド | CNS障害の処置における使用のためのアザ、オキサ、およびチア-プレグナン-20-オン-3α-オール化合物 |
| US12139508B2 (en) | 2018-02-11 | 2024-11-12 | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. | Steroid derivative regulators, method for preparing the same, and uses thereof |
| CN109503694A (zh) | 2018-11-21 | 2019-03-22 | 苏州闻天医药科技有限公司 | 一种新型gabaa受体调节剂及其用途 |
| IL312610B2 (en) | 2018-12-05 | 2026-05-01 | Sage Therapeutics Llc | Neuroactive steroids and methods of using them |
| CN113272315B (zh) | 2018-12-26 | 2023-08-08 | 张家口华健致远生物科技有限公司 | 一类类固醇化合物及其用途 |
| AU2021238346A1 (en) | 2020-03-18 | 2022-09-29 | Sage Therapeutics, Inc. | Neuroactive steroids and their methods of use |
-
2019
- 2019-01-11 JP JP2020538573A patent/JP7538040B2/ja active Active
- 2019-01-11 EP EP25209494.1A patent/EP4706761A3/fr active Pending
- 2019-01-11 MA MA051568A patent/MA51568A/fr unknown
- 2019-01-11 TW TW114119429A patent/TW202612704A/zh unknown
- 2019-01-11 TW TW108101261A patent/TW201930269A/zh unknown
- 2019-01-11 WO PCT/US2019/013315 patent/WO2019140272A1/fr not_active Ceased
- 2019-01-11 EP EP19703816.9A patent/EP3737687B1/fr active Active
- 2019-01-11 US US16/961,097 patent/US11718642B2/en active Active
-
2023
- 2023-06-05 US US18/328,865 patent/US12421275B2/en active Active
- 2023-08-03 JP JP2023127398A patent/JP7817214B2/ja active Active
-
2025
- 2025-04-02 JP JP2025061337A patent/JP2025106370A/ja active Pending
- 2025-08-06 US US19/291,992 patent/US20260078143A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2025106370A (ja) | 2025-07-15 |
| JP7817214B2 (ja) | 2026-02-18 |
| EP3737687B1 (fr) | 2025-10-22 |
| JP2023145726A (ja) | 2023-10-11 |
| WO2019140272A1 (fr) | 2019-07-18 |
| US20260078143A1 (en) | 2026-03-19 |
| US20240150393A1 (en) | 2024-05-09 |
| TW201930269A (zh) | 2019-08-01 |
| JP2021510695A (ja) | 2021-04-30 |
| TW202612704A (zh) | 2026-04-01 |
| US12421275B2 (en) | 2025-09-23 |
| EP3737687A1 (fr) | 2020-11-18 |
| US20200354399A1 (en) | 2020-11-12 |
| EP4706761A3 (fr) | 2026-05-06 |
| EP4706761A2 (fr) | 2026-03-11 |
| US11718642B2 (en) | 2023-08-08 |
| JP7538040B2 (ja) | 2024-08-21 |
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