MA52662A - Conjugués d'il-2 - Google Patents
Conjugués d'il-2Info
- Publication number
- MA52662A MA52662A MA052662A MA52662A MA52662A MA 52662 A MA52662 A MA 52662A MA 052662 A MA052662 A MA 052662A MA 52662 A MA52662 A MA 52662A MA 52662 A MA52662 A MA 52662A
- Authority
- MA
- Morocco
- Prior art keywords
- conjugates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18164682 | 2018-03-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA52662A true MA52662A (fr) | 2021-02-17 |
Family
ID=61832449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA052662A MA52662A (fr) | 2018-03-28 | 2019-03-27 | Conjugués d'il-2 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US12565525B2 (fr) |
| EP (1) | EP3773680A1 (fr) |
| JP (2) | JP7490563B2 (fr) |
| KR (2) | KR102950463B1 (fr) |
| CN (2) | CN119504973A (fr) |
| AU (2) | AU2019246389B2 (fr) |
| BR (1) | BR112020019639A2 (fr) |
| CA (1) | CA3093722A1 (fr) |
| IL (3) | IL308797B2 (fr) |
| MA (1) | MA52662A (fr) |
| MX (2) | MX2020009857A (fr) |
| SG (1) | SG11202007524QA (fr) |
| WO (1) | WO2019185705A1 (fr) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20250145137A (ko) | 2017-08-03 | 2025-10-13 | 신톡스, 인크. | 자가면역 질환의 치료를 위한 사이토카인 접합체 |
| CN119504973A (zh) | 2018-03-28 | 2025-02-25 | 阿森迪斯药物肿瘤股份有限公司 | Il-2缀合物 |
| BR112021005401A2 (pt) | 2018-11-08 | 2021-06-29 | Synthorx, Inc. | conjugados de interleucina 10 e usos dos mesmos |
| TWI856997B (zh) | 2019-01-04 | 2024-10-01 | 丹麥商阿仙帝斯製藥公司 | 模式辨別受體(pattern recognition receptor)促效劑的共軛物 |
| US20220054476A1 (en) | 2019-01-04 | 2022-02-24 | Ascendis Pharma Oncology Division A/S | Sustained local drug levels for innate immune agonists |
| SG11202105833WA (en) | 2019-01-04 | 2021-07-29 | Ascendis Pharma Oncology Div A/S | Minimization of systemic inflammation |
| US20200246467A1 (en) | 2019-02-06 | 2020-08-06 | Synthorx, Inc. | Il-2 conjugates and methods of use thereof |
| TW202114738A (zh) | 2019-06-21 | 2021-04-16 | 丹麥商阿仙帝斯製藥公司 | 抗ctla4結合物 |
| WO2020254607A1 (fr) | 2019-06-21 | 2020-12-24 | Ascendis Pharma Oncology Division A/S | Composés anti-ctla4 à propriétés pd localisées |
| PH12022500004A1 (en) | 2019-08-23 | 2023-04-03 | Synthorx Inc | Il-15 conjugates and uses thereof |
| MX2022002740A (es) | 2019-09-10 | 2022-03-25 | Synthorx Inc | Conjugados de il-2 y metodos de uso para tratar enfermedades autoinmunes. |
| KR20220127249A (ko) * | 2019-12-13 | 2022-09-19 | 신테카인, 인크. | Il-2 오르토로그 및 사용 방법 |
| CN114478743A (zh) * | 2019-12-17 | 2022-05-13 | 北京志道生物科技有限公司 | 白介素-2衍生物 |
| PH12022552719A1 (en) | 2020-04-22 | 2024-02-05 | Merck Sharp & Dohme Llc | HUMAN INTERLEUKIN-2 CONJUGATES BIASED FOR THE INTERLEUKIN-2 RECEPTOR BETA GAMMAc DIMER AND CONJUGATED TO A NONPEPTIDIC, WATER-SOLUBLE POLYMER |
| IL298642A (en) | 2020-06-03 | 2023-01-01 | Ascendis Pharma Oncology Div A/S | il-2 sequences and uses thereof |
| CA3189715A1 (fr) | 2020-08-28 | 2022-03-03 | Ascendis Pharma Oncology Division A/S | Proteines il-2 glycosylees et utilisations correspondantes |
| IL304365B2 (en) * | 2021-03-31 | 2025-04-01 | Hanmi Pharmaceutical Co Ltd | A novel conjugate of an IL2 immunostimulatory analog and method of preparation thereof |
| CA3225815A1 (fr) | 2021-08-13 | 2023-02-16 | Cytune Pharma | Combinaison d'agonistes de l'il-2/il-15rbetagamma avec des conjugues anticorps-medicament pour le traitement du cancer |
Family Cites Families (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5206344A (en) | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
| US4766106A (en) | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
| US4902502A (en) | 1989-01-23 | 1990-02-20 | Cetus Corporation | Preparation of a polymer/interleukin-2 conjugate |
| US5089261A (en) | 1989-01-23 | 1992-02-18 | Cetus Corporation | Preparation of a polymer/interleukin-2 conjugate |
| US6624142B2 (en) | 1997-12-30 | 2003-09-23 | Enzon, Inc. | Trimethyl lock based tetrapartate prodrugs |
| DZ2788A1 (fr) | 1998-05-15 | 2003-12-01 | Bayer Ag | Agonistes et antagonistes selectifs à IL-2. |
| US6689353B1 (en) | 2000-06-28 | 2004-02-10 | Bayer Pharmaceuticals Corporation | Stabilized interleukin 2 |
| AU2000202A (en) | 2000-10-31 | 2002-05-15 | Pr Pharmaceuticals Inc | Methods and compositions for enhanced delivery of bioactive molecules |
| WO2003015697A2 (fr) | 2001-08-13 | 2003-02-27 | University Of Southern California | Mutants d'interleukine-2 a toxicite reduite |
| ATE542137T1 (de) * | 2001-12-04 | 2012-02-15 | Merck Patent Gmbh | Immunocytokine mit modulierter selektivität |
| US7122189B2 (en) | 2002-08-13 | 2006-10-17 | Enzon, Inc. | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
| US7332164B2 (en) | 2003-03-21 | 2008-02-19 | Enzon Pharmaceuticals, Inc. | Heterobifunctional polymeric bioconjugates |
| CA2521784C (fr) | 2003-04-08 | 2012-03-27 | Yeda Research And Development Co. Ltd. | Medicaments pegyles reversibles |
| US7690003B2 (en) | 2003-08-29 | 2010-03-30 | Fuller Jeffrey C | System and method for increasing data throughput using thread scheduling |
| KR101241862B1 (ko) | 2003-09-19 | 2013-03-13 | 노보 노르디스크 에이/에스 | 신규 ｇｌｐ-1 유도체 |
| ES2367027T3 (es) * | 2004-02-27 | 2011-10-27 | Inserm (Institut National De La Santé Et De La Recherche Medicale) | Sitio de unión de la il-15 para il-15ralfa y mutantes específicos de il-15 que tienen actividad agonista/antagonista. |
| EP1723251A4 (fr) | 2004-03-05 | 2008-04-23 | Novartis Vaccines & Diagnostic | Systeme de tests in vitro permettant de predire la tolerabilite d'agents therapeutiques chez des patients |
| WO2005099768A2 (fr) | 2004-03-23 | 2005-10-27 | Complex Biosystems Gmbh | Lieur de promedicaments |
| US7385028B2 (en) | 2004-12-22 | 2008-06-10 | Ambrx, Inc | Derivatization of non-natural amino acids and polypeptides |
| US8450269B2 (en) | 2006-02-03 | 2013-05-28 | Prolor Biotech Ltd. | Long-acting growth hormone and methods of producing same |
| MX2009002859A (es) | 2006-09-15 | 2009-03-30 | Enzon Pharmaceuticals Inc | Enlazadores biodegradables a base de ester impedido para suministro de oligonucleotidos. |
| JP5351889B2 (ja) | 2007-06-21 | 2013-11-27 | テクニシェ ユニバーシタット ミュンヘン | インビボおよび／またはインビトロ安定性が増大した生物学的に活性なタンパク質 |
| EP2175878A4 (fr) | 2007-07-11 | 2014-12-03 | Belrose Pharma Inc | Système d'administration de médicament polymérique contenant un groupement aromatique multi-substitué |
| CA2712224C (fr) | 2008-02-01 | 2016-03-08 | Ascendis Pharma As | Promedicament comprenant un conjugue medicament-lieur |
| HUE054585T2 (hu) * | 2008-04-29 | 2021-09-28 | Ascendis Pharma Endocrinology Div A/S | Pegilezett rekombináns humán növekedési hormon vegyületek |
| US20110105413A1 (en) | 2008-05-23 | 2011-05-05 | Enzon Pharmaceuticals, Inc. | Polymeric systems containing intracellular releasable disulfide linker for the delivery of oligonucleotides |
| US20110274650A1 (en) | 2009-01-21 | 2011-11-10 | Amgen Inc. | Compositions and methods of treating inflammatory and autoimmune diseases |
| CN108530543B (zh) | 2009-02-03 | 2023-06-23 | 阿穆尼克斯制药公司 | 延伸重组多肽和包含该延伸重组多肽的组合物 |
| US20110007134A1 (en) | 2009-07-13 | 2011-01-13 | Raytheon Company | Synchronizing video images and three dimensional visualization images |
| US8331611B2 (en) | 2009-07-13 | 2012-12-11 | Raytheon Company | Overlay information over video |
| WO2011008613A1 (fr) | 2009-07-16 | 2011-01-20 | Skyhook Wireless, Inc. | Systemes et procedes pour utiliser un satellite hybride et un systeme de positionnement wlan |
| RU2554854C9 (ru) | 2009-07-31 | 2017-02-03 | Асцендис Фарма Ас | Биоразлагаемые нерастворимые в воде гидрогели на основе полиэтиленгликоля |
| WO2011018613A1 (fr) | 2009-08-10 | 2011-02-17 | Ucl Business Plc | Fonctionnalisation de substrats solides |
| CU23734A1 (es) | 2009-11-27 | 2011-11-15 | Centro Inmunologia Molecular | Polipéptidos inmunomoduladores derivados de la il-2 con actividad antagonista de esta citocina útiles en la terapia del cáncer y enfermedades infecciosas crónicas |
| CA2783296C (fr) * | 2009-12-15 | 2019-01-15 | Ascendis Pharma As | Composition d'hormone de croissance |
| US20120289571A1 (en) | 2009-12-31 | 2012-11-15 | Enzon Pharmaceuticals, Inc. | Polymeric conjugates of aromatic amine containing compounds including releasable urea linker |
| WO2011089214A1 (fr) * | 2010-01-22 | 2011-07-28 | Ascendis Pharma As | Lieurs de précurseurs à base de carbamates liés à des supports |
| ES2584381T3 (es) | 2010-05-05 | 2016-09-27 | Prolynx Llc | Liberación controlada de compuestos activos desde conjugados macromoleculares |
| WO2011140392A1 (fr) | 2010-05-05 | 2011-11-10 | Prolynx Llc | Supports solides pour la libération contrôlée de médicaments |
| MX338914B (es) | 2010-05-21 | 2016-05-06 | Xl Protein Gmbh | Polipeptidos biosinteticos de espira aleatoria de prolina/alanina y sus usos. |
| CN102959585B (zh) | 2010-06-30 | 2016-03-30 | 日本电气方案创新株式会社 | 属性确定方法、属性确定装置及属性确定系统 |
| KR102591732B1 (ko) * | 2010-11-12 | 2023-10-19 | 넥타르 테라퓨틱스 | Ｉｌ-2 부분 및 중합체의 접합체 |
| WO2012088446A1 (fr) | 2010-12-22 | 2012-06-28 | Board Of Trustees Of The Leland Stanford Junior University | Super-agonistes et antagonistes de l'interleukine-2 |
| HUE029139T2 (hu) | 2011-02-10 | 2017-02-28 | Roche Glycart Ag | Mutáns interleukin-2 polipeptidek |
| EP2741778A1 (fr) | 2011-08-12 | 2014-06-18 | Ascendis Pharma A/S | Promédicaments liés à des excipients polymériques hyperbranchés |
| US20140322344A1 (en) * | 2011-08-31 | 2014-10-30 | National University Corporation Tokyo Medical And Dental University | Vaccine preparation for cancer treatment |
| WO2013036857A1 (fr) | 2011-09-07 | 2013-03-14 | Prolynx Llc | Coupleurs au sulfone |
| WO2014028748A1 (fr) | 2012-08-15 | 2014-02-20 | Irm Llc | Anticorps d'interleukine 2 et complexes d'anticorps |
| AU2013328785B2 (en) | 2012-10-11 | 2016-07-21 | Ascendis Pharma A/S | Hydrogel prodrugs |
| US10519226B2 (en) | 2012-10-11 | 2019-12-31 | Ascendis Pharma Opthalmology Division A/S | VEGF neutralizing prodrugs for the treatment of ocular conditions |
| EP2908845A1 (fr) | 2012-10-17 | 2015-08-26 | Novo Nordisk Health Care AG | Acides aminés acylés par un acide gras pour l'administration d'hormone de croissance |
| WO2014100014A1 (fr) | 2012-12-17 | 2014-06-26 | The Board Of Trustees Of The Leland Stanford Junior University | Super-complexes 2 avec anticorps pour une amélioration de la thérapie par il-2 |
| US10781242B2 (en) | 2013-09-24 | 2020-09-22 | Medicenna Therapeutics Inc. | Interleukin-2 fusion proteins and uses thereof |
| EP3834838A1 (fr) | 2014-02-21 | 2021-06-16 | Nektar Therapeutics (India) Pvt. Ltd. | Agonistes sélectifs de l'il-2rbeta en combinaison avec un anticorps anti-pd-1 |
| EP3193941B1 (fr) | 2014-08-06 | 2024-05-22 | Ascendis Pharma A/S | Promédicaments comprenant un liant de type aminoalkylglycine |
| SI3482766T1 (sl) | 2014-08-11 | 2020-09-30 | Delinia, Inc. | Spremenjene variante IL-2, ki selektivno aktivirajo regulatorne T celice za zdravljenje avtoimunskih bolezni |
| WO2016025647A1 (fr) | 2014-08-12 | 2016-02-18 | Massachusetts Institute Of Technology | Traitement tumoral synergique avec l'il-2, un anticorps thérapeutique, et un vaccin contre le cancer |
| ES2947818T3 (es) | 2014-11-18 | 2023-08-21 | Ascendis Pharma Endocrinology Div A/S | Nuevos profármacos poliméricos de la HCh |
| US10835578B2 (en) * | 2016-01-08 | 2020-11-17 | Ascendis Pharma Growth Disorders A/S | CNP prodrugs with large carrier moieties |
| IL317744A (en) | 2016-03-01 | 2025-02-01 | Ascendis Pharma Bone Diseases As | PTH drug agonists |
| FI3518982T3 (fi) * | 2016-09-29 | 2025-02-11 | Ascendis Pharma Bone Diseases As | Säädellysti vapautuvia PTH-yhdisteitä |
| CU24483B1 (es) | 2016-11-15 | 2020-04-02 | Ct Inmunologia Molecular | Método para incrementar los niveles de secreción de la interleucina-2 |
| IL269506B2 (en) | 2017-03-22 | 2024-04-01 | Genentech Inc | Hydrogel cross-linked hyaluronic acid prodrug compositions and methods |
| KR20250145137A (ko) | 2017-08-03 | 2025-10-13 | 신톡스, 인크. | 자가면역 질환의 치료를 위한 사이토카인 접합체 |
| WO2019091384A1 (fr) | 2017-11-08 | 2019-05-16 | Yafei Shanghai Biolog Medicine Science & Technology Co., Ltd. | Conjugués à base d'une biomolécule et leur utilisation |
| JP7275049B2 (ja) | 2017-12-27 | 2023-05-17 | 協和キリン株式会社 | Ｉｌ－２改変体 |
| CN119504973A (zh) | 2018-03-28 | 2025-02-25 | 阿森迪斯药物肿瘤股份有限公司 | Il-2缀合物 |
| CA3093083A1 (fr) * | 2018-03-28 | 2019-10-03 | Ascendis Pharma A/S | Conjugues |
| JP7550745B2 (ja) | 2018-07-24 | 2024-09-13 | バイオエヌテック エスエー | Ｉｌ２アゴニスト |
| US12269855B2 (en) | 2018-09-21 | 2025-04-08 | Innovent Biologics (Suzhou) Co., Ltd. | Interleukin-2 and use thereof |
| JP2022533254A (ja) | 2019-05-24 | 2022-07-21 | プロヴィヴァ セラピューティクス （ホン コン） リミテッド | Ｉｌ－２組成物およびその使用方法 |
| WO2020254607A1 (fr) | 2019-06-21 | 2020-12-24 | Ascendis Pharma Oncology Division A/S | Composés anti-ctla4 à propriétés pd localisées |
| CN114478743A (zh) | 2019-12-17 | 2022-05-13 | 北京志道生物科技有限公司 | 白介素-2衍生物 |
| IL298642A (en) | 2020-06-03 | 2023-01-01 | Ascendis Pharma Oncology Div A/S | il-2 sequences and uses thereof |
| CA3189715A1 (fr) | 2020-08-28 | 2022-03-03 | Ascendis Pharma Oncology Division A/S | Proteines il-2 glycosylees et utilisations correspondantes |
-
2019
- 2019-03-27 CN CN202411614476.4A patent/CN119504973A/zh active Pending
- 2019-03-27 JP JP2020552812A patent/JP7490563B2/ja active Active
- 2019-03-27 EP EP19713040.4A patent/EP3773680A1/fr active Pending
- 2019-03-27 CN CN201980022172.XA patent/CN111918665B/zh active Active
- 2019-03-27 KR KR1020207031136A patent/KR102950463B1/ko active Active
- 2019-03-27 BR BR112020019639-8A patent/BR112020019639A2/pt unknown
- 2019-03-27 CA CA3093722A patent/CA3093722A1/fr active Pending
- 2019-03-27 KR KR1020257027619A patent/KR20250130705A/ko active Pending
- 2019-03-27 IL IL308797A patent/IL308797B2/en unknown
- 2019-03-27 AU AU2019246389A patent/AU2019246389B2/en active Active
- 2019-03-27 SG SG11202007524QA patent/SG11202007524QA/en unknown
- 2019-03-27 US US17/042,610 patent/US12565525B2/en active Active
- 2019-03-27 IL IL324874A patent/IL324874A/en unknown
- 2019-03-27 MA MA052662A patent/MA52662A/fr unknown
- 2019-03-27 WO PCT/EP2019/057709 patent/WO2019185705A1/fr not_active Ceased
- 2019-03-27 IL IL277572A patent/IL277572B2/en unknown
- 2019-03-27 MX MX2020009857A patent/MX2020009857A/es unknown
-
2020
- 2020-09-22 MX MX2025007999A patent/MX2025007999A/es unknown
-
2024
- 2024-02-22 JP JP2024025984A patent/JP7857984B2/ja active Active
- 2024-11-05 AU AU2024259730A patent/AU2024259730A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA3093722A1 (fr) | 2019-10-03 |
| IL277572A (en) | 2020-11-30 |
| WO2019185705A1 (fr) | 2019-10-03 |
| IL308797A (en) | 2024-01-01 |
| KR20200139730A (ko) | 2020-12-14 |
| IL308797B2 (en) | 2026-05-01 |
| IL277572B2 (en) | 2024-05-01 |
| IL324874A (en) | 2026-01-01 |
| IL277572B1 (en) | 2024-01-01 |
| JP2024073467A (ja) | 2024-05-29 |
| AU2019246389A1 (en) | 2020-08-27 |
| RU2020135268A (ru) | 2022-04-28 |
| US12565525B2 (en) | 2026-03-03 |
| AU2024259730A1 (en) | 2024-12-05 |
| SG11202007524QA (en) | 2020-09-29 |
| KR102950463B1 (ko) | 2026-04-09 |
| CN119504973A (zh) | 2025-02-25 |
| JP7857984B2 (ja) | 2026-05-13 |
| EP3773680A1 (fr) | 2021-02-17 |
| AU2019246389B2 (en) | 2024-08-22 |
| CN111918665A (zh) | 2020-11-10 |
| JP7490563B2 (ja) | 2024-05-27 |
| MX2020009857A (es) | 2021-01-08 |
| JP2021519336A (ja) | 2021-08-10 |
| BR112020019639A2 (pt) | 2021-01-05 |
| MX2025007999A (es) | 2025-08-01 |
| KR20250130705A (ko) | 2025-09-02 |
| US20210024602A1 (en) | 2021-01-28 |
| CN111918665B (zh) | 2024-11-26 |
| IL308797B1 (en) | 2026-01-01 |
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