MA52712A - Anticorps anti-(poly-ga) dirigé contre des répétitions dipeptidiques (dpr) d'origine humaine - Google Patents
Anticorps anti-(poly-ga) dirigé contre des répétitions dipeptidiques (dpr) d'origine humaineInfo
- Publication number
- MA52712A MA52712A MA052712A MA52712A MA52712A MA 52712 A MA52712 A MA 52712A MA 052712 A MA052712 A MA 052712A MA 52712 A MA52712 A MA 52712A MA 52712 A MA52712 A MA 52712A
- Authority
- MA
- Morocco
- Prior art keywords
- dipeptidic
- dpr
- repetitions
- poly
- directed against
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Neurology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Optics & Photonics (AREA)
- Food Science & Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18169888 | 2018-04-27 | ||
| US201862772809P | 2018-11-29 | 2018-11-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA52712A true MA52712A (fr) | 2021-03-31 |
Family
ID=68293585
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA052712A MA52712A (fr) | 2018-04-27 | 2019-04-25 | Anticorps anti-(poly-ga) dirigé contre des répétitions dipeptidiques (dpr) d'origine humaine |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US12162952B2 (fr) |
| EP (1) | EP3797114A4 (fr) |
| JP (1) | JP2021521896A (fr) |
| KR (1) | KR20210018807A (fr) |
| CN (1) | CN112638932A (fr) |
| AU (1) | AU2019261450B2 (fr) |
| BR (1) | BR112020021855A2 (fr) |
| CA (1) | CA3097872A1 (fr) |
| CO (1) | CO2020014663A2 (fr) |
| MA (1) | MA52712A (fr) |
| MX (1) | MX2020011312A (fr) |
| TW (1) | TWI842708B (fr) |
| UY (1) | UY38203A (fr) |
| WO (1) | WO2019210054A1 (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113365640A (zh) | 2018-12-06 | 2021-09-07 | 比奥根Ma公司 | 引导肌萎缩侧索硬化症的治疗性干预的神经丝蛋白 |
| US20230218730A1 (en) * | 2019-09-23 | 2023-07-13 | University Of Florida Research Foundation, Incorporated | Vaccine therapy for ran protein diseases |
| WO2023077153A1 (fr) * | 2021-11-01 | 2023-05-04 | University Of Florida Research Foundation, Incorporated | Protéines de poly-ga dans la maladie d'alzheimer |
| CA3239708A1 (fr) | 2021-12-03 | 2023-06-08 | Aubin MICHALON | Nouveau dosage de puissance pour des medicaments a base d'anticorps et moyens utiles associes |
| AU2023294616A1 (en) * | 2022-06-13 | 2025-01-09 | Yeefan Med Inc | Methods for detecting b-isox precipitates or captured proteins as biofluid biomarkers |
| CN115819513B (zh) * | 2022-07-25 | 2023-10-17 | 东北农业大学 | 一种月桂酸修饰抗酶解肽及其制备方法和应用 |
| CN115819543B (zh) * | 2022-11-29 | 2023-07-21 | 华南师范大学 | 转录因子Tbx20启动子区G4调控元件在害虫防治中的应用 |
| CN120535617B (zh) * | 2025-04-28 | 2026-02-03 | 首都医科大学附属北京佑安医院 | 抗新型冠状病毒SARS-CoV-2和变异株的中和抗体GR58及其应用 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU584417B2 (en) | 1985-04-01 | 1989-05-25 | Lonza Group Ag | Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same |
| GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
| GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
| IE922437A1 (en) | 1991-07-25 | 1993-01-27 | Idec Pharma Corp | Recombinant antibodies for human therapy |
| US5837821A (en) | 1992-11-04 | 1998-11-17 | City Of Hope | Antibody construct |
| DE69332859T2 (de) | 1992-11-13 | 2003-12-18 | Idec Pharmaceuticals Corp., San Diego | Konsensus-kozak-sequenzen zur säugetier-exprimierung |
| US5736137A (en) | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
| GB9524973D0 (en) | 1995-12-06 | 1996-02-07 | Lynxvale Ltd | Viral vectors |
| CN1175111C (zh) | 1997-03-14 | 2004-11-10 | 艾德药品公司 | 将基因整合至哺乳动物细胞特定位点的方法及所用载体 |
| AU1631700A (en) | 1998-11-23 | 2000-06-13 | Idec Pharmaceuticals Corporation | Tumor antigen-specific antibody-gp39 chimeric protein constructs |
| US20040110938A1 (en) | 2000-02-24 | 2004-06-10 | Parekh Rajesh Bhikhu | Proteins, genes and their use for diagnosis and treatment of schizophrenia |
| CA2436092A1 (fr) | 2001-01-29 | 2002-08-08 | Idec Pharmaceutical Corporation | Anticorps modifies et procedes d'utilisation |
| AU2002327164A1 (en) | 2001-01-29 | 2002-12-09 | Idec Pharmaceuticals Corporation | Engineered tetravalent antibodies and methods of use |
| US20030157641A1 (en) | 2001-11-16 | 2003-08-21 | Idec Pharmaceuticals Corporation | Polycistronic expression of antibodies |
| NZ545776A (en) | 2003-08-22 | 2009-05-31 | Biogen Idec Inc | Improved antibodies having altered effector function and methods for making the same |
| AU2007222798A1 (en) | 2006-03-06 | 2007-09-13 | Symphogen A/S | Recombinant polyclonal antibody for treatment of respiratory syncytial virus infections |
| GB0624500D0 (en) | 2006-12-07 | 2007-01-17 | Istituto Superiore Di Sanito | A novel passive vaccine for candida infections |
| US8709382B2 (en) | 2007-01-11 | 2014-04-29 | Immunomedics, Inc. | Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules |
| AU2008329221B2 (en) | 2007-11-26 | 2013-11-07 | Bayer Intellectual Property Gmbh | Anti-mesothelin antibodies and uses therefor |
| MX2013010011A (es) | 2011-03-01 | 2014-10-24 | Amgen Inc | Agentes de unión biespecífica. |
| WO2012143523A1 (fr) | 2011-04-20 | 2012-10-26 | Genmab A/S | Anticorps bispécifiques contre her2 |
| EA201990685A1 (ru) | 2011-05-17 | 2019-12-30 | Дзе Рокфеллер Юниверсити | Нейтрализующие вирус иммунодефицита человека антитела и способы их применения |
| CN106841594A (zh) | 2011-11-11 | 2017-06-13 | 美艾利尔圣地亚哥公司 | 检测杀白细胞的毒素(pvl)的装置和方法 |
| EP2948777B1 (fr) | 2013-01-22 | 2019-06-26 | Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. | Protéines à répétition dipeptidique en tant que cible thérapeutique dans des maladies neurodégénératives ayant une expansion de répétition hexanucléotidique |
| WO2014114303A1 (fr) * | 2013-01-22 | 2014-07-31 | Deutsches Zentrum Für Neurodegenerative Erkrankungen | Protéines à répétitions de dipeptides comme cible thérapeutique dans des maladies neurodégénératives avec expansion de répétitions hexanucléotidiques |
| WO2014116865A1 (fr) | 2013-01-24 | 2014-07-31 | Mayo Foundation For Medical Education And Research | Procédés et matériaux de détection d'une dégénérescence du lobe frontotemporal positive aux expansions de répétitions hexanucléotidiques du gène c9orf72 ou d'une sclérose latérale amyotrophique positive aux expansions de répétitions hexanucléotidiques du gène c9orf72 |
| AU2015326911C1 (en) * | 2014-09-30 | 2025-12-18 | Neurimmune Holding Ag | Human-derived anti-dipeptide repeats (DPRs) antibody |
| CA2874083C (fr) | 2014-12-05 | 2024-01-02 | Universite Laval | Polypeptides liant le tdp-43 utiles pour le traitement de maladies neurodegeneratives |
| US11518800B2 (en) | 2016-02-01 | 2022-12-06 | The Board Of Regents Of The University Of Texas System | Mutations that drive VH4 antibody autoreactivity |
| WO2018018031A1 (fr) | 2016-07-22 | 2018-01-25 | New York University | Murine spécifique et anticorps monoclonaux humanisés détectant des changements de structure secondaire associés à une pathologie dans des protéines et des peptides |
-
2019
- 2019-04-25 KR KR1020207033783A patent/KR20210018807A/ko not_active Withdrawn
- 2019-04-25 AU AU2019261450A patent/AU2019261450B2/en active Active
- 2019-04-25 JP JP2021509960A patent/JP2021521896A/ja active Pending
- 2019-04-25 CA CA3097872A patent/CA3097872A1/fr active Pending
- 2019-04-25 WO PCT/US2019/029109 patent/WO2019210054A1/fr not_active Ceased
- 2019-04-25 MX MX2020011312A patent/MX2020011312A/es unknown
- 2019-04-25 BR BR112020021855-3A patent/BR112020021855A2/pt not_active Application Discontinuation
- 2019-04-25 EP EP19793769.1A patent/EP3797114A4/fr active Pending
- 2019-04-25 CN CN201980038572.XA patent/CN112638932A/zh active Pending
- 2019-04-25 MA MA052712A patent/MA52712A/fr unknown
- 2019-04-25 US US17/050,353 patent/US12162952B2/en active Active
- 2019-04-26 UY UY0001038203A patent/UY38203A/es not_active Application Discontinuation
- 2019-04-26 TW TW108114765A patent/TWI842708B/zh active
-
2020
- 2020-11-26 CO CONC2020/0014663A patent/CO2020014663A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2019261450B2 (en) | 2024-09-19 |
| MX2020011312A (es) | 2021-03-26 |
| WO2019210054A1 (fr) | 2019-10-31 |
| CN112638932A (zh) | 2021-04-09 |
| BR112020021855A2 (pt) | 2021-02-23 |
| KR20210018807A (ko) | 2021-02-18 |
| JP2021521896A (ja) | 2021-08-30 |
| EP3797114A4 (fr) | 2022-05-11 |
| US20220153874A1 (en) | 2022-05-19 |
| AU2019261450A1 (en) | 2020-11-05 |
| TWI842708B (zh) | 2024-05-21 |
| EP3797114A1 (fr) | 2021-03-31 |
| CA3097872A1 (fr) | 2019-10-31 |
| US12162952B2 (en) | 2024-12-10 |
| TW202014438A (zh) | 2020-04-16 |
| UY38203A (es) | 2019-11-29 |
| CO2020014663A2 (es) | 2021-03-08 |
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