MA53126A - Agents de dégradation sélectifs du récepteur des oestrogènes - Google Patents

Agents de dégradation sélectifs du récepteur des oestrogènes

Info

Publication number
MA53126A
MA53126A MA053126A MA53126A MA53126A MA 53126 A MA53126 A MA 53126A MA 053126 A MA053126 A MA 053126A MA 53126 A MA53126 A MA 53126A MA 53126 A MA53126 A MA 53126A
Authority
MA
Morocco
Prior art keywords
estrogen receptor
selective estrogen
degradation agents
receptor degradation
agents
Prior art date
Application number
MA053126A
Other languages
English (en)
Other versions
MA53126B1 (fr
Inventor
Jeffrey Daniel Cohen
Daniel Jon Sall
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=67470734&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA53126(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Priority claimed from PCT/US2019/041342 external-priority patent/WO2020014440A1/fr
Publication of MA53126A publication Critical patent/MA53126A/fr
Publication of MA53126B1 publication Critical patent/MA53126B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Finger-Pressure Massage (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
MA53126A 2018-07-12 2019-07-11 Agents de dégradation sélectifs du récepteur des oestrogènes MA53126B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862697100P 2018-07-12 2018-07-12
PCT/US2019/041342 WO2020014440A1 (fr) 2018-07-12 2019-07-11 Agents de dégradation sélectifs du récepteur des oestrogènes

Publications (2)

Publication Number Publication Date
MA53126A true MA53126A (fr) 2021-05-19
MA53126B1 MA53126B1 (fr) 2023-02-28

Family

ID=67470734

Family Applications (2)

Application Number Title Priority Date Filing Date
MA53126A MA53126B1 (fr) 2018-07-12 2019-07-11 Agents de dégradation sélectifs du récepteur des oestrogènes
MA53124A MA53124B1 (fr) 2018-07-12 2019-07-11 Agents de dégradation sélectifs des récepteurs des oestrogènes

Family Applications After (1)

Application Number Title Priority Date Filing Date
MA53124A MA53124B1 (fr) 2018-07-12 2019-07-11 Agents de dégradation sélectifs des récepteurs des oestrogènes

Country Status (37)

Country Link
US (4) US10654866B2 (fr)
EP (2) EP4155310A1 (fr)
JP (6) JP6995241B2 (fr)
KR (3) KR102550538B1 (fr)
CN (2) CN112638916B (fr)
AR (3) AR115694A1 (fr)
AU (2) AU2019299947B2 (fr)
BR (1) BR122023025061A2 (fr)
CA (1) CA3105501C (fr)
CL (1) CL2021000045A1 (fr)
CO (1) CO2021000043A2 (fr)
CR (1) CR20210007A (fr)
DK (1) DK3820873T3 (fr)
EA (1) EA202092975A1 (fr)
EC (1) ECSP21001770A (fr)
ES (1) ES2933980T3 (fr)
FI (2) FI3820873T3 (fr)
HR (1) HRP20230009T1 (fr)
HU (1) HUE060963T2 (fr)
IL (3) IL289871B2 (fr)
JO (1) JOP20210005B1 (fr)
LT (1) LT3820873T (fr)
MA (2) MA53126B1 (fr)
MD (1) MD3820873T2 (fr)
MX (2) MX2021000375A (fr)
MY (1) MY198962A (fr)
PE (1) PE20210400A1 (fr)
PH (1) PH12021550049A1 (fr)
PL (1) PL3820873T3 (fr)
PT (1) PT3820873T (fr)
RS (1) RS63809B1 (fr)
SA (1) SA521421008B1 (fr)
SG (1) SG11202100148TA (fr)
SI (1) SI3820873T1 (fr)
TW (1) TWI702219B (fr)
UA (1) UA127507C2 (fr)
WO (1) WO2020014435A1 (fr)

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KR20240142622A (ko) 2015-10-01 2024-09-30 올레마 파마슈티컬스 인코포레이티드 테트라히드로-1H-피리도[3,4-b]인돌 항에스트로겐 약물
CN112424205B (zh) * 2018-07-12 2023-10-31 伊莱利利公司 选择性的雌激素受体降解剂
TWI702219B (zh) * 2018-07-12 2020-08-21 美商美國禮來大藥廠 選擇性雌激素受體降解劑
KR20220034129A (ko) 2019-07-07 2022-03-17 올레마 파마슈티컬스 인코포레이티드 에스트로겐 수용체 길항제 요법
EP4037768B1 (fr) 2019-10-01 2023-10-11 Sanofi Nouveaux composés 6,7-dihydro-5h-benzo[7]annulène, leurs procédés de préparation et leurs utilisations thérapeutiques
AU2020399168A1 (en) 2019-12-09 2022-07-28 Sanofi Crystalline form of a 7H-benzo[7]annulene-2-carboxylic acid derivative
TW202146007A (zh) 2020-02-27 2021-12-16 法商賽諾菲公司 包含阿培利司（ａｌｐｅｌｉｓｉｂ）與６－（２，４－二氯苯基）－５－［４－［（３ｓ）－１－（３－氟丙基）吡咯啶－３－基］氧苯基］－８，９－二氫－７ｈ－苯并［７］輪烯－２－羧酸之組合
TW202233572A (zh) 2020-10-19 2022-09-01 法商賽諾菲公司 新穎之經取代的6,7-二氫-5h-苯並[7]輪烯衍生物，其製備方法及其治療用途
WO2022084280A1 (fr) 2020-10-19 2022-04-28 Sanofi Composés 6,7-dihydro-5h-benzo[7]annulène substitués et leurs dérivés, processus permettant leur préparation et utilisations thérapeutiques associées
WO2022106711A1 (fr) * 2020-11-23 2022-05-27 Sanofi Combinaison comprenant de l'abémaciclib et de l'acide 6-(2,4-dichlorophényl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphényl]-8,9-dihydro-7h-benzo[7]annulène-2-carboxylique
AU2022222660A1 (en) * 2021-02-16 2023-07-27 Genentech, Inc. Treatment of breast cancer using combination therapies comprising gdc-9545 and abemaciclib or ribociclib
CN114957114A (zh) * 2021-02-26 2022-08-30 冷志 一种4-溴-3-氯-7-甲氧基喹啉的合成方法
CN117042771A (zh) * 2021-03-09 2023-11-10 伊莱利利公司 使用serd给药方案的组合治疗癌症的方法
TWI837605B (zh) 2021-03-09 2024-04-01 美商美國禮來大藥廠 使用serd組合給藥方案治療癌症之方法
TWI894443B (zh) * 2021-03-16 2025-08-21 美商美國禮來大藥廠 選擇性雌激素受體降解劑
CA3243621A1 (fr) * 2022-02-01 2023-08-10 Eli Lilly And Company Procédés de préparation d'agents de dégradation sélectifs du récepteur des œstrogènes
US20240199629A1 (en) * 2022-02-01 2024-06-20 Eli Lilly And Company Processes for the preparation of selective estrogen receptor degraders
IL320302A (en) 2022-10-17 2025-06-01 Astrazeneca Ab SERD combinations for cancer treatment
CN120456897A (zh) 2022-11-02 2025-08-08 佩特拉制药公司 用于治疗疾病的磷酸肌醇3-激酶(pi3k)变构色原酮抑制剂
WO2024100236A1 (fr) 2022-11-11 2024-05-16 Astrazeneca Ab Polythérapies pour le traitement du cancer
US20240180893A1 (en) 2022-11-17 2024-06-06 Astrazeneca Ab Methods of treatment of breast cancer
KR20260005985A (ko) 2023-05-05 2026-01-12 일라이 릴리 앤드 캄파니 Er+ 유방암을 갖는 대상체에서 중추 신경계 (cns) 전이를 치료 및 예방하는 데 사용하기 위한 임루네스트란트 또는 그의 염
TW202508573A (zh) 2023-05-11 2025-03-01 瑞典商阿斯特捷利康公司 用於治療癌症之組合療法

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US6756388B1 (en) * 1993-10-12 2004-06-29 Pfizer Inc. Benzothiophenes and related compounds as estrogen agonists
EP1395563B1 (fr) * 2001-05-22 2006-03-29 Eli Lilly And Company 1,2,3,4-tetrahydroquinoline 2-substituees et leurs derives, ainsi que leurs composition et leurs procedes
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KR100849559B1 (ko) 2004-01-22 2008-07-31 일라이 릴리 앤드 캄파니 혈관운동 증상의 치료를 위한 선택적 에스트로겐 수용체조절제
US20080221163A1 (en) * 2005-01-18 2008-09-11 Jeffrey Alan Dodge Selective Estrogen Receptor Modulators
AR088082A1 (es) * 2011-10-13 2014-05-07 Lilly Co Eli Moduladores selectivos del receptor androgeno
CA2915534A1 (fr) 2013-06-19 2014-12-24 Seragon Pharmaceuticals, Inc. Modulateurs azetidine des recepteurs d'oestrogenes et leurs utilisations
WO2016097071A1 (fr) 2014-12-18 2016-06-23 F. Hoffmann-La Roche Ag Modulateurs du récepteur des œstrogènes et leurs utilisations
TWI874834B (zh) * 2014-12-18 2025-03-01 瑞士商赫孚孟拉羅股份公司 四氫-吡啶并[3,4-b]吲哚雌激素受體調節劑及其用途
WO2017127442A1 (fr) * 2016-01-18 2017-07-27 The Regents Of The University Of California Méthodes de traitement du cancer à l'aide d'inhibiteurs ror gamma
WO2017182493A1 (fr) * 2016-04-20 2017-10-26 Astrazeneca Ab Dérivés d'indazole destinés à être utilisés dans la régulation négative du récepteur d'œstrogène pour le traitement du cancer
WO2018108954A1 (fr) 2016-12-12 2018-06-21 F. Hoffmann-La Roche Ag Procédé de préparation de 2-(3-(fluorométhyl)azétidin-1-yl)éthan-1-ol
CN112424205B (zh) * 2018-07-12 2023-10-31 伊莱利利公司 选择性的雌激素受体降解剂
TWI702219B (zh) * 2018-07-12 2020-08-21 美商美國禮來大藥廠 選擇性雌激素受體降解劑

Also Published As

Publication number Publication date
JP2023081954A (ja) 2023-06-13
US20200347073A1 (en) 2020-11-05
CN112638916B (zh) 2023-09-12
PE20210400A1 (es) 2021-03-02
MA53126B1 (fr) 2023-02-28
JP2024169490A (ja) 2024-12-05
BR112020025654A2 (pt) 2021-04-06
US20210403480A1 (en) 2021-12-30
MX2021000375A (es) 2021-05-27
JP7009672B1 (ja) 2022-01-25
KR102589886B1 (ko) 2023-10-17
PL3820873T3 (pl) 2023-02-13
WO2020014435A1 (fr) 2020-01-16
RS63809B1 (sr) 2023-01-31
CL2021000045A1 (es) 2021-07-19
IL289871A (en) 2022-03-01
SI3820873T1 (sl) 2023-02-28
HRP20230009T1 (hr) 2023-02-17
JP2021530484A (ja) 2021-11-11
PH12021550049A1 (en) 2021-09-20
IL295598A (en) 2022-10-01
CA3105501A1 (fr) 2020-01-16
KR20230148386A (ko) 2023-10-24
AR115694A1 (es) 2021-02-17
JP7557564B2 (ja) 2024-09-27
CN117379428A (zh) 2024-01-12
EP3820873B1 (fr) 2022-11-23
EA202092975A1 (ru) 2021-04-14
EP3820873A1 (fr) 2021-05-19
JP2022037102A (ja) 2022-03-08
KR20210019065A (ko) 2021-02-19
AU2019299947B2 (en) 2022-03-17
JOP20210005A1 (ar) 2021-01-10
FIC20260010I1 (fi) 2026-04-07
LT3820873T (lt) 2023-01-10
US10654866B2 (en) 2020-05-19
PT3820873T (pt) 2022-12-23
BR122023025061A2 (pt) 2024-02-20
CR20210007A (es) 2021-02-08
IL295598B1 (en) 2023-05-01
AR134487A2 (es) 2026-01-21
MY198962A (en) 2023-10-05
TWI702219B (zh) 2020-08-21
MA53124A (fr) 2021-05-19
CO2021000043A2 (es) 2021-01-18
NZ771718A (en) 2024-05-31
US11634426B2 (en) 2023-04-25
JP7241211B2 (ja) 2023-03-16
US11117902B2 (en) 2021-09-14
IL289871B (en) 2022-10-01
JP7746496B2 (ja) 2025-09-30
IL280065B (en) 2022-04-01
IL295598B2 (en) 2023-09-01
FI3820873T3 (fi) 2023-03-02
JP2025186400A (ja) 2025-12-23
IL280065A (en) 2021-03-01
AU2019299947A1 (en) 2021-01-07
ECSP21001770A (es) 2021-02-26
EP4155310A1 (fr) 2023-03-29
CN112638916A (zh) 2021-04-09
ES2933980T3 (es) 2023-02-15
IL289871B2 (en) 2023-02-01
SG11202100148TA (en) 2021-02-25
AU2022203969B2 (en) 2024-02-15
AU2022203969A1 (en) 2022-06-30
JOP20210005B1 (ar) 2023-03-28
KR20230005404A (ko) 2023-01-09
KR102783756B1 (ko) 2025-03-21
US20200017516A1 (en) 2020-01-16
MD3820873T2 (ro) 2023-05-31
KR102550538B1 (ko) 2023-07-04
HUE060963T2 (hu) 2023-04-28
CA3105501C (fr) 2023-10-31
MX2023006047A (es) 2023-06-02
US11993608B2 (en) 2024-05-28
SA521421008B1 (ar) 2022-10-30
TW202019935A (zh) 2020-06-01
UA127507C2 (uk) 2023-09-13
MA53124B1 (fr) 2023-02-28
DK3820873T3 (da) 2022-12-12
JP6995241B2 (ja) 2022-01-14
JP2022050591A (ja) 2022-03-30
US20230234960A1 (en) 2023-07-27
AR134662A2 (es) 2026-03-04

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