MA52351A - Production du facteur de croissance nerveuse (ngf) et de mutéines de celui-ci - Google Patents

Production du facteur de croissance nerveuse (ngf) et de mutéines de celui-ci

Info

Publication number
MA52351A
MA52351A MA052351A MA52351A MA52351A MA 52351 A MA52351 A MA 52351A MA 052351 A MA052351 A MA 052351A MA 52351 A MA52351 A MA 52351A MA 52351 A MA52351 A MA 52351A
Authority
MA
Morocco
Prior art keywords
muteins
ngf
production
growth factor
nervous growth
Prior art date
Application number
MA052351A
Other languages
English (en)
Inventor
Bruno Pietro Imbimbo
Original Assignee
Chiesi Farm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farm Spa filed Critical Chiesi Farm Spa
Publication of MA52351A publication Critical patent/MA52351A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/48—Nerve growth factor [NGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6427—Chymotrypsins (3.4.21.1; 3.4.21.2); Trypsin (3.4.21.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
MA052351A 2018-04-27 2019-04-26 Production du facteur de croissance nerveuse (ngf) et de mutéines de celui-ci MA52351A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP18169859 2018-04-27

Publications (1)

Publication Number Publication Date
MA52351A true MA52351A (fr) 2021-05-26

Family

ID=62165341

Family Applications (1)

Application Number Title Priority Date Filing Date
MA052351A MA52351A (fr) 2018-04-27 2019-04-26 Production du facteur de croissance nerveuse (ngf) et de mutéines de celui-ci

Country Status (4)

Country Link
US (2) US12378293B2 (fr)
EP (1) EP3784691B1 (fr)
MA (1) MA52351A (fr)
WO (1) WO2019207106A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12378293B2 (en) 2018-04-27 2025-08-05 Chiesi Farmaceutici Spa Production of nerve growth factor (NGF) and of muteins thereof
IT202000005542A1 (it) 2020-03-16 2021-09-16 Themis S R L Metodo cosmetico per il trattamento della pelle e per la ricrescita dei capelli
DK4313114T3 (da) * 2021-03-25 2025-10-20 Chiesi Farm Spa Kombineret behandling af hjerneskade
CN113214379A (zh) * 2021-04-07 2021-08-06 云南龙凤谷生物药业有限公司 一种眼镜蛇毒神经生长因子的制备方法
WO2023004784A1 (fr) 2021-07-30 2023-02-02 成都优洛生物科技有限公司 Cellule cho recombinante, son procédé de construction, et système de détection et procédé l'utilisant
WO2023141754A1 (fr) * 2022-01-25 2023-08-03 青岛万明赛伯药业有限公司 Mutant de prongf et son utilisation
EP4316505A1 (fr) 2022-08-05 2024-02-07 Dompé farmaceutici S.p.a. Administration intranasale de ngf pour le traitement de la perte auditive neurosensorielle
EP4342485A1 (fr) 2022-09-23 2024-03-27 Dompe' Farmaceutici S.P.A. Ngf pour le traitement de la spasticité
EP4659759A1 (fr) 2024-06-04 2025-12-10 Dompé farmaceutici SpA Administration de ngf pour le traitement de la maladie de niemann-pick de type c
WO2026022244A1 (fr) 2024-07-23 2026-01-29 Chiesi Farmaceutici S.P.A. Polypeptide destiné à être utilisé dans la prise en charge thérapeutique de l'accident vasculaire cérébral ischémique aigu
CN119302994B (zh) * 2024-09-25 2025-07-22 广州博士派生物科技有限公司 一种脐带提取物的制备方法及应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU729459B2 (en) * 1996-11-15 2001-02-01 Genentech Inc. Purification of neurotrophins
ES2213861T3 (es) 1998-10-09 2004-09-01 Scil Proteins Gmbh Procedimiento de obtencion de ngf-beta activa.
US7205387B2 (en) * 2003-08-28 2007-04-17 Agency For Science, Technology And Research Recombinant polypeptide useful for neurotrophin receptor mediated gene delivery and as neurotrophin agonist
ITRM20060367A1 (it) 2006-07-13 2008-01-14 Lay Line Genomics Spa Muteine del hngf usi terapeutici e composizioni farmaceutiche
EP2907521B1 (fr) 2011-12-19 2017-11-22 Wacker Chemie AG Nouveaux mutants de prongf et leurs utilisations dans la production de bêta-ngf
US20180086805A1 (en) * 2016-05-20 2018-03-29 Chiesi Farmaceutici S.P.A. proNGF mutants and uses thereof for the preparation of NGF mutants
CN108314723A (zh) * 2018-01-11 2018-07-24 温州医科大学 一种人源突变型神经生长因子及其制备方法和应用
US12378293B2 (en) 2018-04-27 2025-08-05 Chiesi Farmaceutici Spa Production of nerve growth factor (NGF) and of muteins thereof

Also Published As

Publication number Publication date
EP3784691B1 (fr) 2026-03-25
WO2019207106A1 (fr) 2019-10-31
US12378293B2 (en) 2025-08-05
US20260092090A1 (en) 2026-04-02
US20210079053A1 (en) 2021-03-18
EP3784691A1 (fr) 2021-03-03

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