MA52796A - Compositions et procédés de détection d'une lésion cérébrale traumatique - Google Patents

Compositions et procédés de détection d'une lésion cérébrale traumatique

Info

Publication number
MA52796A
MA52796A MA052796A MA52796A MA52796A MA 52796 A MA52796 A MA 52796A MA 052796 A MA052796 A MA 052796A MA 52796 A MA52796 A MA 52796A MA 52796 A MA52796 A MA 52796A
Authority
MA
Morocco
Prior art keywords
compositions
detection
methods
brain injury
traumatic brain
Prior art date
Application number
MA052796A
Other languages
English (en)
Inventor
Lyndsay M Randolph
Suhail Rasool
Stella Sarraf
Original Assignee
Amydis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amydis Inc filed Critical Amydis Inc
Publication of MA52796A publication Critical patent/MA52796A/fr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/0019Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/12Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14546Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/40Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4058Detecting, measuring or recording for evaluating the nervous system for evaluating the central nervous system
    • A61B5/4064Evaluating the brain
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896Neurological disorders, e.g. Alzheimer's disease
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701Details
    • G01N2333/4709Amyloid plaque core protein
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2871Cerebrovascular disorders, e.g. stroke, cerebral infarct, cerebral haemorrhage, transient ischemic event

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Pathology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Physiology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Eye Examination Apparatus (AREA)
MA052796A 2018-05-31 2019-05-31 Compositions et procédés de détection d'une lésion cérébrale traumatique MA52796A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862678900P 2018-05-31 2018-05-31
US201862733025P 2018-09-18 2018-09-18

Publications (1)

Publication Number Publication Date
MA52796A true MA52796A (fr) 2021-04-14

Family

ID=68697319

Family Applications (1)

Application Number Title Priority Date Filing Date
MA052796A MA52796A (fr) 2018-05-31 2019-05-31 Compositions et procédés de détection d'une lésion cérébrale traumatique

Country Status (8)

Country Link
US (1) US12478693B2 (fr)
EP (1) EP3803416A4 (fr)
JP (3) JP7381500B2 (fr)
CN (2) CN112424606B9 (fr)
AU (1) AU2019279001B2 (fr)
CA (1) CA3100700A1 (fr)
MA (1) MA52796A (fr)
WO (1) WO2019232422A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2019372432B2 (en) * 2018-11-02 2025-05-29 Amydis, Inc. Phosphate compounds for detecting neurological disorders
AU2020348382A1 (en) * 2019-09-18 2022-04-28 Amydis, Inc. Methods of detecting neurological disorders via binding to phosphorylated tau protein
JP2024525693A (ja) * 2021-07-15 2024-07-12 アミディス, インコーポレイテッド 神経変性障害の診断のためにアミロイドおよびアミロイド様タンパク質を検出するためのフルオロフォアとしてのn-ヘテロシクリル置換2-シアノ-3-(ナフタレン-2-イル)アクリルアミド誘導体
WO2024155678A1 (fr) * 2023-01-18 2024-07-25 Amydis, Inc. Agents de ciblage d'amyloïde

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5043013A (en) 1987-12-30 1991-08-27 Milliken Research Corporation Washable ink compositions
US5177064A (en) 1990-07-13 1993-01-05 University Of Florida Targeted drug delivery via phosphonate derivatives
US6541454B1 (en) 1995-04-04 2003-04-01 Yissum Research Development Company Of The Hebrew University Jerusalem Phosphonates, biphosphonates and pharmaceutical compositions containing them
US6048662A (en) 1998-12-15 2000-04-11 Bruhnke; John D. Antireflective coatings comprising poly(oxyalkylene) colorants
DE10047237A1 (de) 2000-09-23 2002-04-11 Physoptics Opto Electronic Gmb System zur Aufnahme des Netzhautreflexbildes
JPWO2003020690A1 (ja) 2001-08-29 2004-12-16 協和醗酵工業株式会社 アリールスルファマート誘導体
JP2007504283A (ja) 2003-05-20 2007-03-01 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア β−アミロイド斑に作用物質を結合させる方法
CN101103018A (zh) * 2004-11-16 2008-01-09 神经化学(国际)有限公司 治疗cns和淀粉样蛋白-相关疾病的化合物
ATE525664T1 (de) 2004-11-22 2011-10-15 Abbott Medical Optics Inc Copolymerisierbare methin- und anthrachinon- verbindungen und artikel damit
JP2009184924A (ja) 2006-05-31 2009-08-20 Eisai R & D Management Co Ltd 生物学的試薬用化合物
JP2008013446A (ja) 2006-07-03 2008-01-24 Neugen Pharma:Kk 酸化ストレスによる細胞変性を分子背景とする難治性疾患の治療または予防剤
EP2046322A4 (fr) 2006-08-02 2010-10-06 Univ Temple Aryl vinyl sulfures, sulfones, sulfoxides et sulfonamides, dérivés de ceux-ci et utilisations thérapeutiques de ceux-ci
WO2009086303A2 (fr) 2007-12-21 2009-07-09 University Of Rochester Procédé permettant de modifier la durée de vie d'organismes eucaryotes
EP3231804B1 (fr) 2008-03-21 2021-03-03 The General Hospital Corporation Composés et compositions pour la détection et le traitement de la maladie d'alzheimer et des troubles apparentés
JP5771525B2 (ja) 2008-09-18 2015-09-02 セダーズ−シナイ メディカル センター アルツハイマー病を検出するための光学的方法
US20120282169A1 (en) 2009-11-06 2012-11-08 Adlyfe, Inc. Detection and treatment of traumatic brain injury
SI2509940T1 (sl) 2009-12-10 2015-09-30 The Regents Of The University Of California Sredstva za vezavo amiloida
CN102115429B (zh) 2010-01-06 2013-02-27 中国科学院上海药物研究所 (e)-1-(3,5-二甲氧基苯基)-2-(3,5-二羟基-4-甲氧基苯基)乙烯及其制备方法和用途
KR101194337B1 (ko) 2010-07-14 2012-10-24 웅진코웨이주식회사 레티노이드 유도체 및 그를 포함하는 화장료 조성물
CA2807683C (fr) 2010-08-16 2020-02-18 Cognoptix, Inc. Systeme et procede pour la detection de proteines amyloides
CA2814198A1 (fr) 2010-10-25 2012-05-10 Steven Verdooner Appareil et procede de detection d'amyloide dans une retine dans un diagnostic, un avancement et un pronostic de la maladie d'alzheimer, d'une lesion cerebrale traumatique, d'une degenerescence maculaire et d'une pluralite de maladies neurodegeneratives, et de maladies oculaires
RU2627694C2 (ru) 2010-10-29 2017-08-10 Клино Лтд. Производные хинолина, визуализирующий белок тау
US9588129B2 (en) 2013-03-15 2017-03-07 Amira Medical Technologies Inc. Methods for analyzing blood to detect diseases associated with abnormal protein aggregation
EP3068388A4 (fr) 2013-11-11 2017-04-12 Board of Regents of the University of Texas System Composés neuroprotecteurs et leur utilisation
EP3068283A1 (fr) 2013-11-12 2016-09-21 Cognoptix, Inc. Procédé de mesure de fluorescence dans le tissu oculaire
AU2015231239B2 (en) 2014-03-19 2018-11-29 Amydis, Inc. Amyloid targeting agents and methods of using the same
US9605315B2 (en) * 2014-03-26 2017-03-28 The University Of Montana Detection of traumatic brain injury
WO2015188142A1 (fr) 2014-06-05 2015-12-10 Cedars-Sinai Medical Center Diagnostic et surveillance d'une lésion cérébrale traumatique par imagerie des anomalies rétiniennes
WO2016040891A2 (fr) 2014-09-12 2016-03-17 Amydis Diagnostics Compositions in vitro comprenant un échantillon humain et un agent ciblant les substances amyloïdes
WO2016055148A2 (fr) 2014-10-06 2016-04-14 Université De Genève Marqueurs et leur utilisation en lien avec une lésion cérébrale
WO2017004560A1 (fr) * 2015-07-02 2017-01-05 The Regents Of The University Of California Procédés et compositions pour des agrégats amyloïdes
GB201603967D0 (en) 2016-03-08 2016-04-20 Univ Birmingham Biomarkers of traumatic brain injury
JP7029718B2 (ja) 2017-07-31 2022-03-04 国立研究開発法人量子科学技術研究開発機構 リン酸化タウタンパク質の測定方法
AU2019372432B2 (en) * 2018-11-02 2025-05-29 Amydis, Inc. Phosphate compounds for detecting neurological disorders
AU2020348382A1 (en) 2019-09-18 2022-04-28 Amydis, Inc. Methods of detecting neurological disorders via binding to phosphorylated tau protein
IL305647A (en) 2021-03-12 2023-11-01 Amydis Inc Methods for the detection of systemic amyloidosis by binding to misfolded protein or aggregates
JP2024525693A (ja) 2021-07-15 2024-07-12 アミディス, インコーポレイテッド 神経変性障害の診断のためにアミロイドおよびアミロイド様タンパク質を検出するためのフルオロフォアとしてのn-ヘテロシクリル置換2-シアノ-3-(ナフタレン-2-イル)アクリルアミド誘導体
WO2024155678A1 (fr) 2023-01-18 2024-07-25 Amydis, Inc. Agents de ciblage d'amyloïde

Also Published As

Publication number Publication date
US20210369873A1 (en) 2021-12-02
CN112424606B9 (zh) 2025-03-07
JP2025016675A (ja) 2025-02-04
EP3803416A4 (fr) 2022-05-18
JP2021525875A (ja) 2021-09-27
JP7381500B2 (ja) 2023-11-15
AU2019279001B2 (en) 2025-11-27
JP2024028695A (ja) 2024-03-05
CA3100700A1 (fr) 2019-12-05
CN112424606A (zh) 2021-02-26
US12478693B2 (en) 2025-11-25
WO2019232422A1 (fr) 2019-12-05
CN112424606B (zh) 2025-01-14
EP3803416A1 (fr) 2021-04-14
JP7583895B2 (ja) 2024-11-14
CN119985995A (zh) 2025-05-13
AU2019279001A1 (en) 2020-12-03

Similar Documents

Publication Publication Date Title
EP3704239A4 (fr) Compositions de casz et procédés d'utilisation
EP3630072A4 (fr) Procédés et compositions pour le traitement d'une somnolence excessive
MA43822A (fr) Compositions et procédés de synthèse de phosphoramidite et d'oligonucléotides
MA46905A (fr) Compositions et procédés de synthèse de phosphoramidites et d'oligonucléotides
EP3377042A4 (fr) Substances et procédés de traitement de myopathies à base de titine et d'autres titinopathies
MA45270A (fr) Compositions d'oligonucléotides et procédés associés
EP3474879A4 (fr) Compositions et procédés de traitement d'un mélanome
EP3510171A4 (fr) Compositions et procédés pour la détection de mutations d'acides nucléiques
MA46427A (fr) Compositions d'oligonucléotides et procédés associés
MA44990A (fr) Polythérapies d'inhibiteurs de hdac et d'inhibiteurs de pd-l1
MA45688A (fr) Compositions et procédés de potentialisation d'agents antimicrobiens
EP3350315A4 (fr) Procédés pour l'édition autocatalytique de génome et la neutralisation de l'édition autocatalytique de génome et leurs compositions
EP3320093A4 (fr) Compositions et procédés d'identification, d'évaluation, de prévention et de traitement du cancer à l'aide d'isoformes de slncr
EP3289064A4 (fr) Compositions et procédés pour la détection d'allergènes
EP3512351A4 (fr) Compositions et procédés d'amélioration de goût d'édulcorants non nutritifs
EP3836926A4 (fr) Procédés d'administration de certains inhibiteurs de vmat2
EP3448421A4 (fr) Procédés et compositions pour la prévention et le traitement d'adhérences chirurgicales
MA52796A (fr) Compositions et procédés de détection d'une lésion cérébrale traumatique
MA53445A (fr) Procédés et compositions pour la modification de plantes
EP3390642A4 (fr) Compositions et procédés pour le traitement de rétinite pigmentaire 18 et de rétinite pigmentaire 13
EP3833340A4 (fr) Compositions et procédés de traitement de la presbytie
EP3803403A4 (fr) Compositions et procédés d'imagerie
EP3810109A4 (fr) Compositions et procédés d'inhibition de cd73
EP3426391A4 (fr) Compositions et procédés d'acylation de lactames
EP3873525A4 (fr) Compositions et procédés de traitement d'une lésion cérébrale