MA53226A - Sel et formes cristallines d'omecamtiv mecarbil - Google Patents

Sel et formes cristallines d'omecamtiv mecarbil

Info

Publication number
MA53226A
MA53226A MA053226A MA53226A MA53226A MA 53226 A MA53226 A MA 53226A MA 053226 A MA053226 A MA 053226A MA 53226 A MA53226 A MA 53226A MA 53226 A MA53226 A MA 53226A
Authority
MA
Morocco
Prior art keywords
salt
crystalline forms
omecamtiv mecarbil
mecarbil
omecamtiv
Prior art date
Application number
MA053226A
Other languages
English (en)
Inventor
Sebastien Caille
Sheng Cui
Alex Eberlin
Ailsa Golightly
Ron C Kelly
Bradley MORGAN
Henry Morrison
Alexander Oblezov
David Pearson
Matthew Peterson
Bin Peter Quan
Kyle Quasdorf
Jaclyn Raeburn
Lingyun Xiao
Evelyn Yanez
Original Assignee
Amgen Inc
Cytokinetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc, Cytokinetics Inc filed Critical Amgen Inc
Publication of MA53226A publication Critical patent/MA53226A/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • C07D213/75Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01Sulfonic acids
    • C07C309/02Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01Sulfonic acids
    • C07C309/02Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/07Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton
    • C07C309/08Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton containing hydroxy groups bound to the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01Sulfonic acids
    • C07C309/28Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/33Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of six-membered aromatic rings being part of condensed ring systems
    • C07C309/34Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of six-membered aromatic rings being part of condensed ring systems formed by two rings
    • C07C309/35Naphthalene sulfonic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02Dicarboxylic acids
    • C07C55/06Oxalic acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02Dicarboxylic acids
    • C07C55/08Malonic acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13Dicarboxylic acids
    • C07C57/145Maleic acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13Dicarboxylic acids
    • C07C57/15Fumaric acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235Saturated compounds containing more than one carboxyl group
    • C07C59/245Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/255Tartaric acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/03Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
    • C07C65/05Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring o-Hydroxy carboxylic acids
    • C07C65/10Salicylic acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)
MA053226A 2018-08-17 2019-08-16 Sel et formes cristallines d'omecamtiv mecarbil MA53226A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862765090P 2018-08-17 2018-08-17

Publications (1)

Publication Number Publication Date
MA53226A true MA53226A (fr) 2021-11-24

Family

ID=67809688

Family Applications (1)

Application Number Title Priority Date Filing Date
MA053226A MA53226A (fr) 2018-08-17 2019-08-16 Sel et formes cristallines d'omecamtiv mecarbil

Country Status (8)

Country Link
US (3) US11465969B2 (fr)
EP (1) EP3837009A1 (fr)
JP (3) JP2021534138A (fr)
AU (2) AU2019321573B2 (fr)
CA (1) CA3108800A1 (fr)
MA (1) MA53226A (fr)
MX (2) MX2021001792A (fr)
WO (1) WO2020037164A1 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA06014495A (es) 2004-06-17 2007-03-01 Cytokinetics Inc Compuestos, composiciones y metodos.
KR102474467B1 (ko) 2013-03-14 2022-12-05 암젠 인크 복소환식 화합물 및 그들의 용도
WO2019006235A1 (fr) 2017-06-30 2019-01-03 Amgen Inc. Procédés de traitement d'une insuffisance cardiaque avec des activateurs de sarcomères cardiaques
TWI769272B (zh) 2017-06-30 2022-07-01 美商安進公司 奧美卡替莫卡必爾的合成
EA202090688A1 (ru) 2017-09-13 2020-07-06 Эмджен Инк. Бис-амидные соединения, активирующие саркомер, и варианты их применения
EP3594199B1 (fr) 2018-07-09 2020-07-01 F.I.S.- Fabbrica Italiana Sintetici S.p.A. 2-fluoro-3-nitrotoluène cristallin et son procédé de préparation
JP2021534138A (ja) * 2018-08-17 2021-12-09 アムジエン・インコーポレーテツド オメカムチブメカルビルの塩及び結晶形態
WO2020131574A1 (fr) 2018-12-18 2020-06-25 Amgen Inc. Procédé de réduction de composés nitro aromatiques
EP4031541A1 (fr) * 2019-09-19 2022-07-27 Synthon B.V. Sels d'omecamtiv mecarbil et formes solides de ceux-ci
US20220348543A1 (en) * 2019-09-19 2022-11-03 Synthon B.V. Salts of omecamtiv mecarbil and solid forms thereof
EP4041198A4 (fr) * 2019-10-09 2023-08-16 Dr. Reddy's Laboratories Limited Formes solides de dichlorhydrate d'omecamtiv mecarbil et procédés associés
SI4243825T1 (sl) 2020-11-12 2026-01-30 Amgen Inc. Omekamtiv mekarbil za zdravljenje srčnega popuščanja pri izbranih skupinah bolnikov
WO2022177927A1 (fr) 2021-02-16 2022-08-25 Assia Chemical Industries Ltd Forme cristalline non hydratée de sel de dihydrobromure d'omecamtiv mecarbil
US11702380B2 (en) 2021-03-10 2023-07-18 Amgen Inc. Synthesis of omecamtiv mecarbil
US11986474B1 (en) 2023-06-27 2024-05-21 Cytokinetics, Incorporated Methods for treating heart failure by administering cardiac sarcomere activators

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
MXPA06014495A (es) 2004-06-17 2007-03-01 Cytokinetics Inc Compuestos, composiciones y metodos.
TW200808321A (en) 2005-12-15 2008-02-16 Cytokinetics Inc Certain chemical entities, compositions and methods
US20090192168A1 (en) * 2008-01-04 2009-07-30 Alex Muci Compounds, Compositions and Methods
CA2902424A1 (fr) 2013-03-14 2014-09-25 Amgen Inc. Composes heterocycliques et leurs utilisations
KR102474467B1 (ko) 2013-03-14 2022-12-05 암젠 인크 복소환식 화합물 및 그들의 용도
US20180022710A1 (en) 2015-01-29 2018-01-25 Signal Pharmaceuticals, Llc Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide
US10543215B2 (en) 2015-06-26 2020-01-28 Amgen Inc. Combination therapy of cardiac myosin activator and sinus node if current inhibitor
TWI769272B (zh) 2017-06-30 2022-07-01 美商安進公司 奧美卡替莫卡必爾的合成
WO2019006235A1 (fr) 2017-06-30 2019-01-03 Amgen Inc. Procédés de traitement d'une insuffisance cardiaque avec des activateurs de sarcomères cardiaques
EP3594199B1 (fr) 2018-07-09 2020-07-01 F.I.S.- Fabbrica Italiana Sintetici S.p.A. 2-fluoro-3-nitrotoluène cristallin et son procédé de préparation
WO2020014406A1 (fr) 2018-07-12 2020-01-16 Assia Chemical Industries Ltd. Formes à l'état solide d'omecamtiv mecarbil et d'omecamtiv mecarbil dihcl
JP2021534138A (ja) * 2018-08-17 2021-12-09 アムジエン・インコーポレーテツド オメカムチブメカルビルの塩及び結晶形態
WO2020131574A1 (fr) 2018-12-18 2020-06-25 Amgen Inc. Procédé de réduction de composés nitro aromatiques
EP4031541A1 (fr) 2019-09-19 2022-07-27 Synthon B.V. Sels d'omecamtiv mecarbil et formes solides de ceux-ci
US20220348543A1 (en) 2019-09-19 2022-11-03 Synthon B.V. Salts of omecamtiv mecarbil and solid forms thereof
EP4041198A4 (fr) 2019-10-09 2023-08-16 Dr. Reddy's Laboratories Limited Formes solides de dichlorhydrate d'omecamtiv mecarbil et procédés associés
EP4041710A1 (fr) 2019-10-09 2022-08-17 Dr. Reddy's Laboratories Limited Nouveaux procédés destinés à la préparation de l'omécamtiv mécarbil
WO2021136477A1 (fr) 2020-01-03 2021-07-08 苏州科睿思制药有限公司 Co-cristal de dichlorhydrate du composé i et son procédé de préparation et son utilisation
WO2021163172A1 (fr) 2020-02-10 2021-08-19 Amgen Inc. Comprimé d'omecamtiv mecarbil
SI4243825T1 (sl) 2020-11-12 2026-01-30 Amgen Inc. Omekamtiv mekarbil za zdravljenje srčnega popuščanja pri izbranih skupinah bolnikov
US11702380B2 (en) 2021-03-10 2023-07-18 Amgen Inc. Synthesis of omecamtiv mecarbil

Also Published As

Publication number Publication date
EP3837009A1 (fr) 2021-06-23
AU2019321573B2 (en) 2025-05-29
US20210221771A1 (en) 2021-07-22
US11465969B2 (en) 2022-10-11
AU2025204014A1 (en) 2025-06-19
AU2019321573A1 (en) 2021-03-04
MX2021001792A (es) 2021-05-27
WO2020037164A1 (fr) 2020-02-20
JP2025108571A (ja) 2025-07-23
JP2021534138A (ja) 2021-12-09
US20240199550A1 (en) 2024-06-20
JP2024123028A (ja) 2024-09-10
MX2023013372A (es) 2023-11-27
US11926592B2 (en) 2024-03-12
US20230108971A1 (en) 2023-04-06
CA3108800A1 (fr) 2020-02-20

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