MA51763A - Nouveaux peptides et combinaison de peptides à utiliser dans l'immunothérapie du cancer du poumon, y compris le cpnpc et d'autres cancers - Google Patents

Nouveaux peptides et combinaison de peptides à utiliser dans l'immunothérapie du cancer du poumon, y compris le cpnpc et d'autres cancers

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Publication number
MA51763A
MA51763A MA051763A MA51763A MA51763A MA 51763 A MA51763 A MA 51763A MA 051763 A MA051763 A MA 051763A MA 51763 A MA51763 A MA 51763A MA 51763 A MA51763 A MA 51763A
Authority
MA
Morocco
Prior art keywords
peptides
immunotherapy
cancers
combination
lung cancer
Prior art date
Application number
MA051763A
Other languages
English (en)
Inventor
Jens Fritsche
Julia Leibold
Andrea Mahr
Oliver Schoor
Harpreet Singh
Colette Song
Claudia Wagner
Toni Weinschenk
Original Assignee
Immatics Biotechnologies Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immatics Biotechnologies Gmbh filed Critical Immatics Biotechnologies Gmbh
Publication of MA51763A publication Critical patent/MA51763A/fr

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201511546D0 (en) 2015-07-01 2015-08-12 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers
CN108026154B (zh) 2015-07-01 2022-03-08 伊玛提克斯生物技术有限公司 用于卵巢癌和其他癌症免疫治疗的新型肽和肽组合物
GB201512369D0 (en) 2015-07-15 2015-08-19 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against epithelial ovarian cancer and other cancers
PH12022551111A1 (en) 2015-10-05 2023-08-23 Immatics Biotechnologies Gmbh Peptides and combination of peptides for use in immunotherapy against small cell lung cancer and other cancers
RU2729116C2 (ru) 2015-12-16 2020-08-04 Гритстоун Онколоджи, Инк. Идентификация, производство и применение неоантигенов
JP7266834B2 (ja) 2015-12-28 2023-05-01 北海道公立大学法人 札幌医科大学 腫瘍抗原ペプチド
GB201604490D0 (en) * 2016-03-16 2016-04-27 Immatics Biotechnologies Gmbh Peptides combination of peptides for use in immunotherapy against cancers
GB201609193D0 (en) 2016-05-25 2016-07-06 Immatics Biotechnologies Gmbh Novel peptides, combination of peptides as targets for use in immunotherapy against gallbladder cancer and cholangiocarcinoma and other cancers
JP7075125B2 (ja) 2016-05-25 2022-05-25 イマティクス バイオテクノロジーズ ゲーエムベーハー 標的としてのおよび胆嚢がんおよび胆管がんおよびその他のがんに対する免疫療法で使用するための新規ペプチド、ペプチド組み合わせ
TW202304970A (zh) 2016-08-26 2023-02-01 德商英麥提克生物技術股份有限公司 用於頭頸鱗狀細胞癌和其他癌症免疫治療的新型肽和支架
DE102016123893A1 (de) 2016-12-08 2018-06-14 Immatics Biotechnologies Gmbh T-Zellrezeptoren mit verbesserter Bindung
EP4317432A3 (fr) 2016-12-08 2024-04-17 Immatics Biotechnologies GmbH Récepteurs de lymphocytes t à appariement amélioré
US11427614B2 (en) 2017-04-10 2022-08-30 Immatics Biotechnologies Gmbh Peptides and combination thereof for use in the immunotherapy against cancers
TW201841937A (zh) 2017-04-10 2018-12-01 德商英麥提克生物技術股份有限公司 用於白血病和其他癌症免疫治療的新穎肽和肽組合物
BR112019020959A2 (pt) * 2017-04-10 2020-05-05 Immatics Biotechnologies Gmbh peptídeos e combinações dos mesmos para uso na imunoterapia contra câncer
MY197772A (en) 2017-04-10 2023-07-13 Immatics Biotechnologies Gmbh Peptides and combination of peptides for use in immunotherapy against leukemias and other cancers
US10800823B2 (en) * 2017-07-07 2020-10-13 Immatics Biotechnologies Gmbh Peptides and combination of peptides for use in immunotherapy against lung cancer, including NSCLC, SCLC and other cancers
DE102017115966A1 (de) 2017-07-14 2019-01-17 Immatics Biotechnologies Gmbh Polypeptidmolekül mit verbesserter zweifacher Spezifität
SG11202000025SA (en) 2017-07-14 2020-02-27 Immatics Biotechnologies Gmbh Improved dual specificity polypeptide molecule
KR20260039788A (ko) 2017-10-10 2026-03-20 시애틀 프로젝트 코포레이션 핫스팟을 이용한 신생항원 동정
CA3083097A1 (fr) 2017-11-22 2019-05-31 Gritstone Oncology, Inc. Reduction de la presentation d'epitope de jonction pour des neo-antigenes
AU2019218128A1 (en) * 2018-02-09 2020-09-17 Genentech, Inc. Therapeutic and diagnostic methods for mast cell-mediated inflammatory diseases
TW202016131A (zh) * 2018-05-16 2020-05-01 德商英麥提克生物技術股份有限公司 用於抗癌免疫治療的肽
CN109116023B (zh) * 2018-06-14 2021-06-04 郑州大学第一附属医院 一种肺癌标志物抗-mmp12自身抗体及其应用
KR20210086612A (ko) 2018-09-04 2021-07-08 트레오스 바이오 리미티드 펩타이드 백신
TW202039535A (zh) 2018-12-18 2020-11-01 德商英麥提克生物技術股份有限公司 B*08限制肽和肽組合物抗癌免疫治療和相關方法
EP3739588A1 (fr) * 2019-05-13 2020-11-18 Koninklijke Philips N.V. Évaluation du score de l'activité des voies de signalisation multiples dans des cellules épithéliales des voies respiratoires pour prédire une anomalie épithéliale des voies respiratoires et le risque de cancer des voies respiratoires
CN110706742B (zh) * 2019-09-30 2020-06-30 中生康元生物科技(北京)有限公司 泛癌种肿瘤新生抗原高通量预测方法及其应用
CN111233972B (zh) * 2020-01-19 2021-08-10 华南理工大学 一种抗炎三肽及其提取分离方法和在改善记忆中的应用
CN111575283A (zh) * 2020-04-20 2020-08-25 中山大学肿瘤防治中心 Dkc1特异小干扰rna及其应用
WO2022032228A1 (fr) * 2020-08-07 2022-02-10 The Broad Institute, Inc. Ciblage thérapeutique d'une dérégulation du phosphate dans le cancer par l'intermédiaire du complexe protéique xpr1 : kidins220
US11430224B2 (en) 2020-10-23 2022-08-30 Argo AI, LLC Systems and methods for camera-LiDAR fused object detection with segment filtering
US11885886B2 (en) 2020-10-23 2024-01-30 Ford Global Technologies, Llc Systems and methods for camera-LiDAR fused object detection with LiDAR-to-image detection matching
US12050273B2 (en) 2020-10-23 2024-07-30 Ford Global Technologies, Llc Systems and methods for camera-LiDAR fused object detection with point pruning
US12135375B2 (en) 2020-10-23 2024-11-05 Ford Global Technologies, Llc Systems and methods for camera-LiDAR fused object detection with local variation segmentation
US12118732B2 (en) 2020-11-23 2024-10-15 Ford Global Technologies, Llc Systems and methods for object detection with LiDAR decorrelation
CN113185597B (zh) * 2021-04-06 2022-08-23 中山大学孙逸仙纪念医院 一种可激活患者的抗肿瘤免疫反应的人肿瘤抗原及其应用
CN113181350B (zh) * 2021-04-27 2023-04-25 浙江大学 以活化成纤维fap为基础的肽类疫苗及其制备方法
CN113136434A (zh) * 2021-05-14 2021-07-20 北京化工大学 Lpcat1基因在制备治疗癌症药物及诊断性试剂盒中的应用
WO2023020624A1 (fr) * 2021-08-20 2023-02-23 Hunilife Biotechnology, Inc. Utilisation d'un antagoniste d'alpha-énolase dans le traitement de fibroses
WO2023039161A1 (fr) * 2021-09-09 2023-03-16 Kartos Therapeutics Procédés de traitement du cancer dépendant de l'expression du gène myc
IT202100024779A1 (it) * 2021-09-28 2023-03-28 Univ Degli Studi Di Torino Vaccino a DNA per l’uso nel trattamento profilattico o terapeutico dell’adenocarcinoma duttale pancreatico
CN113995841A (zh) * 2021-11-04 2022-02-01 上海市胸科医院 Mettl3/alkbh5/eno1调控轴作为靶位点在制备治疗肺腺癌药物中的应用
CN116083434A (zh) * 2021-11-08 2023-05-09 成都医学院 一种mcm5基因及其新用途
JP2025510795A (ja) * 2022-03-24 2025-04-15 アンスティテュ・クリー 神経膠芽腫における腫瘍転位因子由来のネオ抗原ペプチドを標的化する免疫療法
CN114957399B (zh) * 2022-06-29 2023-05-09 湖北工业大学 一种多肽、多肽衍生物及其在制备抗肿瘤药物中的应用
CN116059361B (zh) * 2023-02-27 2023-08-15 华中科技大学协和深圳医院 三价铬离子和/或金属铬在制备肿瘤免疫治疗药物中的应用
CN116270523B (zh) * 2023-05-15 2023-08-08 四川厌氧生物科技有限责任公司 一种耐酸的口服双层胶囊及其制备方法
WO2026046995A1 (fr) * 2024-08-28 2026-03-05 Pairx Bio Pte. Ltd Récepteurs de cellules t et leurs utilisations
CN121154672B (zh) * 2025-11-21 2026-03-27 浙江省肿瘤医院 Tmem43抑制剂在制备抗胃癌药物中的应用

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA92037A (fr) 1904-11-25 1905-03-07 The Hooven, Owens, Rentchler Company Coussinet pour turbines
US4440859A (en) 1977-05-27 1984-04-03 The Regents Of The University Of California Method for producing recombinant bacterial plasmids containing the coding sequences of higher organisms
US4704362A (en) 1977-11-08 1987-11-03 Genentech, Inc. Recombinant cloning vehicle microbial polypeptide expression
IL59007A (en) 1978-12-22 1983-11-30 Biogen Nv Recombinant dna molecules coding for polypeptides displaying hepatitis b virus antigenicity,method of their production and compositions containing the same
US4530901A (en) 1980-01-08 1985-07-23 Biogen N.V. Recombinant DNA molecules and their use in producing human interferon-like polypeptides
US4342566A (en) 1980-02-22 1982-08-03 Scripps Clinic & Research Foundation Solid phase anti-C3 assay for detection of immune complexes
US4678751A (en) 1981-09-25 1987-07-07 Genentech, Inc. Hybrid human leukocyte interferons
US4766075A (en) 1982-07-14 1988-08-23 Genentech, Inc. Human tissue plasminogen activator
US4582800A (en) 1982-07-12 1986-04-15 Hoffmann-La Roche Inc. Novel vectors and method for controlling interferon expression
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4757006A (en) 1983-10-28 1988-07-12 Genetics Institute, Inc. Human factor VIII:C gene and recombinant methods for production
US4677063A (en) 1985-05-02 1987-06-30 Cetus Corporation Human tumor necrosis factor
US4810648A (en) 1986-01-08 1989-03-07 Rhone Poulenc Agrochimie Haloarylnitrile degrading gene, its use, and cells containing the gene
US4897445A (en) 1986-06-27 1990-01-30 The Administrators Of The Tulane Educational Fund Method for synthesizing a peptide containing a non-peptide bond
US6252052B1 (en) 1996-10-03 2001-06-26 Cornell Research Foundation, Inc Antibodies which bind to NY-ESO-1 cancer associated proteins, and hybridomas which produce these antibodies
AU6852594A (en) 1993-06-03 1995-01-03 Therapeutic Antibodies Inc. Production of antibody fragments
AUPM322393A0 (en) 1993-12-24 1994-01-27 Austin Research Institute, The Mucin carbohydrate compounds and their use in immunotherapy
ES2203782T3 (es) 1996-01-17 2004-04-16 Imperial College Innovations Limited Inmunoterapia que utiliza linfocitos t citotoxicos (ctl).
US5849589A (en) 1996-03-11 1998-12-15 Duke University Culturing monocytes with IL-4, TNF-α and GM-CSF TO induce differentiation to dendric cells
US6406705B1 (en) 1997-03-10 2002-06-18 University Of Iowa Research Foundation Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
US6221585B1 (en) * 1998-01-15 2001-04-24 Valigen, Inc. Method for identifying genes underlying defined phenotypes
US20030236209A1 (en) * 1998-03-18 2003-12-25 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
US7579160B2 (en) 1998-03-18 2009-08-25 Corixa Corporation Methods for the detection of cervical cancer
US6703491B1 (en) * 1999-03-17 2004-03-09 Exelixis, Inc. Drosophila sequences
CA2365918A1 (fr) 1999-04-09 2000-10-19 Human Genome Sciences, Inc. 49 proteines humaines secretees
CA2311201A1 (fr) 1999-08-05 2001-02-05 Genset S.A. Sequences marqueurs exprimees et proteines humaines codees
WO2001053349A2 (fr) 2000-01-21 2001-07-26 Ludwig Institute For Cancer Research Antigenes associes au cancer du poumon a petites cellules et utilisations de ces antigenes
US20040191260A1 (en) 2003-03-26 2004-09-30 Technion Research & Development Foundation Ltd. Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof
DE60142475D1 (de) 2000-03-27 2010-08-12 Technion Res And Dev Of Founda Einkettige haupthistokompatibilitätskomplexe der klasse i (mhc-i), kodierende konstrukte und methoden ihrer erzeugung
EP2322228B1 (fr) 2000-06-05 2018-01-10 Altor BioScience Corporation Protéines de fusion et conjugués de récepteurs de lymphocytes T et procédés d'utilisation de ceux-ci
MXPA03009510A (es) * 2001-04-17 2005-04-29 Univ Arkansas Secuencias de repeticion del gen ca125 y su uso para intervenciones de diagnosticos y terapeuticas.
US7892559B2 (en) 2002-01-30 2011-02-22 Survac Aps Survivin-derived peptides and use thereof
EP1332760A1 (fr) * 2002-02-04 2003-08-06 Academisch Ziekenhuis Leiden Nouveaux épitopes de la maladie coeliaque et de maladies autoimmunes; méthodes de détection de ces épitopes et de nouveaux composés alimentaires non-antigéniques
US6992176B2 (en) 2002-02-13 2006-01-31 Technion Research & Development Foundation Ltd. Antibody having a T-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease
AU2003216341A1 (en) 2002-02-20 2003-09-09 Dyax Corporation Mhc-peptide complex binding ligands
WO2004030616A2 (fr) * 2002-09-17 2004-04-15 Antigen Express, Inc. Vaccins a base d'epitope antigenique ii-key peptidique hybride
CA2498854A1 (fr) * 2002-10-02 2004-04-15 Harald Kropshofer Nouveaux peptides associes au mhc ii
AU2003271904B2 (en) 2002-10-09 2009-03-05 Adaptimmune Limited Single chain recombinant T cell receptors
DE60327795D1 (de) 2002-11-09 2009-07-09 Immunocore Ltd T zell rezeptor "display"
GB0304068D0 (en) 2003-02-22 2003-03-26 Avidex Ltd Substances
WO2006106912A1 (fr) * 2005-03-31 2006-10-12 Chugai Seiyaku Kabushiki Kaisha Peptide analogue d’antigene associe au cancer et son utilisation
CN100393745C (zh) 2005-05-27 2008-06-11 北京大学 一种肿瘤抗原蛋白质和肿瘤抗原肽
ES2341802T3 (es) 2005-09-05 2010-06-28 Immatics Biotechnologies Gmbh Peptidos asociados a tumores unidos promiscuamente a moleculas del antigeno de leucocito humano (hla) de clase ii.
PL1760089T3 (pl) * 2005-09-05 2010-03-31 Immatics Biotechnologies Gmbh Peptydy towarzyszące nowotworom, wiążące się z cząsteczkami klasy I i II antygenów ludzkich leukocytów (HLA) i związana z nimi szczepionka przeciwnowotworowa
WO2007103770A2 (fr) * 2006-03-02 2007-09-13 Ppd Biomarker Discovery Sciences, Llc Compositions et procedes pour l'analyse du cancer du rein
EP2520935A3 (fr) * 2006-08-09 2013-02-13 Homestead Clinical Corporation Protéines spécifiques d'organes et leurs procédés d'utilisation
US8097242B2 (en) * 2006-10-05 2012-01-17 The Board Of Trustees Of The University Of Arkansas Target CA125 peptides for cancer immunotherapy
PL2565204T3 (pl) * 2007-07-27 2016-03-31 Immatics Biotechnologies Gmbh Nowe immunogenne epitopy do immunoterapii
BRPI0817209A2 (pt) 2007-09-20 2015-03-10 David Gladstone Inst Composições de polipeptídeo de elemento nuclear intercalado longo e métodos de uso das mesmas
US7892760B2 (en) 2007-11-19 2011-02-22 Celera Corporation Lung cancer markers, and uses thereof
WO2009075883A2 (fr) * 2007-12-12 2009-06-18 University Of Georgia Research Foundation, Inc. Biomarqueur de cancer de glycoprotéine
WO2009126805A2 (fr) 2008-04-11 2009-10-15 The Board Of Regents Of The Univeristy Of Texas System Ciblage thérapeutique de mmps dans des liposomes neutres
US20090263574A1 (en) 2008-04-21 2009-10-22 Quinn Daniel E Method of restoring an article
ITMI20081119A1 (it) * 2008-06-19 2009-12-20 Menarini Internat Operation Luxembourg Sa Frammenti di muc16 ad attivita antigenica e composizioni farmaceutiche che li contengono
US9382544B2 (en) * 2009-05-15 2016-07-05 Nec Solution Innovators, Ltd. Aptamer that recognizes peptide
US9132178B2 (en) 2009-08-26 2015-09-15 Immunotope, Inc. Cytotoxic T lymphocyte inducing immunogens for prevention treatment and diagnosis of cancer
GB201004575D0 (en) * 2010-03-19 2010-05-05 Immatics Biotechnologies Gmbh Composition of tumor associated peptides and related anti cancer vaccine for the treatment of gastric cancer and other cancers
GB201019331D0 (en) * 2010-03-19 2010-12-29 Immatics Biotechnologies Gmbh Methods for the diagnosis and treatment of cancer based on AVL9
GB201004551D0 (en) * 2010-03-19 2010-05-05 Immatics Biotechnologies Gmbh NOvel immunotherapy against several tumors including gastrointestinal and gastric cancer
EP4012714A1 (fr) * 2010-03-23 2022-06-15 Iogenetics, LLC. Procédés bioinformatiques pour déterminer la liaison de peptides
GB201006360D0 (en) 2010-04-16 2010-06-02 Immatics Biotechnologies Gmbh Method for differentially quantifying naturally processed HLA-restricted peptides for cancer, autoimmune and infectious diseases immunotherapy development
BR112012029066A2 (pt) 2010-05-14 2020-09-01 The General Hospital Corporation composições e processos de identificação de neoantígenos específicos de tumor.
WO2012048291A2 (fr) 2010-10-08 2012-04-12 Proteapex Therapeutics Llc Compositions et procédés pour l'inhibition d'interactions de substrat de mmp:mmp
US20140170168A1 (en) 2010-10-26 2014-06-19 Yoram Reiter Antibodies which bind soluble t-cell receptor ligands
WO2012100023A1 (fr) 2011-01-19 2012-07-26 Thomas Jefferson University Détection d'un adénocarcinome du canal pancréatique
AU2012306258A1 (en) 2011-09-07 2014-04-17 Immunotope, Inc. Nanoparticle tumour vaccines
WO2013057586A1 (fr) 2011-10-19 2013-04-25 Oslo Universitetssykehus Hf Compositions et procédés de production de récepteurs solubles des lymphocytes t
US12540318B2 (en) 2012-11-08 2026-02-03 Roche Diagnostics Operations, Inc. Nucleic acids encoding chimeric polypeptides for library screening
TWI643867B (zh) 2013-05-24 2018-12-11 日商腫瘤療法 科學股份有限公司 對於ｔｈ１細胞之ｉｍｐ－３抗原決定位胜肽及含此之疫苗
EP2808392A1 (fr) 2013-05-28 2014-12-03 Rheinische Friedrich-Wilhelms-Universität Bonn Aptamères et utilisation de ces aptamères dans le diagnostic et le traitement du cancer
TWI775117B (zh) * 2013-08-05 2022-08-21 德商伊瑪提克斯生物科技有限公司 新穎肽類，細胞及其用於治療多種腫瘤的用途，其製造方法及包含其等之醫藥組成物（二）
GB201512369D0 (en) * 2015-07-15 2015-08-19 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against epithelial ovarian cancer and other cancers
GB201515321D0 (en) 2015-08-28 2015-10-14 Immatics Biotechnologies Gmbh Novel peptides, combination of peptides and scaffolds for use in immunotherapeutic treatment of various cancers

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