MA52410B1 - Procédés et systèmes d'étalonnage et d'utilisation d'une caméra pour détecter un analyte dans un échantillon - Google Patents

Procédés et systèmes d'étalonnage et d'utilisation d'une caméra pour détecter un analyte dans un échantillon

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Publication number
MA52410B1
MA52410B1 MA52410A MA52410A MA52410B1 MA 52410 B1 MA52410 B1 MA 52410B1 MA 52410 A MA52410 A MA 52410A MA 52410 A MA52410 A MA 52410A MA 52410 B1 MA52410 B1 MA 52410B1
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MA
Morocco
Prior art keywords
test
color
analyte
coordinate systems
color coordinate
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MA52410A
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English (en)
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MA52410A (fr
Inventor
Bernd Limburg
Max Berg
Fredrik Hailer
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Hoffmann La Roche
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Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA52410A publication Critical patent/MA52410A/fr
Publication of MA52410B1 publication Critical patent/MA52410B1/fr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G01N21/274—Calibration, base line adjustment, drift correction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G01N21/272—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration for following a reaction, e.g. for determining photometrically a reaction rate (photometric cinetic analysis)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/8483—Investigating reagent band
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F17/00—Digital computing or data processing equipment or methods, specially adapted for specific functions
    • G06F17/10—Complex mathematical operations
    • G06F17/18—Complex mathematical operations for evaluating statistical data, e.g. average values, frequency distributions, probability functions, regression analysis

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Mathematical Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Plasma & Fusion (AREA)
  • Data Mining & Analysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mathematical Optimization (AREA)
  • Mathematical Analysis (AREA)
  • Computational Mathematics (AREA)
  • Pure & Applied Mathematics (AREA)
  • Algebra (AREA)
  • Software Systems (AREA)
  • Operations Research (AREA)
  • Probability & Statistics with Applications (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Databases & Information Systems (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)

Abstract

L'invention concerne des méthodes, des programmes d'ordinateur et des systèmes (110, 112, 114) permettant d'étalonner et d'utiliser une caméra (116) afin de détecter un analyte dans un échantillon (131). La méthode d'étalonnage permettant d'étalonner une caméra (116) afin de détecter un analyte dans un échantillon (131) comprend : a) la fourniture d'un ensemble de systèmes de coordonnées de couleur, l'ensemble de systèmes de coordonnées de couleur comprenant une pluralité de systèmes de coordonnées de couleur différents conçus pour décrire une couleur d'un objet ; b) la fourniture d'un ensemble d'échantillons d'essai (122) présentant des concentrations connues de l'analyte ; c) l'application des échantillons d'essai (124) à un ensemble d'éléments d'essai (126), chaque élément d'essai (128) présentant au moins un champ d'essai (130) comprenant au moins un produit chimique d'essai conçu pour effectuer une réaction de détection optiquement détectable avec l'analyte, ce qui permet de créer au moins un champ d'essai coloré (130) pour chacun des échantillons d'essai (124) ; l'acquisition d'images des champs d'essai colorés (130) à l'aide de la caméra (116) ; e) la génération de coordonnées de couleur pour les images des champs d'essai colorés (130), à l'aide des systèmes de coordonnées de couleur de l'ensemble de systèmes de coordonnées de couleur, ce qui permet de créer un ensemble de coordonnées de couleur pour les échantillons d'essai (124) et pour les systèmes de coordonnées de couleur ; f) la fourniture d'un ensemble de fonctions de codage, l'ensemble de fonctions de codage comprenant une pluralité de fonctions de codage permettant de transformer des coordonnées de couleur d'un champ d'essai (130) en une concentration correspondante de l'analyte dans l'échantillon ; g) la transformation de l'ensemble de coordonnées de couleur générées à l'étape e) en un ensemble de concentrations mesurées à l'aide de l'ensemble de fonctions de codage ; et h) la comparaison de l'ensemble de concentrations mesurées aux concentrations connues des échantillons d'essai (124) de l'ensemble d'échantillons d'essai (122) et la détermination du meilleur système de coordonnées de couleur de correspondance de l'ensemble de systèmes de coordonnées de couleur et de la meilleure fonction de codage de correspondance de l'ensemble de fonctions de codage pour lesquelles l'ensemble de concentrations mesurées correspond le mieux aux concentrations connues.
MA52410A 2018-02-26 2019-02-25 Procédés et systèmes d'étalonnage et d'utilisation d'une caméra pour détecter un analyte dans un échantillon MA52410B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18158626 2018-02-26
PCT/EP2019/054583 WO2019162496A1 (fr) 2018-02-26 2019-02-25 Méthodes et systèmes d'étalonnage et d'utilisation d'une caméra permettant la détection d'un analyte dans un échantillon

Publications (2)

Publication Number Publication Date
MA52410A MA52410A (fr) 2021-06-02
MA52410B1 true MA52410B1 (fr) 2023-10-31

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MA52410A MA52410B1 (fr) 2018-02-26 2019-02-25 Procédés et systèmes d'étalonnage et d'utilisation d'une caméra pour détecter un analyte dans un échantillon

Country Status (11)

Country Link
US (1) US11781973B2 (fr)
EP (1) EP3759465B1 (fr)
JP (1) JP7185701B2 (fr)
KR (1) KR102340166B1 (fr)
CN (1) CN112020640B (fr)
ES (1) ES2957337T3 (fr)
MA (1) MA52410B1 (fr)
PL (1) PL3759465T3 (fr)
RU (1) RU2754208C1 (fr)
TW (1) TWI810247B (fr)
WO (1) WO2019162496A1 (fr)

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Also Published As

Publication number Publication date
EP3759465B1 (fr) 2023-08-02
ES2957337T3 (es) 2024-01-17
CN112020640A (zh) 2020-12-01
JP2021515203A (ja) 2021-06-17
CA3091988A1 (fr) 2019-08-29
US11781973B2 (en) 2023-10-10
TWI810247B (zh) 2023-08-01
WO2019162496A1 (fr) 2019-08-29
TW202004163A (zh) 2020-01-16
JP7185701B2 (ja) 2022-12-07
MA52410A (fr) 2021-06-02
CN112020640B (zh) 2024-03-08
BR112020017213A2 (pt) 2020-12-22
US20200386672A1 (en) 2020-12-10
RU2754208C1 (ru) 2021-08-30
PL3759465T3 (pl) 2023-12-11
EP3759465A1 (fr) 2021-01-06
KR20200122375A (ko) 2020-10-27
KR102340166B1 (ko) 2021-12-16
EP3759465C0 (fr) 2023-08-02

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